MIR15A (microRNA 15a)

Gene

• Entrez ID: 406948
• Gene name: MicroRNA 15a
• Gene symbol: MIR15A
• Synonyms (NCBI Gene): MIRN15A, hsa-mir-15a, miRNA15A, mir-15a
• Chromosome: 13
• Chromosome location: 13q14.2
• Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003730	Function	MRNA 3'-UTR binding	IDA	26440600
GO:0005615	Component	Extracellular space	HDA	26646931
GO:0008285	Process	Negative regulation of cell population proliferation	IGI	22139073
GO:0016442	Component	RISC complex	IEA
GO:0016525	Process	Negative regulation of angiogenesis	IDA	23233752
GO:0016525	Process	Negative regulation of angiogenesis	IMP	23867820
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	HDA	18320040
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IDA	15131085, 16166262, 19823025, 21454377, 21532615, 22139073, 22692216, 23353574, 23487264, 23867820, 25261849, 25594541, 25743273, 26440600, 27343180
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IEA
GO:0035278	Process	MiRNA-mediated gene silencing by inhibition of translation	IDA	23233752
GO:0043065	Process	Positive regulation of apoptotic process	IDA	25261849
GO:0043124	Process	Negative regulation of canonical NF-kappaB signal transduction	IDA	23487264, 30365148
GO:0050728	Process	Negative regulation of inflammatory response	IDA	30365148
GO:0070062	Component	Extracellular exosome	IDA	23233752
GO:0071333	Process	Cellular response to glucose stimulus	IDA	30365148
GO:0090051	Process	Negative regulation of cell migration involved in sprouting angiogenesis	IDA	22692216
GO:1900119	Process	Positive regulation of execution phase of apoptosis	IDA	23353574
GO:1902430	Process	Negative regulation of amyloid-beta formation	IDA	27343180
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	HDA	18320040
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	IDA	15131085, 16166262, 19823025, 21532615, 22139073, 22692216, 23233752, 23353574, 23487264, 23867820, 25261849, 25594541, 25743273, 26440600, 27343180
GO:1903561	Component	Extracellular vesicle	HDA	28798470
GO:1903588	Process	Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IDA	22692216
GO:1904046	Process	Negative regulation of vascular endothelial growth factor production	HMP	18320040
GO:1904706	Process	Negative regulation of vascular associated smooth muscle cell proliferation	IDA	23233752
GO:1904753	Process	Negative regulation of vascular associated smooth muscle cell migration	IDA	23233752
GO:1904848	Process	Negative regulation of cell chemotaxis to fibroblast growth factor	IDA	23233752
GO:2000134	Process	Negative regulation of G1/S transition of mitotic cell cycle	IDA	21454377, 25261849
GO:2000134	Process	Negative regulation of G1/S transition of mitotic cell cycle	IMP	23867820
GO:2000353	Process	Positive regulation of endothelial cell apoptotic process	ISS
GO:2001244	Process	Positive regulation of intrinsic apoptotic signaling pathway	IGI	16166262

Other IDs

• MIM: 609703
• HGNC: 31543
• e!Ensembl: ENSG00000283785

Interactions View interactions

Pathways

KEGG:

MicroRNAs in cancer