MIR146A (microRNA 146a)

Gene

• Entrez ID: 406938
• Gene name: MicroRNA 146a
• Gene symbol: MIR146A
• Synonyms (NCBI Gene): MIRN146, MIRN146A, miR-146a, miRNA146A
• Chromosome: 5
• Chromosome location: 5q33.3
• Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001937	Process	Negative regulation of endothelial cell proliferation	IDA	23619365
GO:0003730	Function	MRNA 3'-UTR binding	IDA	21329689, 27221467, 30779466, 31926946
GO:0005615	Component	Extracellular space	HDA	18766170
GO:0005615	Component	Extracellular space	IDA	26646931
GO:0007249	Process	Canonical NF-kappaB signal transduction	IMP	20937840
GO:0010628	Process	Positive regulation of gene expression	IDA	27121396, 29384235
GO:0010629	Process	Negative regulation of gene expression	IDA	29384235
GO:0010887	Process	Negative regulation of cholesterol storage	IDA	21329689
GO:0016442	Component	RISC complex	IEA
GO:0016525	Process	Negative regulation of angiogenesis	IMP	23619365
GO:0032715	Process	Negative regulation of interleukin-6 production	IDA	21329689, 29896267
GO:0032715	Process	Negative regulation of interleukin-6 production	IDA	28433754, 29896267, 31086599
GO:0032717	Process	Negative regulation of interleukin-8 production	IDA	21329689
GO:0034121	Process	Regulation of toll-like receptor signaling pathway	IDA	16885212
GO:0034144	Process	Negative regulation of toll-like receptor 4 signaling pathway	IC	21329689
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IDA	16885212, 19333922, 20181935, 21329689, 23619365, 24863965, 25515214, 27121396, 28727754, 29896267, 31086599, 31926946
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IEA
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IMP	18801740, 20937840
GO:0035278	Process	MiRNA-mediated gene silencing by inhibition of translation	IDA	27221467, 27241555
GO:0035279	Process	MiRNA-mediated gene silencing by mRNA destabilization	IDA	30779466
GO:0043065	Process	Positive regulation of apoptotic process	IGI	27241555
GO:0043124	Process	Negative regulation of canonical NF-kappaB signal transduction	IDA	25515214
GO:0045087	Process	Innate immune response	IDA	19333922
GO:0045666	Process	Positive regulation of neuron differentiation	IC	29384235
GO:0045743	Process	Positive regulation of fibroblast growth factor receptor signaling pathway	IDA	27121396
GO:0046426	Process	Negative regulation of receptor signaling pathway via JAK-STAT	IDA	28433754
GO:0050728	Process	Negative regulation of inflammatory response	IMP	21329689
GO:0051898	Process	Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI	27241555
GO:0060253	Process	Negative regulation of glial cell proliferation	IDA	29384235
GO:0060354	Process	Negative regulation of cell adhesion molecule production	IDA	31926946
GO:0060392	Process	Negative regulation of SMAD protein signal transduction	IMP	30779466
GO:0070062	Component	Extracellular exosome	IDA	23619365, 31926946
GO:0070062	Component	Extracellular exosome	ISS
GO:0070104	Process	Negative regulation of interleukin-6-mediated signaling pathway	IMP	28433754
GO:0070498	Process	Interleukin-1-mediated signaling pathway	IMP	20937840
GO:0071222	Process	Cellular response to lipopolysaccharide	IDA	16885212
GO:0071222	Process	Cellular response to lipopolysaccharide	ISS
GO:0071333	Process	Cellular response to glucose stimulus	IDA	28433754
GO:0071345	Process	Cellular response to cytokine stimulus	IDA	25515214
GO:0071456	Process	Cellular response to hypoxia	IMP	18801740
GO:0090050	Process	Positive regulation of cell migration involved in sprouting angiogenesis	IDA	27121396
GO:0090050	Process	Positive regulation of cell migration involved in sprouting angiogenesis	IMP	24863965
GO:0090051	Process	Negative regulation of cell migration involved in sprouting angiogenesis	IMP	28727754
GO:0090051	Process	Negative regulation of cell migration involved in sprouting angiogenesis	ISS
GO:0098586	Process	Cellular response to virus	IDA	20181935
GO:0120132	Process	Positive regulation of apoptotic process in bone marrow cell	ISS
GO:0140052	Process	Cellular response to oxidised low-density lipoprotein particle stimulus	IDA	21329689
GO:1900016	Process	Negative regulation of cytokine production involved in inflammatory response	IDA	29896267
GO:1902532	Process	Negative regulation of intracellular signal transduction	IDA	21329689
GO:1902532	Process	Negative regulation of intracellular signal transduction	IDA	27221467
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	IDA	16885212, 19333922, 20181935, 21329689, 23619365, 25515214, 27121396, 27221467, 27241555, 28727754, 29896267, 30779466, 31086599, 31926946
GO:1903589	Process	Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IDA	27121396
GO:1904046	Process	Negative regulation of vascular endothelial growth factor production	IDA	28433754
GO:1904465	Process	Negative regulation of matrix metallopeptidase secretion	IDA	21329689
GO:1904646	Process	Cellular response to amyloid-beta	IMP	20937840
GO:1904707	Process	Positive regulation of vascular associated smooth muscle cell proliferation	IMP	30779466
GO:1904754	Process	Positive regulation of vascular associated smooth muscle cell migration	IMP	30779466
GO:1904995	Process	Negative regulation of leukocyte adhesion to vascular endothelial cell	IDA	25515214
GO:1905709	Process	Negative regulation of membrane permeability	IDA	31926946
GO:2000342	Process	Negative regulation of chemokine (C-X-C motif) ligand 2 production	IDA	21329689
GO:2000438	Process	Negative regulation of monocyte extravasation	IDA	31926946
GO:2000736	Process	Regulation of stem cell differentiation	IDA	29384235
GO:2000774	Process	Positive regulation of cellular senescence	ISS
GO:2001234	Process	Negative regulation of apoptotic signaling pathway	IDA	28433754

Other IDs

• MIM: 610566
• HGNC: 31533
• e!Ensembl: ENSG00000283733

Interactions View interactions

Pathways

KEGG:

MicroRNAs in cancer