Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene Gene ontology Other IDs Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	406937
Gene name Gene Name - the full gene name approved by the HGNC.	MicroRNA 145
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MIR145
Synonyms (NCBI Gene) Gene synonyms aliases	MIRN145, miR-145, miRNA145
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q32
Summary Summary of gene provided in NCBI Entrez Gene.	microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003730	Function	MRNA 3'-UTR binding	IDA	23076445, 23128394, 26823772, 31150684
GO:0006940	Process	Regulation of smooth muscle contraction	ISS
GO:0010614	Process	Negative regulation of cardiac muscle hypertrophy	ISS
GO:0010667	Process	Negative regulation of cardiac muscle cell apoptotic process	IDA	23028672
GO:0010667	Process	Negative regulation of cardiac muscle cell apoptotic process	ISS
GO:0010668	Process	Ectodermal cell differentiation	IDA	19409607
GO:0010719	Process	Negative regulation of epithelial to mesenchymal transition	IDA	24384875
GO:0010763	Process	Positive regulation of fibroblast migration	ISS
GO:0016442	Component	RISC complex	IEA
GO:0016525	Process	Negative regulation of angiogenesis	IDA	25801897
GO:0030036	Process	Actin cytoskeleton organization	ISS
GO:0030336	Process	Negative regulation of cell migration	IDA	24384875
GO:0030336	Process	Negative regulation of cell migration	IDA	23076445
GO:0030512	Process	Negative regulation of transforming growth factor beta receptor signaling pathway	IGI	25323858
GO:0032699	Process	Negative regulation of interleukin-16 production	IDA	30634164
GO:0032733	Process	Positive regulation of interleukin-10 production	IDA	30634164
GO:0032965	Process	Regulation of collagen biosynthetic process	ISS
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IDA	15131085, 19409607, 19915607, 20332243, 21351259, 23028672, 23128394, 23390502, 23441135, 23632450, 24001939, 24065611, 24135019, 24384875, 25801897, 26823772, 30634164, 31150684
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IEA
GO:0035278	Process	MiRNA-mediated gene silencing by inhibition of translation	IDA	19360360, 20737575, 23076445
GO:0035279	Process	MiRNA-mediated gene silencing by mRNA destabilization	IDA	25323858, 29883722
GO:0035279	Process	MiRNA-mediated gene silencing by mRNA destabilization	IMP	25704091
GO:0035886	Process	Vascular associated smooth muscle cell differentiation	ISS
GO:0036446	Process	Myofibroblast differentiation	ISS
GO:0038166	Process	Angiotensin-activated signaling pathway	ISS
GO:0043032	Process	Positive regulation of macrophage activation	IDA	30634164
GO:0044663	Process	Establishment or maintenance of cell type involved in phenotypic switching	ISS
GO:0045651	Process	Positive regulation of macrophage differentiation	IDA	30634164
GO:0048333	Process	Mesodermal cell differentiation	IDA	19409607
GO:0048662	Process	Negative regulation of smooth muscle cell proliferation	ISS
GO:0050728	Process	Negative regulation of inflammatory response	IDA	30634164
GO:0051898	Process	Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS
GO:0060392	Process	Negative regulation of SMAD protein signal transduction	IMP	25704091
GO:0060414	Process	Aorta smooth muscle tissue morphogenesis	ISS
GO:0070062	Component	Extracellular exosome	IDA	31926946
GO:0070372	Process	Regulation of ERK1 and ERK2 cascade	ISS
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	ISS
GO:0090370	Process	Negative regulation of cholesterol efflux	IDA	24135019
GO:1900039	Process	Positive regulation of cellular response to hypoxia	IDA	31150684
GO:1900239	Process	Regulation of phenotypic switching	ISS
GO:1901202	Process	Negative regulation of extracellular matrix assembly	IGI	25323858
GO:1901202	Process	Negative regulation of extracellular matrix assembly	IMP	25704091
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	IDA	15131085, 19360360, 19409607, 19915607, 20332243, 20737575, 21351259, 23028672, 23076445, 23128394, 23390502, 23441135, 23541921, 23632450, 24001939, 24135019, 24384875, 25323858, 25801897, 26823772, 29883722, 30634164, 31150684
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	IMP	25704091
GO:1903845	Process	Negative regulation of cellular response to transforming growth factor beta stimulus	IGI	25323858
GO:1904673	Process	Negative regulation of somatic stem cell population maintenance	IDA	19409607
GO:1904676	Process	Negative regulation of somatic stem cell division	IDA	19409607
GO:1905175	Process	Negative regulation of vascular associated smooth muscle cell dedifferentiation	ISS
GO:2000724	Process	Positive regulation of cardiac vascular smooth muscle cell differentiation	ISS

MIM	HGNC	e!Ensembl
611795	31532	ENSG00000276365

	KEGG
	MicroRNAs in cancer

MIR145 (microRNA 145)