MIR145 (microRNA 145)

Gene

• Entrez ID: 406937
• Gene name: MicroRNA 145
• Gene symbol: MIR145
• Synonyms (NCBI Gene): MIRN145, miR-145, miRNA145
• Chromosome: 5
• Chromosome location: 5q32
• Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000993	Function	RNA polymerase II complex binding	IDA	25336585
GO:0003730	Function	MRNA 3'-UTR binding	IDA	23076445, 23128394, 26823772
GO:0006940	Process	Regulation of smooth muscle contraction	ISS
GO:0010614	Process	Negative regulation of cardiac muscle hypertrophy	ISS
GO:0010667	Process	Negative regulation of cardiac muscle cell apoptotic process	IDA	23028672
GO:0010667	Process	Negative regulation of cardiac muscle cell apoptotic process	ISS
GO:0010668	Process	Ectodermal cell differentiation	IDA	19409607
GO:0010763	Process	Positive regulation of fibroblast migration	ISS
GO:0016525	Process	Negative regulation of angiogenesis	IDA	25801897
GO:0030036	Process	Actin cytoskeleton organization	ISS
GO:0030336	Process	Negative regulation of cell migration	IDA	23076445
GO:0032699	Process	Negative regulation of interleukin-16 production	IDA	30634164
GO:0032733	Process	Positive regulation of interleukin-10 production	IDA	30634164
GO:0032965	Process	Regulation of collagen biosynthetic process	ISS
GO:0035195	Process	Gene silencing by miRNA	IDA	15131085, 19409607, 19915607, 20332243, 21351259, 22370644, 23028672, 23128394, 23390502, 23441135, 24001939, 24065611, 25801897, 26823772, 30634164
GO:0035195	Process	Gene silencing by miRNA	IEA
GO:0035278	Process	MiRNA mediated inhibition of translation	IDA	19360360, 20737575, 23076445
GO:0035886	Process	Vascular associated smooth muscle cell differentiation	ISS
GO:0036446	Process	Myofibroblast differentiation	ISS
GO:0038166	Process	Angiotensin-activated signaling pathway	ISS
GO:0043032	Process	Positive regulation of macrophage activation	IDA	30634164
GO:0044663	Process	Establishment or maintenance of cell type involved in phenotypic switching	ISS
GO:0045651	Process	Positive regulation of macrophage differentiation	IDA	30634164
GO:0048333	Process	Mesodermal cell differentiation	IDA	19409607
GO:0048662	Process	Negative regulation of smooth muscle cell proliferation	ISS
GO:0050728	Process	Negative regulation of inflammatory response	IDA	30634164
GO:0051898	Process	Negative regulation of protein kinase B signaling	ISS
GO:0060414	Process	Aorta smooth muscle tissue morphogenesis	ISS
GO:0070062	Component	Extracellular exosome	IDA	31926946
GO:0070372	Process	Regulation of ERK1 and ERK2 cascade	ISS
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	ISS
GO:1900239	Process	Regulation of phenotypic switching	ISS
GO:1903231	Function	MRNA binding involved in posttranscriptional gene silencing	IDA	15131085, 19360360, 19409607, 19915607, 20332243, 20737575, 21351259, 22370644, 23028672, 23076445, 23128394, 23390502, 23441135, 24001939, 25801897, 26823772, 30634164
GO:1904673	Process	Negative regulation of somatic stem cell population maintenance	IDA	19409607
GO:1904676	Process	Negative regulation of somatic stem cell division	IDA	19409607
GO:1905175	Process	Negative regulation of vascular associated smooth muscle cell dedifferentiation	ISS
GO:2000724	Process	Positive regulation of cardiac vascular smooth muscle cell differentiation	ISS

Other IDs

• MIM: 611795
• HGNC: 31532
• e!Ensembl: ENSG00000276365

Pathways

KEGG:

MicroRNAs in cancer

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243	21463514
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038	21463514
Esophagus neoplasm	Esophageal Neoplasms, Malignant neoplasm of esophagus	rs28934578, rs121918714, rs1567556006, rs1575166666	21248297
Lung carcinoma	Non-Small Cell Lung Carcinoma	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193	20097187
Marfan syndrome	Mammary Carcinoma, Human	rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465, rs137854466, rs137854467, rs387906547, rs387906548, rs137854469, rs137854473, rs1131692050, rs112989722, rs137854474, rs137854476, rs140593, rs1555395819, rs137854478, rs137854479, rs137854480, rs137854481, rs137854482, rs137854483, rs137854484, rs137854485, rs112289537, rs193922181, rs193922182, rs193922185, rs140603, rs193922187, rs193922188, rs193921256, rs112660651, rs193922193, rs193922194, rs193922197, rs193922198, rs193922199, rs193922203, rs193922204, rs193922205, rs193922206, rs111401431, rs193922207, rs113871094, rs111671429, rs193922216, rs193922219, rs193922220, rs193922223, rs193922224, rs193922225, rs193922226, rs193922227, rs193922228, rs193922230, rs193922235, rs147195031, rs193922236, rs193922239, rs193922240, rs193922241, rs193922246, rs397514558, rs398122934, rs397515753, rs397515754, rs397515755, rs397515756, rs397515757, rs113812345, rs397515758, rs397515759, rs397515762, rs25403, rs397515765, rs397515766, rs397515767, rs397515768, rs397515769, rs397515770, rs397515771, rs25404, rs397515773, rs397515774, rs397515775, rs397515776, rs397515778, rs397515779, rs397515781, rs112202622, rs397515782, rs397515784, rs397515785, rs397515786, rs397515788, rs397515789, rs397515790, rs397515791, rs397515792, rs397515793, rs397515794, rs397515797, rs397515798, rs397515799, rs397515801, rs397515802, rs397515803, rs397515804, rs397515805, rs397515808, rs397515810, rs397515811, rs397515812, rs111231312, rs267606798, rs397515814, rs113905529, rs397515816, rs397515817, rs397515818, rs397515819, rs397515820, rs363853, rs113249837, rs397515821, rs111929350, rs397515823, rs397515824, rs113086760, rs397515825, rs397515826, rs397515827, rs363807, rs397515828, rs397515829, rs397515830, rs397515831, rs397515833, rs111687884, rs113080385, rs397515834, rs397515836, rs113001196, rs397515840, rs397515845, rs397515846, rs397515847, rs397515848, rs397515851, rs397515852, rs397515853, rs397515854, rs111856492, rs397515859, rs397515861, rs397515863, rs397515864, rs397515865, rs397515866, rs397515867, rs137854855, rs199474693, rs587782944, rs587782947, rs587782948, rs672601352, rs876658120, rs727504651, rs727503054, rs727504315, rs727504411, rs727503057, rs727504454, rs200309328, rs363811, rs727504410, rs363821, rs727504347, rs727505006, rs727505110, rs730880356, rs727505269, rs727503058, rs727504421, rs730880107, rs730880104, rs730880103, rs730880102, rs730880101, rs730880106, rs730880100, rs730880105, rs730880099, rs112645512, rs730880108, rs730880098, rs730880097, rs794728321, rs794728283, rs794728280, rs794728336, rs794728272, rs794728160, rs794728271, rs794728270, rs794728319, rs794728262, rs794728251, rs76702162, rs794728335, rs794728334, rs794728246, rs763091520, rs794728333, rs794728237, rs761857514, rs794728234, rs140630, rs794728231, rs794728228, rs794728225, rs794728308, rs794728216, rs794728221, rs763449629, rs201058219, rs794728210, rs794728208, rs794728206, rs794728199, rs794728195, rs794728194, rs794728193, rs794728190, rs1555399381, rs794728176, rs1555399968, rs113422242, rs794728326, rs794728166, rs794728325, rs794728165, rs794728162, rs794728213, rs869025417, rs112642323, rs869025416, rs869025415, rs869025424, rs869025423, rs869025414, rs869025422, rs869025413, rs869025412, rs869025411, rs869025418, rs869025426, rs869025406, rs869025421, rs869025425, rs869025404, rs869025420, rs869025403, rs398122833, rs876657645, rs878853686, rs878853676, rs886038919, rs886038795, rs187553035, rs886038869, rs886038949, rs886038967, rs886038976, rs886038848, rs886038940, rs886038877, rs886039038, rs886038817, rs886038963, rs886039036, rs886038797, rs886039550, rs886041482, rs1057517855, rs1057518912, rs1057518973, rs1057519502, rs1057521100, rs1057521102, rs1057518881, rs1057520617, rs1057521101, rs1555394445, rs369058466, rs1060501069, rs1060501031, rs778966916, rs1060501043, rs1555397663, rs1060501017, rs1060501094, rs1060501065, rs1555393848, rs1555394151, rs1060501051, rs1060501013, rs1060501054, rs1060501048, rs1060501089, rs1060501039, rs1555398160, rs1060501022, rs1060501024, rs1060501086, rs1060501058, rs1060501036, rs1060501100, rs1060501042, rs1060501059, rs1555397743, rs1060501021, rs1060501027, rs1060501096, rs1060501038, rs1060501050, rs1064794130, rs112118237, rs1064793980, rs1064793118, rs1064793636, rs1064794282, rs1064793559, rs1085307921, rs1085308004, rs1085307468, rs112907302, rs1131691479, rs1131691373, rs1131691467, rs1131691938, rs1131691311, rs1131691806, rs1131691317, rs1555393827, rs363804, rs1555397738, rs1555399144, rs1555400274, rs1555394195, rs1555398836, rs113543334, rs1555399825, rs1555394626, rs1555395256, rs1555395257, rs1555396427, rs1555397548, rs1555398173, rs1555404803, rs1232880706, rs1555393825, rs1555394567, rs1555396998, rs1555394928, rs1555397203, rs112375043, rs1555397720, rs140599, rs1555399150, rs1555400373, rs1555405041, rs1555395229, rs1555397671, rs775417975, rs1555398774, rs1555399368, rs1555394904, rs1555395987, rs1555397424, rs1555398377, rs1555398835, rs1555401011, rs1555405043, rs1555394580, rs1555397404, rs1555398511, rs1555395826, rs1555399372, rs1555399821, rs1555399836, rs1555400063, rs363810, rs1555397655, rs1555395756, rs1555395742, rs1555393844, rs112550005, rs1555395002, rs1555395658, rs765387131, rs1555396429, rs1555396835, rs1555397014, rs1555397016, rs778710767, rs1555397557, rs1555397704, rs140648, rs1555398406, rs1555398681, rs1555399257, rs1555399361, rs1555399764, rs1555405056, rs1555393510, rs1555395980, rs1555396789, rs1555399094, rs1555399378, rs1555399816, rs1555395645, rs371097218, rs1555398278, rs1555394238, rs1555396418, rs1206813753, rs1555399271, rs1555405044, rs113544411, rs1555395663, rs1555397216, rs1555398989, rs1555399149, rs1555401670, rs1555395001, rs1445085747, rs1555393538, rs1555393565, rs1404133653, rs1555394450, rs1555394581, rs1555394633, rs1555394900, rs1555395189, rs1555395261, rs1052480459, rs1555395480, rs1555395670, rs363806, rs1555395820, rs1555396419, rs1555396765, rs1296209846, rs794728233, rs1555396853, rs1555396863, rs1555397197, rs1555397204, rs1555397212, rs1555397713, rs1555397736, rs1555398139, rs1555398144, rs1555398409, rs1555398510, rs1555398520, rs1555398524, rs1555398667, rs1555399089, rs1555399482, rs1555399763, rs1555401002, rs794728323, rs1555393508, rs1555393514, rs1555393525, rs1555393532, rs1555393653, rs1555393657, rs1555393824, rs1555393831, rs112196241, rs1555393847, rs1555393862, rs1555393863, rs1555393866, rs113935744, rs1555393882, rs1555393886, rs1555393889, rs1555394138, rs1555394144, rs1555394146, rs1555394148, rs1555394149, rs1555394152, rs1555394153, rs1555394189, rs1555394197, rs1555394206, rs1555394212, rs1555394218, rs1555394220, rs1555394235, rs1555394245, rs1555394246, rs1057520728, rs1555394390, rs1555394391, rs537570299, rs1555394397, rs1555394398, rs1555394399, rs1555394402, rs1555394407, rs1555394412, rs1555394435, rs1555394436, rs1555394441, rs1555394556, rs1555394557, rs1555394559, rs1555394561, rs1555394570, rs397515844, rs1555394571, rs1555394574, rs1555394579, rs1555394582, rs534811966, rs111588631, rs1555394628, rs1555394629, rs1555394630, rs1555394631, rs1555394641, rs1555394644, rs1555394647, rs1555394756, rs886051245, rs1555394775, rs1555394776, rs1555394777, rs1555394779, rs1555394780, rs1555394783, rs1555394901, rs1555394906, rs1555394925, rs794728253, rs886039158, rs1555395013, rs1555395187, rs1555395188, rs1555395203, rs1555395205, rs363815, rs1246984265, rs794728245, rs1555395263, rs1555395267, rs1555395456, rs1555395475, rs1555395482, rs1555395638, rs1555395641, rs1555395648, rs1555395653, rs1555395659, rs111239111, rs1555395745, rs1555395747, rs1555395753, rs1555395757, rs1555395766, rs1555395767, rs1555395843, rs1555395846, rs1555395849, rs1555395978, rs1555395981, rs1555395984, rs1555395989, rs1555395990, rs1260109901, rs1555396186, rs1555396188, rs1555396198, rs1555396199, rs1555396201, rs1555396202, rs1555396205, rs1555396213, rs1555396424, rs1555396426, rs1555396428, rs1555396435, rs1555396630, rs1555396635, rs1555396636, rs1555396639, rs1555396757, rs1555396769, rs1555396838, rs1555396844, rs140627, rs1555396858, rs1555396990, rs1555396991, rs1555396993, rs769588424, rs1555397022, rs1555397024, rs1555397160, rs1555397174, rs1555397176, rs1555397193, rs1555397209, rs1555397210, rs1555397214, rs1060501076, rs113082854, rs113693945, rs111978932, rs1555397403, rs1555397419, rs1555397420, rs1555397421, rs1555397536, rs1555397537, rs1555397540, rs1555397542, rs1555397543, rs1555397545, rs1555397546, rs1555397670, rs1555397692, rs1555397718, rs1555397723, rs1555397744, rs113393517, rs1555398148, rs1555398152, rs1555398174, rs1555398176, rs1555398179, rs1555398282, rs1555398287, rs1555398380, rs1555398394, rs1555398397, rs1555398401, rs1555398404, rs1555398407, rs1555398413, rs1555398501, rs1555398508, rs1555398512, rs1555398513, rs1555398515, rs1555398521, rs794728205, rs1555398527, rs1555398551, rs1060501075, rs1555398566, rs1555398572, rs1555398580, rs1555398582, rs140597, rs1555398622, rs1555398624, rs1555398625, rs112547596, rs1555398627, rs1555398633, rs1555398637, rs1555398642, rs778867355, rs1555398648, rs1555398659, rs1293095681, rs1060501040, rs987202268, rs1555398672, rs1555398673, rs1555398677, rs1555398793, rs1555398803, rs1555398811, rs1555398826, rs1555398833, rs1555398974, rs1555398981, rs778900586, rs1555398988, rs1555398994, rs1555398995, rs1555398996, rs1555399093, rs869025405, rs1555399101, rs1555399146, rs1555399160, rs1555399162, rs1555399164, rs1555399165, rs1555399193, rs1555399195, rs1555399202, rs1555399204, rs1555399206, rs201778577, rs1555399210, rs1555399214, rs1555399270, rs1555399273, rs1555399281, rs1555399371, rs1555399385, rs1555399477, rs1555399484, rs1555399761, rs1555399775, rs1555399802, rs1555399804, rs1555399837, rs1555399840, rs1555399940, rs1555399944, rs1555399949, rs1555399953, rs1555399954, rs1555399955, rs1555399959, rs1555399962, rs1555399963, rs1060501041, rs1555399974, rs1555399976, rs1555399977, rs1555400049, rs794728172, rs1555400062, rs1555400064, rs1555400066, rs1555400267, rs1555400268, rs1555400278, rs794728168, rs1555400279, rs1156747241, rs1555400288, rs1555400371, rs1555400372, rs1555400379, rs1555400385, rs587782943, rs1555400387, rs1555400406, rs1439533354, rs746201757, rs1555400595, rs1555400603, rs1555400604, rs1555400606, rs1555400609, rs752010116, rs1555400612, rs1555400616, rs1555401004, rs1555401005, rs146348130, rs1555401667, rs1555401671, rs1555401676, rs1555401679, rs1555401687, rs1555401689, rs1555401695, rs1555401697, rs1555401701, rs1555404799, rs1555404800, rs200295020, rs1555404810, rs1555404820, rs1555405031, rs1555405039, rs1555405045, rs1555405530, rs794728292, rs1555405533, rs1555405536, rs1555405537, rs111764111, rs1555405658, rs1555405664, rs774371494, rs1555405673, rs1555407399, rs1555407414, rs1555407423, rs1555407429, rs886041536, rs1555404806, rs1566911709, rs1566913974, rs1566894226, rs1566895223, rs1566897376, rs1566902526, rs1566915277, rs1566897374, rs1566897420, rs1566891655, rs1346043320, rs1566922396, rs1566891706, rs1566894783, rs1566913670, rs1555394196, rs1566891454, rs1566891406, rs1566891404, rs1566895262, rs1566891645, rs1566895225, rs1566896114, rs1566898399, rs1566904011, rs1566906537, rs1566908956, rs1566909766, rs1566919599, rs1566937712, rs1566915335, rs1566891675, rs1566904526, rs1566906506, rs1566900540, rs1566894230, rs1555395206, rs1566891797, rs1597512576, rs1597523873, rs1597581001, rs1597516325, rs1057524757, rs1597506641, rs1597520781, rs1597593695, rs1597529829, rs1597520625, rs1597579923, rs1597531796, rs1008275504, rs1597567249, rs1597569265, rs1597652471, rs1597516347, rs1597577114, rs1597633163, rs1597519658, rs1597593852, rs1597516501, rs1566913982, rs1555393859, rs1597513708, rs368978109, rs1480832655, rs1597520683, rs1597522390, rs1597522553, rs1597529748, rs1597533707, rs1597537815, rs1597545309, rs1597545836, rs1597563234, rs1597563280, rs1597564359, rs772108557, rs1597568968, rs1597574236, rs1597574308, rs1597577975, rs193922179, rs1597581005, rs1597593736, rs1597623670, rs1597625734, rs1597631662, rs113604459, rs1597633183, rs1597633219, rs1597518951, rs1555394781, rs1597525871, rs1597526073, rs1597569159, rs1597569536, rs1597563934, rs1597545199, rs1364210063, rs1597552583, rs1597520619, rs1597540854, rs1597591602, rs1597569551, rs1597548716, rs1597553721, rs112728248, rs1597537858, rs1597517935, rs1597540907, rs1597552388, rs1597591643, rs1597529841, rs1597506547, rs1597509836, rs1597529686, rs1566897404, rs1597533713, rs1597543486, rs1597545257, rs1597545345, rs1597548672, rs1597562812, rs1597563287, rs1597571391, rs1555400052, rs1597583989, rs363852, rs1597547226, rs363808, rs974604498, rs2043595650, rs2043526284, rs2042997306, rs1555397195, rs886039054, rs1555397213, rs2042873946	21463514

Unknown
Disease term	Disease name	Evidence	References	Source
Myocardial infarction	Myocardial Infarction		29956747	ClinVar

Associations from Text Mining
Disease Name	Relationship Type	References
Abortion Habitual	Associate	39941094
Abortion Spontaneous	Associate	37373283
Acute Kidney Injury	Inhibit	31039814
Adenocarcinoma	Associate	25091571, 25551563, 25584614, 26465597
Adenocarcinoma of Lung	Associate	21289483, 24026105, 28388536
Adenocarcinoma of Lung	Inhibit	26582602
Adenoma	Associate	24791633
Adenoma	Inhibit	30258124
Adenomyosis	Associate	33728345
Albuminuria	Associate	36292960
Aneurysm	Associate	26918470, 34185228
Aneurysm Ascending Aorta	Associate	25465469
Angina Stable	Associate	24260372
Angina Unstable	Stimulate	24260372
Aortic Aneurysm	Associate	25465469
Aortic Aneurysm Abdominal	Associate	28425970, 35478113
Aortic Aneurysm Familial Abdominal 1	Inhibit	28425970
Aortic Dissection	Inhibit	31489719
Aphasia	Associate	29713155
Aphasia Wernicke	Associate	32343942
Arthritis Rheumatoid	Associate	28775366
Asthma	Associate	27902892, 36071121
Asthma	Stimulate	28694694, 31703106
Asthma Chronic Obstructive Pulmonary Disease Overlap Syndrome	Associate	28694694
Astrocytoma	Inhibit	23390502
Atherosclerosis	Associate	26992033, 28633641, 30688091, 31585905, 34551209
Atrial myxoma familial	Associate	37026908
Autoimmune Diseases	Associate	24799764
Barrett Esophagus	Associate	27374102, 29906417
Bicuspid Aortic Valve Disease	Associate	30059548
Biliary Atresia	Inhibit	28902846
Biliary Tract Neoplasms	Associate	21858175, 35750139
Brain Neoplasms	Associate	24026105
Breast Neoplasms	Associate	16103053, 19730444, 23049906, 23063121, 23301032, 23334650, 24694649, 25339470, 25961039, 26577090, 27071407, 27396353, 28349828, 29073169, 29081035, 29565493, 29687853, 30840191, 30891102, 33028151, 33371806, 34048164, 34307654, 35499128, 35876391, 36653507, 37997376
Breast Neoplasms	Inhibit	21092188, 25047098, 26715279, 29324832, 30381907, 31400480, 36459290, 39337574
Breast Neoplasms	Stimulate	34204158, 36648259
Breast Neoplasms Male	Associate	20331864
Burkitt Lymphoma	Inhibit	17892514
Calcinosis Cutis	Inhibit	20037573
Carcinogenesis	Associate	17892514, 22897626, 23489501, 24791633, 27067546, 30258124, 32948220
Carcinogenesis	Inhibit	18596939, 23076445, 32083506
Carcinoma Hepatocellular	Stimulate	25519019
Carcinoma Hepatocellular	Associate	26231037, 26615424, 27120784, 28104805, 30572504, 32339066, 33274225, 35931993
Carcinoma Hepatocellular	Inhibit	26512974, 29333940, 31002128, 32102538
Carcinoma Mucoepidermoid	Associate	35980523
Carcinoma Non Small Cell Lung	Inhibit	21092188
Carcinoma Non Small Cell Lung	Associate	22835608, 23876001, 25257143, 25421010, 25961369, 26909466, 29867125, 30428030, 31298334, 31554377, 33125430, 34747300, 38200421
Carcinoma Non Small Cell Lung	Stimulate	25755772
Carcinoma Ovarian Epithelial	Associate	23919393, 32948220, 33081171
Carcinoma Ovarian Epithelial	Inhibit	30864742
Carcinoma Renal Cell	Associate	22452920, 23441135, 23799849, 34628264
Carcinoma Renal Cell	Inhibit	24033605, 24384875
Carcinoma Small Cell	Associate	22438992
Carcinoma Squamous Cell	Associate	26252302, 27765924
Cardiomyopathy Hypertrophic	Stimulate	24161319
Cardiovascular Diseases	Associate	31936594, 34551209
Carotid Stenosis	Associate	26238333
Cartilage Diseases	Associate	24873879
Central Nervous System Diseases	Associate	25130212
Cerebral Infarction	Stimulate	27708363
Cerebral Infarction	Associate	32626985
Choroidal Effusions	Inhibit	20716115
Chromosome 5q Deletion Syndrome	Associate	21211043
Colitis Ulcerative	Inhibit	21557394
Colitis Ulcerative	Associate	39238649
Colonic Diseases	Inhibit	19242066
Colonic Neoplasms	Associate	20413677, 22529906, 30278464, 32871920
Colonic Neoplasms	Inhibit	20737575, 21557394
Colorectal Neoplasms	Associate	16854228, 19242066, 19843336, 20098684, 20429937, 21092188, 22529906, 22751122, 23121918, 24078156, 24447928, 25019299, 25069957, 25249558, 25584614, 25896668, 25973017, 26045793, 26250939, 26465597, 26756616, 27058418, 27067546, 27071407, 27444415, 27556691, 27658891, 27775664, 28964256, 29360852, 29459716, 29475734, 29552756, 30361904, 30985693, 32221048, 32672054, 33825830, 34479583
Colorectal Neoplasms	Inhibit	17827156, 20737575, 21557394, 22897626, 24631504, 25474488, 25477374, 26824186, 26973415, 30922567, 32871920, 37561735
Coronary Artery Disease	Inhibit	20595655, 28205634
Coronary Artery Disease	Associate	25938589, 34551209, 35751015, 38139440, 39684689
Coronary Occlusion	Stimulate	30230713
Craniopharyngioma	Associate	21761366
Crohn Disease	Associate	39238649
Cystic Fibrosis	Associate	23632450, 29232160, 32059764
Death	Associate	30428030
Diabetes Gestational	Associate	32244558, 37951512
Diabetes Mellitus	Associate	24927876, 27396353, 33923614, 36292960
Diabetes Mellitus	Inhibit	34381015
Diabetes Mellitus Type 2	Associate	27396353, 28185533, 35778952
Diabetic Angiopathies	Associate	24927876
Diabetic Nephropathies	Stimulate	36292960
Dissection Thoracic Aorta	Associate	31489719
Down Syndrome	Associate	31257513
Drug Related Side Effects and Adverse Reactions	Associate	26824186
Endometrial Neoplasms	Associate	34528556, 36751747
Endometriosis	Associate	19074548, 27179784, 27323121, 34528556, 36751747, 38050316
Esophageal Neoplasms	Associate	21218087, 25551563, 26156802, 26657507, 27771733
Esophageal Neoplasms	Stimulate	22457808
Esophageal Squamous Cell Carcinoma	Inhibit	21218087
Esophageal Squamous Cell Carcinoma	Associate	22457808, 26657507, 27771733, 34586751
Essential Hypertension	Stimulate	29609545
Essential Hypertension	Inhibit	31556476
Facial Nerve Diseases	Associate	30551550
Fallopian Tube Diseases	Associate	32343942
Femur Head Necrosis	Associate	36435763
Fetal Growth Retardation	Associate	37951512
Fibrocartilaginous embolism	Associate	35094651
Fibromyalgia	Associate	24205312, 25803872
Focal Cortical Dysplasia	Associate	32785072
Gallbladder Neoplasms	Associate	24966896, 30886199, 35035811
Gastroesophageal Reflux	Stimulate	23297865
Gastrointestinal Neoplasms	Associate	25333257, 29459716
Gastrointestinal Stromal Tumors	Associate	26019448
Giant Cell Arteritis	Associate	36675088
Glioblastoma	Associate	21211035, 23577178, 24531649, 24609385, 24691539, 26681767, 26857280, 28284220, 33684100, 37175410
Glioblastoma	Inhibit	23390502
Glioma	Inhibit	23076445
Glioma	Associate	23390502, 23577178
Heart Failure	Associate	23736534
Hypertension	Inhibit	31556476
Hypertension Pulmonary	Associate	36945942
Hypoxia	Stimulate	25129238, 35682972
Hypoxia	Associate	31164009, 37517933
Infections	Associate	18596939
Inflammation	Associate	21557394, 26918470, 27412561, 30551550, 31016755, 32343942, 35697289
Inflammation	Inhibit	27060571
Inflammatory Bowel Diseases	Associate	39238649
Insulin Resistance	Inhibit	26672043
Intervertebral Disc Degeneration	Associate	35094651
Intracranial Aneurysm	Associate	24079748, 25300531, 26918470, 28272526
Invasive Pulmonary Aspergillosis	Stimulate	32771440
Keloid	Inhibit	23709205
Kidney Diseases	Associate	36292960
Kidney Failure Chronic	Associate	26045793
Kidney Neoplasms	Associate	23441135, 25833690
Leukemia	Associate	31894299, 32945355
Leukemia Lymphocytic Chronic B Cell	Inhibit	17892514
Leukemia Lymphocytic Chronic B Cell	Associate	33507687
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	24629639
Leukemia Myeloid	Associate	30982491
Leukemia Myeloid Acute	Associate	21455993
Leukoplakia	Associate	38536520
Liposarcoma	Inhibit	26878133
Liposarcoma	Associate	28036291
Liver Cirrhosis	Associate	28902846
Liver Diseases	Associate	27458792
Lung Diseases	Associate	21289483, 31554377
Lung Neoplasms	Inhibit	21289483, 25852169
Lung Neoplasms	Associate	26356817, 30594785, 31554377, 32633367
Lung Neoplasms	Stimulate	35302725
Lupus Erythematosus Systemic	Associate	23199328, 30198366
Lupus Nephritis	Inhibit	26722454
Lupus Nephritis	Associate	31430759
Lymphatic Metastasis	Associate	22438992, 22457808, 25019299, 26317418, 26909466, 27396353, 32633367
Lymphatic Metastasis	Inhibit	25560490
Lymphatic Metastasis	Stimulate	28223425
Lymphoma	Associate	21803762
Lymphoma B Cell	Inhibit	17892514
Lymphoma B Cell Marginal Zone	Associate	23429603
Lymphoma Follicular	Associate	18537969
Lymphoma Large B Cell Diffuse	Associate	18537969
Lymphoma Non Hodgkin	Associate	33086588
Lymphoma T Cell Peripheral	Associate	34426436
Lymphoproliferative Disorders	Associate	25130212
Marfan Syndrome	Associate	32961817
Melanoma	Associate	35156321, 37384650
Meningioma	Associate	32720739, 34772393
Mesothelioma Malignant	Inhibit	24912849
Mesothelioma Malignant	Associate	28600498
Metabolic Syndrome	Associate	28178938
MINOCA	Associate	38139440
Mixed Connective Tissue Disease	Associate	33430976
Mouth Neoplasms	Stimulate	29506142
Mouth Neoplasms	Associate	29936107, 36674758
Mucocutaneous Lymph Node Syndrome	Associate	23483985
Multiple Sclerosis	Associate	19823682, 36329419
Multiple Sclerosis Relapsing Remitting	Inhibit	36329419
Myocardial Infarction	Inhibit	31039814
Nasopharyngeal Carcinoma	Associate	19293812, 25578496, 33943007, 35836107
Nasopharyngeal Neoplasms	Associate	25578496
Nausea	Stimulate	37540289
Neoplasm Invasiveness	Inhibit	25560490
Neoplasm Metastasis	Inhibit	21647377, 22472569, 25578496, 26605780, 26657507, 27107594, 29022908, 30864704, 32788878, 33081171
Neoplasm Metastasis	Associate	22331473, 22457808, 24026105, 25253741, 25969144, 26490990, 26615424, 26909466, 27775664, 28349828, 30704524, 30922567, 31554377, 34307654
Neoplasm Metastasis	Stimulate	32871920
Neoplasms	Associate	16854228, 18537969, 18596939, 20382729, 20687965, 21218087, 21647377, 21722265, 21803762, 22457808, 22835608, 23049906, 23063121, 24337069, 24520312, 24691539, 25047098, 25091571, 25253741, 25969144, 26010149, 26356817, 26657507, 26823772, 27058413, 27072587, 27107594, 28223425, 28349828, 28428713, 28490034, 28902136, 29360852, 29506142, 29552756, 29867125, 29936107, 30572504, 30688091, 31186527, 31353030, 32080184, 32720739, 32929059, 33081171, 33125430, 34307654, 34397934, 34628264, 35616620, 35931993, 37517933
Neoplasms	Inhibit	17827156, 19202062, 19242066, 19293812, 19730444, 20037573, 20098684, 20160723, 20353999, 20429937, 20525177, 20737575, 21092188, 21289483, 21349819, 22472569, 22495929, 22897626, 23076445, 23489501, 23577178, 23703249, 24033605, 24447928, 24631504, 24801908, 24912849, 24966896, 25257143, 25260533, 25354783, 25474488, 25477374, 25551563, 25578496, 25584614, 25961369, 25973017, 26153983, 26156802, 26252302, 26490990, 26615424, 26715279, 26733177, 26909466, 26988859, 27404381, 27438131, 27507554, 27765914, 27765924, 28535533, 29073169, 29115582, 30361904, 30381907, 30594785, 30864704, 30864742, 30886199, 32083506, 33684100, 33990639, 35980523, 36653507, 37384650, 37561735
Neoplasms Glandular and Epithelial	Associate	35475887
Neural Tube Defects	Associate	33086588
Neuroblastoma	Inhibit	32083506
Neuroendocrine Tumors	Associate	30223590
Neurofibroma Plexiform	Associate	23848554
Neurofibrosarcoma	Associate	32076030
Neuronal intestinal pseudoobstruction	Associate	31776429
Niemann Pick Disease Type C	Associate	35028969
Non alcoholic Fatty Liver Disease	Associate	38115130
Norrie disease	Associate	24927876
Obesity	Associate	24690978
Oncogene Addiction	Stimulate	36708560
Osteoarthritis	Stimulate	24873879
Osteoarthritis	Inhibit	31637891
Osteoarthritis	Associate	32016955
Osteogenesis imperfecta type 1A	Stimulate	31597886
Osteosarcoma	Associate	22472569, 26605780
Osteosarcoma	Inhibit	24801908
Ovarian Diseases	Associate	33081171
Ovarian Neoplasms	Associate	17875710, 22452920, 23919393, 24609385, 30365097, 30864742, 31821542, 32588730, 32948220, 34397934
Ovarian Neoplasms	Stimulate	31353030, 34528556, 36751747
Pancreatic Neoplasms	Associate	22751122, 25646678, 27507554, 27765914
Papillomavirus Infections	Associate	39941094
Pericarditis	Associate	33430976
Plaque Atherosclerotic	Associate	26722454, 28633641
Pleural Effusion Malignant	Associate	32633367
Pleurisy	Associate	33430976
Polycythemia Vera	Associate	18508790
Precancerous Conditions	Associate	28349828
Premature Birth	Associate	35409311
Prostatic Hyperplasia	Associate	24474452
Prostatic Neoplasms	Associate	19996289, 20353999, 20588276, 21647377, 22298119, 24967583, 25969144, 28628624, 29784056, 30136305, 30674952, 31186527, 31484346, 35835374, 36082407, 37434219
Prostatic Neoplasms	Inhibit	21349819, 23480797, 23703249
Prostatic Neoplasms Castration Resistant	Associate	26540468
Prostatic Neoplasms Castration Resistant	Inhibit	28641312
Prostatitis	Associate	22864280
Prostatitis	Inhibit	24337069
Pulmonary Arterial Hypertension	Associate	30285853
Pulmonary Disease Chronic Obstructive	Associate	27060571, 28694694, 29713155
Pyelonephritis	Associate	24521778
Radiation Injuries	Inhibit	29475734
Rectal Diseases	Inhibit	19242066
Rectal Neoplasms	Associate	27258547
Rectal Neoplasms	Inhibit	33825830
Retinoblastoma	Associate	26823772
Retinoblastoma	Inhibit	36293469
Rhabdomyosarcoma	Associate	26878133
Rheumatic Heart Disease	Associate	37026908
Sarcoma Ewing	Associate	21217773, 21853155, 37597508
Sarcoma Synovial	Inhibit	26878133
Scleroderma Systemic	Associate	36142646
Sepsis	Associate	31415369
Skin Diseases	Associate	37016095
Sleep Apnea Obstructive	Associate	30285853, 37517933
Sleep Wake Disorders	Associate	31016755
Small Cell Lung Carcinoma	Associate	35441564
Smooth Muscle Tumor	Associate	33923614
Spinal Cord Injuries	Associate	37235195
Spondylitis Ankylosing	Associate	33676382
Squamous Cell Carcinoma of Head and Neck	Inhibit	26317418, 26490990
Squamous Cell Carcinoma of Head and Neck	Associate	29115582, 31138255, 32016969, 34288804
ST Elevation Myocardial Infarction	Inhibit	25938589
Stillbirth	Associate	37373283
Stomach Neoplasms	Associate	24613927, 25612651, 28428713, 28490034, 29168576, 29568201, 30876463, 31524946, 31701767, 31885423, 31940247, 32020674, 34686186, 37696973
Stomach Neoplasms	Inhibit	26010149, 29022908, 30864704, 35616620
Stroke	Associate	26238333, 32626985
Subarachnoid Hemorrhage	Associate	34185228
Tertiary Lymphoid Structures	Associate	18537969
Thrombosis	Inhibit	37026908
Thyroid Cancer Papillary	Associate	28645161
Thyroid Cancer Papillary	Inhibit	32788878, 33285775
Thyroid Neoplasms	Associate	28645161
Triple Negative Breast Neoplasms	Associate	25253741, 26733177, 27404381, 30704524, 34913063
Ulcer	Stimulate	23297865
Urethral Neoplasms	Associate	23469001, 26514209
Urinary Bladder Neoplasms	Inhibit	20160723, 24999188, 27072587
Urinary Bladder Neoplasms	Associate	21133599, 22108519, 23392170, 23489501, 23945108, 24520312, 25991007, 26318860, 26356996, 26544536, 27438131, 28223425, 28380435, 31198976, 32471285, 36045117, 36708560
Uterine Cervical Neoplasms	Associate	18596939, 26311052, 28717180, 31271056, 31789421, 32232409, 32329829, 33990639
Uterine Cervical Neoplasms	Inhibit	25560490, 26252302, 28534701
Uterine Diseases	Associate	32343942
Vascular Diseases	Associate	31430759
Vascular System Injuries	Associate	26722454, 31430759
Venous Thromboembolism	Inhibit	38211336
Vitiligo	Inhibit	26941046
Vitiligo	Associate	37016095
Vomiting	Stimulate	37540289
Wolfram Syndrome	Associate	33132210
Zika Virus Infection	Associate	31213064