MIR133A1 (microRNA 133a-1)

Gene

• Entrez ID: 406922
• Gene name: MicroRNA 133a-1
• Gene symbol: MIR133A1
• Synonyms (NCBI Gene): MIRN133A1, mir-133a-1
• Chromosome: 18
• Chromosome location: 18q11.2
• Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003064	Process	Regulation of heart rate by hormone	ISS
GO:0003730	Function	MRNA 3'-UTR binding	IDA	25714665
GO:0005615	Component	Extracellular space	HDA	26646931
GO:0005615	Component	Extracellular space	IDA	20159880, 28257760
GO:0008285	Process	Negative regulation of cell population proliferation	IDA	25607810
GO:0010455	Process	Positive regulation of cell fate commitment	ISS
GO:0010614	Process	Negative regulation of cardiac muscle hypertrophy	ISS
GO:0010628	Process	Positive regulation of gene expression	IDA	23069713
GO:0010667	Process	Negative regulation of cardiac muscle cell apoptotic process	ISS
GO:0010831	Process	Positive regulation of myotube differentiation	ISS
GO:0010881	Process	Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	ISS
GO:0010989	Process	Negative regulation of low-density lipoprotein particle clearance	IDA	28257760
GO:0016442	Component	RISC complex	IEA
GO:0030336	Process	Negative regulation of cell migration	IDA	25607810
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IDA	21109942, 22163007, 23069713, 24920580, 25607810, 25714665, 28257760
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IEA
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IMP	23157812
GO:0035279	Process	MiRNA-mediated gene silencing by mRNA destabilization	IDA	32205184
GO:0042059	Process	Negative regulation of epidermal growth factor receptor signaling pathway	IDA	23069713
GO:0060307	Process	Regulation of ventricular cardiac muscle cell membrane repolarization	ISS
GO:0070373	Process	Negative regulation of ERK1 and ERK2 cascade	ISS
GO:0071345	Process	Cellular response to cytokine stimulus	IDA	28257760
GO:0071877	Process	Regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway	ISS
GO:0160195	Process	Negative regulation of phospholipase C/protein kinase C signal transduction	ISS
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	IDA	21109942, 22163007, 23069713, 24920580, 25607810, 25714665, 28257760, 32205184
GO:1903751	Process	Negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide	ISS
GO:1904706	Process	Negative regulation of vascular associated smooth muscle cell proliferation	IDA	28257760
GO:1905024	Process	Regulation of membrane repolarization during ventricular cardiac muscle cell action potential	ISS
GO:1905032	Process	Negative regulation of membrane repolarization during cardiac muscle cell action potential	IMP	23157812
GO:1905209	Process	Positive regulation of cardiocyte differentiation	IDA	23069713
GO:1905700	Process	Negative regulation of xenobiotic detoxification by transmembrane export across the plasma membrane	IDA	25714665
GO:2000134	Process	Negative regulation of G1/S transition of mitotic cell cycle	ISS
GO:2000818	Process	Negative regulation of myoblast proliferation	ISS

Other IDs

• MIM: 610254
• HGNC: 31517
• e!Ensembl: ENSG00000283927

Interactions View interactions

Pathways

KEGG:

MicroRNAs in cancer