MIR133A1 (microRNA 133a-1)

Gene

• Entrez ID: 406922
• Gene name: MicroRNA 133a-1
• Gene symbol: MIR133A1
• Synonyms (NCBI Gene): MIRN133A1, mir-133a-1
• Chromosome: 18
• Chromosome location: 18q11.2
• Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005615	Component	Extracellular space	HDA	26646931
GO:0005615	Component	Extracellular space	IDA	20159880, 28257760
GO:0008285	Process	Negative regulation of cell population proliferation	IDA	25607810
GO:0010455	Process	Positive regulation of cell fate commitment	ISS
GO:0010614	Process	Negative regulation of cardiac muscle hypertrophy	ISS
GO:0010628	Process	Positive regulation of gene expression	IDA	23069713
GO:0010667	Process	Negative regulation of cardiac muscle cell apoptotic process	ISS
GO:0010831	Process	Positive regulation of myotube differentiation	ISS
GO:0010881	Process	Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	ISS
GO:0010989	Process	Negative regulation of low-density lipoprotein particle clearance	IDA	28257760
GO:0030336	Process	Negative regulation of cell migration	IDA	25607810
GO:0031586	Process	Negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	ISS
GO:0035195	Process	Gene silencing by miRNA	IDA	21109942, 22163007, 23069713, 24920580, 25607810, 28257760
GO:0035195	Process	Gene silencing by miRNA	IEA
GO:0035195	Process	Gene silencing by miRNA	IMP	23157812
GO:0060307	Process	Regulation of ventricular cardiac muscle cell membrane repolarization	ISS
GO:0070373	Process	Negative regulation of ERK1 and ERK2 cascade	ISS
GO:0071345	Process	Cellular response to cytokine stimulus	IDA	28257760
GO:0071877	Process	Regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway	ISS
GO:0140199	Process	Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process	ISS
GO:1902260	Process	Negative regulation of delayed rectifier potassium channel activity	IMP	23157812
GO:1903206	Process	Negative regulation of hydrogen peroxide-induced cell death	ISS
GO:1903231	Function	MRNA binding involved in posttranscriptional gene silencing	IDA	21109942, 22163007, 23069713, 24920580, 25607810, 28257760
GO:1904706	Process	Negative regulation of vascular associated smooth muscle cell proliferation	IDA	28257760
GO:1905024	Process	Regulation of membrane repolarization during ventricular cardiac muscle cell action potential	ISS
GO:1905032	Process	Negative regulation of membrane repolarization during cardiac muscle cell action potential	IMP	23157812
GO:1905209	Process	Positive regulation of cardiocyte differentiation	IDA	23069713
GO:1905283	Process	Negative regulation of epidermal growth factor receptor signaling pathway involved in heart process	IDA	23069713
GO:2000134	Process	Negative regulation of G1/S transition of mitotic cell cycle	ISS
GO:2000480	Process	Negative regulation of cAMP-dependent protein kinase activity	ISS
GO:2000818	Process	Negative regulation of myoblast proliferation	ISS

Other IDs

• MIM: 610254
• HGNC: 31517
• e!Ensembl: ENSG00000283927

Pathways

KEGG:

MicroRNAs in cancer

Associated diseases

Unknown
Disease term	Disease name	Evidence	References	Source
Cirrhosis	Cirrhosis		19893015	ClinVar

Associations from Text Mining
Disease Name	Relationship Type	References
Asthma	Inhibit	27383317
Carcinoma Pancreatic Ductal	Associate	36290970
Diabetes Mellitus Type 2	Associate	33628196
Long QT Syndrome	Associate	24809446
Neoplasms	Associate	27080237
Pancreatitis Chronic	Associate	36290970