MIR126 (microRNA 126)

Gene

• Entrez ID: 406913
• Gene name: MicroRNA 126
• Gene symbol: MIR126
• Synonyms (NCBI Gene): MIRN126, miRNA126, mir-126
• Chromosome: 9
• Chromosome location: 9q34.3
• Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003730	Function	MRNA 3'-UTR binding	IGI	23437250
GO:0003730	Function	MRNA 3'-UTR binding	IMP	23437250
GO:0005615	Component	Extracellular space	HDA	18766170
GO:0005615	Component	Extracellular space	IDA	26646931
GO:0016442	Component	RISC complex	IEA
GO:0030336	Process	Negative regulation of cell migration	IDA	23437250
GO:0030336	Process	Negative regulation of cell migration	IMP	20619534
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IDA	26646931, 26934179, 27780851, 28065883, 28124060
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IGI	23437250
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IMP	23437250
GO:0035278	Process	MiRNA-mediated gene silencing by inhibition of translation	IDA	20619534
GO:0043410	Process	Positive regulation of MAPK cascade	IMP	18694566
GO:0043410	Process	Positive regulation of MAPK cascade	ISS
GO:0043536	Process	Positive regulation of blood vessel endothelial cell migration	IMP	18694566
GO:0045747	Process	Positive regulation of Notch signaling pathway	ISS
GO:0045766	Process	Positive regulation of angiogenesis	IMP	23136161
GO:0045766	Process	Positive regulation of angiogenesis	ISS
GO:0045861	Process	Negative regulation of proteolysis	IGI	23437250
GO:0050729	Process	Positive regulation of inflammatory response	ISS
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	ISS
GO:0071499	Process	Cellular response to laminar fluid shear stress	ISS
GO:0090050	Process	Positive regulation of cell migration involved in sprouting angiogenesis	IDA	28065883, 28124060
GO:0090050	Process	Positive regulation of cell migration involved in sprouting angiogenesis	ISS
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	IDA	20619534, 26934179, 27780851, 28065883, 28124060
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	IGI	23437250
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	IMP	23437250
GO:1903561	Component	Extracellular vesicle	HDA	28798470
GO:1903589	Process	Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IDA	28065883, 28124060
GO:1903589	Process	Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISS
GO:1903672	Process	Positive regulation of sprouting angiogenesis	IGI	27780851
GO:1904018	Process	Positive regulation of vasculature development	ISS
GO:1905563	Process	Negative regulation of vascular endothelial cell proliferation	IMP	18694566
GO:1905564	Process	Positive regulation of vascular endothelial cell proliferation	ISS
GO:2000352	Process	Negative regulation of endothelial cell apoptotic process	IMP	18694566

Other IDs

• MIM: 611767
• HGNC: 31508
• e!Ensembl: ENSG00000199161

Interactions View interactions

Pathways

KEGG:

MicroRNAs in cancer