MIR125B1 (microRNA 125b-1)

Gene

• Entrez ID: 406911
• Gene name: MicroRNA 125b-1
• Gene symbol: MIR125B1
• Synonyms (NCBI Gene): MIRN125B1, mir-125b-1
• Chromosome: 11
• Chromosome location: 11q24.1
• Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003730	Function	MRNA 3'-UTR binding	IDA	28214897
GO:0005615	Component	Extracellular space	HDA	26646931
GO:0010629	Process	Negative regulation of gene expression	IGI	28214897
GO:0010804	Process	Negative regulation of tumor necrosis factor-mediated signaling pathway	IDA	26435691
GO:0010839	Process	Negative regulation of keratinocyte proliferation	IMP	21412257
GO:0016442	Component	RISC complex	IEA
GO:0016525	Process	Negative regulation of angiogenesis	IDA	22391569
GO:0030514	Process	Negative regulation of BMP signaling pathway	IMP	28214897
GO:0032720	Process	Negative regulation of tumor necrosis factor production	IDA	26435691
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IDA	19437538, 26435691, 26455324, 28389358, 30237497
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IEA
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IMP	20347935
GO:0035278	Process	MiRNA-mediated gene silencing by inhibition of translation	IDA	21412257, 22391569
GO:0035279	Process	MiRNA-mediated gene silencing by mRNA destabilization	IDA	28214897
GO:0045618	Process	Positive regulation of keratinocyte differentiation	IMP	21412257
GO:0045656	Process	Negative regulation of monocyte differentiation	IDA	28389358
GO:0045668	Process	Negative regulation of osteoblast differentiation	IMP	28214897
GO:0060252	Process	Positive regulation of glial cell proliferation	IMP	20347935
GO:0070062	Component	Extracellular exosome	IDA	31926946
GO:0070104	Process	Negative regulation of interleukin-6-mediated signaling pathway	IDA	26455324
GO:0071305	Process	Cellular response to vitamin D	IDA	28389358
GO:0071354	Process	Cellular response to interleukin-6	IMP	20347935
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	IDA	19437538, 21412257, 22391569, 26435691, 26455324, 28214897, 28389358, 30237497
GO:1903561	Component	Extracellular vesicle	HDA	28798470
GO:1904893	Process	Negative regulation of receptor signaling pathway via STAT	IDA	26455324
GO:1905065	Process	Positive regulation of vascular associated smooth muscle cell differentiation	IMP	18548003

Other IDs

• MIM: 610104
• HGNC: 31506
• e!Ensembl: ENSG00000207971

Interactions View interactions

Pathways

KEGG:

MicroRNAs in cancer