MIRLET7B (microRNA let-7b)

Gene

• Entrez ID: 406884
• Gene name: MicroRNA let-7b
• Gene symbol: MIRLET7B
• Synonyms (NCBI Gene): LET7B, MIRNLET7B, hsa-let-7b, let-7b
• Chromosome: 22
• Chromosome location: 22q13.31
• Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005615	Component	Extracellular space	HDA	18766170, 26646931
GO:0016442	Component	RISC complex	IEA
GO:0030512	Process	Negative regulation of transforming growth factor beta receptor signaling pathway	IGI	24978044
GO:0034614	Process	Cellular response to reactive oxygen species	IDA	26296645
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IDA	15131085, 24978044, 26296645, 27809873, 28159509
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IEA
GO:0035279	Process	MiRNA-mediated gene silencing by mRNA destabilization	IDA	29471394
GO:0043537	Process	Negative regulation of blood vessel endothelial cell migration	IMP	24978044
GO:0045766	Process	Positive regulation of angiogenesis	IDA	28159509
GO:0045766	Process	Positive regulation of angiogenesis	IDA	26296645
GO:0070062	Component	Extracellular exosome	IDA	28159509, 31926946
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IDA	26296645
GO:0140367	Process	Antibacterial innate immune response	IDA	29471394
GO:1900118	Process	Negative regulation of execution phase of apoptosis	IDA	26296645
GO:1901299	Process	Negative regulation of hydrogen peroxide-mediated programmed cell death	IDA	26296645
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	IDA	15131085, 24978044, 26296645, 27809873, 29471394
GO:1903561	Component	Extracellular vesicle	HDA	28798470
GO:1903589	Process	Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IDA	28159509
GO:1903845	Process	Negative regulation of cellular response to transforming growth factor beta stimulus	IMP	24978044
GO:1904753	Process	Negative regulation of vascular associated smooth muscle cell migration	IMP	24978044
GO:2000110	Process	Negative regulation of macrophage apoptotic process	IDA	29471394

Other IDs

• MIM: 611249
• HGNC: 31479
• e!Ensembl: ENSG00000284520

Interactions View interactions

Pathways

KEGG:

MicroRNAs in cancer
Chemical carcinogenesis - receptor activation