Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4067
Gene name Gene Name - the full gene name approved by the HGNC.
LYN proto-oncogene, Src family tyrosine kinase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LYN
Synonyms (NCBI Gene) Gene synonyms aliases
JTK8, SAIDV, p53Lyn, p56Lyn
Disease Acronyms (UniProt) Disease acronyms from UniProt database
SAIDV
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q12.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided b
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT046575 hsa-miR-222-3p CLASH 23622248
MIRT322915 hsa-miR-32-3p PAR-CLIP 20371350
MIRT322916 hsa-miR-4731-3p PAR-CLIP 20371350
MIRT322917 hsa-miR-4801 PAR-CLIP 20371350
MIRT570814 hsa-miR-4789-3p PAR-CLIP 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001782 Process B cell homeostasis ISS
GO:0001817 Process Regulation of cytokine production ISS
GO:0001932 Process Regulation of protein phosphorylation TAS 15489917
GO:0001933 Process Negative regulation of protein phosphorylation ISS
GO:0001934 Process Positive regulation of protein phosphorylation IGI 24217950
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
165120 6735 ENSG00000254087
Protein
UniProt ID P07948
Protein name Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Protein function Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin sig
PDB 1W1F , 1WA7 , 3A4O , 5XY1 , 6NMW , 8WFF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00018 SH3_1 69 115 SH3 domain Domain
PF00017 SH2 129 211 SH2 domain Domain
PF07714 PK_Tyr_Ser-Thr 247 497 Protein tyrosine and serine/threonine kinase Domain
Tissue specificity TISSUE SPECIFICITY: Detected in monocytes (at protein level). Detected in placenta, and in fetal brain, lung, liver and kidney. Widely expressed in a variety of organs, tissues, and cell types such as epidermoid, hematopoietic, and neuronal cells. Express
Sequence
Sequence length 512
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Chemokine signaling pathway
NF-kappa B signaling pathway
Platelet activation
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Long-term depression
Epithelial cell signaling in Helicobacter pylori infection
Kaposi sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Viral carcinogenesis
Lipid and atherosclerosis
  GPVI-mediated activation cascade
Signaling by SCF-KIT
Regulation of KIT signaling
Cell surface interactions at the vascular wall
FCGR activation
PECAM1 interactions
Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation
CD28 co-stimulation
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
Dectin-2 family
CD209 (DC-SIGN) signaling
CD22 mediated BCR regulation
Cyclin D associated events in G1
Platelet Adhesion to exposed collagen
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates RAS
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Growth hormone receptor signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Hypertension Hypertensive disease rs13306026 28498854
Unknown
Disease term Disease name Evidence References Source
Autoinflammatory Disease autoinflammatory disease, systemic, with vasculitis GenCC
Insomnia Insomnia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 26708841, 27756880, 36991000
Adenocarcinoma of Lung Associate 23866081, 27756880
Anovulation Associate 40287692
Atherosclerosis Associate 28260035, 34122426
Autoimmune Diseases Associate 36215934, 36267464
Bone Resorption Associate 9844106
Brain Ischemia Associate 33460396
Breast Neoplasms Associate 20215510, 30969999
Bruton type agammaglobulinemia Associate 10688822
Burkitt Lymphoma Associate 26731115