Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
406
Gene name Gene Name - the full gene name approved by the HGNC.
Basic helix-loop-helix ARNT like 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
BMAL1
Synonyms (NCBI Gene) Gene synonyms aliases
ARNTL, ARNTL1, BMAL1c, JAP3, MOP3, PASD3, TIC, bHLHe5
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11p15.3
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006653 hsa-miR-494-3p Luciferase reporter assay, qRT-PCR 21799909
MIRT006654 hsa-miR-142-3p Luciferase reporter assay, qRT-PCR 21799909
MIRT006654 hsa-miR-142-3p Luciferase reporter assay 22958478
MIRT018183 hsa-miR-335-5p Microarray 18185580
MIRT006654 hsa-miR-142-3p Microarray 17612493
Transcription factors
Transcription factor Regulation Reference
MTA1 Activation 24089055
NR1D1 Repression 21881539
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000976 Function Transcription regulatory region sequence-specific DNA binding ISS
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602550 701 ENSG00000133794
Protein
UniProt ID O00327
Protein name Basic helix-loop-helix ARNT-like protein 1 (Aryl hydrocarbon receptor nuclear translocator-like protein 1) (Basic-helix-loop-helix-PAS protein MOP3) (Brain and muscle ARNT-like 1) (Class E basic helix-loop-helix protein 5) (bHLHe5) (Member of PAS protein
Protein function Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in g
PDB 4H10 , 8RW6 , 8RW8
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00010 HLH 73 126 Helix-loop-helix DNA-binding domain Domain
PF00989 PAS 146 253 PAS fold Domain
PF14598 PAS_11 337 444 Domain
Tissue specificity TISSUE SPECIFICITY: Hair follicles (at protein level). Highly expressed in the adult brain, skeletal muscle and heart. {ECO:0000269|PubMed:24005054}.
Sequence
MADQRMDISSTISDFMSPGPTDLLSSSLGTSGVDCNRKRKGSSTDYQESMDTDKDDPHGR
LEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQ
HMKTLR
GATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKIL
NYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLC
SGARRSFFCRMKC
NRPSVKVEDKDFPSTCSKKKADRKSFCTIHSTGYLKSWPPTKMGLDE
DNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAI
LAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRW
FSFMNPWTKEVEYIVSTNTVVLAN
VLEGGDPTFPQLTASPHSMDSMLPSGEGGPKRTHPT
VPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPPDASSPGGKKI
LNGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQGSSSPSNDEAAM
AVIMSLLEADAGLGGPVDFSDLPWPL
Sequence length 626
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Circadian rhythm
Dopaminergic synapse
  BMAL1:CLOCK,NPAS2 activates circadian gene expression
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Coronary artery disease Coronary Artery Disease rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537 29212778, 28714975
Multiple congenital anomalies Multiple congenital anomalies rs1057517732 24652800
Unknown
Disease term Disease name Evidence References Source
Mental depression Mental Depression, Depressive disorder 24673294, 19693801, 19708722 ClinVar
Neuroticism Neuroticism GWAS
Metabolic Syndrome Metabolic Syndrome GWAS
Schizophrenia Schizophrenia GWAS