Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4058
Gene name Gene Name - the full gene name approved by the HGNC.	Leukocyte receptor tyrosine kinase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	LTK
Synonyms (NCBI Gene) Gene synonyms aliases	TYK1
Chromosome Chromosome number	15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	15q15.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript

Show/Hide all(95)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018950	hsa-miR-335-5p	Microarray	18185580
MIRT1122214	hsa-miR-296-5p	CLIP-seq
MIRT1122215	hsa-miR-320a	CLIP-seq
MIRT1122216	hsa-miR-320b	CLIP-seq
MIRT1122217	hsa-miR-320c	CLIP-seq
MIRT1122218	hsa-miR-320d	CLIP-seq
MIRT1122219	hsa-miR-320e	CLIP-seq
MIRT1122220	hsa-miR-3652	CLIP-seq
MIRT1122221	hsa-miR-4429	CLIP-seq
MIRT1122222	hsa-miR-4430	CLIP-seq
MIRT1122223	hsa-miR-4494	CLIP-seq
MIRT1122224	hsa-miR-4505	CLIP-seq
MIRT1122225	hsa-miR-4795-5p	CLIP-seq
MIRT1122214	hsa-miR-296-5p	CLIP-seq
MIRT1122215	hsa-miR-320a	CLIP-seq
MIRT1122216	hsa-miR-320b	CLIP-seq
MIRT1122217	hsa-miR-320c	CLIP-seq
MIRT1122218	hsa-miR-320d	CLIP-seq
MIRT1122219	hsa-miR-320e	CLIP-seq
MIRT1122220	hsa-miR-3652	CLIP-seq
MIRT1122221	hsa-miR-4429	CLIP-seq
MIRT1122222	hsa-miR-4430	CLIP-seq
MIRT1122224	hsa-miR-4505	CLIP-seq
MIRT1122225	hsa-miR-4795-5p	CLIP-seq
MIRT1122214	hsa-miR-296-5p	CLIP-seq
MIRT1122226	hsa-miR-3192	CLIP-seq
MIRT1122215	hsa-miR-320a	CLIP-seq
MIRT1122216	hsa-miR-320b	CLIP-seq
MIRT1122217	hsa-miR-320c	CLIP-seq
MIRT1122218	hsa-miR-320d	CLIP-seq
MIRT1122219	hsa-miR-320e	CLIP-seq
MIRT1122220	hsa-miR-3652	CLIP-seq
MIRT1122227	hsa-miR-3689a-3p	CLIP-seq
MIRT1122228	hsa-miR-3689c	CLIP-seq
MIRT1122229	hsa-miR-4292	CLIP-seq
MIRT1122230	hsa-miR-4308	CLIP-seq
MIRT1122221	hsa-miR-4429	CLIP-seq
MIRT1122222	hsa-miR-4430	CLIP-seq
MIRT1122224	hsa-miR-4505	CLIP-seq
MIRT1122231	hsa-miR-4728-5p	CLIP-seq
MIRT1122225	hsa-miR-4795-5p	CLIP-seq
MIRT1122232	hsa-miR-670	CLIP-seq
MIRT1122214	hsa-miR-296-5p	CLIP-seq
MIRT1122215	hsa-miR-320a	CLIP-seq
MIRT1122216	hsa-miR-320b	CLIP-seq
MIRT1122217	hsa-miR-320c	CLIP-seq
MIRT1122218	hsa-miR-320d	CLIP-seq
MIRT1122219	hsa-miR-320e	CLIP-seq
MIRT1122220	hsa-miR-3652	CLIP-seq
MIRT1122221	hsa-miR-4429	CLIP-seq
MIRT1122222	hsa-miR-4430	CLIP-seq
MIRT1122224	hsa-miR-4505	CLIP-seq
MIRT1122225	hsa-miR-4795-5p	CLIP-seq
MIRT2034536	hsa-miR-1587	CLIP-seq
MIRT2034537	hsa-miR-378g	CLIP-seq
MIRT2034538	hsa-miR-4492	CLIP-seq
MIRT2034539	hsa-miR-4498	CLIP-seq
MIRT2034540	hsa-miR-4656	CLIP-seq
MIRT2034541	hsa-miR-4675	CLIP-seq
MIRT2034542	hsa-miR-4741	CLIP-seq
MIRT2034543	hsa-miR-661	CLIP-seq
MIRT2034544	hsa-miR-762	CLIP-seq
MIRT1122214	hsa-miR-296-5p	CLIP-seq
MIRT1122215	hsa-miR-320a	CLIP-seq
MIRT1122216	hsa-miR-320b	CLIP-seq
MIRT1122217	hsa-miR-320c	CLIP-seq
MIRT1122218	hsa-miR-320d	CLIP-seq
MIRT1122219	hsa-miR-320e	CLIP-seq
MIRT1122220	hsa-miR-3652	CLIP-seq
MIRT1122221	hsa-miR-4429	CLIP-seq
MIRT1122222	hsa-miR-4430	CLIP-seq
MIRT1122224	hsa-miR-4505	CLIP-seq
MIRT1122225	hsa-miR-4795-5p	CLIP-seq
MIRT2564063	hsa-miR-1321	CLIP-seq
MIRT2564064	hsa-miR-3126-5p	CLIP-seq
MIRT2564065	hsa-miR-3150b-3p	CLIP-seq
MIRT2564066	hsa-miR-3162-5p	CLIP-seq
MIRT2564067	hsa-miR-4293	CLIP-seq
MIRT2564068	hsa-miR-4689	CLIP-seq
MIRT1122231	hsa-miR-4728-5p	CLIP-seq
MIRT2564069	hsa-miR-4739	CLIP-seq
MIRT2564070	hsa-miR-4756-5p	CLIP-seq
MIRT2564071	hsa-miR-4784	CLIP-seq
MIRT2564072	hsa-miR-544b	CLIP-seq
MIRT2564063	hsa-miR-1321	CLIP-seq
MIRT2564064	hsa-miR-3126-5p	CLIP-seq
MIRT2564065	hsa-miR-3150b-3p	CLIP-seq
MIRT2564066	hsa-miR-3162-5p	CLIP-seq
MIRT2564067	hsa-miR-4293	CLIP-seq
MIRT2564068	hsa-miR-4689	CLIP-seq
MIRT1122231	hsa-miR-4728-5p	CLIP-seq
MIRT2564069	hsa-miR-4739	CLIP-seq
MIRT2564070	hsa-miR-4756-5p	CLIP-seq
MIRT2564071	hsa-miR-4784	CLIP-seq
MIRT2564072	hsa-miR-544b	CLIP-seq

Show/Hide all(38)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IDA	10445845
GO:0004672	Function	Protein kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	EXP	7650032, 8084603, 8910363, 10445845, 34819663
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	TAS	7685902
GO:0004714	Function	Transmembrane receptor protein tyrosine kinase activity	IBA
GO:0004714	Function	Transmembrane receptor protein tyrosine kinase activity	IDA	30061385
GO:0004714	Function	Transmembrane receptor protein tyrosine kinase activity	IEA
GO:0004714	Function	Transmembrane receptor protein tyrosine kinase activity	TAS	7685902
GO:0005515	Function	Protein binding	IPI	9223670, 26418745, 35384245
GO:0005524	Function	ATP binding	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	34646012
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	7685902
GO:0006468	Process	Protein phosphorylation	TAS	7685902
GO:0007165	Process	Signal transduction	TAS	7685902
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IBA
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IDA	30061385
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IEA
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IMP	9223670
GO:0008283	Process	Cell population proliferation	IDA	10445845
GO:0010666	Process	Positive regulation of cardiac muscle cell apoptotic process	IDA	10445845
GO:0010976	Process	Positive regulation of neuron projection development	IMP	17910947
GO:0016020	Component	Membrane	IDA	10445845
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030298	Function	Receptor signaling protein tyrosine kinase activator activity	IDA	30061385
GO:0030298	Function	Receptor signaling protein tyrosine kinase activator activity	IEA
GO:0038083	Process	Peptidyl-tyrosine autophosphorylation	IDA	30061385
GO:0042127	Process	Regulation of cell population proliferation	IBA
GO:0043066	Process	Negative regulation of apoptotic process	IMP	9223670
GO:0043235	Component	Receptor complex	IBA
GO:0045664	Process	Regulation of neuron differentiation	IBA
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP	9223670
GO:0071300	Process	Cellular response to retinoic acid	IMP	17910947

MIM	HGNC	e!Ensembl
151520	6721	ENSG00000062524

Protein

UniProt ID

P29376

Protein name

Leukocyte tyrosine kinase receptor (EC 2.7.10.1) (Protein tyrosine kinase 1)

Protein function

Receptor with a tyrosine-protein kinase activity (PubMed:10445845, PubMed:20548102, PubMed:30061385). Following activation by ALKAL1 or ALKAL2 ligands at the cell surface, transduces an extracellular signal into an intracellular response (PubMed

PDB

7NX0 , 7NX1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12810	Gly_rich	112 → 383		Family
PF07714	PK_Tyr_Ser-Thr	510 → 777	Protein tyrosine and serine/threonine kinase	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in non-hematopoietic cell lines and T- and B-cell lines. {ECO:0000269|PubMed:2156206}.

Sequence

MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN
SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL
ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL
RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC
SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF
LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK
PPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTA
PNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQ
VAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKS
FLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVA
KIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLG
YMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYC
TQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWL
SSGLKPLKSRGLQPQNLWNPTYRS

Sequence length

864

Interactions

View interactions

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Asthma	Age of onset of adult onset asthma	N/A	N/A	GWAS
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Parkinson Disease	Parkinson's disease	N/A	N/A	GWAS

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Carcinoma	Associate	38517106
Carcinoma Hepatocellular	Associate	31730575
Carcinoma Non Small Cell Lung	Associate	35016028
Gastrointestinal Stromal Tumors	Associate	27974047
Leukemia	Associate	22347506
Lung Neoplasms	Associate	35016028
Neoplasms	Associate	22347506, 33853673, 34127544, 36871023, 37387515
Rectal Diseases	Associate	37387515
Soft Tissue Neoplasms	Associate	38517106
Thymoma	Associate	37703595

LTK (leukocyte receptor tyrosine kinase)