Gene Gene information from NCBI Gene database.
Entrez ID 405
Gene name Aryl hydrocarbon receptor nuclear translocator
Gene symbol ARNT
Synonyms (NCBI Gene)
ARNT1HIF-1-betaHIF-1betaHIF1-betaHIF1BHIF1BETATANGObHLHe2
Chromosome 1
Chromosome location 1q21.3
Summary This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus,
miRNA miRNA information provided by mirtarbase database.
818
miRTarBase ID miRNA Experiments Reference
MIRT004537 hsa-miR-107 qRT-PCRLuciferase reporter assayWestern blotNorthern blot 20308559
MIRT004537 hsa-miR-107 qRT-PCRLuciferase reporter assayWestern blotNorthern blot 20308559
MIRT004537 hsa-miR-107 Reporter assay;Western blot 20308559
MIRT043236 hsa-miR-324-5p CLASH 23622248
MIRT037117 hsa-miR-877-3p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
3
Transcription factor Regulation Reference
AHR Unknown 19255421;8631989
HIF1A Unknown 12239177
PHB2 Repression 21256954
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
59
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IDA 7539918, 8756616
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
126110 700 ENSG00000143437
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P27540
Protein name Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Class E basic helix-loop-helix protein 2) (bHLHe2) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta)
Protein function Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit
PDB 1X0O , 2A24 , 2B02 , 2HV1 , 2K7S , 3F1N , 3F1O , 3F1P , 3H7W , 3H82 , 4EQ1 , 4GHI , 4GS9 , 4H6J , 4LPZ , 4PKY , 4XT2 , 5TBM , 5UFP , 5V0L , 6CZW , 6D09 , 6D0B , 6D0C , 6X21 , 6X28 , 6X2H , 6X37 , 6X3D , 8CK3 , 8CK4 , 8CK8 , 8G4A , 8XS6 , 8XS7 , 8XS8 , 8XS9 , 8XSA , 8XSB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00010 HLH 90 143 Helix-loop-helix DNA-binding domain Domain
PF00989 PAS 163 270 PAS fold Domain
PF14598 PAS_11 360 469 Domain
Sequence
MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFL
RCDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCS
ALARKPDKLTILRMAVSHMKSLR
GTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVS
CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLK
TGTVKKEGQQSSMRMCMGSRRSFICRMRCG
SSSVDPVSVNRLSFVRNRCRNGLGSVKDGE
PHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQP
TEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKG
QVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQ
EPRPTLSNTIQ
RPQLGPTANLPLEMGSGQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSK
PLEKSDGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENF
RNSGLAPPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKT
RTSQFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAPETGQTAGQFQTRTA
EGVGVWPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYNNEEFPD
LTMFPPFSE
Sequence length 789
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  HIF-1 signaling pathway
Efferocytosis
Cushing syndrome
Pathways in cancer
Chemical carcinogenesis - receptor activation
Chemical carcinogenesis - reactive oxygen species
Renal cell carcinoma
  Regulation of gene expression by Hypoxia-inducible Factor
PPARA activates gene expression
Phase I - Functionalization of compounds
Endogenous sterols
Xenobiotics
Aryl hydrocarbon receptor signalling