LTA (lymphotoxin alpha)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4049
Gene name Gene Name - the full gene name approved by the HGNC.
Lymphotoxin alpha
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LTA
Synonyms (NCBI Gene) Gene synonyms aliases
LT, TNFB, TNFSF1, TNLG1E
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p21.33
Summary Summary of gene provided in NCBI Entrez Gene.
The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This pro
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT1122078 hsa-miR-1587 CLIP-seq
MIRT1122079 hsa-miR-384 CLIP-seq
MIRT1122080 hsa-miR-4492 CLIP-seq
MIRT1122081 hsa-miR-4498 CLIP-seq
MIRT1122082 hsa-miR-4505 CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
MSC Repression 15052269
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001666 Process Response to hypoxia IEA
GO:0002876 Process Positive regulation of chronic inflammatory response to antigenic stimulus IEA
GO:0002925 Process Positive regulation of humoral immune response mediated by circulating immunoglobulin IEA
GO:0005102 Function Signaling receptor binding IEA
GO:0005102 Function Signaling receptor binding TAS 3001529
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
153440 6709 ENSG00000226979
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P01374
Protein name Lymphotoxin-alpha (LT-alpha) (TNF-beta) (Tumor necrosis factor ligand superfamily member 1)
Protein function Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (PubMed:9462508). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR (PubMed:24248355). Lymphotoxin is produced by lymphocytes and is cytotox
PDB 1TNR , 4MXV , 4MXW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00229 TNF 77 → 205 TNF(Tumour Necrosis Factor) family Domain
Sequence
Sequence length 205
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
NF-kappa B signaling pathway
TNF signaling pathway
Type I diabetes mellitus
Human T-cell leukemia virus 1 infection
Herpes simplex virus 1 infection 		  TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (6)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Asthma Asthma, Asthma (childhood onset), Atopic asthma N/A N/A GWAS
Cervical Cancer Cervical cancer N/A N/A GWAS
Crohn Disease Crohn's disease N/A N/A GWAS
Leprosy Leprosy, early-onset, susceptibility to N/A N/A ClinVar
Show/Hide Text Mining Associations (209)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Abortion Habitual Associate 18394614
Abortion Spontaneous Associate 18394614
Acquired Immunodeficiency Syndrome Associate 19654554
Acute On Chronic Liver Failure Inhibit 34774066
Adenocarcinoma of Lung Associate 7641214
Adrenal Hyperplasia Congenital Associate 26657940
AIDS Associated Nephropathy Inhibit 24896147
AIDS Associated Nephropathy Associate 24896147, 31936167
Alzheimer Disease Stimulate 37584418
Alzheimer Disease Associate 37762058