Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	4046
Gene name	Lymphocyte specific protein 1
Gene symbol	LSP1
Synonyms (NCBI Gene)	WP34pp52
Chromosome	11
Chromosome location	11p15.5
Summary	This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Al

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018132	hsa-miR-335-5p	Microarray	18185580
MIRT437982	hsa-miR-196a-5p	Luciferase reporter assay	24681820
MIRT437982	hsa-miR-196a-5p	Luciferase reporter assay	24681820
MIRT489821	hsa-miR-6858-3p	PAR-CLIP	20371350
MIRT489819	hsa-miR-4676-5p	PAR-CLIP	20371350
MIRT489818	hsa-miR-575	PAR-CLIP	20371350
MIRT489817	hsa-miR-3918	PAR-CLIP	20371350
MIRT489816	hsa-miR-4685-5p	PAR-CLIP	20371350
MIRT489815	hsa-miR-6837-5p	PAR-CLIP	20371350
MIRT489814	hsa-miR-3656	PAR-CLIP	20371350
MIRT489813	hsa-miR-6781-5p	PAR-CLIP	20371350
MIRT489812	hsa-miR-328-5p	PAR-CLIP	20371350
MIRT489811	hsa-miR-6885-5p	PAR-CLIP	20371350
MIRT489810	hsa-miR-4662a-5p	PAR-CLIP	20371350
MIRT489821	hsa-miR-6858-3p	PAR-CLIP	23592263
MIRT489819	hsa-miR-4676-5p	PAR-CLIP	23592263
MIRT489818	hsa-miR-575	PAR-CLIP	23592263
MIRT489817	hsa-miR-3918	PAR-CLIP	23592263
MIRT489816	hsa-miR-4685-5p	PAR-CLIP	23592263
MIRT489815	hsa-miR-6837-5p	PAR-CLIP	23592263
MIRT489814	hsa-miR-3656	PAR-CLIP	23592263
MIRT489813	hsa-miR-6781-5p	PAR-CLIP	23592263
MIRT489812	hsa-miR-328-5p	PAR-CLIP	23592263
MIRT489811	hsa-miR-6885-5p	PAR-CLIP	23592263
MIRT489810	hsa-miR-4662a-5p	PAR-CLIP	23592263
MIRT489812	hsa-miR-328-5p	PAR-CLIP	26701625
MIRT489814	hsa-miR-3656	PAR-CLIP	26701625
MIRT489817	hsa-miR-3918	PAR-CLIP	26701625
MIRT489810	hsa-miR-4662a-5p	PAR-CLIP	26701625
MIRT489819	hsa-miR-4676-5p	PAR-CLIP	26701625
MIRT489816	hsa-miR-4685-5p	PAR-CLIP	26701625
MIRT489818	hsa-miR-575	PAR-CLIP	26701625
MIRT489813	hsa-miR-6781-5p	PAR-CLIP	26701625
MIRT489815	hsa-miR-6837-5p	PAR-CLIP	26701625
MIRT489821	hsa-miR-6858-3p	PAR-CLIP	26701625
MIRT489811	hsa-miR-6885-5p	PAR-CLIP	26701625
MIRT489821	hsa-miR-6858-3p	PAR-CLIP	20371350
MIRT489819	hsa-miR-4676-5p	PAR-CLIP	20371350
MIRT489818	hsa-miR-575	PAR-CLIP	20371350
MIRT489817	hsa-miR-3918	PAR-CLIP	20371350
MIRT489816	hsa-miR-4685-5p	PAR-CLIP	20371350
MIRT489815	hsa-miR-6837-5p	PAR-CLIP	20371350
MIRT489814	hsa-miR-3656	PAR-CLIP	20371350
MIRT489813	hsa-miR-6781-5p	PAR-CLIP	20371350
MIRT489812	hsa-miR-328-5p	PAR-CLIP	20371350
MIRT489811	hsa-miR-6885-5p	PAR-CLIP	20371350
MIRT489810	hsa-miR-4662a-5p	PAR-CLIP	20371350
MIRT489821	hsa-miR-6858-3p	PAR-CLIP	23592263
MIRT489819	hsa-miR-4676-5p	PAR-CLIP	23592263
MIRT489818	hsa-miR-575	PAR-CLIP	23592263
MIRT489817	hsa-miR-3918	PAR-CLIP	23592263
MIRT489816	hsa-miR-4685-5p	PAR-CLIP	23592263
MIRT489815	hsa-miR-6837-5p	PAR-CLIP	23592263
MIRT489814	hsa-miR-3656	PAR-CLIP	23592263
MIRT489813	hsa-miR-6781-5p	PAR-CLIP	23592263
MIRT489812	hsa-miR-328-5p	PAR-CLIP	23592263
MIRT489811	hsa-miR-6885-5p	PAR-CLIP	23592263
MIRT489810	hsa-miR-4662a-5p	PAR-CLIP	23592263
MIRT1121960	hsa-miR-1231	CLIP-seq
MIRT1121961	hsa-miR-149	CLIP-seq
MIRT1121962	hsa-miR-3064-5p	CLIP-seq
MIRT1121963	hsa-miR-331-3p	CLIP-seq
MIRT1121964	hsa-miR-3652	CLIP-seq
MIRT1121965	hsa-miR-4292	CLIP-seq
MIRT1121966	hsa-miR-4430	CLIP-seq
MIRT1121967	hsa-miR-4505	CLIP-seq
MIRT1121968	hsa-miR-4794	CLIP-seq
MIRT1121969	hsa-miR-4487	CLIP-seq
MIRT1121970	hsa-miR-802	CLIP-seq
MIRT2442332	hsa-miR-1238	CLIP-seq
MIRT2442333	hsa-miR-3124-3p	CLIP-seq
MIRT2442334	hsa-miR-361-3p	CLIP-seq
MIRT2442335	hsa-miR-383	CLIP-seq
MIRT2442336	hsa-miR-4433	CLIP-seq
MIRT2442337	hsa-miR-4459	CLIP-seq
MIRT2442338	hsa-miR-4691-5p	CLIP-seq
MIRT2442339	hsa-miR-4768-3p	CLIP-seq
MIRT2442340	hsa-miR-4772-5p	CLIP-seq

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Transcription factor	Regulation	Reference
SP1	Unknown	9257843

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IEA
GO:0003779	Function	Actin binding	TAS	8274738
GO:0005515	Function	Protein binding	IPI	35156780
GO:0005886	Component	Plasma membrane	IEA
GO:0006935	Process	Chemotaxis	IEA
GO:0006952	Process	Defense response	IEA
GO:0006968	Process	Cellular defense response	TAS	2174784
GO:0007165	Process	Signal transduction	IEA
GO:0015629	Component	Actin cytoskeleton	TAS	8274738
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0098761	Process	Cellular response to interleukin-7	IEA

MIM	HGNC	e!Ensembl
153432	6707	ENSG00000130592

P33241

Protein name

Lymphocyte-specific protein 1 (47 kDa actin-binding protein) (52 kDa phosphoprotein) (pp52) (Lymphocyte-specific antigen WP34)

Protein function

May play a role in mediating neutrophil activation and chemotaxis.

PDB

3BH8 , 4NO0 , 4NO2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02029	Caldesmon	159 → 317	Caldesmon	Disordered

Tissue specificity

TISSUE SPECIFICITY: Activated T-lymphocytes.

Sequence

MAEASSDPGAEEREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPK
QEMLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRP
GLHAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQKCQQPRTPSPLV
LEGTIEQSSPPLSPTTKLIDRTESLNRSIEKSNSVKKSQPDLPISKIDQWLEQYTQAIET
AGRTPKLARQASIELPSMAVASTKSRWETGEVQAQSAAKTPSCKDIVAGDMSKKSLWEQK
GGSKTSSTIKSTPSGKRYKFVATGHGKYEKVLVEGGPAP

Sequence length

339

Interactions

View interactions

	KEGG
	C-type lectin receptor signaling pathway Tuberculosis

LSP1 (lymphocyte specific protein 1)