Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4045
Gene name Gene Name - the full gene name approved by the HGNC.
Limbic system associated membrane protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LSAMP
Synonyms (NCBI Gene) Gene synonyms aliases
IGLON3, LAMP
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q13.31
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the immunoglobulin LAMP, OBCAM and neurotrimin (IgLON) family of proteins. The encoded preproprotein is proteolytically processed to generate a neuronal surface glycoprotein. This protein may act as a selective homophilic adh
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT018263 hsa-miR-335-5p Microarray 18185580
MIRT029724 hsa-miR-26b-5p Microarray 19088304
MIRT628037 hsa-miR-361-3p HITS-CLIP 19536157
MIRT628036 hsa-miR-7110-3p HITS-CLIP 19536157
MIRT628035 hsa-miR-6817-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 21982860, 32814053
GO:0005576 Component Extracellular region TAS
GO:0005829 Component Cytosol IDA
GO:0005886 Component Plasma membrane TAS
GO:0007155 Process Cell adhesion IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603241 6705 ENSG00000185565
Protein
UniProt ID Q13449
Protein name Limbic system-associated membrane protein (LSAMP) (IgLON family member 3)
Protein function Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hippocampal mossy fiber projection (By similarity).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07679 I-set 32 128 Immunoglobulin I-set domain Domain
PF13927 Ig_3 131 201 Domain
PF13927 Ig_3 218 294 Domain
Tissue specificity TISSUE SPECIFICITY: Expressed on limbic neurons and fiber tracts as well as in single layers of the superior colliculus, spinal cord and cerebellum.
Sequence
Sequence length 338
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Post-translational modification: synthesis of GPI-anchored proteins
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colonic neoplasms Malignant tumor of colon rs267607789, rs774277300, rs781222233, rs1060502734, rs1060503333, rs1339238483 26621817
Colorectal cancer Colorectal Carcinoma, Adenocarcinoma of large intestine rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
26621817
Colorectal neoplasms Colorectal Neoplasms, Malignant neoplasm of large intestine rs28929483, rs63751108, rs28929484, rs63749831, rs63750047, rs63751207, rs63749811, rs1553350126, rs63750875, rs63750955, rs587776706, rs63750871, rs587776715, rs63751466, rs63750049
View all (1682 more)
26621817
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 21743057
Unknown
Disease term Disease name Evidence References Source
Mental depression Unipolar Depression, Major Depressive Disorder 22892717 ClinVar
Neuroticism Neuroticism GWAS
Insomnia Insomnia GWAS
Metabolic Syndrome Metabolic Syndrome GWAS
Associations from Text Mining
Disease Name Relationship Type References
Anxiety Disorders Associate 22892717
Atherosclerosis Associate 18318786
Carcinoma Ovarian Epithelial Associate 16115914
Colonic Neoplasms Associate 36518255, 37686013
Coronary Artery Disease Associate 18318786, 27187494
Depressive Disorder Major Associate 22892717
Glioblastoma Associate 24354918
Leukemia Myeloid Acute Associate 22234698
Meniere Disease Associate 32383616
Neoplasms Inhibit 16115914, 18318786, 22234698, 24354918, 36601748