CUEDC1 (CUE domain containing 1)

Gene

• Entrez ID: 404093
• Gene name: CUE domain containing 1
• Gene symbol: CUEDC1
• Synonyms (NCBI Gene): -
• Chromosome: 17
• Chromosome location: 17q22

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018044	hsa-miR-335-5p	Microarray	18185580
MIRT021437	hsa-miR-9-5p	Microarray	17612493
MIRT1971776	hsa-miR-1269	CLIP-seq
MIRT1971777	hsa-miR-1269b	CLIP-seq
MIRT1971778	hsa-miR-1273g	CLIP-seq
MIRT1971779	hsa-miR-1288	CLIP-seq
MIRT1971780	hsa-miR-140-5p	CLIP-seq
MIRT1971781	hsa-miR-1587	CLIP-seq
MIRT1971782	hsa-miR-3147	CLIP-seq
MIRT1971783	hsa-miR-3168	CLIP-seq
MIRT1971784	hsa-miR-34a	CLIP-seq
MIRT1971785	hsa-miR-34c-5p	CLIP-seq
MIRT1971786	hsa-miR-3652	CLIP-seq
MIRT1971787	hsa-miR-3688-3p	CLIP-seq
MIRT1971788	hsa-miR-378	CLIP-seq
MIRT1971789	hsa-miR-378b	CLIP-seq
MIRT1971790	hsa-miR-378c	CLIP-seq
MIRT1971791	hsa-miR-378d	CLIP-seq
MIRT1971792	hsa-miR-378e	CLIP-seq
MIRT1971793	hsa-miR-378f	CLIP-seq
MIRT1971794	hsa-miR-378h	CLIP-seq
MIRT1971795	hsa-miR-378i	CLIP-seq
MIRT1971796	hsa-miR-3978	CLIP-seq
MIRT1971797	hsa-miR-422a	CLIP-seq
MIRT1971798	hsa-miR-4263	CLIP-seq
MIRT1971799	hsa-miR-4318	CLIP-seq
MIRT1971800	hsa-miR-4430	CLIP-seq
MIRT1971801	hsa-miR-4492	CLIP-seq
MIRT1971802	hsa-miR-4498	CLIP-seq
MIRT1971803	hsa-miR-449a	CLIP-seq
MIRT1971804	hsa-miR-449b	CLIP-seq
MIRT1971805	hsa-miR-4515	CLIP-seq
MIRT1971806	hsa-miR-4656	CLIP-seq
MIRT1971807	hsa-miR-4671-5p	CLIP-seq
MIRT1971808	hsa-miR-4674	CLIP-seq
MIRT1971809	hsa-miR-4675	CLIP-seq
MIRT1971810	hsa-miR-4740-5p	CLIP-seq
MIRT1971811	hsa-miR-4741	CLIP-seq
MIRT1971812	hsa-miR-4796-3p	CLIP-seq
MIRT1971813	hsa-miR-762	CLIP-seq
MIRT2207472	hsa-miR-1280	CLIP-seq
MIRT2207473	hsa-miR-1913	CLIP-seq
MIRT2207474	hsa-miR-199a-5p	CLIP-seq
MIRT2207475	hsa-miR-199b-5p	CLIP-seq
MIRT2207476	hsa-miR-22	CLIP-seq
MIRT2207477	hsa-miR-3160-5p	CLIP-seq
MIRT2207478	hsa-miR-3180-5p	CLIP-seq
MIRT2207479	hsa-miR-324-3p	CLIP-seq
MIRT1971786	hsa-miR-3652	CLIP-seq
MIRT2207480	hsa-miR-3692	CLIP-seq
MIRT2207481	hsa-miR-4267	CLIP-seq
MIRT2207482	hsa-miR-4313	CLIP-seq
MIRT1971800	hsa-miR-4430	CLIP-seq
MIRT2207483	hsa-miR-4436b-5p	CLIP-seq
MIRT2207484	hsa-miR-4488	CLIP-seq
MIRT2207485	hsa-miR-4640-5p	CLIP-seq
MIRT1971809	hsa-miR-4675	CLIP-seq
MIRT2207486	hsa-miR-4697-5p	CLIP-seq
MIRT2207487	hsa-miR-4726-5p	CLIP-seq
MIRT1971811	hsa-miR-4741	CLIP-seq
MIRT2207488	hsa-miR-591	CLIP-seq
MIRT2207489	hsa-miR-637	CLIP-seq
MIRT1971786	hsa-miR-3652	CLIP-seq
MIRT1971800	hsa-miR-4430	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15231748, 24510904, 29513927, 32296183, 33961781
GO:0043130	Function	Ubiquitin binding	IEA

Other IDs

• MIM: 620552
• HGNC: 31350
• e!Ensembl: ENSG00000180891

Protein

• UniProt ID: Q9NWM3
• Protein name: CUE domain-containing protein 1
• PDB: 2DHY
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02845	CUE	47 → 88	CUE domain	Domain

• Sequence:

  MTSLFRRSSSGSGGGGTAGARGGGGGTAAPQELNNSRPARQVRRLEFNQAMDDFKTMFPN
  MDYDIIECVLRANSGAVDATIDQLLQMNLEGGGSSGGVYEDSSDSEDSIPPEILERTLEP
  DSSDEEPPPVYSPPAYHMHVFDRPYPLAPPTPPPRIDALGSGAPTSQRRYRNWNPPLLGN
  LPDDFLRILPQQLDSIQGNAGGPKPGSGEGCPPAMAGPGPGDQESRWKQYLEDERIALFL
  QNEEFMKELQRNRDFLLALERDRLKYESQKSKSSSVAVGNDFGFSSPVPGTGDANPAVSE
  DALFRDKLKHMGKSTRRKLFELARAFSEKTKMRKSKRKHLLKHQSLGAAASTANLLDDVE
  GHACDEDFRGRRQEAPKVEEGLREGQ

• Sequence length: 386

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATRIAL FIBRILLATION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Breast Neoplasms	Associate	30145202	★☆☆☆☆ Found in Text Mining only