Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	404037
Gene name	Hyaluronan and proteoglycan link protein 4
Gene symbol	HAPLN4
Synonyms (NCBI Gene)	BRAL2
Chromosome	19
Chromosome location	19p13.11

150

Show/Hide all (150)

miRTarBase ID	miRNA	Experiments
MIRT1040744	hsa-miR-1	CLIP-seq
MIRT1040745	hsa-miR-1205	CLIP-seq
MIRT1040746	hsa-miR-1231	CLIP-seq
MIRT1040747	hsa-miR-1266	CLIP-seq
MIRT1040748	hsa-miR-1275	CLIP-seq
MIRT1040749	hsa-miR-146b-3p	CLIP-seq
MIRT1040750	hsa-miR-1909	CLIP-seq
MIRT1040751	hsa-miR-198	CLIP-seq
MIRT1040752	hsa-miR-199a-5p	CLIP-seq
MIRT1040753	hsa-miR-199b-5p	CLIP-seq
MIRT1040754	hsa-miR-206	CLIP-seq
MIRT1040755	hsa-miR-2110	CLIP-seq
MIRT1040756	hsa-miR-3120-5p	CLIP-seq
MIRT1040757	hsa-miR-3150a-3p	CLIP-seq
MIRT1040758	hsa-miR-3175	CLIP-seq
MIRT1040759	hsa-miR-3176	CLIP-seq
MIRT1040760	hsa-miR-3179	CLIP-seq
MIRT1040761	hsa-miR-3202	CLIP-seq
MIRT1040762	hsa-miR-339-5p	CLIP-seq
MIRT1040763	hsa-miR-3621	CLIP-seq
MIRT1040764	hsa-miR-3656	CLIP-seq
MIRT1040765	hsa-miR-3664-3p	CLIP-seq
MIRT1040766	hsa-miR-3922-3p	CLIP-seq
MIRT1040767	hsa-miR-4259	CLIP-seq
MIRT1040768	hsa-miR-4270	CLIP-seq
MIRT1040769	hsa-miR-4271	CLIP-seq
MIRT1040770	hsa-miR-4312	CLIP-seq
MIRT1040771	hsa-miR-4418	CLIP-seq
MIRT1040772	hsa-miR-4421	CLIP-seq
MIRT1040773	hsa-miR-4434	CLIP-seq
MIRT1040774	hsa-miR-4435	CLIP-seq
MIRT1040775	hsa-miR-4441	CLIP-seq
MIRT1040776	hsa-miR-4516	CLIP-seq
MIRT1040777	hsa-miR-4518	CLIP-seq
MIRT1040778	hsa-miR-4525	CLIP-seq
MIRT1040779	hsa-miR-4531	CLIP-seq
MIRT1040780	hsa-miR-4652-5p	CLIP-seq
MIRT1040781	hsa-miR-4665-5p	CLIP-seq
MIRT1040782	hsa-miR-4667-5p	CLIP-seq
MIRT1040783	hsa-miR-4688	CLIP-seq
MIRT1040784	hsa-miR-4700-5p	CLIP-seq
MIRT1040785	hsa-miR-4723-5p	CLIP-seq
MIRT1040786	hsa-miR-4725-3p	CLIP-seq
MIRT1040787	hsa-miR-4734	CLIP-seq
MIRT1040788	hsa-miR-4738-3p	CLIP-seq
MIRT1040789	hsa-miR-4747-5p	CLIP-seq
MIRT1040790	hsa-miR-4757-5p	CLIP-seq
MIRT1040791	hsa-miR-486-3p	CLIP-seq
MIRT1040792	hsa-miR-490-5p	CLIP-seq
MIRT1040793	hsa-miR-509-3-5p	CLIP-seq
MIRT1040794	hsa-miR-509-5p	CLIP-seq
MIRT1040795	hsa-miR-571	CLIP-seq
MIRT1040796	hsa-miR-596	CLIP-seq
MIRT1040797	hsa-miR-613	CLIP-seq
MIRT1040798	hsa-miR-625	CLIP-seq
MIRT1040799	hsa-miR-637	CLIP-seq
MIRT1040800	hsa-miR-663b	CLIP-seq
MIRT1040801	hsa-miR-939	CLIP-seq
MIRT1040745	hsa-miR-1205	CLIP-seq
MIRT1040747	hsa-miR-1266	CLIP-seq
MIRT1040750	hsa-miR-1909	CLIP-seq
MIRT1040765	hsa-miR-3664-3p	CLIP-seq
MIRT1040771	hsa-miR-4418	CLIP-seq
MIRT1040777	hsa-miR-4518	CLIP-seq
MIRT2008516	hsa-miR-4651	CLIP-seq
MIRT1040780	hsa-miR-4652-5p	CLIP-seq
MIRT2008517	hsa-miR-4695-5p	CLIP-seq
MIRT1040788	hsa-miR-4738-3p	CLIP-seq
MIRT2008518	hsa-miR-4802-5p	CLIP-seq
MIRT1040793	hsa-miR-509-3-5p	CLIP-seq
MIRT1040794	hsa-miR-509-5p	CLIP-seq
MIRT2008519	hsa-miR-608	CLIP-seq
MIRT1040799	hsa-miR-637	CLIP-seq
MIRT2008520	hsa-miR-661	CLIP-seq
MIRT2008521	hsa-miR-662	CLIP-seq
MIRT2240967	hsa-miR-1207-3p	CLIP-seq
MIRT2240968	hsa-miR-3145-5p	CLIP-seq
MIRT2240969	hsa-miR-3155	CLIP-seq
MIRT2240970	hsa-miR-3155b	CLIP-seq
MIRT2240971	hsa-miR-3616-3p	CLIP-seq
MIRT2240972	hsa-miR-409-5p	CLIP-seq
MIRT1040774	hsa-miR-4435	CLIP-seq
MIRT2240973	hsa-miR-4446-3p	CLIP-seq
MIRT2240974	hsa-miR-4471	CLIP-seq
MIRT2240975	hsa-miR-4492	CLIP-seq
MIRT2240976	hsa-miR-4498	CLIP-seq
MIRT2240977	hsa-miR-4685-5p	CLIP-seq
MIRT2240978	hsa-miR-4709-5p	CLIP-seq
MIRT2240979	hsa-miR-4710	CLIP-seq
MIRT2240980	hsa-miR-4721	CLIP-seq
MIRT2240981	hsa-miR-4755-3p	CLIP-seq
MIRT2240982	hsa-miR-484	CLIP-seq
MIRT2240983	hsa-miR-615-5p	CLIP-seq
MIRT2240984	hsa-miR-762	CLIP-seq
MIRT2388900	hsa-miR-150	CLIP-seq
MIRT1040758	hsa-miR-3175	CLIP-seq
MIRT2388901	hsa-miR-4713-5p	CLIP-seq
MIRT2388902	hsa-miR-4716-3p	CLIP-seq
MIRT1040785	hsa-miR-4723-5p	CLIP-seq
MIRT2388903	hsa-miR-4779	CLIP-seq
MIRT2388904	hsa-miR-532-3p	CLIP-seq
MIRT2240983	hsa-miR-615-5p	CLIP-seq
MIRT2008521	hsa-miR-662	CLIP-seq
MIRT2388905	hsa-miR-765	CLIP-seq
MIRT2450956	hsa-miR-122	CLIP-seq
MIRT1040746	hsa-miR-1231	CLIP-seq
MIRT2450957	hsa-miR-125a-3p	CLIP-seq
MIRT1040749	hsa-miR-146b-3p	CLIP-seq
MIRT2450958	hsa-miR-2861	CLIP-seq
MIRT1040756	hsa-miR-3120-5p	CLIP-seq
MIRT2450959	hsa-miR-3144-5p	CLIP-seq
MIRT2450960	hsa-miR-3150b-3p	CLIP-seq
MIRT2450961	hsa-miR-3191	CLIP-seq
MIRT1040762	hsa-miR-339-5p	CLIP-seq
MIRT1040772	hsa-miR-4421	CLIP-seq
MIRT2450962	hsa-miR-4481	CLIP-seq
MIRT1040780	hsa-miR-4652-5p	CLIP-seq
MIRT1040782	hsa-miR-4667-5p	CLIP-seq
MIRT2450963	hsa-miR-4689	CLIP-seq
MIRT1040784	hsa-miR-4700-5p	CLIP-seq
MIRT2240979	hsa-miR-4710	CLIP-seq
MIRT2388902	hsa-miR-4716-3p	CLIP-seq
MIRT1040785	hsa-miR-4723-5p	CLIP-seq
MIRT2450964	hsa-miR-4745-5p	CLIP-seq
MIRT2388903	hsa-miR-4779	CLIP-seq
MIRT2450965	hsa-miR-4784	CLIP-seq
MIRT2008520	hsa-miR-661	CLIP-seq
MIRT2388905	hsa-miR-765	CLIP-seq
MIRT2450956	hsa-miR-122	CLIP-seq
MIRT2450958	hsa-miR-2861	CLIP-seq
MIRT2450959	hsa-miR-3144-5p	CLIP-seq
MIRT2450961	hsa-miR-3191	CLIP-seq
MIRT2450962	hsa-miR-4481	CLIP-seq
MIRT1040780	hsa-miR-4652-5p	CLIP-seq
MIRT1040782	hsa-miR-4667-5p	CLIP-seq
MIRT1040784	hsa-miR-4700-5p	CLIP-seq
MIRT2450964	hsa-miR-4745-5p	CLIP-seq
MIRT2008520	hsa-miR-661	CLIP-seq
MIRT2544478	hsa-miR-1204	CLIP-seq
MIRT2544479	hsa-miR-361-3p	CLIP-seq
MIRT2544480	hsa-miR-4648	CLIP-seq
MIRT2008516	hsa-miR-4651	CLIP-seq
MIRT2008519	hsa-miR-608	CLIP-seq
MIRT1040800	hsa-miR-663b	CLIP-seq
MIRT2544478	hsa-miR-1204	CLIP-seq
MIRT2544479	hsa-miR-361-3p	CLIP-seq
MIRT2544480	hsa-miR-4648	CLIP-seq
MIRT2008516	hsa-miR-4651	CLIP-seq
MIRT2008519	hsa-miR-608	CLIP-seq
MIRT1040800	hsa-miR-663b	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence
GO:0001501	Process	Skeletal system development	IBA
GO:0005540	Function	Hyaluronic acid binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007417	Process	Central nervous system development	IBA
GO:0045202	Component	Synapse	IBA
GO:0051932	Process	Synaptic transmission, GABAergic	IEA
GO:0051932	Process	Synaptic transmission, GABAergic	ISS
GO:0072534	Component	Perineuronal net	IBA
GO:0072534	Component	Perineuronal net	IEA
GO:0072534	Component	Perineuronal net	ISS
GO:0150043	Function	Structural constituent of synapse-associated extracellular matrix	IEA
GO:0150043	Function	Structural constituent of synapse-associated extracellular matrix	ISS
GO:1904862	Process	Inhibitory synapse assembly	IEA
GO:1904862	Process	Inhibitory synapse assembly	ISS

MIM	HGNC	e!Ensembl
619710	31357	ENSG00000187664

Q86UW8

Protein name

Hyaluronan and proteoglycan link protein 4 (Brain link protein 2)

Protein function

Essential for the proper localization of brevican (BCAN), mainly as a perineuronal nets (PNNs)-type deposition in the brainstem and cerebellum thereby playing a key role in the formation and structural organization of PNNs (By similarity). Contr

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07686	V-set	51 → 159	Immunoglobulin V-set domain	Domain
PF00193	Xlink	163 → 267	Extracellular link domain	Domain
PF00193	Xlink	274 → 364	Extracellular link domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed predominantly in brain. {ECO:0000269|PubMed:12663660}.

Sequence

MVCARAALGPGALWAAAWGVLLLTAPAGAQRGRKKVVHVLEGESGSVVVQTAPGQVVSHR
GGTIVLPCRYHYEAAAHGHDGVRLKWTKVVDPLAFTDVFVALGPQHRAFGSYRGRAELQG
DGPGDASLVLRNVTLQDYGRYECEVTNELEDDAGMVKLDLEGVVFPYHPRGGRYKLTFAE
AQRACAEQDGILASAEQLHAAWRDGLDWCNAGWLRDGSVQYPVNRPREPCGGLGGTGSAG
GGGDANGGLRNYGYRHNAEERYDAFCFTSNLPGRVFFLKPLRPVPFSGAARACAARGAAV
AKVGQLFAAWKLQLLDRCTAGWLADGSARYPIVNPRARCGGRRPGVRSLGFPDATRRLFG
VYCYRAPGAPDPAPGGWGWGWAGGGGWAGGARDPAAWTPLHV

Sequence length

402

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BREAST NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC EYE DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESOPHAGEAL VARICES	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PORTAL HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Attention Deficit Disorder with Hyperactivity	Associate	37418754	★★★★★ ★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Associate	37418754	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Associate	19633295	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	19633295	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Associate	37418754	★★★★★ ★☆☆☆☆ Found in Text Mining only

HAPLN4 (hyaluronan and proteoglycan link protein 4)