Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	4035
Gene name	LDL receptor related protein 1
Gene symbol	LRP1
Synonyms (NCBI Gene)	A2MRAPOERAPRCD91DDH3IGFBP-3RIGFBP3RIGFBP3R1KPALRPLRP1ATGFBR5
Chromosome	12
Chromosome location	12q13.3
Summary	This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is

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SNP ID	Visualize variation	Clinical significance	Consequence
rs483353013	A>C,G	Not-provided, pathogenic	Missense variant, coding sequence variant

240

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miRTarBase ID	miRNA	Experiments	Reference
MIRT001163	hsa-miR-205-5p	qRT-PCRLuciferase reporter assayWestern blot	19665999
MIRT001162	hsa-miR-545-3p	qRT-PCRLuciferase reporter assayWestern blot	19665999
MIRT001161	hsa-miR-338-5p	qRT-PCRLuciferase reporter assayWestern blot	19665999
MIRT001163	hsa-miR-205-5p	Luciferase reporter assay	19665999
MIRT001359	hsa-miR-1-3p	pSILAC	18668040
MIRT017720	hsa-miR-335-5p	Microarray	18185580
MIRT021326	hsa-miR-9-5p	Microarray	17612493
MIRT001359	hsa-miR-1-3p	Proteomics;Other	18668040
MIRT1117833	hsa-miR-1207-5p	CLIP-seq
MIRT1117834	hsa-miR-1292	CLIP-seq
MIRT1117835	hsa-miR-1321	CLIP-seq
MIRT1117836	hsa-miR-1324	CLIP-seq
MIRT1117837	hsa-miR-205	CLIP-seq
MIRT1117838	hsa-miR-3133	CLIP-seq
MIRT1117839	hsa-miR-3150a-5p	CLIP-seq
MIRT1117840	hsa-miR-3150b-5p	CLIP-seq
MIRT1117841	hsa-miR-3180-5p	CLIP-seq
MIRT1117842	hsa-miR-380	CLIP-seq
MIRT1117843	hsa-miR-3925-3p	CLIP-seq
MIRT1117844	hsa-miR-4270	CLIP-seq
MIRT1117845	hsa-miR-4292	CLIP-seq
MIRT1117846	hsa-miR-4441	CLIP-seq
MIRT1117847	hsa-miR-4447	CLIP-seq
MIRT1117848	hsa-miR-4471	CLIP-seq
MIRT1117849	hsa-miR-4472	CLIP-seq
MIRT1117850	hsa-miR-4480	CLIP-seq
MIRT1117851	hsa-miR-4511	CLIP-seq
MIRT1117852	hsa-miR-4514	CLIP-seq
MIRT1117853	hsa-miR-4534	CLIP-seq
MIRT1117854	hsa-miR-4646-5p	CLIP-seq
MIRT1117855	hsa-miR-4688	CLIP-seq
MIRT1117856	hsa-miR-4690-5p	CLIP-seq
MIRT1117857	hsa-miR-4692	CLIP-seq
MIRT1117858	hsa-miR-4728-5p	CLIP-seq
MIRT1117859	hsa-miR-4739	CLIP-seq
MIRT1117860	hsa-miR-4756-5p	CLIP-seq
MIRT1117861	hsa-miR-4763-3p	CLIP-seq
MIRT1117862	hsa-miR-486-3p	CLIP-seq
MIRT1117863	hsa-miR-520a-5p	CLIP-seq
MIRT1117864	hsa-miR-525-5p	CLIP-seq
MIRT1117865	hsa-miR-545	CLIP-seq
MIRT1117866	hsa-miR-579	CLIP-seq
MIRT1117867	hsa-miR-766	CLIP-seq
MIRT1117868	hsa-miR-940	CLIP-seq
MIRT1117833	hsa-miR-1207-5p	CLIP-seq
MIRT1117835	hsa-miR-1321	CLIP-seq
MIRT1550910	hsa-miR-342-5p	CLIP-seq
MIRT1550911	hsa-miR-3689a-3p	CLIP-seq
MIRT1550912	hsa-miR-3689c	CLIP-seq
MIRT1117844	hsa-miR-4270	CLIP-seq
MIRT1550913	hsa-miR-4291	CLIP-seq
MIRT1550914	hsa-miR-4434	CLIP-seq
MIRT1117846	hsa-miR-4441	CLIP-seq
MIRT1117850	hsa-miR-4480	CLIP-seq
MIRT1117852	hsa-miR-4514	CLIP-seq
MIRT1550915	hsa-miR-4516	CLIP-seq
MIRT1550916	hsa-miR-4531	CLIP-seq
MIRT1117853	hsa-miR-4534	CLIP-seq
MIRT1550917	hsa-miR-4664-5p	CLIP-seq
MIRT1117856	hsa-miR-4690-5p	CLIP-seq
MIRT1117857	hsa-miR-4692	CLIP-seq
MIRT1117858	hsa-miR-4728-5p	CLIP-seq
MIRT1117859	hsa-miR-4739	CLIP-seq
MIRT1550918	hsa-miR-4747-5p	CLIP-seq
MIRT1117860	hsa-miR-4756-5p	CLIP-seq
MIRT1117861	hsa-miR-4763-3p	CLIP-seq
MIRT1550919	hsa-miR-539	CLIP-seq
MIRT1117865	hsa-miR-545	CLIP-seq
MIRT1550920	hsa-miR-548p	CLIP-seq
MIRT1117868	hsa-miR-940	CLIP-seq
MIRT2033328	hsa-miR-3064-5p	CLIP-seq
MIRT2033329	hsa-miR-3150a-3p	CLIP-seq
MIRT2033330	hsa-miR-3175	CLIP-seq
MIRT2033331	hsa-miR-3184	CLIP-seq
MIRT2033332	hsa-miR-3652	CLIP-seq
MIRT2033333	hsa-miR-423-5p	CLIP-seq
MIRT2033334	hsa-miR-4283	CLIP-seq
MIRT2033335	hsa-miR-4284	CLIP-seq
MIRT2033336	hsa-miR-4420	CLIP-seq
MIRT2033337	hsa-miR-4430	CLIP-seq
MIRT2033338	hsa-miR-4437	CLIP-seq
MIRT2033339	hsa-miR-4505	CLIP-seq
MIRT2033340	hsa-miR-4667-5p	CLIP-seq
MIRT2033341	hsa-miR-4700-5p	CLIP-seq
MIRT1117858	hsa-miR-4728-5p	CLIP-seq
MIRT2033342	hsa-miR-4731-5p	CLIP-seq
MIRT2033343	hsa-miR-485-5p	CLIP-seq
MIRT2033344	hsa-miR-939	CLIP-seq
MIRT2263669	hsa-miR-1291	CLIP-seq
MIRT1117834	hsa-miR-1292	CLIP-seq
MIRT2263670	hsa-miR-1908	CLIP-seq
MIRT1117839	hsa-miR-3150a-5p	CLIP-seq
MIRT1117840	hsa-miR-3150b-5p	CLIP-seq
MIRT2263671	hsa-miR-3202	CLIP-seq
MIRT1117843	hsa-miR-3925-3p	CLIP-seq
MIRT1117845	hsa-miR-4292	CLIP-seq
MIRT2263672	hsa-miR-4308	CLIP-seq
MIRT2033336	hsa-miR-4420	CLIP-seq
MIRT2263673	hsa-miR-4446-3p	CLIP-seq
MIRT1117848	hsa-miR-4471	CLIP-seq
MIRT2263674	hsa-miR-4488	CLIP-seq
MIRT2263675	hsa-miR-4640-5p	CLIP-seq
MIRT1117854	hsa-miR-4646-5p	CLIP-seq
MIRT2263676	hsa-miR-4697-5p	CLIP-seq
MIRT2263677	hsa-miR-4726-5p	CLIP-seq
MIRT1117858	hsa-miR-4728-5p	CLIP-seq
MIRT1550918	hsa-miR-4747-5p	CLIP-seq
MIRT2263678	hsa-miR-663	CLIP-seq
MIRT2263679	hsa-miR-744	CLIP-seq
MIRT1117867	hsa-miR-766	CLIP-seq
MIRT2438436	hsa-miR-1226	CLIP-seq
MIRT1117835	hsa-miR-1321	CLIP-seq
MIRT2438437	hsa-miR-150	CLIP-seq
MIRT2438438	hsa-miR-3130-3p	CLIP-seq
MIRT1550910	hsa-miR-342-5p	CLIP-seq
MIRT2438439	hsa-miR-4267	CLIP-seq
MIRT2438440	hsa-miR-4271	CLIP-seq
MIRT2438441	hsa-miR-4651	CLIP-seq
MIRT1550917	hsa-miR-4664-5p	CLIP-seq
MIRT2438442	hsa-miR-4713-5p	CLIP-seq
MIRT2438443	hsa-miR-4725-3p	CLIP-seq
MIRT1117858	hsa-miR-4728-5p	CLIP-seq
MIRT1117859	hsa-miR-4739	CLIP-seq
MIRT1550918	hsa-miR-4747-5p	CLIP-seq
MIRT1117860	hsa-miR-4756-5p	CLIP-seq
MIRT2438444	hsa-miR-532-3p	CLIP-seq
MIRT2438445	hsa-miR-608	CLIP-seq
MIRT2438446	hsa-miR-767-5p	CLIP-seq
MIRT2562996	hsa-miR-103a	CLIP-seq
MIRT2562997	hsa-miR-107	CLIP-seq
MIRT1117833	hsa-miR-1207-5p	CLIP-seq
MIRT2438436	hsa-miR-1226	CLIP-seq
MIRT2562998	hsa-miR-125a-5p	CLIP-seq
MIRT2562999	hsa-miR-125b	CLIP-seq
MIRT1117835	hsa-miR-1321	CLIP-seq
MIRT2438437	hsa-miR-150	CLIP-seq
MIRT2438438	hsa-miR-3130-3p	CLIP-seq
MIRT1550910	hsa-miR-342-5p	CLIP-seq
MIRT1550911	hsa-miR-3689a-3p	CLIP-seq
MIRT1550912	hsa-miR-3689c	CLIP-seq
MIRT2563000	hsa-miR-3689d	CLIP-seq
MIRT2563001	hsa-miR-3714	CLIP-seq
MIRT2563002	hsa-miR-3944-5p	CLIP-seq
MIRT2563003	hsa-miR-4266	CLIP-seq
MIRT2438439	hsa-miR-4267	CLIP-seq
MIRT1117844	hsa-miR-4270	CLIP-seq
MIRT2438440	hsa-miR-4271	CLIP-seq
MIRT2563004	hsa-miR-4287	CLIP-seq
MIRT2563005	hsa-miR-4290	CLIP-seq
MIRT2563006	hsa-miR-4299	CLIP-seq
MIRT2563007	hsa-miR-4319	CLIP-seq
MIRT2563008	hsa-miR-4323	CLIP-seq
MIRT2563009	hsa-miR-4421	CLIP-seq
MIRT1117846	hsa-miR-4441	CLIP-seq
MIRT2563010	hsa-miR-4456	CLIP-seq
MIRT2563011	hsa-miR-4469	CLIP-seq
MIRT1117850	hsa-miR-4480	CLIP-seq
MIRT2563012	hsa-miR-4493	CLIP-seq
MIRT1117852	hsa-miR-4514	CLIP-seq
MIRT2438441	hsa-miR-4651	CLIP-seq
MIRT1550917	hsa-miR-4664-5p	CLIP-seq
MIRT2563013	hsa-miR-4685-3p	CLIP-seq
MIRT2563014	hsa-miR-4687-5p	CLIP-seq
MIRT1117856	hsa-miR-4690-5p	CLIP-seq
MIRT1117857	hsa-miR-4692	CLIP-seq
MIRT2563015	hsa-miR-4695-5p	CLIP-seq
MIRT2438442	hsa-miR-4713-5p	CLIP-seq
MIRT2438443	hsa-miR-4725-3p	CLIP-seq
MIRT1117858	hsa-miR-4728-5p	CLIP-seq
MIRT2563016	hsa-miR-4732-3p	CLIP-seq
MIRT1117859	hsa-miR-4739	CLIP-seq
MIRT1550918	hsa-miR-4747-5p	CLIP-seq
MIRT1117860	hsa-miR-4756-5p	CLIP-seq
MIRT1117861	hsa-miR-4763-3p	CLIP-seq
MIRT2563017	hsa-miR-4779	CLIP-seq
MIRT2563018	hsa-miR-4789-5p	CLIP-seq
MIRT2438444	hsa-miR-532-3p	CLIP-seq
MIRT2563019	hsa-miR-541	CLIP-seq
MIRT2563020	hsa-miR-548q	CLIP-seq
MIRT2438445	hsa-miR-608	CLIP-seq
MIRT2563021	hsa-miR-654-5p	CLIP-seq
MIRT2563022	hsa-miR-670	CLIP-seq
MIRT2438446	hsa-miR-767-5p	CLIP-seq
MIRT1117868	hsa-miR-940	CLIP-seq
MIRT2562996	hsa-miR-103a	CLIP-seq
MIRT2562997	hsa-miR-107	CLIP-seq
MIRT1117833	hsa-miR-1207-5p	CLIP-seq
MIRT2438436	hsa-miR-1226	CLIP-seq
MIRT2562998	hsa-miR-125a-5p	CLIP-seq
MIRT2562999	hsa-miR-125b	CLIP-seq
MIRT1117835	hsa-miR-1321	CLIP-seq
MIRT2438437	hsa-miR-150	CLIP-seq
MIRT2438438	hsa-miR-3130-3p	CLIP-seq
MIRT1550910	hsa-miR-342-5p	CLIP-seq
MIRT1550911	hsa-miR-3689a-3p	CLIP-seq
MIRT1550912	hsa-miR-3689c	CLIP-seq
MIRT2563000	hsa-miR-3689d	CLIP-seq
MIRT2563001	hsa-miR-3714	CLIP-seq
MIRT2563002	hsa-miR-3944-5p	CLIP-seq
MIRT2563003	hsa-miR-4266	CLIP-seq
MIRT2438439	hsa-miR-4267	CLIP-seq
MIRT1117844	hsa-miR-4270	CLIP-seq
MIRT2438440	hsa-miR-4271	CLIP-seq
MIRT2563004	hsa-miR-4287	CLIP-seq
MIRT2563005	hsa-miR-4290	CLIP-seq
MIRT2563006	hsa-miR-4299	CLIP-seq
MIRT2563007	hsa-miR-4319	CLIP-seq
MIRT2563008	hsa-miR-4323	CLIP-seq
MIRT2563009	hsa-miR-4421	CLIP-seq
MIRT1117846	hsa-miR-4441	CLIP-seq
MIRT2563010	hsa-miR-4456	CLIP-seq
MIRT2563011	hsa-miR-4469	CLIP-seq
MIRT1117850	hsa-miR-4480	CLIP-seq
MIRT2563012	hsa-miR-4493	CLIP-seq
MIRT1117852	hsa-miR-4514	CLIP-seq
MIRT2438441	hsa-miR-4651	CLIP-seq
MIRT1550917	hsa-miR-4664-5p	CLIP-seq
MIRT2563013	hsa-miR-4685-3p	CLIP-seq
MIRT2563014	hsa-miR-4687-5p	CLIP-seq
MIRT1117856	hsa-miR-4690-5p	CLIP-seq
MIRT1117857	hsa-miR-4692	CLIP-seq
MIRT2563015	hsa-miR-4695-5p	CLIP-seq
MIRT2438442	hsa-miR-4713-5p	CLIP-seq
MIRT2438443	hsa-miR-4725-3p	CLIP-seq
MIRT1117858	hsa-miR-4728-5p	CLIP-seq
MIRT2563016	hsa-miR-4732-3p	CLIP-seq
MIRT1117859	hsa-miR-4739	CLIP-seq
MIRT1550918	hsa-miR-4747-5p	CLIP-seq
MIRT1117860	hsa-miR-4756-5p	CLIP-seq
MIRT1117861	hsa-miR-4763-3p	CLIP-seq
MIRT2563017	hsa-miR-4779	CLIP-seq
MIRT2563018	hsa-miR-4789-5p	CLIP-seq
MIRT2438444	hsa-miR-532-3p	CLIP-seq
MIRT2563019	hsa-miR-541	CLIP-seq
MIRT2563020	hsa-miR-548q	CLIP-seq
MIRT2438445	hsa-miR-608	CLIP-seq
MIRT2563021	hsa-miR-654-5p	CLIP-seq
MIRT2563022	hsa-miR-670	CLIP-seq
MIRT2438446	hsa-miR-767-5p	CLIP-seq
MIRT1117868	hsa-miR-940	CLIP-seq

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Transcription factor	Regulation	Reference
SREBF1	Repression	20980003
SREBF2	Repression	16697011;20980003

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001523	Process	Retinoid metabolic process	IEA
GO:0001523	Process	Retinoid metabolic process	TAS
GO:0001540	Function	Amyloid-beta binding	IC
GO:0002265	Process	Astrocyte activation involved in immune response	ISS
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005041	Function	Low-density lipoprotein particle receptor activity	IEA
GO:0005041	Function	Low-density lipoprotein particle receptor activity	TAS	20005821
GO:0005044	Function	Scavenger receptor activity	TAS	11240025
GO:0005509	Function	Calcium ion binding	IEA
GO:0005509	Function	Calcium ion binding	ISS
GO:0005515	Function	Protein binding	IPI	8626514, 10772929, 15182176, 17326667, 17360663, 20030366, 20472562, 21054788, 21968187, 24284412, 26005850, 28514442, 29547901, 32814053, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005765	Component	Lysosomal membrane	HDA	17897319
GO:0005769	Component	Early endosome	IDA	26005850
GO:0005769	Component	Early endosome	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005815	Component	Microtubule organizing center	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS	14645246
GO:0005905	Component	Clathrin-coated pit	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006629	Process	Lipid metabolic process	TAS	21289173
GO:0006897	Process	Endocytosis	IEA
GO:0006898	Process	Receptor-mediated endocytosis	IBA
GO:0006898	Process	Receptor-mediated endocytosis	IEA
GO:0006898	Process	Receptor-mediated endocytosis	IMP	23152628, 24305823, 26005850, 26781079
GO:0006898	Process	Receptor-mediated endocytosis	ISS
GO:0006909	Process	Phagocytosis	IBA
GO:0006909	Process	Phagocytosis	IMP	23152628
GO:0006909	Process	Phagocytosis	NAS	20199584
GO:0007041	Process	Lysosomal transport	ISS
GO:0007167	Process	Enzyme-linked receptor protein signaling pathway	ISS	31023188
GO:0010605	Process	Negative regulation of macromolecule metabolic process	IEA
GO:0010629	Process	Negative regulation of gene expression	ISS	31023188
GO:0010715	Process	Regulation of extracellular matrix disassembly	TAS	14645246
GO:0010875	Process	Positive regulation of cholesterol efflux	ISS
GO:0014912	Process	Negative regulation of smooth muscle cell migration	ISS
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	23386614
GO:0016323	Component	Basolateral plasma membrane	IDA	26005850
GO:0016964	Function	Alpha-2 macroglobulin receptor activity	IMP	26142438
GO:0016964	Function	Alpha-2 macroglobulin receptor activity	TAS	21289173
GO:0030100	Process	Regulation of endocytosis	IEA
GO:0030178	Process	Negative regulation of Wnt signaling pathway	ISS
GO:0030226	Function	Apolipoprotein receptor activity	TAS	21289173
GO:0030666	Component	Endocytic vesicle membrane	TAS
GO:0031623	Process	Receptor internalization	TAS	22293988
GO:0032050	Function	Clathrin heavy chain binding	IEA
GO:0032050	Function	Clathrin heavy chain binding	IPI	26005850
GO:0032370	Process	Positive regulation of lipid transport	ISS
GO:0032956	Process	Regulation of actin cytoskeleton organization	ISS
GO:0034185	Function	Apolipoprotein binding	IBA
GO:0034185	Function	Apolipoprotein binding	IDA	2779654
GO:0034185	Function	Apolipoprotein binding	IPI	18635818
GO:0035909	Process	Aorta morphogenesis	ISS
GO:0038023	Function	Signaling receptor activity	TAS	10880251
GO:0038024	Function	Cargo receptor activity	IBA
GO:0038024	Function	Cargo receptor activity	IMP	23152628, 24305823
GO:0038024	Function	Cargo receptor activity	ISS
GO:0038024	Function	Cargo receptor activity	NAS	3266596
GO:0042953	Process	Lipoprotein transport	NAS	3266596
GO:0043235	Component	Receptor complex	IDA	23382219
GO:0043277	Process	Apoptotic cell clearance	ISS
GO:0043395	Function	Heparan sulfate proteoglycan binding	TAS	21289173
GO:0044877	Function	Protein-containing complex binding	IDA	8626514
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045056	Process	Transcytosis	TAS	22293988
GO:0045807	Process	Positive regulation of endocytosis	IGI	23386614
GO:0046872	Function	Metal ion binding	IEA
GO:0051050	Process	Positive regulation of transport	IEA
GO:0051246	Process	Regulation of protein metabolic process	IEA
GO:0060392	Process	Negative regulation of SMAD protein signal transduction	ISS	31023188
GO:0070325	Function	Lipoprotein particle receptor binding	IC	18635818
GO:0097242	Process	Amyloid-beta clearance	NAS	20199584
GO:0097242	Process	Amyloid-beta clearance	TAS	19098903
GO:0098797	Component	Plasma membrane protein complex	TAS	21289173
GO:0150093	Process	Amyloid-beta clearance by transcytosis	IBA
GO:0150093	Process	Amyloid-beta clearance by transcytosis	IGI	26005850
GO:0150093	Process	Amyloid-beta clearance by transcytosis	ISS
GO:0150094	Process	Amyloid-beta clearance by cellular catabolic process	IBA
GO:0150094	Process	Amyloid-beta clearance by cellular catabolic process	IMP	23152628, 24305823
GO:0150094	Process	Amyloid-beta clearance by cellular catabolic process	ISS
GO:0150104	Process	Transport across blood-brain barrier	ISS
GO:0150104	Process	Transport across blood-brain barrier	NAS	26590417, 30280653
GO:1900223	Process	Positive regulation of amyloid-beta clearance	ISS
GO:1900223	Process	Positive regulation of amyloid-beta clearance	TAS	22383525
GO:1903053	Process	Regulation of extracellular matrix organization	IMP	26781079
GO:1903064	Process	Positive regulation of reverse cholesterol transport	ISS
GO:1903078	Process	Positive regulation of protein localization to plasma membrane	IGI	23386614
GO:1904300	Process	Positive regulation of transcytosis	ISS
GO:1904646	Process	Cellular response to amyloid-beta	ISS
GO:1905167	Process	Positive regulation of lysosomal protein catabolic process	IMP	23152628
GO:2000587	Process	Negative regulation of platelet-derived growth factor receptor-beta signaling pathway	ISS

MIM	HGNC	e!Ensembl
107770	6692	ENSG00000123384

Q07954

Protein name

Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-dens

Protein function

Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed:11907044, PubMed:12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma cleara

PDB

1CR8 , 1D2L , 1J8E , 2FYJ , 2FYL , 2KNX , 2KNY

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00057	Ldl_recept_a	25 → 64	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	70 → 108	Low-density lipoprotein receptor domain class A	Repeat
PF07645	EGF_CA	150 → 188	Calcium-binding EGF domain	Domain
PF00058	Ldl_recept_b	614 → 657	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	660 → 708	Low-density lipoprotein receptor repeat class B	Repeat
PF14670	FXa_inhibition	807 → 842		Domain
PF00057	Ldl_recept_a	852 → 890	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	893 → 931	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	934 → 971	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	974 → 1011	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	1013 → 1051	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	1060 → 1097	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	1102 → 1140	Low-density lipoprotein receptor domain class A	Repeat
PF14670	FXa_inhibition	1185 → 1221		Domain
PF00058	Ldl_recept_b	1356 → 1396	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	1399 → 1443	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	1627 → 1667	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	1977 → 2017	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	2020 → 2061	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	2344 → 2386	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	2389 → 2428	Low-density lipoprotein receptor repeat class B	Repeat
PF00057	Ldl_recept_a	2522 → 2561	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	2564 → 2600	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	2603 → 2639	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	2657 → 2688	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	2694 → 2730	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	2732 → 2769	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	2772 → 2812	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	2816 → 2853	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	2856 → 2897	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	2902 → 2939	Low-density lipoprotein receptor domain class A	Repeat
PF12662	cEGF	2962 → 2985	Complement Clr-like EGF-like	Domain
PF16472	DUF5050	3022 → 3258	Domain of unknown function (DUF5050)	Domain
PF14670	FXa_inhibition	3294 → 3330		Domain
PF00057	Ldl_recept_a	3332 → 3369	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3372 → 3408	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3411 → 3448	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3451 → 3489	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3492 → 3531	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3534 → 3570	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3573 → 3609	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3611 → 3647	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3652 → 3690	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3739 → 3776	Low-density lipoprotein receptor domain class A	Repeat
PF07645	EGF_CA	3824 → 3861	Calcium-binding EGF domain	Domain
PF00058	Ldl_recept_b	3970 → 4010	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	4013 → 4054	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	4057 → 4099	Low-density lipoprotein receptor repeat class B	Repeat

Tissue specificity

TISSUE SPECIFICITY: Most abundant in liver, brain and lung.

Sequence

MLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEA
PEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGC
QHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYL
LQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANE
TVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDI
DDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTK
LVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFE
NYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACEN
DQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRG
MDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDG
IHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNG
WMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFY
DRIETILLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVT
LLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGV
TCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRF
KCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDD
CGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQF
KCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRW
RCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENC
ESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAP
GEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGES
CRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDK
IYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTT
LLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLT
VDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNT
LAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHLCLINYNRT
VSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVL
DYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTN
KKQINVARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTDGDNISMANMDGSNRTLLFSG
QKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLW
WADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQL
CLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSG
TSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIY
WTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDG
TERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFS
VSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCA
VANGGCQQLCLYRGRGQRACACAHGMLAEDGASCREYAGYLLYSERTILKSIHLSDERNL
NAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVE
NVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLD
ECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDK
IERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDI
PQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAV
NSSCRAQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVS
NMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCS
ATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNY
FACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCG
DGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDD
REFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDG
ENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCH
INECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTH
GSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAV
ALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCD
KGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSR
SVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLF
EDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGG
CSNLCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCG
DHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKC
TNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCV
DGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQ
FRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDC
ADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQ
CNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTD
NCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDP
KLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNN
TKGGHLCSCARNFMKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESV
RIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMP
RGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDW
GNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPI
VAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYH
QHKQPEVTNPCDRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTC
NLQCFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPT
GFTGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENFGTCQM
AADGSRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGH
CSNGGSCTMNSKMMPECQCPPHMTGPRCEEHVFSQQQPGHIASILIPLLLLLLLVLVAGV
VFWYKRRVQGAKGFQHQRMTNGAMNVEIGNPTYKMYEGGEPDDVGGLLDADFALDPDKPT
NFTNPVYATLYMGGHGSRHSLASTDEKRELLGRGPEDEIGDPLA

Sequence length

4544

Interactions

View interactions

	KEGG		Reactome
	Efferocytosis Cholesterol metabolism Alzheimer disease Malaria		Scavenging of heme from plasma Retinoid metabolism and transport

117

Show/Hide Causal Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Atrophoderma vermiculatum	Pathogenic	rs483353013	RCV000119304
Developmental dysplasia of the hip 3	Pathogenic	rs762970763, rs767319988, rs2548053933, rs200106514	RCV003493368 RCV003493369 RCV003493370 RCV003493371
Global developmental delay	Likely pathogenic	rs2136703640	RCV001779398
Keratosis pilaris	Pathogenic	rs483353013	RCV000258847

Show/Hide Unknown Diseases (25)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs1800141	RCV005916459
Adrenocortical carcinoma, hereditary	Benign	rs1800141	RCV005916461
Cervical cancer	Benign; Likely benign	rs2229281, rs138980324	RCV005903665 RCV005913339
Colon adenocarcinoma	Benign	rs1800141	RCV005916458
Colorectal cancer	Benign	rs1800141	RCV005916463
Developmental disorder	Uncertain significance	rs1565750061	RCV001843464
Familial cancer of breast	Likely benign	rs36011472	RCV005933501
Gastric cancer	Uncertain significance	rs543562619	RCV005930683
Hepatocellular carcinoma	Benign; Likely benign	rs1800180, rs2229281, rs138966453, rs771447920	RCV005920506 RCV005903664 RCV005907582 RCV005906302
Keratosis pilaris atrophicans	Uncertain significance; Conflicting classifications of pathogenicity	rs368737311, rs149099223, rs1799986	RCV003492830 RCV003492831 RCV005647377
LRP1-related disorder	Benign; Uncertain significance; Likely benign; Conflicting classifications of pathogenicity	rs12814239, rs2548066269, rs138150221, rs754352470, rs147797119, rs757521900, rs769789309, rs148345722, rs749898308, rs2548075480, rs1423891630, rs145068367, rs146906834, rs200442207, rs766779347 View all (46 more)	RCV003921304 RCV003414099 RCV003980877 RCV003906736 RCV003946632 RCV003907216 RCV003981724 RCV003906870 RCV003904403 RCV003904494 RCV003964502 RCV003981420 RCV003979689 RCV003911788 RCV003903939 RCV003903981 RCV003916822 RCV003979465 RCV003909367 RCV003913879 RCV003933829 RCV003939859 RCV003942040 RCV003934547 RCV003944231 RCV003947386 RCV003959764 RCV003963881 RCV003964178 RCV003971877 RCV003917227 RCV003931817 RCV003939648 RCV003917385 RCV003924523 RCV003949263 RCV003944749 RCV003969349 RCV003934311 RCV003946831 RCV003947014 RCV003956863 RCV003944626 RCV003954479 RCV003979145 RCV003978920 RCV003964235 RCV003970754 RCV003913319 RCV003953322 RCV003916018 RCV003936072 RCV003940403 RCV003968232 RCV003968364 RCV003902929 RCV004751807 RCV003977995 RCV003933177 RCV003978255 RCV003983847
Lung cancer	Likely benign	rs138980324	RCV005913340
Malignant lymphoma, large B-cell, diffuse	Benign	rs1800141	RCV005916462
Malignant tumor of esophagus	Likely benign	rs771447920	RCV005906303
Melanoma	Benign; Likely benign	rs1800141, rs36011472	RCV005916467 RCV005933502
Nonpapillary renal cell carcinoma	Benign	rs1800141	RCV005916460
Ovarian serous cystadenocarcinoma	Benign	rs2229281	RCV005903666
Prostate cancer	Uncertain significance	rs769851229	RCV000206857
Sarcoma	Benign	rs1800141	RCV005916464
Thymoma	Benign	rs1800141	RCV005916466
Tricuspid atresia	Uncertain significance	rs770169648, rs1396150729	RCV001007928 RCV001007929
Uterine carcinosarcoma	Benign	rs1800141	RCV005916465
Uterine corpus endometrial carcinoma	Benign	rs1800141	RCV005916468
Variant of unknown significance	Uncertain significance	rs1565750061	RCV000033099
Ventricular septal defect	Uncertain significance	rs770169648, rs1396150729	RCV001007928 RCV001007929

Show/Hide Text Mining Associations (136)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
AA amyloidosis	Associate	24596678, 38067191, 39394110
Adenocarcinoma of Lung	Associate	21325077
Alzheimer Disease	Associate	10899157, 11461976, 12888553, 12951770, 19664312, 19665999, 21593627, 21676498, 23167255, 24596678, 26856603, 28578378, 34387022, 38067191, 38417436, 9350853, 9837937 View all (2 more)
Alzheimer Disease	Inhibit	25757756, 33246059
Aneurysm	Inhibit	24054777
Aortic Aneurysm Abdominal	Associate	22055160, 24423473, 25198969, 37893562
Aortic Aneurysm Abdominal	Inhibit	24054777, 26781079
Aortic Dissection	Associate	27569546
Arthritis Rheumatoid	Associate	26814849
Atherosclerosis	Associate	24423473, 24639232, 8182133
Autism Spectrum Disorder	Associate	31094488
Autistic Disorder	Associate	31094488
Autoimmune Diseases	Associate	26031516
Bicuspid Aortic Valve Disease	Associate	36071494
Brain Injuries	Associate	8307199
Brain Ischemia	Stimulate	38067191
Breast Neoplasms	Associate	12793904, 21299862, 22570085, 37684436
Bronchopulmonary Dysplasia	Stimulate	34104089
Carcinoma Hepatocellular	Associate	22427881
Carcinoma Intraductal Noninfiltrating	Associate	38615592
Carcinoma Non Small Cell Lung	Associate	12684672, 39752787, 8879378
Carcinoma Ovarian Epithelial	Associate	36842607
Carcinoma Renal Cell	Associate	19393132, 33828127
Carcinoma Small Cell	Associate	8879378
Carcinoma Squamous Cell	Stimulate	8879378
Cardiomyopathy Dilated	Associate	24423473, 28557183
Cardiotoxicity	Stimulate	37684436
Cardiovascular Diseases	Associate	22819221, 24639232, 32455133
Carotid Artery Injuries	Associate	32374345
Central Nervous System Diseases	Associate	27986809
Cerebral Amyloid Angiopathy	Stimulate	18055545
Cerebral Infarction	Associate	26031789, 35241660
Cerebrovascular Disorders	Associate	32374345
Choroidal Neovascularization	Inhibit	20561980
Cognition Disorders	Associate	21676498
Cognitive Dysfunction	Associate	19664312
Colorectal Neoplasms	Associate	20558745, 25550888, 33172883, 37310025
Communicable Diseases	Associate	15498042
Coronary Artery Disease	Associate	12732394, 28209224, 31247347, 32374345
Coronary Artery Dissection Spontaneous	Associate	32374345
Coronary Disease	Associate	15121769, 37147786
COVID 19	Associate	37924708
Cystic Fibrosis	Inhibit	30177416
Death	Associate	33172883
Dementia	Associate	21676498, 38067191
Demyelinating Diseases	Associate	35241660
Diabetes Gestational	Inhibit	23898049
Diabetes Mellitus	Associate	20561980, 32455133
Diabetes Mellitus Type 2	Inhibit	12393177
Disease	Associate	21907175
Disease Resistance	Associate	12684672
Dissection Thoracic Aorta	Associate	27569546
Down Syndrome	Associate	10207158
Drug Related Side Effects and Adverse Reactions	Associate	36356021
Dyslipidemias	Associate	37147786
Endometriosis	Associate	35421980
Episodic Ataxia	Associate	38067191
Esophageal Squamous Cell Carcinoma	Associate	32217514, 33311557
Glioblastoma	Associate	19176371, 21408136, 7961982
Glioma	Associate	26164207, 34831480, 35862252, 8307199
Glomerulonephritis Membranous	Associate	30067725
Gout	Associate	32569156
Headache	Associate	29397368
Helicobacter Infections	Associate	30176157
Hemophilia A	Associate	28393618
Hereditary Breast and Ovarian Cancer Syndrome	Inhibit	38615592
HTLV I Infections	Inhibit	15800028
Hypercholesterolemia	Associate	12837856
Hyperlipoproteinemia Type II	Associate	22819221, 33028190
Hypertension	Associate	29989339, 33566965
Hypertriglyceridemia	Associate	32115487
Hypoxia	Associate	19383717
Hypoxia	Stimulate	21408136
Idiopathic Pulmonary Fibrosis	Associate	38225283
Infections	Associate	22817990
Inflammation	Associate	24639232, 26031516, 35421980
Inflammation	Inhibit	33246059
Ischemia	Stimulate	38067191
Ischemic Stroke	Associate	28431990
Kidney Neoplasms	Stimulate	33828127
Leukemia	Associate	18200595
Leukemia Myeloid Acute	Associate	18200595, 36781600, 9886324
Leukemia Promyelocytic Acute	Associate	15108169
Lung Neoplasms	Associate	21325077, 8879378
Lupus Erythematosus Systemic	Associate	16645988
Lymphatic Metastasis	Associate	37310025
Lymphoma Large B Cell Diffuse	Associate	23531283
Lymphoma Primary Effusion	Associate	22412839
Malnutrition	Associate	34433325
Marfan Syndrome	Associate	24484584
Melanoma	Associate	15498042, 7495278
Mental Disorders	Associate	31094488
Migraine Disorders	Associate	21666692, 22683712, 24674449, 24852292, 26660531, 29397368, 39333847
Migraine with Aura	Associate	26660531
Mohr Tranebjaerg syndrome	Stimulate	32400857
Multiple Myeloma	Associate	26762414
Myocardial Ischemia	Associate	29396305
Nasal Polyps	Associate	32047813
Nasopharyngeal Carcinoma	Associate	32400857
Neoplasm Metastasis	Associate	19665999, 35628341, 37310025, 7495278
Neoplasms	Associate	12122280, 12793904, 15498042, 18316405, 19176371, 19383717, 19665999, 21325077, 21542898, 22427881, 22711991, 25300797, 26185130, 26202601, 28662213 View all (8 more)
Neuroblastoma	Associate	11461976
Neurodegenerative Diseases	Associate	34696705
Neuroinflammatory Diseases	Associate	37305557
Nevus	Associate	7495278
Noonan Syndrome	Associate	32514133
Obesity	Associate	22347399
Obesity Metabolically Benign	Associate	32957486
Olfaction Disorders	Associate	37924708
Optic Nerve Diseases	Associate	21593627
Osteoarthritis	Associate	28235248, 31560818
Osteoarthritis	Inhibit	31560818
Osteoarthritis Knee	Associate	31560818
Osteoporosis	Associate	22957024
Osteosarcoma	Associate	25300797, 25418192
Ototoxicity	Associate	30505321, 37768946
Pancreatic Neoplasms	Associate	35628341
Parkinson Disease	Associate	21907175, 25556233
Personality Disorders	Associate	22427881
Plaque Amyloid	Associate	24596678
Plaque Atherosclerotic	Associate	22819221
Post Acute COVID 19 Syndrome	Associate	37924708
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	35488386
Preeclamptic toxemia	Associate	23898049
Prostatitis	Associate	28662213
Retinal Drusen	Associate	33776059
Schizophrenia	Associate	31094488
Squamous Cell Carcinoma of Head and Neck	Inhibit	28662213
Stomach Neoplasms	Associate	36430456
Stroke	Associate	26031789
Systemic Inflammatory Response Syndrome	Associate	17458880
Thyroid Cancer Papillary	Associate	30904818, 37733241
Tuberculosis Multidrug Resistant	Associate	10817511, 11862483, 12122280, 18200595, 22664042, 28668966, 29387293, 30505321, 32400857
Urinary Bladder Neoplasms	Associate	34819038, 36030212, 37153545
Venous Thromboembolism	Associate	17155964
Weight Gain	Associate	23404896

LRP1 (LDL receptor related protein 1)