APOBEC4 (apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4)

Gene

• Entrez ID: 403314
• Gene name: Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4
• Gene symbol: APOBEC4
• Synonyms (NCBI Gene): C1orf169
• Chromosome: 1
• Chromosome location: 1q25.3
• Summary: This gene encodes a member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases, which convert cytidine to uridine. Other AID/APOBEC family members are involved in mRNA editing, somatic hypermutation and recombination of immunoglobulin ge

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016856	hsa-miR-335-5p	Microarray	18185580
MIRT789979	hsa-miR-106a	CLIP-seq
MIRT789980	hsa-miR-106b	CLIP-seq
MIRT789981	hsa-miR-17	CLIP-seq
MIRT789982	hsa-miR-190	CLIP-seq
MIRT789983	hsa-miR-190b	CLIP-seq
MIRT789984	hsa-miR-20a	CLIP-seq
MIRT789985	hsa-miR-20b	CLIP-seq
MIRT789986	hsa-miR-302a	CLIP-seq
MIRT789987	hsa-miR-302b	CLIP-seq
MIRT789988	hsa-miR-302c	CLIP-seq
MIRT789989	hsa-miR-302d	CLIP-seq
MIRT789990	hsa-miR-302e	CLIP-seq
MIRT789991	hsa-miR-3154	CLIP-seq
MIRT789992	hsa-miR-3160-5p	CLIP-seq
MIRT789993	hsa-miR-369-3p	CLIP-seq
MIRT789994	hsa-miR-372	CLIP-seq
MIRT789995	hsa-miR-373	CLIP-seq
MIRT789996	hsa-miR-374a	CLIP-seq
MIRT789997	hsa-miR-374b	CLIP-seq
MIRT789998	hsa-miR-4434	CLIP-seq
MIRT789999	hsa-miR-4502	CLIP-seq
MIRT790000	hsa-miR-4516	CLIP-seq
MIRT790001	hsa-miR-4531	CLIP-seq
MIRT790002	hsa-miR-4663	CLIP-seq
MIRT790003	hsa-miR-4670-3p	CLIP-seq
MIRT790004	hsa-miR-4682	CLIP-seq
MIRT790005	hsa-miR-4711-5p	CLIP-seq
MIRT790006	hsa-miR-4728-3p	CLIP-seq
MIRT790007	hsa-miR-4729	CLIP-seq
MIRT790008	hsa-miR-519a	CLIP-seq
MIRT790009	hsa-miR-519b-3p	CLIP-seq
MIRT790010	hsa-miR-519c-3p	CLIP-seq
MIRT790011	hsa-miR-519d	CLIP-seq
MIRT790012	hsa-miR-520a-3p	CLIP-seq
MIRT790013	hsa-miR-520b	CLIP-seq
MIRT790014	hsa-miR-520c-3p	CLIP-seq
MIRT790015	hsa-miR-520d-3p	CLIP-seq
MIRT790016	hsa-miR-520e	CLIP-seq
MIRT790017	hsa-miR-520f	CLIP-seq
MIRT790018	hsa-miR-520g	CLIP-seq
MIRT790019	hsa-miR-520h	CLIP-seq
MIRT790020	hsa-miR-544	CLIP-seq
MIRT790021	hsa-miR-579	CLIP-seq
MIRT790022	hsa-miR-633	CLIP-seq
MIRT790023	hsa-miR-93	CLIP-seq
MIRT790005	hsa-miR-4711-5p	CLIP-seq
MIRT790020	hsa-miR-544	CLIP-seq
MIRT2173199	hsa-miR-3658	CLIP-seq
MIRT2173200	hsa-miR-4307	CLIP-seq
MIRT2173201	hsa-miR-4699-5p	CLIP-seq
MIRT2675165	hsa-miR-3157-5p	CLIP-seq
MIRT2675166	hsa-miR-3680	CLIP-seq
MIRT2675167	hsa-miR-4798-3p	CLIP-seq
MIRT2675168	hsa-miR-616	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32814053
GO:0006397	Process	MRNA processing	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 609908
• HGNC: 32152
• e!Ensembl: ENSG00000173627

Protein

• UniProt ID: Q8WW27
• Protein name: Putative C->U-editing enzyme APOBEC-4 (EC 3.5.4.-) (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4)
• Protein function: Putative C to U editing enzyme whose physiological substrate is not yet known.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08210	APOBEC_N	47 → 230	APOBEC-like N-terminal domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Predominantly expressed in testis. {ECO:0000269|PubMed:16082223}.
• Sequence:

  MEPIYEEYLANHGTIVKPYYWLSFSLDCSNCPYHIRTGEEARVSLTEFCQIFGFPYGTTF
  PQTKHLTFYELKTSSGSLVQKGHASSCTGNYIHPESMLFEMNGYLDSAIYNNDSIRHIIL
  YSNNSPCNEANHCCISKMYNFLITYPGITLSIYFSQLYHTEMDFPASAWNREALRSLASL
  WPRVVLSPISGGIWHSVLHSFISGVSGSHVFQPILTGRALADRHNAYEINAITGVKPYFT
  DVLLQTKRNPNTKAQEALESYPLNNAFPGQFFQMPSGQLQPNLPPDLRAPVVFVLVPLRD
  LPPMHMGQNPNKPRNIVRHLNMPQMSFQETKDLGRLPTGRSVEIVEITEQFASSKEADEK
  KKKKGKK

• Sequence length: 367

Pathways

Reactome:

mRNA Editing: C to U Conversion
Formation of the Editosome

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Multiple Myeloma	Associate	25904160	★☆☆☆☆ Found in Text Mining only