ARL2 (ARF like GTPase 2)

Gene

• Entrez ID: 402
• Gene name: ARF like GTPase 2
• Gene symbol: ARL2
• Synonyms (NCBI Gene): ARFL2, MRCS1
• Disease Acronyms (UniProt): MRCS1
• Chromosome: 11
• Chromosome location: 11q13.1
• Summary: This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT001478	hsa-miR-16-5p	pSILAC	18668040
MIRT001478	hsa-miR-16-5p	Luciferase reporter assay, qRT-PCR, Western blot	21199864
MIRT001478	hsa-miR-16-5p	Luciferase reporter assay, qRT-PCR, Western blot	21199864
MIRT024965	hsa-miR-214-3p	Microarray;Other	19859982
MIRT001478	hsa-miR-16-5p	Proteomics;Other	18668040
MIRT001478	hsa-miR-16-5p	Reporter assay;Microarray;Other	21199864
MIRT049673	hsa-miR-92a-3p	CLASH	23622248
MIRT037049	hsa-miR-877-3p	CLASH	23622248
MIRT053467	hsa-miR-195-5p	Flow, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23807224
MIRT053467	hsa-miR-195-5p	Flow, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23807224
MIRT053467	hsa-miR-195-5p	Flow, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23807224
MIRT053467	hsa-miR-195-5p	Flow, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23807224
MIRT053467	hsa-miR-195-5p	Flow, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23807224
MIRT053467	hsa-miR-195-5p	Flow, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23807224
MIRT053467	hsa-miR-195-5p	Flow, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23807224
MIRT024965	hsa-miR-214-3p	Luciferase reporter assay, qRT-PCR, Western blot	25621032
MIRT024965	hsa-miR-214-3p	Luciferase reporter assay, qRT-PCR, Western blot	25621032
MIRT797653	hsa-miR-1252	CLIP-seq
MIRT797654	hsa-miR-1255a	CLIP-seq
MIRT797655	hsa-miR-1255b	CLIP-seq
MIRT797656	hsa-miR-15a	CLIP-seq
MIRT797657	hsa-miR-15b	CLIP-seq
MIRT797658	hsa-miR-16	CLIP-seq
MIRT797659	hsa-miR-195	CLIP-seq
MIRT797660	hsa-miR-424	CLIP-seq
MIRT797661	hsa-miR-4433	CLIP-seq
MIRT797662	hsa-miR-4459	CLIP-seq
MIRT797663	hsa-miR-4524	CLIP-seq
MIRT797664	hsa-miR-4662a-5p	CLIP-seq
MIRT797665	hsa-miR-4685-5p	CLIP-seq
MIRT797666	hsa-miR-4753-5p	CLIP-seq
MIRT797667	hsa-miR-4765	CLIP-seq
MIRT797668	hsa-miR-4768-3p	CLIP-seq
MIRT797669	hsa-miR-4778-3p	CLIP-seq
MIRT797670	hsa-miR-497	CLIP-seq
MIRT797671	hsa-miR-503	CLIP-seq
MIRT797672	hsa-miR-513b	CLIP-seq
MIRT797673	hsa-miR-646	CLIP-seq
MIRT797653	hsa-miR-1252	CLIP-seq
MIRT797654	hsa-miR-1255a	CLIP-seq
MIRT797655	hsa-miR-1255b	CLIP-seq
MIRT797656	hsa-miR-15a	CLIP-seq
MIRT797657	hsa-miR-15b	CLIP-seq
MIRT797658	hsa-miR-16	CLIP-seq
MIRT797659	hsa-miR-195	CLIP-seq
MIRT797674	hsa-miR-214	CLIP-seq
MIRT797675	hsa-miR-2278	CLIP-seq
MIRT797676	hsa-miR-3619-5p	CLIP-seq
MIRT797660	hsa-miR-424	CLIP-seq
MIRT797677	hsa-miR-4508	CLIP-seq
MIRT797663	hsa-miR-4524	CLIP-seq
MIRT797678	hsa-miR-4660	CLIP-seq
MIRT797679	hsa-miR-4701-5p	CLIP-seq
MIRT797667	hsa-miR-4765	CLIP-seq
MIRT797670	hsa-miR-497	CLIP-seq
MIRT797671	hsa-miR-503	CLIP-seq
MIRT797672	hsa-miR-513b	CLIP-seq
MIRT797680	hsa-miR-588	CLIP-seq
MIRT797673	hsa-miR-646	CLIP-seq
MIRT797681	hsa-miR-761	CLIP-seq
MIRT1935638	hsa-miR-122	CLIP-seq
MIRT797654	hsa-miR-1255a	CLIP-seq
MIRT797655	hsa-miR-1255b	CLIP-seq
MIRT797656	hsa-miR-15a	CLIP-seq
MIRT797657	hsa-miR-15b	CLIP-seq
MIRT797658	hsa-miR-16	CLIP-seq
MIRT797659	hsa-miR-195	CLIP-seq
MIRT797674	hsa-miR-214	CLIP-seq
MIRT797676	hsa-miR-3619-5p	CLIP-seq
MIRT797660	hsa-miR-424	CLIP-seq
MIRT1935639	hsa-miR-4268	CLIP-seq
MIRT797663	hsa-miR-4524	CLIP-seq
MIRT797678	hsa-miR-4660	CLIP-seq
MIRT797670	hsa-miR-497	CLIP-seq
MIRT797671	hsa-miR-503	CLIP-seq
MIRT797673	hsa-miR-646	CLIP-seq
MIRT797681	hsa-miR-761	CLIP-seq
MIRT1935638	hsa-miR-122	CLIP-seq
MIRT2175693	hsa-miR-1236	CLIP-seq
MIRT797653	hsa-miR-1252	CLIP-seq
MIRT797654	hsa-miR-1255a	CLIP-seq
MIRT797655	hsa-miR-1255b	CLIP-seq
MIRT2175694	hsa-miR-1269	CLIP-seq
MIRT2175695	hsa-miR-1269b	CLIP-seq
MIRT2175696	hsa-miR-1288	CLIP-seq
MIRT2175697	hsa-miR-142-3p	CLIP-seq
MIRT2175698	hsa-miR-150	CLIP-seq
MIRT797656	hsa-miR-15a	CLIP-seq
MIRT797657	hsa-miR-15b	CLIP-seq
MIRT797658	hsa-miR-16	CLIP-seq
MIRT797659	hsa-miR-195	CLIP-seq
MIRT797674	hsa-miR-214	CLIP-seq
MIRT797675	hsa-miR-2278	CLIP-seq
MIRT2175699	hsa-miR-3126-5p	CLIP-seq
MIRT2175700	hsa-miR-3132	CLIP-seq
MIRT2175701	hsa-miR-3183	CLIP-seq
MIRT2175702	hsa-miR-345	CLIP-seq
MIRT797676	hsa-miR-3619-5p	CLIP-seq
MIRT2175703	hsa-miR-3649	CLIP-seq
MIRT2175704	hsa-miR-3661	CLIP-seq
MIRT2175705	hsa-miR-3690	CLIP-seq
MIRT2175706	hsa-miR-378	CLIP-seq
MIRT2175707	hsa-miR-378b	CLIP-seq
MIRT2175708	hsa-miR-378c	CLIP-seq
MIRT2175709	hsa-miR-378d	CLIP-seq
MIRT2175710	hsa-miR-378e	CLIP-seq
MIRT2175711	hsa-miR-378f	CLIP-seq
MIRT2175712	hsa-miR-378h	CLIP-seq
MIRT2175713	hsa-miR-378i	CLIP-seq
MIRT2175714	hsa-miR-422a	CLIP-seq
MIRT797660	hsa-miR-424	CLIP-seq
MIRT2175715	hsa-miR-4255	CLIP-seq
MIRT2175716	hsa-miR-4258	CLIP-seq
MIRT1935639	hsa-miR-4268	CLIP-seq
MIRT2175717	hsa-miR-4290	CLIP-seq
MIRT2175718	hsa-miR-4300	CLIP-seq
MIRT2175719	hsa-miR-4419a	CLIP-seq
MIRT797661	hsa-miR-4433	CLIP-seq
MIRT2175720	hsa-miR-4447	CLIP-seq
MIRT797662	hsa-miR-4459	CLIP-seq
MIRT2175721	hsa-miR-4472	CLIP-seq
MIRT2175722	hsa-miR-4510	CLIP-seq
MIRT2175723	hsa-miR-4515	CLIP-seq
MIRT797663	hsa-miR-4524	CLIP-seq
MIRT797678	hsa-miR-4660	CLIP-seq
MIRT797664	hsa-miR-4662a-5p	CLIP-seq
MIRT797665	hsa-miR-4685-5p	CLIP-seq
MIRT2175724	hsa-miR-4687-5p	CLIP-seq
MIRT797679	hsa-miR-4701-5p	CLIP-seq
MIRT2175725	hsa-miR-4723-3p	CLIP-seq
MIRT2175726	hsa-miR-4740-5p	CLIP-seq
MIRT2175727	hsa-miR-4743	CLIP-seq
MIRT797666	hsa-miR-4753-5p	CLIP-seq
MIRT797667	hsa-miR-4765	CLIP-seq
MIRT797668	hsa-miR-4768-3p	CLIP-seq
MIRT797669	hsa-miR-4778-3p	CLIP-seq
MIRT2175728	hsa-miR-492	CLIP-seq
MIRT2175729	hsa-miR-493	CLIP-seq
MIRT797670	hsa-miR-497	CLIP-seq
MIRT797671	hsa-miR-503	CLIP-seq
MIRT797672	hsa-miR-513b	CLIP-seq
MIRT797680	hsa-miR-588	CLIP-seq
MIRT2175730	hsa-miR-619	CLIP-seq
MIRT2175731	hsa-miR-631	CLIP-seq
MIRT797673	hsa-miR-646	CLIP-seq
MIRT797681	hsa-miR-761	CLIP-seq
MIRT2175732	hsa-miR-920	CLIP-seq
MIRT1935638	hsa-miR-122	CLIP-seq
MIRT2175693	hsa-miR-1236	CLIP-seq
MIRT797654	hsa-miR-1255a	CLIP-seq
MIRT797655	hsa-miR-1255b	CLIP-seq
MIRT2175697	hsa-miR-142-3p	CLIP-seq
MIRT2175698	hsa-miR-150	CLIP-seq
MIRT797656	hsa-miR-15a	CLIP-seq
MIRT797657	hsa-miR-15b	CLIP-seq
MIRT797658	hsa-miR-16	CLIP-seq
MIRT797659	hsa-miR-195	CLIP-seq
MIRT797674	hsa-miR-214	CLIP-seq
MIRT797675	hsa-miR-2278	CLIP-seq
MIRT2175700	hsa-miR-3132	CLIP-seq
MIRT2175701	hsa-miR-3183	CLIP-seq
MIRT797676	hsa-miR-3619-5p	CLIP-seq
MIRT797660	hsa-miR-424	CLIP-seq
MIRT2175715	hsa-miR-4255	CLIP-seq
MIRT2175716	hsa-miR-4258	CLIP-seq
MIRT1935639	hsa-miR-4268	CLIP-seq
MIRT2175717	hsa-miR-4290	CLIP-seq
MIRT2175718	hsa-miR-4300	CLIP-seq
MIRT797663	hsa-miR-4524	CLIP-seq
MIRT797678	hsa-miR-4660	CLIP-seq
MIRT2175724	hsa-miR-4687-5p	CLIP-seq
MIRT797679	hsa-miR-4701-5p	CLIP-seq
MIRT2175725	hsa-miR-4723-3p	CLIP-seq
MIRT797670	hsa-miR-497	CLIP-seq
MIRT797671	hsa-miR-503	CLIP-seq
MIRT797680	hsa-miR-588	CLIP-seq
MIRT797673	hsa-miR-646	CLIP-seq
MIRT797681	hsa-miR-761	CLIP-seq
MIRT2175732	hsa-miR-920	CLIP-seq
MIRT2175694	hsa-miR-1269	CLIP-seq
MIRT2175695	hsa-miR-1269b	CLIP-seq
MIRT2175696	hsa-miR-1288	CLIP-seq
MIRT2175697	hsa-miR-142-3p	CLIP-seq
MIRT2175698	hsa-miR-150	CLIP-seq
MIRT797656	hsa-miR-15a	CLIP-seq
MIRT797657	hsa-miR-15b	CLIP-seq
MIRT797658	hsa-miR-16	CLIP-seq
MIRT797659	hsa-miR-195	CLIP-seq
MIRT797674	hsa-miR-214	CLIP-seq
MIRT2175699	hsa-miR-3126-5p	CLIP-seq
MIRT2175700	hsa-miR-3132	CLIP-seq
MIRT797676	hsa-miR-3619-5p	CLIP-seq
MIRT2175703	hsa-miR-3649	CLIP-seq
MIRT2175704	hsa-miR-3661	CLIP-seq
MIRT2175705	hsa-miR-3690	CLIP-seq
MIRT2175706	hsa-miR-378	CLIP-seq
MIRT2175707	hsa-miR-378b	CLIP-seq
MIRT2175708	hsa-miR-378c	CLIP-seq
MIRT2175709	hsa-miR-378d	CLIP-seq
MIRT2175710	hsa-miR-378e	CLIP-seq
MIRT2175711	hsa-miR-378f	CLIP-seq
MIRT2175712	hsa-miR-378h	CLIP-seq
MIRT2175713	hsa-miR-378i	CLIP-seq
MIRT2175714	hsa-miR-422a	CLIP-seq
MIRT797660	hsa-miR-424	CLIP-seq
MIRT2175715	hsa-miR-4255	CLIP-seq
MIRT2175719	hsa-miR-4419a	CLIP-seq
MIRT2175722	hsa-miR-4510	CLIP-seq
MIRT2175723	hsa-miR-4515	CLIP-seq
MIRT2175726	hsa-miR-4740-5p	CLIP-seq
MIRT2175728	hsa-miR-492	CLIP-seq
MIRT2175729	hsa-miR-493	CLIP-seq
MIRT797670	hsa-miR-497	CLIP-seq
MIRT2175730	hsa-miR-619	CLIP-seq
MIRT2175731	hsa-miR-631	CLIP-seq
MIRT797681	hsa-miR-761	CLIP-seq
MIRT797656	hsa-miR-15a	CLIP-seq
MIRT797657	hsa-miR-15b	CLIP-seq
MIRT797658	hsa-miR-16	CLIP-seq
MIRT797659	hsa-miR-195	CLIP-seq
MIRT797674	hsa-miR-214	CLIP-seq
MIRT797676	hsa-miR-3619-5p	CLIP-seq
MIRT797660	hsa-miR-424	CLIP-seq
MIRT797670	hsa-miR-497	CLIP-seq
MIRT797681	hsa-miR-761	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003924	Function	GTPase activity	IMP	10831612
GO:0005095	Function	GTPase inhibitor activity	TAS	10831612
GO:0005515	Function	Protein binding	IPI	10831612, 11847227, 16189514, 18234692, 18588884, 19368893, 21516116, 21988832, 25416956, 25502805, 27107012, 27173435, 29997244, 31515488, 32296183
GO:0005525	Function	GTP binding	IBA	21873635
GO:0005525	Function	GTP binding	IMP	10831612
GO:0005634	Component	Nucleus	IDA	18234692
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005758	Component	Mitochondrial intermembrane space	IDA	11809823
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0005794	Component	Golgi apparatus	IDA
GO:0005813	Component	Centrosome	IDA	16525022
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005925	Component	Focal adhesion	IDA
GO:0005929	Component	Cilium	IDA	17646400
GO:0007021	Process	Tubulin complex assembly	TAS	10831612
GO:0007098	Process	Centrosome cycle	IMP	16525022
GO:0010811	Process	Positive regulation of cell-substrate adhesion	ISS
GO:0015630	Component	Microtubule cytoskeleton	IBA	21873635
GO:0016328	Component	Lateral plasma membrane	ISS
GO:0019003	Function	GDP binding	IEA
GO:0031113	Process	Regulation of microtubule polymerization	IMP	16525022
GO:0031116	Process	Positive regulation of microtubule polymerization	IBA	21873635
GO:0031116	Process	Positive regulation of microtubule polymerization	IDA	10831612, 20740604
GO:0034260	Process	Negative regulation of GTPase activity	IDA	10831612
GO:0050796	Process	Regulation of insulin secretion	TAS
GO:0051457	Process	Maintenance of protein location in nucleus	IDA	18234692
GO:0070830	Process	Bicellular tight junction assembly	ISS

Other IDs

• MIM: 601175
• HGNC: 693
• e!Ensembl: ENSG00000213465

Protein

• UniProt ID: P36404
• Protein name: ADP-ribosylation factor-like protein 2
• Protein function: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that d
• PDB: 3DOE, 3DOF
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00025	Arf	3 → 176	ADP-ribosylation factor family	Domain

• Sequence:

  MGLLTILKKMKQKERELRLLMLGLDNAGKTTILKKFNGEDIDTISPTLGFNIKTLEHRGF
  KLNIWDVGGQKSLRSYWRNYFESTDGLIWVVDSADRQRMQDCQRELQSLLVEERLAGATL
  LIFANKQDLPGALSSNAIREVLELDSIRSHHWCIQGCSAVTGENLLPGIDWLLDDISSRI
  FTAD

• Sequence length: 184

Pathways

Reactome:

Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Melanoma	melanoma	rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050	22535842

Unknown
Disease term	Disease name	Evidence	References	Source
Microcornea, Rod-Cone Dystrophy, Cataract, And Posterior Staphyloma	microcornea, rod-cone dystrophy, cataract, and posterior staphyloma 1			GenCC
Schizophrenia	Schizophrenia			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Associate	18818514
Cardiomyopathy Dilated	Associate	36042172
Colorectal Neoplasms	Associate	35567502
Inflammation	Associate	33617480
Neoplasm Metastasis	Associate	31858533
Neoplasms	Associate	18818514, 33955587
Niemann Pick Disease Type C	Associate	23807224
Osteosarcoma	Associate	33617480
Uterine Cervical Neoplasms	Associate	31858533