Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4017
Gene name Gene Name - the full gene name approved by the HGNC.
Lysyl oxidase like 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LOXL2
Synonyms (NCBI Gene) Gene synonyms aliases
LOR, LOR2, WS9-14
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8p21.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation o
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004135 hsa-miR-192-5p Microarray 16822819
MIRT438918 hsa-miR-29b-3p Luciferase reporter assay, qRT-PCR 23354167
MIRT438918 hsa-miR-29b-3p Luciferase reporter assay, qRT-PCR 23354167
MIRT709489 hsa-miR-128-3p HITS-CLIP 19536157
MIRT709488 hsa-miR-216a-3p HITS-CLIP 19536157
Transcription factors
Transcription factor Regulation Reference
E2F5 Unknown 20012301
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 25959397
GO:0000785 Component Chromatin IDA 27735137
GO:0001666 Process Response to hypoxia ISS
GO:0001837 Process Epithelial to mesenchymal transition IDA 16096638
GO:0001935 Process Endothelial cell proliferation IMP 21835952
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606663 6666 ENSG00000134013
Protein
UniProt ID Q9Y4K0
Protein name Lysyl oxidase homolog 2 (EC 1.4.3.13) (Lysyl oxidase-like protein 2) (Lysyl oxidase-related protein 2) (Lysyl oxidase-related protein WS9-14)
Protein function Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine) (PubMed:27735137). Acts as a transcription corepressor and specifically mediates deamination of
PDB 5ZE3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00530 SRCR 62 159 Scavenger receptor cysteine-rich domain Domain
PF00530 SRCR 196 302 Scavenger receptor cysteine-rich domain Domain
PF00530 SRCR 329 425 Scavenger receptor cysteine-rich domain Domain
PF00530 SRCR 438 544 Scavenger receptor cysteine-rich domain Domain
PF01186 Lysyl_oxidase 548 748 Lysyl oxidase Family
Tissue specificity TISSUE SPECIFICITY: Expressed in many tissues (PubMed:10212285). Highest expression in reproductive tissues, placenta, uterus and prostate (PubMed:10212285). In esophageal epithelium, expressed in the basal, prickle and granular cell layers (PubMed:222047
Sequence
Sequence length 774
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Elastic fibre formation
Crosslinking of collagen fibrils
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
19330836, 24014025
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
19330836, 24014025
Esophagus neoplasm Squamous cell carcinoma of esophagus rs28934578, rs121918714, rs1567556006, rs1575166666 24716982
Marfan syndrome Mammary Carcinoma, Human rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465
View all (942 more)
19330836, 24014025
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 34040139, 34323652, 36524120
Asthma Associate 19710636, 38375886
Biliary Atresia Associate 30358741
Breast Neoplasms Associate 21732535, 23933800, 23971878, 24014025, 28332555, 34011405, 36454513, 38518152
Breast Neoplasms Inhibit 27655685
Calcinosis Cutis Associate 37146419
Carcinogenesis Associate 35509127
Carcinoma Basal Cell Associate 21732535
Carcinoma Ductal Associate 30499665, 34011405
Carcinoma Hepatocellular Associate 23684136, 27430160, 28449718, 29728125, 29938458, 32323822, 32964626, 34206143, 36254230