Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	4015
Gene name	Lysyl oxidase
Gene symbol	LOX
Synonyms (NCBI Gene)	AAT10
Chromosome	5
Chromosome location	5q23.1
Summary	This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the m

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SNP ID	Visualize variation	Clinical significance	Consequence
rs886040966	C>T	Likely-pathogenic, pathogenic	Coding sequence variant, upstream transcript variant, genic upstream transcript variant, stop gained
rs1372924173	G>-	Likely-pathogenic	Coding sequence variant, genic upstream transcript variant, frameshift variant, upstream transcript variant
rs1473260982	C>A,T	Pathogenic	Missense variant, stop gained, coding sequence variant, genic upstream transcript variant, upstream transcript variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT003516	hsa-miR-124-3p	Review	20144549
MIRT018405	hsa-miR-335-5p	Microarray	18185580
MIRT437550	hsa-miR-29a-3p	Luciferase reporter assay	22745231
MIRT437556	hsa-miR-29b-3p	Luciferase reporter assay	22745231
MIRT437561	hsa-miR-29c-3p	Luciferase reporter assay	22745231
MIRT437571	hsa-miR-767-5p	Luciferase reporter assay	22745231
MIRT437556	hsa-miR-29b-3p	Luciferase reporter assayqRT-PCR	23354167
MIRT438051	hsa-miR-200b-3p	Luciferase reporter assayqRT-PCRWestern blot	23975428
MIRT437556	hsa-miR-29b-3p	Luciferase reporter assayqRT-PCR	23354167
MIRT438051	hsa-miR-200b-3p	Luciferase reporter assayqRT-PCRWestern blot	23975428
MIRT442626	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT442625	hsa-miR-4280	PAR-CLIP	22100165
MIRT442624	hsa-miR-3120-5p	PAR-CLIP	22100165
MIRT442623	hsa-miR-6830-3p	PAR-CLIP	22100165
MIRT442622	hsa-miR-142-3p	PAR-CLIP	22100165
MIRT442621	hsa-miR-6888-3p	PAR-CLIP	22100165
MIRT442620	hsa-miR-511-5p	PAR-CLIP	22100165
MIRT442619	hsa-miR-3591-5p	PAR-CLIP	22100165
MIRT442618	hsa-miR-4743-3p	PAR-CLIP	22100165
MIRT442626	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT442625	hsa-miR-4280	PAR-CLIP	22100165
MIRT442624	hsa-miR-3120-5p	PAR-CLIP	22100165
MIRT442623	hsa-miR-6830-3p	PAR-CLIP	22100165
MIRT442622	hsa-miR-142-3p	PAR-CLIP	22100165
MIRT442621	hsa-miR-6888-3p	PAR-CLIP	22100165
MIRT442620	hsa-miR-511-5p	PAR-CLIP	22100165
MIRT442619	hsa-miR-3591-5p	PAR-CLIP	22100165
MIRT442618	hsa-miR-4743-3p	PAR-CLIP	22100165
MIRT731147	hsa-miR-30a-5p	Western blotLuciferase reporter assayImmunohistochemistry	25488748
MIRT731147	hsa-miR-30a-5p	Western blotLuciferase reporter assayImmunohistochemistry	25488748
MIRT437556	hsa-miR-29b-3p	qRT-PCR	25744716
MIRT437556	hsa-miR-29b-3p	qRT-PCR	25744716
MIRT442626	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT442625	hsa-miR-4280	PAR-CLIP	22100165
MIRT442624	hsa-miR-3120-5p	PAR-CLIP	22100165
MIRT442623	hsa-miR-6830-3p	PAR-CLIP	22100165
MIRT442622	hsa-miR-142-3p	PAR-CLIP	22100165
MIRT442621	hsa-miR-6888-3p	PAR-CLIP	22100165
MIRT442620	hsa-miR-511-5p	PAR-CLIP	22100165
MIRT442619	hsa-miR-3591-5p	PAR-CLIP	22100165
MIRT442618	hsa-miR-4743-3p	PAR-CLIP	22100165
MIRT442626	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT442625	hsa-miR-4280	PAR-CLIP	22100165
MIRT442624	hsa-miR-3120-5p	PAR-CLIP	22100165
MIRT442623	hsa-miR-6830-3p	PAR-CLIP	22100165
MIRT442622	hsa-miR-142-3p	PAR-CLIP	22100165
MIRT442621	hsa-miR-6888-3p	PAR-CLIP	22100165
MIRT442620	hsa-miR-511-5p	PAR-CLIP	22100165
MIRT442619	hsa-miR-3591-5p	PAR-CLIP	22100165
MIRT442618	hsa-miR-4743-3p	PAR-CLIP	22100165
MIRT1115331	hsa-miR-124	CLIP-seq
MIRT1115332	hsa-miR-1273g	CLIP-seq
MIRT1115333	hsa-miR-3065-5p	CLIP-seq
MIRT1115334	hsa-miR-3714	CLIP-seq
MIRT1115335	hsa-miR-3910	CLIP-seq
MIRT1115336	hsa-miR-4477b	CLIP-seq
MIRT1115337	hsa-miR-506	CLIP-seq
MIRT1115338	hsa-miR-583	CLIP-seq
MIRT1115339	hsa-miR-935	CLIP-seq
MIRT1115340	hsa-miR-1260	CLIP-seq
MIRT1115341	hsa-miR-1260b	CLIP-seq
MIRT1115342	hsa-miR-188-3p	CLIP-seq
MIRT1115343	hsa-miR-3145-3p	CLIP-seq
MIRT1115344	hsa-miR-3156-3p	CLIP-seq
MIRT1115345	hsa-miR-3653	CLIP-seq
MIRT1115346	hsa-miR-3658	CLIP-seq
MIRT1115347	hsa-miR-3689a-5p	CLIP-seq
MIRT1115348	hsa-miR-3689b	CLIP-seq
MIRT1115349	hsa-miR-3689e	CLIP-seq
MIRT1115350	hsa-miR-3689f	CLIP-seq
MIRT1115351	hsa-miR-3713	CLIP-seq
MIRT1115352	hsa-miR-3924	CLIP-seq
MIRT1115353	hsa-miR-4279	CLIP-seq
MIRT1115354	hsa-miR-4301	CLIP-seq
MIRT1115355	hsa-miR-4446-5p	CLIP-seq
MIRT1115356	hsa-miR-4474-5p	CLIP-seq
MIRT1115357	hsa-miR-4477a	CLIP-seq
MIRT1115358	hsa-miR-4670-3p	CLIP-seq
MIRT1115359	hsa-miR-4711-3p	CLIP-seq
MIRT1115360	hsa-miR-4724-5p	CLIP-seq
MIRT1115361	hsa-miR-4790-3p	CLIP-seq
MIRT1115362	hsa-miR-942	CLIP-seq
MIRT1550797	hsa-miR-1200	CLIP-seq
MIRT1550798	hsa-miR-1273d	CLIP-seq
MIRT1550799	hsa-miR-134	CLIP-seq
MIRT1550800	hsa-miR-200b	CLIP-seq
MIRT1550801	hsa-miR-200c	CLIP-seq
MIRT1550802	hsa-miR-24	CLIP-seq
MIRT1550803	hsa-miR-3118	CLIP-seq
MIRT1550804	hsa-miR-3136-5p	CLIP-seq
MIRT1550805	hsa-miR-3140-5p	CLIP-seq
MIRT1550806	hsa-miR-3148	CLIP-seq
MIRT1550807	hsa-miR-3164	CLIP-seq
MIRT1550808	hsa-miR-3675-3p	CLIP-seq
MIRT1550809	hsa-miR-374c	CLIP-seq
MIRT1550810	hsa-miR-4284	CLIP-seq
MIRT1550811	hsa-miR-429	CLIP-seq
MIRT1550812	hsa-miR-4427	CLIP-seq
MIRT1550813	hsa-miR-4439	CLIP-seq
MIRT1550814	hsa-miR-4496	CLIP-seq
MIRT1550815	hsa-miR-4513	CLIP-seq
MIRT1550816	hsa-miR-4659a-5p	CLIP-seq
MIRT1550817	hsa-miR-4659b-5p	CLIP-seq
MIRT1550818	hsa-miR-4720-3p	CLIP-seq
MIRT1550819	hsa-miR-4768-5p	CLIP-seq
MIRT1550820	hsa-miR-4776-3p	CLIP-seq
MIRT1550821	hsa-miR-4777-5p	CLIP-seq
MIRT1550822	hsa-miR-4795-3p	CLIP-seq
MIRT1550823	hsa-miR-488	CLIP-seq
MIRT1550824	hsa-miR-518d-5p	CLIP-seq
MIRT1550825	hsa-miR-519b-5p	CLIP-seq
MIRT1550826	hsa-miR-519c-5p	CLIP-seq
MIRT1550827	hsa-miR-520c-5p	CLIP-seq
MIRT1550828	hsa-miR-526a	CLIP-seq
MIRT1550829	hsa-miR-655	CLIP-seq
MIRT1550830	hsa-miR-889	CLIP-seq
MIRT1550797	hsa-miR-1200	CLIP-seq
MIRT1550798	hsa-miR-1273d	CLIP-seq
MIRT1550799	hsa-miR-134	CLIP-seq
MIRT1550800	hsa-miR-200b	CLIP-seq
MIRT1550801	hsa-miR-200c	CLIP-seq
MIRT1550803	hsa-miR-3118	CLIP-seq
MIRT1550804	hsa-miR-3136-5p	CLIP-seq
MIRT1550805	hsa-miR-3140-5p	CLIP-seq
MIRT1550807	hsa-miR-3164	CLIP-seq
MIRT1550811	hsa-miR-429	CLIP-seq
MIRT1550812	hsa-miR-4427	CLIP-seq
MIRT1550813	hsa-miR-4439	CLIP-seq
MIRT1550815	hsa-miR-4513	CLIP-seq
MIRT1550831	hsa-miR-514	CLIP-seq
MIRT1550832	hsa-miR-514b-3p	CLIP-seq
MIRT1550833	hsa-miR-526b	CLIP-seq
MIRT1550834	hsa-miR-578	CLIP-seq
MIRT2032453	hsa-miR-145	CLIP-seq
MIRT2262949	hsa-miR-2054	CLIP-seq
MIRT2262950	hsa-miR-3646	CLIP-seq
MIRT1550809	hsa-miR-374c	CLIP-seq
MIRT2262951	hsa-miR-380	CLIP-seq
MIRT2262952	hsa-miR-425	CLIP-seq
MIRT2262953	hsa-miR-4495	CLIP-seq
MIRT2262954	hsa-miR-4698	CLIP-seq
MIRT2262955	hsa-miR-590-3p	CLIP-seq
MIRT1550829	hsa-miR-655	CLIP-seq
MIRT1550800	hsa-miR-200b	CLIP-seq
MIRT1550801	hsa-miR-200c	CLIP-seq
MIRT2262950	hsa-miR-3646	CLIP-seq
MIRT1550811	hsa-miR-429	CLIP-seq
MIRT1550822	hsa-miR-4795-3p	CLIP-seq
MIRT1550800	hsa-miR-200b	CLIP-seq
MIRT1550801	hsa-miR-200c	CLIP-seq
MIRT1550802	hsa-miR-24	CLIP-seq
MIRT2262950	hsa-miR-3646	CLIP-seq
MIRT1550810	hsa-miR-4284	CLIP-seq
MIRT1550811	hsa-miR-429	CLIP-seq
MIRT2262953	hsa-miR-4495	CLIP-seq
MIRT2430796	hsa-miR-4775	CLIP-seq
MIRT1550822	hsa-miR-4795-3p	CLIP-seq
MIRT1550823	hsa-miR-488	CLIP-seq
MIRT2430797	hsa-miR-591	CLIP-seq
MIRT1115335	hsa-miR-3910	CLIP-seq
MIRT2262950	hsa-miR-3646	CLIP-seq
MIRT1550822	hsa-miR-4795-3p	CLIP-seq
MIRT1550823	hsa-miR-488	CLIP-seq
MIRT2562218	hsa-miR-105	CLIP-seq
MIRT1550797	hsa-miR-1200	CLIP-seq
MIRT2562219	hsa-miR-1244	CLIP-seq
MIRT2562220	hsa-miR-1257	CLIP-seq
MIRT1550798	hsa-miR-1273d	CLIP-seq
MIRT2562221	hsa-miR-128	CLIP-seq
MIRT2562222	hsa-miR-129-5p	CLIP-seq
MIRT2562223	hsa-miR-1910	CLIP-seq
MIRT2562224	hsa-miR-1914	CLIP-seq
MIRT2562225	hsa-miR-199a-3p	CLIP-seq
MIRT2562226	hsa-miR-199b-3p	CLIP-seq
MIRT1550800	hsa-miR-200b	CLIP-seq
MIRT1550801	hsa-miR-200c	CLIP-seq
MIRT2562227	hsa-miR-219-5p	CLIP-seq
MIRT2562228	hsa-miR-27a	CLIP-seq
MIRT2562229	hsa-miR-27b	CLIP-seq
MIRT2562230	hsa-miR-28-5p	CLIP-seq
MIRT2562231	hsa-miR-298	CLIP-seq
MIRT2562232	hsa-miR-29a	CLIP-seq
MIRT2562233	hsa-miR-29b	CLIP-seq
MIRT2562234	hsa-miR-29c	CLIP-seq
MIRT2562235	hsa-miR-3065-3p	CLIP-seq
MIRT2562236	hsa-miR-3129-5p	CLIP-seq
MIRT2562237	hsa-miR-3139	CLIP-seq
MIRT1550805	hsa-miR-3140-5p	CLIP-seq
MIRT2562238	hsa-miR-3143	CLIP-seq
MIRT1550806	hsa-miR-3148	CLIP-seq
MIRT2562239	hsa-miR-3163	CLIP-seq
MIRT2562240	hsa-miR-3189-3p	CLIP-seq
MIRT2562241	hsa-miR-337-3p	CLIP-seq
MIRT2562242	hsa-miR-3591-3p	CLIP-seq
MIRT2562243	hsa-miR-3611	CLIP-seq
MIRT2562244	hsa-miR-3613-3p	CLIP-seq
MIRT2262950	hsa-miR-3646	CLIP-seq
MIRT1115345	hsa-miR-3653	CLIP-seq
MIRT2562245	hsa-miR-3657	CLIP-seq
MIRT1115346	hsa-miR-3658	CLIP-seq
MIRT2562246	hsa-miR-3662	CLIP-seq
MIRT2562247	hsa-miR-3671	CLIP-seq
MIRT2562248	hsa-miR-3672	CLIP-seq
MIRT1550808	hsa-miR-3675-3p	CLIP-seq
MIRT2562249	hsa-miR-3678-3p	CLIP-seq
MIRT2562250	hsa-miR-3680	CLIP-seq
MIRT1550809	hsa-miR-374c	CLIP-seq
MIRT1115352	hsa-miR-3924	CLIP-seq
MIRT2562251	hsa-miR-4263	CLIP-seq
MIRT2562252	hsa-miR-4282	CLIP-seq
MIRT1550811	hsa-miR-429	CLIP-seq
MIRT2562253	hsa-miR-4325	CLIP-seq
MIRT2562254	hsa-miR-4326	CLIP-seq
MIRT2562255	hsa-miR-4328	CLIP-seq
MIRT2562256	hsa-miR-4420	CLIP-seq
MIRT1550812	hsa-miR-4427	CLIP-seq
MIRT2562257	hsa-miR-4445	CLIP-seq
MIRT1550814	hsa-miR-4496	CLIP-seq
MIRT2562258	hsa-miR-4503	CLIP-seq
MIRT2562259	hsa-miR-450b-5p	CLIP-seq
MIRT2562260	hsa-miR-451b	CLIP-seq
MIRT2562261	hsa-miR-4540	CLIP-seq
MIRT2562262	hsa-miR-4637	CLIP-seq
MIRT2562263	hsa-miR-4645-3p	CLIP-seq
MIRT2562264	hsa-miR-4652-3p	CLIP-seq
MIRT2562265	hsa-miR-4668-3p	CLIP-seq
MIRT2562266	hsa-miR-4669	CLIP-seq
MIRT1115358	hsa-miR-4670-3p	CLIP-seq
MIRT2262954	hsa-miR-4698	CLIP-seq
MIRT2562267	hsa-miR-4714-5p	CLIP-seq
MIRT2562268	hsa-miR-4717-3p	CLIP-seq
MIRT1550818	hsa-miR-4720-3p	CLIP-seq
MIRT2562269	hsa-miR-4735-5p	CLIP-seq
MIRT2562270	hsa-miR-4764-3p	CLIP-seq
MIRT2562271	hsa-miR-4766-5p	CLIP-seq
MIRT1550821	hsa-miR-4777-5p	CLIP-seq
MIRT2562272	hsa-miR-4781-3p	CLIP-seq
MIRT2562273	hsa-miR-4782-3p	CLIP-seq
MIRT2562274	hsa-miR-4799-5p	CLIP-seq
MIRT2562275	hsa-miR-4804-3p	CLIP-seq
MIRT1550823	hsa-miR-488	CLIP-seq
MIRT2562276	hsa-miR-507	CLIP-seq
MIRT2562277	hsa-miR-508-3p	CLIP-seq
MIRT2562278	hsa-miR-511	CLIP-seq
MIRT2562279	hsa-miR-513a-5p	CLIP-seq
MIRT1550824	hsa-miR-518d-5p	CLIP-seq
MIRT1550825	hsa-miR-519b-5p	CLIP-seq
MIRT1550826	hsa-miR-519c-5p	CLIP-seq
MIRT1550827	hsa-miR-520c-5p	CLIP-seq
MIRT1550828	hsa-miR-526a	CLIP-seq
MIRT2562280	hsa-miR-543	CLIP-seq
MIRT2562281	hsa-miR-548l	CLIP-seq
MIRT2562282	hsa-miR-550b	CLIP-seq
MIRT2562283	hsa-miR-557	CLIP-seq
MIRT2562284	hsa-miR-576-3p	CLIP-seq
MIRT2562285	hsa-miR-576-5p	CLIP-seq
MIRT2562286	hsa-miR-577	CLIP-seq
MIRT2562287	hsa-miR-607	CLIP-seq
MIRT2562288	hsa-miR-626	CLIP-seq
MIRT1550829	hsa-miR-655	CLIP-seq
MIRT2562289	hsa-miR-656	CLIP-seq
MIRT2562290	hsa-miR-708	CLIP-seq
MIRT2562291	hsa-miR-875-3p	CLIP-seq
MIRT1550830	hsa-miR-889	CLIP-seq
MIRT2562218	hsa-miR-105	CLIP-seq
MIRT1550797	hsa-miR-1200	CLIP-seq
MIRT1115331	hsa-miR-124	CLIP-seq
MIRT2562219	hsa-miR-1244	CLIP-seq
MIRT2562220	hsa-miR-1257	CLIP-seq
MIRT1550798	hsa-miR-1273d	CLIP-seq
MIRT2562221	hsa-miR-128	CLIP-seq
MIRT2684008	hsa-miR-1283	CLIP-seq
MIRT2562222	hsa-miR-129-5p	CLIP-seq
MIRT2684009	hsa-miR-1297	CLIP-seq
MIRT2684010	hsa-miR-140-3p	CLIP-seq
MIRT2684011	hsa-miR-155	CLIP-seq
MIRT2562223	hsa-miR-1910	CLIP-seq
MIRT2684012	hsa-miR-1913	CLIP-seq
MIRT2562224	hsa-miR-1914	CLIP-seq
MIRT2684013	hsa-miR-197	CLIP-seq
MIRT2684014	hsa-miR-1976	CLIP-seq
MIRT2562225	hsa-miR-199a-3p	CLIP-seq
MIRT2562226	hsa-miR-199b-3p	CLIP-seq
MIRT1550800	hsa-miR-200b	CLIP-seq
MIRT1550801	hsa-miR-200c	CLIP-seq
MIRT2262949	hsa-miR-2054	CLIP-seq
MIRT2684015	hsa-miR-218	CLIP-seq
MIRT2562227	hsa-miR-219-5p	CLIP-seq
MIRT2684016	hsa-miR-223	CLIP-seq
MIRT2684017	hsa-miR-26a	CLIP-seq
MIRT2684018	hsa-miR-26b	CLIP-seq
MIRT2562228	hsa-miR-27a	CLIP-seq
MIRT2562229	hsa-miR-27b	CLIP-seq
MIRT2562230	hsa-miR-28-5p	CLIP-seq
MIRT2562231	hsa-miR-298	CLIP-seq
MIRT2562232	hsa-miR-29a	CLIP-seq
MIRT2562233	hsa-miR-29b	CLIP-seq
MIRT2562234	hsa-miR-29c	CLIP-seq
MIRT2562235	hsa-miR-3065-3p	CLIP-seq
MIRT2684019	hsa-miR-30a	CLIP-seq
MIRT2684020	hsa-miR-30b	CLIP-seq
MIRT2684021	hsa-miR-30c	CLIP-seq
MIRT2684022	hsa-miR-30d	CLIP-seq
MIRT2684023	hsa-miR-30e	CLIP-seq
MIRT2684024	hsa-miR-3121-5p	CLIP-seq
MIRT2562236	hsa-miR-3129-5p	CLIP-seq
MIRT2562237	hsa-miR-3139	CLIP-seq
MIRT1550805	hsa-miR-3140-5p	CLIP-seq
MIRT2562238	hsa-miR-3143	CLIP-seq
MIRT2684025	hsa-miR-3146	CLIP-seq
MIRT1550806	hsa-miR-3148	CLIP-seq
MIRT2684026	hsa-miR-3153	CLIP-seq
MIRT2562239	hsa-miR-3163	CLIP-seq
MIRT2562240	hsa-miR-3189-3p	CLIP-seq
MIRT2684027	hsa-miR-324-3p	CLIP-seq
MIRT2684028	hsa-miR-331-5p	CLIP-seq
MIRT2562241	hsa-miR-337-3p	CLIP-seq
MIRT2562242	hsa-miR-3591-3p	CLIP-seq
MIRT2562243	hsa-miR-3611	CLIP-seq
MIRT2562244	hsa-miR-3613-3p	CLIP-seq
MIRT2684029	hsa-miR-361-5p	CLIP-seq
MIRT2262950	hsa-miR-3646	CLIP-seq
MIRT1115345	hsa-miR-3653	CLIP-seq
MIRT2562245	hsa-miR-3657	CLIP-seq
MIRT1115346	hsa-miR-3658	CLIP-seq
MIRT2562246	hsa-miR-3662	CLIP-seq
MIRT2562247	hsa-miR-3671	CLIP-seq
MIRT2562248	hsa-miR-3672	CLIP-seq
MIRT1550808	hsa-miR-3675-3p	CLIP-seq
MIRT2562249	hsa-miR-3678-3p	CLIP-seq
MIRT2562250	hsa-miR-3680	CLIP-seq
MIRT1115334	hsa-miR-3714	CLIP-seq
MIRT1550809	hsa-miR-374c	CLIP-seq
MIRT2684030	hsa-miR-375	CLIP-seq
MIRT2262951	hsa-miR-380	CLIP-seq
MIRT1115335	hsa-miR-3910	CLIP-seq
MIRT1115352	hsa-miR-3924	CLIP-seq
MIRT2684031	hsa-miR-410	CLIP-seq
MIRT2262952	hsa-miR-425	CLIP-seq
MIRT2562251	hsa-miR-4263	CLIP-seq
MIRT2562252	hsa-miR-4282	CLIP-seq
MIRT1550811	hsa-miR-429	CLIP-seq
MIRT2684032	hsa-miR-4307	CLIP-seq
MIRT2562253	hsa-miR-4325	CLIP-seq
MIRT2562254	hsa-miR-4326	CLIP-seq
MIRT2562255	hsa-miR-4328	CLIP-seq
MIRT2562256	hsa-miR-4420	CLIP-seq
MIRT2684033	hsa-miR-4421	CLIP-seq
MIRT1550812	hsa-miR-4427	CLIP-seq
MIRT2562257	hsa-miR-4445	CLIP-seq
MIRT2684034	hsa-miR-4452	CLIP-seq
MIRT2684035	hsa-miR-4465	CLIP-seq
MIRT1115336	hsa-miR-4477b	CLIP-seq
MIRT2262953	hsa-miR-4495	CLIP-seq
MIRT1550814	hsa-miR-4496	CLIP-seq
MIRT2562258	hsa-miR-4503	CLIP-seq
MIRT2562259	hsa-miR-450b-5p	CLIP-seq
MIRT2562260	hsa-miR-451b	CLIP-seq
MIRT2562261	hsa-miR-4540	CLIP-seq
MIRT2684036	hsa-miR-455-5p	CLIP-seq
MIRT2684037	hsa-miR-4635	CLIP-seq
MIRT2562262	hsa-miR-4637	CLIP-seq
MIRT2684038	hsa-miR-4639-5p	CLIP-seq
MIRT2684039	hsa-miR-4641	CLIP-seq
MIRT2562263	hsa-miR-4645-3p	CLIP-seq
MIRT2562264	hsa-miR-4652-3p	CLIP-seq
MIRT2562265	hsa-miR-4668-3p	CLIP-seq
MIRT2684040	hsa-miR-4668-5p	CLIP-seq
MIRT2562266	hsa-miR-4669	CLIP-seq
MIRT1115358	hsa-miR-4670-3p	CLIP-seq
MIRT2684041	hsa-miR-4697-3p	CLIP-seq
MIRT2262954	hsa-miR-4698	CLIP-seq
MIRT2684042	hsa-miR-4700-3p	CLIP-seq
MIRT2562267	hsa-miR-4714-5p	CLIP-seq
MIRT2562268	hsa-miR-4717-3p	CLIP-seq
MIRT1550818	hsa-miR-4720-3p	CLIP-seq
MIRT2562269	hsa-miR-4735-5p	CLIP-seq
MIRT2684043	hsa-miR-4760-3p	CLIP-seq
MIRT2562270	hsa-miR-4764-3p	CLIP-seq
MIRT2562271	hsa-miR-4766-5p	CLIP-seq
MIRT2430796	hsa-miR-4775	CLIP-seq
MIRT1550821	hsa-miR-4777-5p	CLIP-seq
MIRT2562272	hsa-miR-4781-3p	CLIP-seq
MIRT2562273	hsa-miR-4782-3p	CLIP-seq
MIRT1550822	hsa-miR-4795-3p	CLIP-seq
MIRT2562274	hsa-miR-4799-5p	CLIP-seq
MIRT2562275	hsa-miR-4804-3p	CLIP-seq
MIRT1550823	hsa-miR-488	CLIP-seq
MIRT2684044	hsa-miR-499-3p	CLIP-seq
MIRT2684045	hsa-miR-499a-3p	CLIP-seq
MIRT1115337	hsa-miR-506	CLIP-seq
MIRT2562276	hsa-miR-507	CLIP-seq
MIRT2562277	hsa-miR-508-3p	CLIP-seq
MIRT2562278	hsa-miR-511	CLIP-seq
MIRT2562279	hsa-miR-513a-5p	CLIP-seq
MIRT1550824	hsa-miR-518d-5p	CLIP-seq
MIRT1550825	hsa-miR-519b-5p	CLIP-seq
MIRT1550826	hsa-miR-519c-5p	CLIP-seq
MIRT1550827	hsa-miR-520c-5p	CLIP-seq
MIRT1550828	hsa-miR-526a	CLIP-seq
MIRT1550833	hsa-miR-526b	CLIP-seq
MIRT2562280	hsa-miR-543	CLIP-seq
MIRT2562281	hsa-miR-548l	CLIP-seq
MIRT2684046	hsa-miR-548n	CLIP-seq
MIRT2684047	hsa-miR-548p	CLIP-seq
MIRT2684048	hsa-miR-548t	CLIP-seq
MIRT2562282	hsa-miR-550b	CLIP-seq
MIRT2562283	hsa-miR-557	CLIP-seq
MIRT2562284	hsa-miR-576-3p	CLIP-seq
MIRT2562285	hsa-miR-576-5p	CLIP-seq
MIRT2562286	hsa-miR-577	CLIP-seq
MIRT1550834	hsa-miR-578	CLIP-seq
MIRT2684049	hsa-miR-579	CLIP-seq
MIRT1115338	hsa-miR-583	CLIP-seq
MIRT2262955	hsa-miR-590-3p	CLIP-seq
MIRT2562287	hsa-miR-607	CLIP-seq
MIRT2562288	hsa-miR-626	CLIP-seq
MIRT2684050	hsa-miR-636	CLIP-seq
MIRT1550829	hsa-miR-655	CLIP-seq
MIRT2562289	hsa-miR-656	CLIP-seq
MIRT2684051	hsa-miR-660	CLIP-seq
MIRT2562290	hsa-miR-708	CLIP-seq
MIRT2562291	hsa-miR-875-3p	CLIP-seq
MIRT2684052	hsa-miR-888	CLIP-seq
MIRT1550830	hsa-miR-889	CLIP-seq
MIRT1115339	hsa-miR-935	CLIP-seq

Show/Hide all (2)

Transcription factor	Regulation	Reference
GATA3	Repression	21892208
HIF1A	Unknown	17685448

Show/Hide all (57)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001568	Process	Blood vessel development	IEA
GO:0001649	Process	Osteoblast differentiation	IEA
GO:0004720	Function	Protein-lysine 6-oxidase activity	IBA
GO:0004720	Function	Protein-lysine 6-oxidase activity	IDA	31152061
GO:0004720	Function	Protein-lysine 6-oxidase activity	IEA
GO:0004720	Function	Protein-lysine 6-oxidase activity	ISS
GO:0004720	Function	Protein-lysine 6-oxidase activity	TAS	1352776
GO:0005507	Function	Copper ion binding	IEA
GO:0005507	Function	Copper ion binding	TAS	1357535
GO:0005515	Function	Protein binding	IPI	19570982, 19855011, 21690299, 22919265, 25118846, 26601954, 27339457, 30082873
GO:0005518	Function	Collagen binding	IDA	31152061
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	ISS
GO:0005576	Component	Extracellular region	TAS
GO:0005581	Component	Collagen trimer	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	31152061
GO:0007507	Process	Heart development	IEA
GO:0009410	Process	Response to xenobiotic stimulus	IEA
GO:0009725	Process	Response to hormone	IEA
GO:0010468	Process	Regulation of gene expression	IEA
GO:0016202	Process	Regulation of striated muscle tissue development	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016641	Function	Oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	IEA
GO:0017015	Process	Regulation of transforming growth factor beta receptor signaling pathway	IEA
GO:0018057	Process	Peptidyl-lysine oxidation	IDA	31152061
GO:0030199	Process	Collagen fibril organization	IBA
GO:0030199	Process	Collagen fibril organization	IEA
GO:0030199	Process	Collagen fibril organization	IEA
GO:0030282	Process	Bone mineralization	IEA
GO:0030324	Process	Lung development	IEA
GO:0031012	Component	Extracellular matrix	IEA
GO:0035791	Process	Platelet-derived growth factor receptor-beta signaling pathway	IBA
GO:0035791	Process	Platelet-derived growth factor receptor-beta signaling pathway	IEA
GO:0035904	Process	Aorta development	IEA
GO:0035905	Process	Ascending aorta development	IEA
GO:0035906	Process	Descending aorta development	IEA
GO:0036094	Function	Small molecule binding	IPI	30082873
GO:0036211	Process	Protein modification process	TAS	1685472
GO:0042981	Process	Regulation of apoptotic process	IEA
GO:0045652	Process	Regulation of megakaryocyte differentiation	IEA
GO:0046716	Process	Muscle cell cellular homeostasis	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048251	Process	Elastic fiber assembly	IEA
GO:0048251	Process	Elastic fiber assembly	IEA
GO:0048514	Process	Blood vessel morphogenesis	IEA
GO:0048514	Process	Blood vessel morphogenesis	ISS
GO:0048545	Process	Response to steroid hormone	IEA
GO:0051898	Process	Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA
GO:0055001	Process	Muscle cell development	IEA
GO:0060090	Function	Molecular adaptor activity	IPI	30082873
GO:0060326	Process	Cell chemotaxis	IEA
GO:0061448	Process	Connective tissue development	IEA
GO:0071897	Process	DNA biosynthetic process	IEA
GO:1903010	Process	Regulation of bone development	IEA
GO:1990869	Process	Cellular response to chemokine	IEA
GO:2000586	Process	Regulation of platelet-derived growth factor receptor-beta signaling pathway	IEA

MIM	HGNC	e!Ensembl
153455	6664	ENSG00000113083

P28300

Protein name

Protein-lysine 6-oxidase (EC 1.4.3.13) (Lysyl oxidase) [Cleaved into: Protein-lysine 6-oxidase, long form; Protein-lysine 6-oxidase, short form]

Protein function

Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787). Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aort

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01186	Lysyl_oxidase	213 → 414	Lysyl oxidase	Family

Tissue specificity

TISSUE SPECIFICITY: Heart, placenta, skeletal muscle, kidney, lung and pancreas. {ECO:0000269|PubMed:7706256}.

Sequence

MRFAWTVLLLGPLQLCALVHCAPPAAGQQQPPREPPAAPGAWRQQIQWENNGQVFSLLSL
GSQYQPQRRRDPGAAVPGAANASAQQPRTPILLIRDNRTAAARTRTAGSSGVTAGRPRPT
ARHWFQAGYSTSRAREAGASRAENQTAPGEVPALSNLRPPSRVDGMVGDDPYNPYKYSDD
NPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAA
EENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDE
FSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADID
CQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY

Sequence length

417

Interactions

View interactions

	Reactome
			Elastic fibre formation Crosslinking of collagen fibrils

361

Show/Hide Causal Diseases (9)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Acute aortic dissection	Pathogenic; Likely pathogenic	rs886040965, rs886040966, rs886040967, rs1473260982	RCV000755148 RCV000755141 RCV000755144 RCV000755142
Aortic aneurysm, familial thoracic 10	Pathogenic; Likely pathogenic	rs766969559, rs1274931972, rs2152591749, rs2532908171, rs2532917019, rs2532918070, rs876657852, rs2532901248, rs886040965, rs886040966, rs886040967, rs1754655630, rs1213452826, rs1754538399	RCV001780381 RCV001780380 RCV001780379 RCV002287219 RCV002468741 RCV002470472 RCV000258026 RCV003159272 RCV000258025 RCV000258033 RCV000258037 RCV003335841 RCV003144387 RCV001251164
Cardiomyopathy	Likely pathogenic; Pathogenic	rs2532911330	RCV006255215
Cardiovascular phenotype	Pathogenic; Likely pathogenic	rs779512296, rs2532911330, rs2532911338, rs2532918093, rs2532917759, rs2532917277, rs2532916357, rs1473260982, rs756849358	RCV002386582 RCV002412612 RCV002445883 RCV002389209 RCV002424210 RCV002441867 RCV004513494 RCV002352260 RCV002366100
Congenital aneurysm of ascending aorta	Pathogenic; Likely pathogenic	rs886040965, rs886040966, rs886040967, rs1473260982	RCV000755148 RCV000755141 RCV000755144 RCV000755142
Cutis laxa	Likely pathogenic	rs1436353084	RCV001530398
Familial thoracic aortic aneurysm and aortic dissection	Likely pathogenic; Pathogenic	rs2532917019, rs876657852, rs886040966	RCV005250251 RCV000213633 RCV000766258
Generalized arterial tortuosity	Likely pathogenic	rs1436353084	RCV001530398
LOX-related disorder	Pathogenic	rs779512296	RCV004545831

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Abnormal facial shape	Conflicting classifications of pathogenicity	rs575190694	RCV000735872
Connective tissue disorder	Conflicting classifications of pathogenicity	rs765126342	RCV000659838
Emphysema	Conflicting classifications of pathogenicity	rs575190694	RCV000735872
Increased number of skin folds	Conflicting classifications of pathogenicity	rs575190694	RCV000735872
Interphalangeal joint contracture of finger	Conflicting classifications of pathogenicity	rs575190694	RCV000735872
LOX POLYMORPHISM	Benign	rs1800449	RCV000015437
Pleural effusion	Conflicting classifications of pathogenicity	rs575190694	RCV000735872

Show/Hide Text Mining Associations (148)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	21523732
Adenoma Pleomorphic	Associate	21553343
Aortic Aneurysm	Associate	34281165
Aortic Aneurysm Abdominal	Associate	29191809, 31473210
Aortic Aneurysm Thoracic	Stimulate	23764410
Aortic Aneurysm Thoracic	Associate	38002926
Aortic Diseases	Associate	23764410, 38002926
Aortic Dissection	Associate	26838787, 34281165
Astrocytoma	Associate	25790191, 36076905
Atherosclerosis	Associate	24588843, 35874788
Atrial Fibrillation	Stimulate	33356379
Axial osteomalacia	Associate	34698138
Bicuspid Aortic Valve Disease	Associate	23764410
Bile Duct Diseases	Associate	38096955
Blister	Associate	35874788
Blood Platelet Disorders	Stimulate	29209148
Bone Fragility with Contractures Arterial Rupture and Deafness	Associate	15831618
Brain Neoplasms	Associate	29775160
Breast Neoplasms	Associate	17130123, 18765548, 19029090, 20498644, 21911388, 22994786, 25141126, 26068592, 27147578, 29261141, 29775160, 31932435, 33087801, 36232621
Breast Neoplasms	Inhibit	19597471
Calcinosis Cutis	Associate	26567111
Carcinogenesis	Associate	20345486, 27367711
Carcinoma Ductal Breast	Associate	9033266
Carcinoma Hepatocellular	Associate	30919528, 34206143
Carcinoma Intraductal Noninfiltrating	Associate	18928525
Carcinoma Non Small Cell Lung	Associate	22948781, 23886154, 25337249, 26515140, 31597217
Carcinoma Non Small Cell Lung	Stimulate	23140307
Carcinoma Ovarian Epithelial	Associate	23545606
Carcinoma Renal Cell	Associate	11720477, 27336447, 27449199, 32013938, 34449964
Cardiomegaly	Associate	36046382
Cell Transformation Neoplastic	Inhibit	38222455
Cholangiocarcinoma	Associate	38096955
Chromosomal Instability	Associate	29167120
Chronic Disease	Associate	34080027
Clubfoot	Associate	34769331, 35292718
Colitis Ulcerative	Associate	31584460
Collagen Diseases	Associate	15831618
Colorectal Neoplasms	Associate	24246612, 27367711, 29209148, 29766649, 32286443, 38267662
Connective Tissue Diseases	Associate	6120954
Coronary Artery Dissection Spontaneous	Associate	15831618, 33125268, 34281165
COVID 19	Associate	36233111
Coxa Magna	Associate	35035862
Cutis Laxa	Associate	7930686
Death	Associate	19667273, 21523732
Diabetes Complications	Associate	35806251
Diabetes Mellitus	Stimulate	27104752, 31546618
Diabetic Nephropathies	Associate	38174742
Diabetic Retinopathy	Associate	31546618
Disease	Associate	30578874
Dissection Ascending Aorta	Associate	26838787
Dissection Blood Vessel	Associate	15831618
Dissection Thoracic Aorta	Associate	31211624, 32199657, 33648514
Ehlers Danlos Syndrome	Associate	25979340, 6120954
Ehlers Danlos syndrome type 5	Associate	7086195
Ehlers Danlos Syndrome Type IV	Associate	38183136
Endometriosis	Associate	25963914, 35616875
Eosinophilic Esophagitis	Associate	30578874
Esophageal Neoplasms	Associate	31599475
Esophageal Squamous Cell Carcinoma	Associate	31599475
Fibrosis	Associate	23494965, 30578874, 34452563, 35792886, 37235663, 38174742
Fibrosis	Stimulate	31584460
Glaucoma	Associate	23748100
Glioblastoma	Associate	20671264, 25790191, 32510239, 34354698, 36076905
Glioblastoma	Stimulate	36397358
Glomerulonephritis IGA	Associate	38174742
Glomerulonephritis Membranous	Associate	38174742
Head and Neck Neoplasms	Associate	19667273
Heart Failure	Associate	19075089, 21329845, 37334749
Helicobacter Infections	Stimulate	20345486
Hepatolenticular Degeneration	Associate	8980283
Hernia Inguinal	Associate	35680855
Hypertension	Associate	29167120
Hypertension Pulmonary	Associate	36483920
Hypoxia	Associate	18427106, 20498644, 21477371, 23140307, 23545606, 25405996, 26515140, 28143503, 28284922, 30919528, 33679749, 34206143
Hypoxia	Stimulate	20026874, 21911388, 25166211
Hypoxia Brain	Associate	20671264
Hypoxia Brain	Stimulate	23140307, 23545606, 26515140
Idiopathic Pulmonary Fibrosis	Stimulate	28467787
Idiopathic Pulmonary Fibrosis	Inhibit	29125826
Idiopathic Pulmonary Fibrosis	Associate	37798725
Inflammation	Associate	24588843, 35701670, 38009683, 38096955
Insulin Resistance	Associate	26672043, 35806251
Intracranial Aneurysm	Associate	28792146, 34393991
Keratoconus	Associate	21976959, 25593510, 25735481, 32246022, 33596621
Keratoconus	Inhibit	32246022
Kidney Diseases	Associate	35792886
Lathyrism	Associate	25979340
Leiomyoma	Associate	29082249
Lung Diseases	Associate	27367711
Lung Neoplasms	Associate	27367711
Lymphatic Metastasis	Associate	19816945, 22994786, 23545606, 23886154, 25060181, 25337249, 31057297
Melanoma	Associate	10594755, 20587415, 2172980, 22719872, 38247872, 8910291, 9065413, 9247085
Menkes Kinky Hair Syndrome	Associate	8980283
Mitral Valve Insufficiency	Associate	28453968
Mitral Valve Stenosis	Associate	28453968
Muscular Dystrophy Duchenne	Associate	34922439
Myocardial Ischemia	Associate	35792886
Nasopharyngeal Carcinoma	Associate	26882568
Neoplasm Invasiveness	Associate	21523732
Neoplasm Metastasis	Associate	18765548, 19667273, 21892208, 21911388, 23140307, 23545606, 23775078, 25060181, 25337249, 26068592, 26515140, 27147578, 27449199, 29766649, 30919528, 31597217 View all (1 more)
Neoplasm Metastasis	Inhibit	25141126, 26882568
Neoplasms	Associate	16475210, 19816945, 20682068, 2172980, 21731642, 23140307, 23494965, 23545606, 23886154, 23886186, 25141126, 25337249, 25790191, 26567111, 26683963 View all (20 more)
Neoplasms	Inhibit	16952303, 19597471, 25141126
Neoplasms Adipose Tissue	Associate	34728615
Neoplasms Cystic Mucinous and Serous	Associate	29766649
Niemann Pick Disease Type C	Associate	26882568
Obesity Metabolically Benign	Stimulate	35008946
Occipital horn syndrome	Associate	11431706, 22134099
Oral Submucous Fibrosis	Stimulate	34452563
Oral Submucous Fibrosis	Associate	34452563
Osteosarcoma	Associate	22911823, 23886186
Ovarian Neoplasms	Associate	22906264, 27028324, 30583585
Pancreatic Neoplasms	Associate	12163367, 30712446, 37588985
Peritonitis	Associate	25060181
Personality Disorders	Stimulate	27296552
Phlebectasia Of Lips	Associate	17482283
Polycystic Kidney Diseases	Associate	38002926
Polycystic Ovary Syndrome	Associate	19583806
Primary Myelofibrosis	Associate	23494965
Prostate Cancer Hereditary 7	Associate	33204318
Prostatic Diseases	Associate	28143503
Prostatic Hyperplasia	Associate	28143503
Prostatic Neoplasms	Inhibit	19597471
Prostatic Neoplasms	Associate	22895552, 26567111, 28510269
Pulmonary Fibrosis	Associate	20418892
Reperfusion Injury	Stimulate	35792886
Retinitis	Associate	31546618
Rhinitis Allergic	Associate	38009683
Rupture	Associate	29191809
Sarcoma	Associate	26055407, 37874682
Scoliosis	Associate	21740577
Squamous Cell Carcinoma of Head and Neck	Associate	19816945, 34930321
Stomach Neoplasms	Associate	25060181, 29343955, 30226558, 31848941, 39251966
Stomach Neoplasms	Stimulate	31057297
Sunburn	Associate	19584301
Thoracic Diseases	Associate	26838787
Thyroid Cancer Papillary	Stimulate	26818109
Thyroid Cancer Papillary	Associate	36120433
Thyroid Carcinoma Anaplastic	Associate	25153510, 26818109, 35971932
Thyroid Neoplasms	Stimulate	26818109
Tooth Loss	Associate	31546618
Transient erythroblastopenia of childhood	Associate	39216306
Tricuspid Valve Stenosis	Associate	23764410
Triple Negative Breast Neoplasms	Associate	21892208
Ureteral Obstruction	Stimulate	35792886
Uterine Cervical Neoplasms	Associate	31205475
Vascular Diseases	Associate	22134099
Ventricular Dysfunction Left	Associate	21329845, 28091585

LOX (lysyl oxidase)