LRRD1 (leucine rich repeats and death domain containing 1)

Gene

• Entrez ID: 401387
• Gene name: Leucine rich repeats and death domain containing 1
• Gene symbol: LRRD1
• Synonyms (NCBI Gene): -
• Chromosome: 7
• Chromosome location: 7q21.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT684732	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT684731	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT684730	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT684729	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT684728	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT684727	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT684726	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT684725	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT684724	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT684723	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT684722	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT684721	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT684720	hsa-miR-302e	HITS-CLIP	23313552
MIRT684719	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT684718	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT684717	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT684716	hsa-miR-520b	HITS-CLIP	23313552
MIRT684715	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT684714	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT684713	hsa-miR-520e	HITS-CLIP	23313552
MIRT684712	hsa-miR-4438	HITS-CLIP	23313552
MIRT684711	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT684710	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT684709	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT684708	hsa-miR-520h	HITS-CLIP	23313552
MIRT684707	hsa-miR-3620-3p	HITS-CLIP	23313552
MIRT684706	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT684705	hsa-miR-6752-3p	HITS-CLIP	23313552
MIRT679261	hsa-miR-6787-3p	HITS-CLIP	23313552
MIRT684704	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT684703	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT684702	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT684701	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT684700	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT684699	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT684698	hsa-miR-5095	HITS-CLIP	23313552
MIRT684697	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT684696	hsa-miR-6807-5p	HITS-CLIP	23313552
MIRT684695	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT679264	hsa-miR-2392	HITS-CLIP	23824327
MIRT679263	hsa-miR-340-3p	HITS-CLIP	23824327
MIRT679262	hsa-miR-6827-3p	HITS-CLIP	23824327
MIRT679261	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT679260	hsa-miR-1913	HITS-CLIP	23824327
MIRT679259	hsa-miR-324-3p	HITS-CLIP	23824327
MIRT679258	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT679257	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT679256	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT679255	hsa-miR-1193	HITS-CLIP	23824327
MIRT679254	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT679253	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT679252	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT684732	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT684731	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT684730	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT684729	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT684728	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT684727	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT684726	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT684725	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT684724	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT684723	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT684722	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT684721	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT684720	hsa-miR-302e	HITS-CLIP	23313552
MIRT684719	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT684718	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT684717	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT684716	hsa-miR-520b	HITS-CLIP	23313552
MIRT684715	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT684714	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT684713	hsa-miR-520e	HITS-CLIP	23313552
MIRT684712	hsa-miR-4438	HITS-CLIP	23313552
MIRT684711	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT684710	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT684709	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT684708	hsa-miR-520h	HITS-CLIP	23313552
MIRT684707	hsa-miR-3620-3p	HITS-CLIP	23313552
MIRT684706	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT684705	hsa-miR-6752-3p	HITS-CLIP	23313552
MIRT679261	hsa-miR-6787-3p	HITS-CLIP	23313552
MIRT684704	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT684703	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT684702	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT684701	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT684700	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT684699	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT684698	hsa-miR-5095	HITS-CLIP	23313552
MIRT684697	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT684696	hsa-miR-6807-5p	HITS-CLIP	23313552
MIRT684695	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT679264	hsa-miR-2392	HITS-CLIP	23824327
MIRT679263	hsa-miR-340-3p	HITS-CLIP	23824327
MIRT679262	hsa-miR-6827-3p	HITS-CLIP	23824327
MIRT679261	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT679260	hsa-miR-1913	HITS-CLIP	23824327
MIRT679259	hsa-miR-324-3p	HITS-CLIP	23824327
MIRT679258	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT679257	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT679256	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT679255	hsa-miR-1193	HITS-CLIP	23824327
MIRT679254	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT679253	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT679252	hsa-miR-6848-3p	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0007165	Process	Signal transduction	IBA	21873635
GO:0046579	Process	Positive regulation of Ras protein signal transduction	IBA	21873635

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: A4D1F6
• Protein name: Leucine-rich repeat and death domain-containing protein 1
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13855	LRR_8	211 → 269	Leucine rich repeat	Repeat
  PF13855	LRR_8	257 → 315	Leucine rich repeat	Repeat
  PF13855	LRR_8	487 → 545	Leucine rich repeat	Repeat
  PF13855	LRR_8	556 → 614	Leucine rich repeat	Repeat

• Sequence:

  MSEKEGMSEVLEDTISQFRKESRSQSMKEPGFIKETSNLINEASDYLEGKSSNQIYETHP
  RQNTLESTSSSGRKSKRNEEQKKNLQFSETSTRTGTSQSLSSLTGRTAEYQALVNFLSHE
  TVGEVSPQVSEENQKQLGLGADNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQ
  GADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLF
  FYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALC
  FLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNK
  LEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNL
  RKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFP
  LGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDL
  GKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICN
  LKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISN
  NAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIF
  SLKEINFDDNPLLRPPVEICKGKQLYTIARYLQRADERDEKILEKIFKIVANNITETNFE
  FLCQKLNLANSETDMPTKSTVSLSERAHQALVIWKTQSNKLSLTAAALRDQLIRALTMIG
  AYEIMDKITALNLFTRAIKF

• Sequence length: 860

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038	29059683

Unknown
Disease term	Disease name	Evidence	References	Source
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA