VWA5A (von Willebrand factor A domain containing 5A)

Gene

• Entrez ID: 4013
• Gene name: Von Willebrand factor A domain containing 5A
• Gene symbol: VWA5A
• Synonyms (NCBI Gene): BCSC-1, BCSC1, LOH11CR2A
• Chromosome: 11
• Chromosome location: 11q24.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT572423	hsa-miR-6761-3p	PAR-CLIP	20371350
MIRT572421	hsa-miR-5193	PAR-CLIP	20371350
MIRT572420	hsa-miR-660-3p	PAR-CLIP	20371350
MIRT572419	hsa-miR-1291	PAR-CLIP	20371350
MIRT572418	hsa-miR-6775-3p	PAR-CLIP	20371350
MIRT572417	hsa-miR-6851-3p	PAR-CLIP	20371350
MIRT572416	hsa-miR-328-3p	PAR-CLIP	20371350
MIRT572423	hsa-miR-6761-3p	PAR-CLIP	20371350
MIRT572421	hsa-miR-5193	PAR-CLIP	20371350
MIRT572420	hsa-miR-660-3p	PAR-CLIP	20371350
MIRT572419	hsa-miR-1291	PAR-CLIP	20371350
MIRT572418	hsa-miR-6775-3p	PAR-CLIP	20371350
MIRT572417	hsa-miR-6851-3p	PAR-CLIP	20371350
MIRT572416	hsa-miR-328-3p	PAR-CLIP	20371350
MIRT1488300	hsa-miR-1264	CLIP-seq
MIRT1488301	hsa-miR-2682	CLIP-seq
MIRT1488302	hsa-miR-3190	CLIP-seq
MIRT1488303	hsa-miR-34a	CLIP-seq
MIRT1488304	hsa-miR-34c-5p	CLIP-seq
MIRT1488305	hsa-miR-3613-5p	CLIP-seq
MIRT1488306	hsa-miR-3617	CLIP-seq
MIRT1488307	hsa-miR-3691-3p	CLIP-seq
MIRT1488308	hsa-miR-4269	CLIP-seq
MIRT1488309	hsa-miR-449a	CLIP-seq
MIRT1488310	hsa-miR-449b	CLIP-seq
MIRT1488311	hsa-miR-449c	CLIP-seq
MIRT1488312	hsa-miR-4514	CLIP-seq
MIRT1488313	hsa-miR-4692	CLIP-seq
MIRT1488314	hsa-miR-4731-3p	CLIP-seq
MIRT1488315	hsa-miR-4742-5p	CLIP-seq
MIRT1488316	hsa-miR-4801	CLIP-seq
MIRT1488317	hsa-miR-641	CLIP-seq
MIRT1488318	hsa-miR-7	CLIP-seq
MIRT1488319	hsa-miR-298	CLIP-seq
MIRT1488302	hsa-miR-3190	CLIP-seq
MIRT1488305	hsa-miR-3613-5p	CLIP-seq
MIRT1488306	hsa-miR-3617	CLIP-seq
MIRT1488320	hsa-miR-3647-3p	CLIP-seq
MIRT1488321	hsa-miR-4684-5p	CLIP-seq
MIRT1488322	hsa-miR-4735-5p	CLIP-seq
MIRT1488323	hsa-miR-4760-3p	CLIP-seq
MIRT1488317	hsa-miR-641	CLIP-seq
MIRT1488318	hsa-miR-7	CLIP-seq
MIRT1488324	hsa-miR-4270	CLIP-seq
MIRT1488325	hsa-miR-4441	CLIP-seq
MIRT1488326	hsa-miR-5095	CLIP-seq
MIRT1488327	hsa-miR-513a-3p	CLIP-seq
MIRT1488328	hsa-miR-539	CLIP-seq
MIRT2147033	hsa-miR-3120-3p	CLIP-seq
MIRT1488314	hsa-miR-4731-3p	CLIP-seq
MIRT1488316	hsa-miR-4801	CLIP-seq
MIRT2661032	hsa-miR-3147	CLIP-seq
MIRT2661033	hsa-miR-3616-3p	CLIP-seq
MIRT2661034	hsa-miR-3945	CLIP-seq
MIRT2661035	hsa-miR-4303	CLIP-seq
MIRT2661036	hsa-miR-4425	CLIP-seq
MIRT2661037	hsa-miR-4649-3p	CLIP-seq
MIRT2661038	hsa-miR-4721	CLIP-seq
MIRT2661039	hsa-miR-4761-3p	CLIP-seq
MIRT2661040	hsa-miR-4762-3p	CLIP-seq
MIRT2661041	hsa-miR-4781-3p	CLIP-seq
MIRT2661042	hsa-miR-668	CLIP-seq
MIRT2695109	hsa-miR-2052	CLIP-seq
MIRT2661032	hsa-miR-3147	CLIP-seq
MIRT2695110	hsa-miR-3153	CLIP-seq
MIRT2695111	hsa-miR-3545-3p	CLIP-seq
MIRT2695112	hsa-miR-3609	CLIP-seq
MIRT2661033	hsa-miR-3616-3p	CLIP-seq
MIRT2695113	hsa-miR-3622a-3p	CLIP-seq
MIRT2695114	hsa-miR-3622b-3p	CLIP-seq
MIRT2661034	hsa-miR-3945	CLIP-seq
MIRT2695115	hsa-miR-4254	CLIP-seq
MIRT2695116	hsa-miR-4292	CLIP-seq
MIRT2661035	hsa-miR-4303	CLIP-seq
MIRT2695117	hsa-miR-4307	CLIP-seq
MIRT2695118	hsa-miR-4308	CLIP-seq
MIRT2661036	hsa-miR-4425	CLIP-seq
MIRT2695119	hsa-miR-4446-5p	CLIP-seq
MIRT2695120	hsa-miR-4468	CLIP-seq
MIRT2661037	hsa-miR-4649-3p	CLIP-seq
MIRT2695121	hsa-miR-4668-5p	CLIP-seq
MIRT2695122	hsa-miR-4680-5p	CLIP-seq
MIRT2661038	hsa-miR-4721	CLIP-seq
MIRT2695123	hsa-miR-4755-5p	CLIP-seq
MIRT2661039	hsa-miR-4761-3p	CLIP-seq
MIRT2661040	hsa-miR-4762-3p	CLIP-seq
MIRT2661041	hsa-miR-4781-3p	CLIP-seq
MIRT2695124	hsa-miR-490-3p	CLIP-seq
MIRT2695125	hsa-miR-520g	CLIP-seq
MIRT2695126	hsa-miR-520h	CLIP-seq
MIRT2695127	hsa-miR-548ah	CLIP-seq
MIRT2695128	hsa-miR-619	CLIP-seq
MIRT2661042	hsa-miR-668	CLIP-seq
MIRT2695129	hsa-miR-670	CLIP-seq
MIRT2695130	hsa-miR-875-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	IDA

Other IDs

• MIM: 602929
• HGNC: 6658
• e!Ensembl: ENSG00000110002

Protein

• UniProt ID: O00534
• Protein name: von Willebrand factor A domain-containing protein 5A (Breast cancer suppressor candidate 1) (BCSC-1) (Loss of heterozygosity 11 chromosomal region 2 gene A protein)
• Protein function: May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08487	VIT	17 → 129	Vault protein inter-alpha-trypsin domain	Family
  PF13768	VWA_3	280 → 443	von Willebrand factor type A domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed at low level in many tissues. Not expressed in 80% of tumor cell lines tested. {ECO:0000269|PubMed:14504409}.
• Sequence:

  MVHFCGLLTLHREPVPLKSISVSVNIYEFVAGVSATLNYENEEKVPLEAFFVFPMDEDSA
  VYSFEALVDGKKIVAELQDKMKARTNYEKAISQGHQAFLLEGDSSSRDVFSCNVGNLQPG
  SKAAVTLKYVQELPLEADGALRFVLPAVLNPRYQFSGSSKDSCLNVKTPIVPVEDLPYTL
  SMVATIDSQHGIEKVQSNCPLSPTEYLGEDKTSAQVSLAAGHKFDRDVELLIYYNEVHTP
  SVVLEMGMPNMKPGHLMGDPSAMVSFYPNIPEDQPSNTCGEFIFLMDRSGSMQSPMSSQD
  TSQLRIQAAKETLILLLKSLPIGCYFNIYGFGSSYEACFPESVKYTQQTMEEALGRVKLM
  QADLGGTEILAPLQNIYRGPSIPGHPLQLFVFTDGEVTDTFSVIKEVRINRQKHRCFSFG
  IGEGTSTSLIKGIARASGGTSEFITGKDRMQSKALRTLKRSLQPVVEDVSLSWHLPPGLS
  AKMLSPEQTVIFRGQRLISYAQLTGRMPAAETTGEVCLKYTLQGKTFEDKVTFPLQPKPD
  VNLTIHRLAAKSLLQTKDMGLRETPASDKKDALNLSLESGVISSFTAFIAINKELNKPVQ
  GPLAHRDVPRPILLGASAPLKIKCQSGFRKALHSDRPPSASQPRGELMCYKAKTFQMDDY
  SLCGLISHKDQHSPGFGENHLVQLIYHQNANGSWDLNEDLAKILGMSLEEIMAAQPAELV
  DSSGWATILAVIWLHSNGKDLKCEWELLERKAVAWMRAHAGSTMPSVVKAAITFLKSSVD
  PAIFAF

• Sequence length: 786

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	27903959

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Associate	21803008
Breast Neoplasms	Inhibit	38291227
Lymphatic Metastasis	Associate	21803008, 38291227
Neoplasm Metastasis	Inhibit	38291227
Neoplasms	Associate	21803008
Schizophrenia	Associate	34716291