RAB44 (RAB44, member RAS oncogene family)

Gene

• Entrez ID: 401258
• Gene name: RAB44, member RAS oncogene family
• Gene symbol: RAB44
• Synonyms (NCBI Gene): RASD3, RASL13, dJ431A14.3
• Chromosome: 6
• Chromosome location: 6p21.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT532407	hsa-miR-449b-3p	PAR-CLIP	22012620
MIRT532406	hsa-miR-22-3p	PAR-CLIP	22012620
MIRT532405	hsa-miR-4691-3p	PAR-CLIP	22012620
MIRT532404	hsa-miR-361-3p	PAR-CLIP	22012620
MIRT532403	hsa-miR-6859-3p	PAR-CLIP	22012620
MIRT532402	hsa-miR-711	PAR-CLIP	22012620
MIRT532401	hsa-miR-4776-5p	PAR-CLIP	22012620
MIRT532399	hsa-miR-4535	PAR-CLIP	22012620
MIRT532407	hsa-miR-449b-3p	PAR-CLIP	22012620
MIRT532406	hsa-miR-22-3p	PAR-CLIP	22012620
MIRT532405	hsa-miR-4691-3p	PAR-CLIP	22012620
MIRT532404	hsa-miR-361-3p	PAR-CLIP	22012620
MIRT532403	hsa-miR-6859-3p	PAR-CLIP	22012620
MIRT532402	hsa-miR-711	PAR-CLIP	22012620
MIRT532401	hsa-miR-4776-5p	PAR-CLIP	22012620
MIRT532399	hsa-miR-4535	PAR-CLIP	22012620

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0002553	Process	Histamine secretion by mast cell	IEA
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IEA
GO:0003925	Function	G protein activity	IMP	33641252
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	33641252
GO:0005525	Function	GTP binding	IBA
GO:0005525	Function	GTP binding	IEA
GO:0005765	Component	Lysosomal membrane	IDA	33641252
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IBA
GO:0035577	Component	Azurophil granule membrane	TAS
GO:0035579	Component	Specific granule membrane	TAS
GO:0042581	Component	Specific granule	IEA
GO:0043303	Process	Mast cell degranulation	IEA
GO:0043303	Process	Mast cell degranulation	IMP	33641252
GO:0097279	Process	Histamine secretion mediated by IgE immunoglobulin	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q7Z6P3
• Protein name: Ras-related protein Rab-44
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00071	Ras	835 → 996	Ras family	Domain

• Sequence:

  METGQRTSRKVRKLGSNRRRQTREPADGEGAAVAPEPESWSSQAAAELQAFFQDCGAKER
  GFVTREDLAVAKFSFLGSKEESEMIFDWVDVERKGHLSLEEFSSGLKNIFGSSQSPHRLR
  RRKPLPSKRVSATTSFPALEEADAEEKEAFLAFMEQLGTGHLLPKQMEIWQLWGQLRQEE
  PQLAGNLAGFLAKMTSRLQEAQADKEALELTLRKRDSDHHREVQQLYEEMEQQIRQEKQQ
  LQAESDSRGLALTSQMQDVLEAKEREVQRLAEGQRELEAQLSHLRSTHQEAASENQQLQE
  AKRDLAGRLEEVRGQLQVTRGRLDAARGRVSWQVEEKLSFPGAGEKTPDPQAASPEEAPL
  PGLFGDNDDWDQLLSNFGSPPHGALQLCWSPPPTPRATSGPQTPRVVRQISISEPQAFLF
  GQEPSSDPDGAPRTPPGVTFSAKDNKGVDPHEQDIRAEQPVEPHDPDPNQEPGSTPEGRL
  LWGLSGSLVAPAFKVLIPLEDGPPPPANSPPPQAPAGSSKQIQASDPDDKGPGSWAPPSG
  AQPGAGAGPQEPTQTPPTMTERETQPGPSPTTALTGVGPAKPPRQRDALQQDLHATGSEP
  RLGTQRARALTLGPAEPFQGLEFVGPVPTERLEQGQAGPAVQEGLPEGLREAHGQVLGLG
  ELSAFPHQELEEEPRSEEGKQEGRGGQDLSSEQSEQSVEAHGLETAHSELPQQDSLLVSL
  PSATPQAQVEAEGPTPGKSAPPRGSPPRGAQPGAGAGPQEPTQTPPTMAEQEAQPRPSLT
  TAHAEEQGPPHSREPRAESRLEDPGMDSREAGLTPSPGDPMAGGGPQANPDYLFHVIFLG
  DSNVGKTSFLHLLHQNSFATGLTATVGVDFRVKTLLVDNKCFVLQLWDTAGQERYHSMTR
  QLLRKADGVVLMYDITSQESFAHVRYWLDCLQDAGSDGVVILLLGNKMDCEEERQVSVEA
  GQQLAQELGVYFGECSAALGHNILEPVVNLARSLRMQEEGLKDSLVKVAPKRPPKRFGCC
  S

• Sequence length: 1021

Pathways

Reactome:

Neutrophil degranulation
RAB geranylgeranylation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations