LMO2 (LIM domain only 2)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4005
Gene name Gene Name - the full gene name approved by the HGNC.
LIM domain only 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LMO2
Synonyms (NCBI Gene) Gene synonyms aliases
LMO-2, RBTN2, RBTNL1, RHOM2, TTG2
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11p13
Summary Summary of gene provided in NCBI Entrez Gene.
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approxima
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(18)
miRTarBase ID miRNA Experiments Reference
MIRT000130 hsa-miR-223-3p Review 20029422
MIRT000130 hsa-miR-223-3p Luciferase reporter assay, qRT-PCR, Western blot 19278969
MIRT000130 hsa-miR-223-3p Luciferase reporter assay, qRT-PCR, Western blot 19278969
MIRT000130 hsa-miR-223-3p Reporter assay 19017354
MIRT000130 hsa-miR-223-3p Luciferase reporter assay, Next Generation Sequencing (NGS), qRT-PCR, RNA-binding protein immunoprecipitation, Western blot 28303002
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
Transcription factor Regulation Reference
MYB Activation 20686118
PRDM1 Repression 21722313
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(12)
GO ID Ontology Definition Evidence Reference
GO:0001102 Function RNA polymerase II activating transcription factor binding IPI 16314316
GO:0001221 Function Transcription coregulator binding IPI 16314316
GO:0003713 Function Transcription coactivator activity IDA 16314316
GO:0005515 Function Protein binding IPI 16189514, 16314316, 21516116, 21988832, 25416956, 29892012, 31515488
GO:0005654 Component Nucleoplasm TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
180385 6642 ENSG00000135363
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P25791
Protein name Rhombotin-2 (Cysteine-rich protein TTG-2) (LIM domain only protein 2) (LMO-2) (T-cell translocation protein 2)
Protein function Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
PDB 2XJY , 2XJZ , 2YPA , 4KFZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00412 LIM 30 → 88 LIM domain Domain
PF00412 LIM 94 → 152 LIM domain Domain
Sequence
Sequence length 158
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Transcriptional misregulation in cancer   RUNX1 regulates transcription of genes involved in differentiation of HSCs
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Lymphoblastic leukemia Precursor T-Cell Lymphoblastic Leukemia-Lymphoma rs387906351, rs104894562, rs398122513, rs398122840, rs1057524466, rs1064796115, rs1064795660, rs1064793129, rs1064796227, rs1567887558, rs1161194345, rs1597558200, rs1406320425, rs1597566470, rs1597566699
View all (13 more)		 24394663, 19246562
Show/Hide Text Mining Associations (60)
Associations from Text Mining
Disease Name Relationship Type References
Adjustment Disorders Associate 21453471
Aicardi Syndrome Associate 35094691
Ataxia Telangiectasia Associate 12086890, 1281693, 38358204
beta Thalassemia Associate 28303002
Breast Neoplasms Associate 28170369
Burkitt Lymphoma Associate 22776842, 29327714, 31484540
Calcinosis Stimulate 21710445
Carcinogenesis Associate 19568416
Carcinoma Acinar Cell Associate 35094691
Carcinoma Ductal Associate 19568416