Gene Gene information from NCBI Gene database.
Entrez ID 399979
Gene name Sorting nexin 19
Gene symbol SNX19
Synonyms (NCBI Gene)
CHET8
Chromosome 11
Chromosome location 11q24.3-q25
Summary Islet antigen-2 (IA-2) is an autoantigen in type 1 diabetes and plays a role in insulin secretion. IA-2 is found in dense-core secretory vesicles and interacts with the product of this gene, a sorting nexin. In mouse pancreatic beta-cells, the encoded pro
miRNA miRNA information provided by mirtarbase database.
414
miRTarBase ID miRNA Experiments Reference
MIRT001858 hsa-miR-376a-5p Luciferase reporter assay 17322061
MIRT001858 hsa-miR-376a-5p Luciferase reporter assay 17322061
MIRT046203 hsa-miR-27b-3p CLASH 23622248
MIRT695996 hsa-miR-3662 HITS-CLIP 23313552
MIRT695995 hsa-miR-548g-3p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
25
GO ID Ontology Definition Evidence Reference
GO:0002062 Process Chondrocyte differentiation IEA
GO:0002062 Process Chondrocyte differentiation IEA
GO:0002062 Process Chondrocyte differentiation IMP 19877062
GO:0005515 Function Protein binding IPI 16273344
GO:0005737 Component Cytoplasm IDA 19877062
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q92543
Protein name Sorting nexin-19
Protein function Plays a role in intracellular vesicle trafficking and exocytosis (PubMed:24843546). May play a role in maintaining insulin-containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin se
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02194 PXA 95 267 PXA domain Family
PF00787 PX 569 659 PX domain Domain
PF08628 Nexin_C 838 946 Sorting nexin C terminal Family
Sequence
MKTETVPPFQETPAGSSCHLNNLLSSRKLMAVGVLLGWLLVIHLLVNVWLLCLLSALLVV
LGGWLGSSLAGVASGRLHLERFIPLATCPPCPEAERQLEREINRTIQMIIRDFVLSWYRS
VSQEPAFEEEMEAAMKGLVQELRRRMSVMDSHAVAQSVLTLCGCHLQSYIQAKEATAGKN
GPVEPSHLWEAYCRATAPHPAVHSPSAEVTYTRGVVNLLLQGLVPKPHLETRTGRHVVVE
LITCNVILPLISRLSDPDWIHLVLVGI
FSKARDPAPCPASAPEQPSVPTSLPLIAEVEQL
PEGRASPVAAPVFLSYSEPEGSAGPSPEVEEGHEAVEGDLGGMCEERKVGNNSSHFLQPN
VRGPLFLCEDSELESPLSELGKETIMLMTPGSFLSDRIQDALCALESSQALEPKDGEASE
GAEAEEGPGTETETGLPVSTLNSCPEIHIDTADKEIEQGDVTASVTALLEGPEKTCPSRP
SCLEKDLTNDVSSLDPTLPPVLLSSSPPGPLSSATFSFEPLSSPDGPVIIQNLRITGTIT
AREHSGTGFHPYTLYTVKYETALDGENSSGLQQLAYHTVNRRYREFLNLQTRLEEKPDLR
KFIKNVKGPKKLFPDLPLGNMDSDRVEARKSLLESFLKQLCAIPEIANSEEVQEFLALN
T
DARIAFVKKPFMVSRIDKMVVSAIVDTLKTAFPRSEPQSPTEELSEAETESKPQTEGKKA
SKSRLRFSSSKISPALSVTEAQDKILYCLQEGNVESETLSMSAMESFIEKQTKLLEMQPT
KAPEKDPEQPPKGRVDSCVSDAAVPAQDPSNSDPGTETELADTALDLLLLLLTEQWKWLC
TENMQKFLRLIFGTLVQRWLEVQVANLTSPQRWVQYLLLLQESIWPGGVLPKFPRPVRTQ
EQKLAAEKQALQSLMGVLPDLVVEILGVNKCRLSWGLVLESLQQPL
INRHLIYCLGDIIL
EFLDLSASVEESAATTSASDTPGNSKRMGVSS
Sequence length 992
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
29
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Acute myeloid leukemia Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ANOREXIA NERVOSA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Atherosclerosis Associate 18073581
★☆☆☆☆
Found in Text Mining only
Autistic Disorder Associate 37794117
★☆☆☆☆
Found in Text Mining only
Coronary Disease Associate 18073581
★☆☆☆☆
Found in Text Mining only
Death Associate 37794117
★☆☆☆☆
Found in Text Mining only
Mental Disorders Associate 37794117
★☆☆☆☆
Found in Text Mining only
Schizophrenia Associate 28552197, 37794117
★★☆☆☆
Found in Text Mining + Unknown/Other Associations