Gene Gene information from NCBI Gene database.
Entrez ID 3992
Gene name Fatty acid desaturase 1
Gene symbol FADS1
Synonyms (NCBI Gene)
D5DFADS6FADSD5LLCDL1TU12
Chromosome 11
Chromosome location 11q12.2
Summary The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family mem
miRNA miRNA information provided by mirtarbase database.
1179
miRTarBase ID miRNA Experiments Reference
MIRT001549 hsa-miR-155-5p pSILAC 18668040
MIRT018342 hsa-miR-335-5p Microarray 18185580
MIRT001549 hsa-miR-155-5p Proteomics;Other 18668040
MIRT023902 hsa-miR-1-3p Proteomics 18668040
MIRT024788 hsa-miR-215-5p Microarray 19074876
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
37
GO ID Ontology Definition Evidence Reference
GO:0000248 Function C-5 sterol desaturase activity TAS 10601301
GO:0005739 Component Mitochondrion IEA
GO:0005739 Component Mitochondrion ISS
GO:0005783 Component Endoplasmic reticulum IEA
GO:0005789 Component Endoplasmic reticulum membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606148 3574 ENSG00000149485
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O60427
Protein name Acyl-CoA (8-3)-desaturase (EC 1.14.19.44) (Delta(5) fatty acid desaturase) (D5D) (Delta(5) desaturase) (Delta-5 desaturase) (Fatty acid desaturase 1)
Protein function [Isoform 1]: Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsa
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00173 Cyt-b5 21 94 Cytochrome b5-like Heme/Steroid binding domain Domain
PF00487 FA_desaturase 155 418 Fatty acid desaturase Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed, with highest levels in liver, brain, adrenal gland and heart. Highly expressed in fetal liver and brain. {ECO:0000269|PubMed:10601301, ECO:0000269|PubMed:10769175, ECO:0000269|PubMed:10860662}.
Sequence
Sequence length 444
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Biosynthesis of unsaturated fatty acids
Metabolic pathways
Fatty acid metabolism
  PPARA activates gene expression
Linoleic acid (LA) metabolism
alpha-linolenic acid (ALA) metabolism