Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3990
Gene name Gene Name - the full gene name approved by the HGNC.
Lipase C, hepatic type
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LIPC
Synonyms (NCBI Gene) Gene synonyms aliases
HDLCQ12, HL, HTGL, LIPH
Chromosome Chromosome number
15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
15q21.3
Summary Summary of gene provided in NCBI Entrez Gene.
LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. [provided by RefSeq, Jul 2008]
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs2070895 G>A,T Risk-factor, association 5 prime UTR variant, genic upstream transcript variant, intron variant, upstream transcript variant
rs113298164 C>T Pathogenic-likely-pathogenic Missense variant, coding sequence variant, genic downstream transcript variant
rs1566946168 G>A Pathogenic Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019266 hsa-miR-148b-3p Microarray 17612493
MIRT023497 hsa-miR-1-3p Microarray 18668037
MIRT714619 hsa-miR-5692a HITS-CLIP 19536157
MIRT714618 hsa-miR-5000-5p HITS-CLIP 19536157
MIRT714617 hsa-miR-4704-3p HITS-CLIP 19536157
Transcription factors
Transcription factor Regulation Reference
HNF4A Unknown 16603721
SREBF2 Unknown 15721010
USF1 Unknown 15721010;19416648
USF2 Unknown 19416648
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004465 Function Lipoprotein lipase activity IBA 21873635
GO:0004620 Function Phospholipase activity IBA 21873635
GO:0004620 Function Phospholipase activity TAS 3244012
GO:0004622 Function Lysophospholipase activity IEA
GO:0004806 Function Triglyceride lipase activity IDA 182536, 2839510, 7592706, 8798474, 12032167, 26193433
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
151670 6619 ENSG00000166035
Protein
UniProt ID P11150
Protein name Hepatic triacylglycerol lipase (HL) (Hepatic lipase) (EC 3.1.1.3) (Lipase member C) (Lysophospholipase) (EC 3.1.1.5) (Phospholipase A1) (EC 3.1.1.32)
Protein function Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00151 Lipase 15 349 Lipase Domain
PF01477 PLAT 354 485 PLAT/LH2 domain Domain
Sequence
Sequence length 499
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Glycerolipid metabolism
Metabolic pathways
Cholesterol metabolism
  Assembly of active LPL and LIPC lipase complexes
Chylomicron clearance
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Atrial fibrillation Atrial Fibrillation rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557
View all (6 more)
27790247
Diabetes Diabetes rs80356611 27790247
Diabetes mellitus Diabetes Mellitus, Diabetes Mellitus, Non-Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
27790247, 15126514, 15656877, 23219720
Hypercholesterolemia Hypercholesterolemia, Hypercholesterolemia, Familial rs28942111, rs28942112, rs137852912, rs121908025, rs28942082, rs28942083, rs121908028, rs121908030, rs28942079, rs28942084, rs121908032, rs387906302, rs387906303, rs121908033, rs121908034
View all (1161 more)
16030523
Unknown
Disease term Disease name Evidence References Source
Coronary heart disease Coronary heart disease 27790247, 21347282 ClinVar
Heart failure Heart failure 27790247 ClinVar
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis GWAS
Metabolic Syndrome Metabolic Syndrome GWAS
Associations from Text Mining
Disease Name Relationship Type References
3 Hydroxy 3 Methylglutaryl CoA Lyase Deficiency Inhibit 17173698
3 Hydroxy 3 Methylglutaryl CoA Lyase Deficiency Associate 22955918, 9392428, 9463337
Abortion Spontaneous Associate 29270100
Altitude Sickness Associate 29625625
Alzheimer Disease Associate 23181436
Arthropathy progressive pseudorheumatoid of childhood Associate 10681408
Atherosclerosis Associate 10681408, 12354428, 15656877, 15961789, 16164573, 23181436, 23991054
Brain Ischemia Associate 12354428
Carcinogenesis Associate 22294764
Carcinoma Hepatocellular Stimulate 2542313