LIMK2 (LIM domain kinase 2)

Gene

• Entrez ID: 3985
• Gene name: LIM domain kinase 2
• Gene symbol: LIMK2
• Synonyms (NCBI Gene): -
• Chromosome: 22
• Chromosome location: 22q12.2
• Summary: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1109730	hsa-miR-3163	CLIP-seq
MIRT1109731	hsa-miR-548ac	CLIP-seq
MIRT1109732	hsa-miR-548ae	CLIP-seq
MIRT1109733	hsa-miR-548aj	CLIP-seq
MIRT1109734	hsa-miR-548am	CLIP-seq
MIRT1109735	hsa-miR-548d-3p	CLIP-seq
MIRT1109736	hsa-miR-548x	CLIP-seq
MIRT1109737	hsa-miR-548z	CLIP-seq
MIRT1109738	hsa-miR-1290	CLIP-seq
MIRT1109739	hsa-miR-1293	CLIP-seq
MIRT1109740	hsa-miR-1323	CLIP-seq
MIRT1109741	hsa-miR-1343	CLIP-seq
MIRT1109742	hsa-miR-145	CLIP-seq
MIRT1109743	hsa-miR-188-3p	CLIP-seq
MIRT1109744	hsa-miR-194	CLIP-seq
MIRT1109745	hsa-miR-24	CLIP-seq
MIRT1109746	hsa-miR-27a	CLIP-seq
MIRT1109747	hsa-miR-27b	CLIP-seq
MIRT1109748	hsa-miR-3136-3p	CLIP-seq
MIRT1109749	hsa-miR-3165	CLIP-seq
MIRT1109750	hsa-miR-3167	CLIP-seq
MIRT1109751	hsa-miR-3180-5p	CLIP-seq
MIRT1109752	hsa-miR-335	CLIP-seq
MIRT1109753	hsa-miR-412	CLIP-seq
MIRT1109754	hsa-miR-4269	CLIP-seq
MIRT1109755	hsa-miR-4270	CLIP-seq
MIRT1109756	hsa-miR-4284	CLIP-seq
MIRT1109757	hsa-miR-4320	CLIP-seq
MIRT1109758	hsa-miR-4441	CLIP-seq
MIRT1109759	hsa-miR-4444	CLIP-seq
MIRT1109760	hsa-miR-4469	CLIP-seq
MIRT1109761	hsa-miR-4474-3p	CLIP-seq
MIRT1109762	hsa-miR-4483	CLIP-seq
MIRT1109763	hsa-miR-4514	CLIP-seq
MIRT1109764	hsa-miR-451b	CLIP-seq
MIRT1109765	hsa-miR-4659a-3p	CLIP-seq
MIRT1109766	hsa-miR-4659b-3p	CLIP-seq
MIRT1109767	hsa-miR-4691-5p	CLIP-seq
MIRT1109768	hsa-miR-4692	CLIP-seq
MIRT1109769	hsa-miR-4712-5p	CLIP-seq
MIRT1109770	hsa-miR-4714-3p	CLIP-seq
MIRT1109771	hsa-miR-4742-5p	CLIP-seq
MIRT1109772	hsa-miR-4753-5p	CLIP-seq
MIRT1109773	hsa-miR-4755-3p	CLIP-seq
MIRT1109774	hsa-miR-4778-3p	CLIP-seq
MIRT1109775	hsa-miR-513a-5p	CLIP-seq
MIRT1109776	hsa-miR-532-3p	CLIP-seq
MIRT1109777	hsa-miR-548o	CLIP-seq
MIRT1109778	hsa-miR-770-5p	CLIP-seq
MIRT1109779	hsa-miR-802	CLIP-seq
MIRT1109780	hsa-miR-876-5p	CLIP-seq
MIRT1109781	hsa-miR-1236	CLIP-seq
MIRT1109782	hsa-miR-2114	CLIP-seq
MIRT1109783	hsa-miR-214	CLIP-seq
MIRT1109784	hsa-miR-3121-5p	CLIP-seq
MIRT1109785	hsa-miR-361-3p	CLIP-seq
MIRT1109786	hsa-miR-3619-5p	CLIP-seq
MIRT1109787	hsa-miR-4530	CLIP-seq
MIRT1109788	hsa-miR-4722-3p	CLIP-seq
MIRT1109789	hsa-miR-554	CLIP-seq
MIRT1109790	hsa-miR-761	CLIP-seq
MIRT2030548	hsa-miR-1178	CLIP-seq
MIRT1109781	hsa-miR-1236	CLIP-seq
MIRT2030549	hsa-miR-1270	CLIP-seq
MIRT2030550	hsa-miR-1273d	CLIP-seq
MIRT2030551	hsa-miR-1289	CLIP-seq
MIRT2030552	hsa-miR-1291	CLIP-seq
MIRT1109783	hsa-miR-214	CLIP-seq
MIRT2030553	hsa-miR-23a	CLIP-seq
MIRT2030554	hsa-miR-23b	CLIP-seq
MIRT2030555	hsa-miR-23c	CLIP-seq
MIRT1109745	hsa-miR-24	CLIP-seq
MIRT1109746	hsa-miR-27a	CLIP-seq
MIRT1109747	hsa-miR-27b	CLIP-seq
MIRT2030556	hsa-miR-3173-5p	CLIP-seq
MIRT2030557	hsa-miR-338-5p	CLIP-seq
MIRT1109786	hsa-miR-3619-5p	CLIP-seq
MIRT2030558	hsa-miR-3675-5p	CLIP-seq
MIRT2030559	hsa-miR-3909	CLIP-seq
MIRT2030560	hsa-miR-3920	CLIP-seq
MIRT2030561	hsa-miR-3925-3p	CLIP-seq
MIRT2030562	hsa-miR-3940-3p	CLIP-seq
MIRT1109760	hsa-miR-4469	CLIP-seq
MIRT2030563	hsa-miR-4477a	CLIP-seq
MIRT2030564	hsa-miR-4645-3p	CLIP-seq
MIRT2030565	hsa-miR-4676-5p	CLIP-seq
MIRT2030566	hsa-miR-4683	CLIP-seq
MIRT2030567	hsa-miR-4690-3p	CLIP-seq
MIRT1109767	hsa-miR-4691-5p	CLIP-seq
MIRT1109769	hsa-miR-4712-5p	CLIP-seq
MIRT2030568	hsa-miR-4747-3p	CLIP-seq
MIRT2030569	hsa-miR-4762-5p	CLIP-seq
MIRT2030570	hsa-miR-486-3p	CLIP-seq
MIRT1109775	hsa-miR-513a-5p	CLIP-seq
MIRT2030571	hsa-miR-543	CLIP-seq
MIRT2030572	hsa-miR-570	CLIP-seq
MIRT2030573	hsa-miR-575	CLIP-seq
MIRT2030574	hsa-miR-620	CLIP-seq
MIRT2030575	hsa-miR-649	CLIP-seq
MIRT2030576	hsa-miR-671-5p	CLIP-seq
MIRT2030577	hsa-miR-718	CLIP-seq
MIRT1109790	hsa-miR-761	CLIP-seq
MIRT2030578	hsa-miR-766	CLIP-seq
MIRT2030579	hsa-miR-767-3p	CLIP-seq
MIRT1109778	hsa-miR-770-5p	CLIP-seq
MIRT1109779	hsa-miR-802	CLIP-seq
MIRT2261288	hsa-miR-1273g	CLIP-seq
MIRT2030551	hsa-miR-1289	CLIP-seq
MIRT1109738	hsa-miR-1290	CLIP-seq
MIRT1109740	hsa-miR-1323	CLIP-seq
MIRT2261289	hsa-miR-1324	CLIP-seq
MIRT1109741	hsa-miR-1343	CLIP-seq
MIRT2261290	hsa-miR-140-5p	CLIP-seq
MIRT2261291	hsa-miR-143	CLIP-seq
MIRT1109743	hsa-miR-188-3p	CLIP-seq
MIRT1109783	hsa-miR-214	CLIP-seq
MIRT2030553	hsa-miR-23a	CLIP-seq
MIRT2030554	hsa-miR-23b	CLIP-seq
MIRT2030555	hsa-miR-23c	CLIP-seq
MIRT1109746	hsa-miR-27a	CLIP-seq
MIRT1109747	hsa-miR-27b	CLIP-seq
MIRT2261292	hsa-miR-30a	CLIP-seq
MIRT2261293	hsa-miR-30b	CLIP-seq
MIRT2261294	hsa-miR-30c	CLIP-seq
MIRT2261295	hsa-miR-30d	CLIP-seq
MIRT2261296	hsa-miR-30e	CLIP-seq
MIRT2261297	hsa-miR-3120-3p	CLIP-seq
MIRT1109748	hsa-miR-3136-3p	CLIP-seq
MIRT1109750	hsa-miR-3167	CLIP-seq
MIRT2261298	hsa-miR-3179	CLIP-seq
MIRT2261299	hsa-miR-3192	CLIP-seq
MIRT2261300	hsa-miR-323b-3p	CLIP-seq
MIRT2030557	hsa-miR-338-5p	CLIP-seq
MIRT2261301	hsa-miR-33a	CLIP-seq
MIRT2261302	hsa-miR-33b	CLIP-seq
MIRT2261303	hsa-miR-3545-3p	CLIP-seq
MIRT1109786	hsa-miR-3619-5p	CLIP-seq
MIRT2261304	hsa-miR-3663-5p	CLIP-seq
MIRT2261305	hsa-miR-3679-3p	CLIP-seq
MIRT2261306	hsa-miR-374c	CLIP-seq
MIRT2261307	hsa-miR-376a	CLIP-seq
MIRT2261308	hsa-miR-376b	CLIP-seq
MIRT2261309	hsa-miR-377	CLIP-seq
MIRT2261310	hsa-miR-384	CLIP-seq
MIRT2261311	hsa-miR-3913-3p	CLIP-seq
MIRT1109753	hsa-miR-412	CLIP-seq
MIRT2261312	hsa-miR-4256	CLIP-seq
MIRT2261313	hsa-miR-4261	CLIP-seq
MIRT1109754	hsa-miR-4269	CLIP-seq
MIRT2261314	hsa-miR-4281	CLIP-seq
MIRT2261315	hsa-miR-4327	CLIP-seq
MIRT2261316	hsa-miR-4468	CLIP-seq
MIRT1109760	hsa-miR-4469	CLIP-seq
MIRT2030563	hsa-miR-4477a	CLIP-seq
MIRT2261317	hsa-miR-4496	CLIP-seq
MIRT1109763	hsa-miR-4514	CLIP-seq
MIRT2261318	hsa-miR-4519	CLIP-seq
MIRT1109764	hsa-miR-451b	CLIP-seq
MIRT2261319	hsa-miR-4539	CLIP-seq
MIRT2261320	hsa-miR-4639-3p	CLIP-seq
MIRT1109765	hsa-miR-4659a-3p	CLIP-seq
MIRT2261321	hsa-miR-4659a-5p	CLIP-seq
MIRT1109766	hsa-miR-4659b-3p	CLIP-seq
MIRT2261322	hsa-miR-4659b-5p	CLIP-seq
MIRT2261323	hsa-miR-4667-5p	CLIP-seq
MIRT1109767	hsa-miR-4691-5p	CLIP-seq
MIRT1109768	hsa-miR-4692	CLIP-seq
MIRT2261324	hsa-miR-4700-5p	CLIP-seq
MIRT2261325	hsa-miR-4709-3p	CLIP-seq
MIRT1109770	hsa-miR-4714-3p	CLIP-seq
MIRT2261326	hsa-miR-4714-5p	CLIP-seq
MIRT2261327	hsa-miR-4728-3p	CLIP-seq
MIRT2261328	hsa-miR-4731-5p	CLIP-seq
MIRT2261329	hsa-miR-4736	CLIP-seq
MIRT1109771	hsa-miR-4742-5p	CLIP-seq
MIRT1109772	hsa-miR-4753-5p	CLIP-seq
MIRT2261330	hsa-miR-4756-3p	CLIP-seq
MIRT2030569	hsa-miR-4762-5p	CLIP-seq
MIRT2261331	hsa-miR-4770	CLIP-seq
MIRT2261332	hsa-miR-4776-3p	CLIP-seq
MIRT1109774	hsa-miR-4778-3p	CLIP-seq
MIRT2261333	hsa-miR-4786-3p	CLIP-seq
MIRT2261334	hsa-miR-4789-3p	CLIP-seq
MIRT2261335	hsa-miR-4792	CLIP-seq
MIRT2261336	hsa-miR-4796-5p	CLIP-seq
MIRT2261337	hsa-miR-489	CLIP-seq
MIRT1109775	hsa-miR-513a-5p	CLIP-seq
MIRT2261338	hsa-miR-518a-5p	CLIP-seq
MIRT2261339	hsa-miR-527	CLIP-seq
MIRT2030571	hsa-miR-543	CLIP-seq
MIRT1109777	hsa-miR-548o	CLIP-seq
MIRT2261340	hsa-miR-603	CLIP-seq
MIRT2261341	hsa-miR-653	CLIP-seq
MIRT2261342	hsa-miR-655	CLIP-seq
MIRT2261343	hsa-miR-657	CLIP-seq
MIRT2261344	hsa-miR-759	CLIP-seq
MIRT1109790	hsa-miR-761	CLIP-seq
MIRT1109780	hsa-miR-876-5p	CLIP-seq
MIRT2261345	hsa-miR-940	CLIP-seq
MIRT1109783	hsa-miR-214	CLIP-seq
MIRT1109786	hsa-miR-3619-5p	CLIP-seq
MIRT1109790	hsa-miR-761	CLIP-seq
MIRT1109781	hsa-miR-1236	CLIP-seq
MIRT1109743	hsa-miR-188-3p	CLIP-seq
MIRT2261304	hsa-miR-3663-5p	CLIP-seq
MIRT2261311	hsa-miR-3913-3p	CLIP-seq
MIRT2261314	hsa-miR-4281	CLIP-seq
MIRT2030567	hsa-miR-4690-3p	CLIP-seq
MIRT2261337	hsa-miR-489	CLIP-seq
MIRT1109781	hsa-miR-1236	CLIP-seq
MIRT2561286	hsa-miR-1245b-5p	CLIP-seq
MIRT2030549	hsa-miR-1270	CLIP-seq
MIRT2030550	hsa-miR-1273d	CLIP-seq
MIRT2261288	hsa-miR-1273g	CLIP-seq
MIRT1109741	hsa-miR-1343	CLIP-seq
MIRT2261290	hsa-miR-140-5p	CLIP-seq
MIRT1109743	hsa-miR-188-3p	CLIP-seq
MIRT2561287	hsa-miR-1976	CLIP-seq
MIRT2030553	hsa-miR-23a	CLIP-seq
MIRT2030554	hsa-miR-23b	CLIP-seq
MIRT2030555	hsa-miR-23c	CLIP-seq
MIRT2261297	hsa-miR-3120-3p	CLIP-seq
MIRT2561288	hsa-miR-3130-3p	CLIP-seq
MIRT2561289	hsa-miR-3142	CLIP-seq
MIRT2561290	hsa-miR-3150a-3p	CLIP-seq
MIRT2561291	hsa-miR-3152-5p	CLIP-seq
MIRT2561292	hsa-miR-3156-3p	CLIP-seq
MIRT2561293	hsa-miR-3175	CLIP-seq
MIRT2261298	hsa-miR-3179	CLIP-seq
MIRT2030557	hsa-miR-338-5p	CLIP-seq
MIRT2561294	hsa-miR-3616-5p	CLIP-seq
MIRT2561295	hsa-miR-3647-5p	CLIP-seq
MIRT2261304	hsa-miR-3663-5p	CLIP-seq
MIRT2561296	hsa-miR-3907	CLIP-seq
MIRT2030559	hsa-miR-3909	CLIP-seq
MIRT2261311	hsa-miR-3913-3p	CLIP-seq
MIRT2261314	hsa-miR-4281	CLIP-seq
MIRT2561297	hsa-miR-4292	CLIP-seq
MIRT2561298	hsa-miR-4301	CLIP-seq
MIRT2561299	hsa-miR-4307	CLIP-seq
MIRT2561300	hsa-miR-4308	CLIP-seq
MIRT2561301	hsa-miR-4423-3p	CLIP-seq
MIRT2561302	hsa-miR-4446-5p	CLIP-seq
MIRT2261316	hsa-miR-4468	CLIP-seq
MIRT1109760	hsa-miR-4469	CLIP-seq
MIRT2561303	hsa-miR-4494	CLIP-seq
MIRT2561304	hsa-miR-4504	CLIP-seq
MIRT2261318	hsa-miR-4519	CLIP-seq
MIRT2561305	hsa-miR-4635	CLIP-seq
MIRT2261320	hsa-miR-4639-3p	CLIP-seq
MIRT2030564	hsa-miR-4645-3p	CLIP-seq
MIRT2561306	hsa-miR-4645-5p	CLIP-seq
MIRT2261321	hsa-miR-4659a-5p	CLIP-seq
MIRT2261322	hsa-miR-4659b-5p	CLIP-seq
MIRT2561307	hsa-miR-4662a-3p	CLIP-seq
MIRT2261323	hsa-miR-4667-5p	CLIP-seq
MIRT2561308	hsa-miR-4673	CLIP-seq
MIRT2030566	hsa-miR-4683	CLIP-seq
MIRT2030567	hsa-miR-4690-3p	CLIP-seq
MIRT1109767	hsa-miR-4691-5p	CLIP-seq
MIRT2561309	hsa-miR-4698	CLIP-seq
MIRT2261324	hsa-miR-4700-5p	CLIP-seq
MIRT2561310	hsa-miR-4715-3p	CLIP-seq
MIRT2030568	hsa-miR-4747-3p	CLIP-seq
MIRT2561311	hsa-miR-4755-5p	CLIP-seq
MIRT2261332	hsa-miR-4776-3p	CLIP-seq
MIRT2261333	hsa-miR-4786-3p	CLIP-seq
MIRT2261335	hsa-miR-4792	CLIP-seq
MIRT2261337	hsa-miR-489	CLIP-seq
MIRT2561312	hsa-miR-499a-5p	CLIP-seq
MIRT2561313	hsa-miR-542-3p	CLIP-seq
MIRT2561314	hsa-miR-548q	CLIP-seq
MIRT2561315	hsa-miR-573	CLIP-seq
MIRT2561316	hsa-miR-577	CLIP-seq
MIRT2030574	hsa-miR-620	CLIP-seq
MIRT2561317	hsa-miR-645	CLIP-seq
MIRT2030575	hsa-miR-649	CLIP-seq
MIRT2261341	hsa-miR-653	CLIP-seq
MIRT2561318	hsa-miR-670	CLIP-seq
MIRT2561319	hsa-miR-939	CLIP-seq
MIRT1109781	hsa-miR-1236	CLIP-seq
MIRT2561286	hsa-miR-1245b-5p	CLIP-seq
MIRT2030550	hsa-miR-1273d	CLIP-seq
MIRT2261288	hsa-miR-1273g	CLIP-seq
MIRT2261290	hsa-miR-140-5p	CLIP-seq
MIRT1109743	hsa-miR-188-3p	CLIP-seq
MIRT2561287	hsa-miR-1976	CLIP-seq
MIRT2030553	hsa-miR-23a	CLIP-seq
MIRT2030554	hsa-miR-23b	CLIP-seq
MIRT2030555	hsa-miR-23c	CLIP-seq
MIRT2261297	hsa-miR-3120-3p	CLIP-seq
MIRT2561288	hsa-miR-3130-3p	CLIP-seq
MIRT2561289	hsa-miR-3142	CLIP-seq
MIRT2561292	hsa-miR-3156-3p	CLIP-seq
MIRT2261298	hsa-miR-3179	CLIP-seq
MIRT2030557	hsa-miR-338-5p	CLIP-seq
MIRT2561294	hsa-miR-3616-5p	CLIP-seq
MIRT2561295	hsa-miR-3647-5p	CLIP-seq
MIRT2261304	hsa-miR-3663-5p	CLIP-seq
MIRT2030559	hsa-miR-3909	CLIP-seq
MIRT2261311	hsa-miR-3913-3p	CLIP-seq
MIRT2261314	hsa-miR-4281	CLIP-seq
MIRT2561298	hsa-miR-4301	CLIP-seq
MIRT2561299	hsa-miR-4307	CLIP-seq
MIRT2561301	hsa-miR-4423-3p	CLIP-seq
MIRT2261316	hsa-miR-4468	CLIP-seq
MIRT1109760	hsa-miR-4469	CLIP-seq
MIRT2561303	hsa-miR-4494	CLIP-seq
MIRT2561304	hsa-miR-4504	CLIP-seq
MIRT2261318	hsa-miR-4519	CLIP-seq
MIRT2561305	hsa-miR-4635	CLIP-seq
MIRT2261320	hsa-miR-4639-3p	CLIP-seq
MIRT2561306	hsa-miR-4645-5p	CLIP-seq
MIRT2261321	hsa-miR-4659a-5p	CLIP-seq
MIRT2261322	hsa-miR-4659b-5p	CLIP-seq
MIRT2561307	hsa-miR-4662a-3p	CLIP-seq
MIRT2561308	hsa-miR-4673	CLIP-seq
MIRT2030567	hsa-miR-4690-3p	CLIP-seq
MIRT1109767	hsa-miR-4691-5p	CLIP-seq
MIRT2561309	hsa-miR-4698	CLIP-seq
MIRT2561310	hsa-miR-4715-3p	CLIP-seq
MIRT2261332	hsa-miR-4776-3p	CLIP-seq
MIRT2261333	hsa-miR-4786-3p	CLIP-seq
MIRT2261335	hsa-miR-4792	CLIP-seq
MIRT2261337	hsa-miR-489	CLIP-seq
MIRT2561312	hsa-miR-499a-5p	CLIP-seq
MIRT2561313	hsa-miR-542-3p	CLIP-seq
MIRT2561315	hsa-miR-573	CLIP-seq
MIRT2561316	hsa-miR-577	CLIP-seq
MIRT2561317	hsa-miR-645	CLIP-seq
MIRT2261341	hsa-miR-653	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	22328514
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	TAS	8537403
GO:0005515	Function	Protein binding	IPI	22328514, 22939624, 25036637, 32707033, 33961781, 35271311, 36931259
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	8954941
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	8537403, 8954941
GO:0005801	Component	Cis-Golgi network	IEA
GO:0005813	Component	Centrosome	IDA	25849865
GO:0005813	Component	Centrosome	IEA
GO:0005819	Component	Spindle	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0006468	Process	Protein phosphorylation	IDA	22328514
GO:0007283	Process	Spermatogenesis	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030036	Process	Actin cytoskeleton organization	IBA
GO:0030953	Process	Astral microtubule organization	IDA	22328514
GO:0046872	Function	Metal ion binding	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0051650	Process	Establishment of vesicle localization	IMP	25849865
GO:0060322	Process	Head development	IEA
GO:0061303	Process	Cornea development in camera-type eye	IEA
GO:0072686	Component	Mitotic spindle	IDA	22328514
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1900182	Process	Positive regulation of protein localization to nucleus	IMP	25849865
GO:1902018	Process	Negative regulation of cilium assembly	IMP	25849865

Other IDs

• MIM: 601988
• HGNC: 6614
• e!Ensembl: ENSG00000182541

Protein

• UniProt ID: P53671
• Protein name: LIM domain kinase 2 (LIMK-2) (EC 2.7.11.1)
• Protein function: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042). Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:1101
• PDB: 1X6A, 4TPT, 5NXD, 7QHG, 8GI4, 8S3X, 8WSW
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00412	LIM	12 → 68	LIM domain	Domain
  PF00412	LIM	72 → 128	LIM domain	Domain
  PF00595	PDZ	152 → 236	PDZ domain	Domain
  PF07714	PK_Tyr_Ser-Thr	331 → 601	Protein tyrosine and serine/threonine kinase	Domain

• Sequence:

  MSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYC
  PKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLY
  CGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTV
  QVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPV
  SQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPK
  EPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMK
  ELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSM
  DPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEER
  KRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII
  GQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDS
  FEALSLYLGELGIPLPAELEELDHTVSMQYGLTRDSPP

• Sequence length: 638

Pathways

KEGG:

Axon guidance
Fc gamma R-mediated phagocytosis
Regulation of actin cytoskeleton
Human immunodeficiency virus 1 infection