Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3977
Gene name Gene Name - the full gene name approved by the HGNC.	LIF receptor subunit alpha
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	LIFR
Synonyms (NCBI Gene) Gene synonyms aliases	CD118, LIF-R, SJS2, STWS, SWS
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5p13.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional c

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SNP ID	Visualize variation	Clinical significance	Consequence
rs3729732	G>A	Uncertain-significance, pathogenic	Coding sequence variant, stop gained
rs3729751	G>A,T	Likely-pathogenic, likely-benign, uncertain-significance, benign	Coding sequence variant, synonymous variant, missense variant
rs10637374	CACACACACACACACA>-,CA,CACA,CACACA,CACACACA,CACACACACA,CACACACACACA,CACACACACACACA,CACACACACACACACACA,CACACACACACACACACACA,CACACACACACACACACACACA,CACACACACACACACACACACACA,CACACACACACACACACACACACACA,CACACACACACACACACACACACACACA,CACACACACACACACACACACACACACAC	Likely-benign, benign, uncertain-significance, conflicting-interpretations-of-pathogenicity	Intron variant
rs79040751	G>A,C,T	Likely-pathogenic, uncertain-significance, benign-likely-benign, benign	Coding sequence variant, missense variant
rs121912501	G>A,C	Pathogenic	Stop gained, coding sequence variant, missense variant
rs139848756	T>C	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, missense variant
rs145163157	T>C	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, missense variant
rs151282774	T>C,G	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant
rs199775294	G>A	Likely-pathogenic	Coding sequence variant, stop gained
rs201711670	C>T	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, synonymous variant
rs779829941	G>A,C	Pathogenic	Coding sequence variant, stop gained, missense variant
rs786205647	C>T	Likely-pathogenic	Splice donor variant
rs863225047	G>C	Pathogenic	Coding sequence variant, missense variant
rs886041545	T>-	Pathogenic	Coding sequence variant, frameshift variant
rs886042160	->A	Pathogenic	Coding sequence variant, frameshift variant
rs1114167358	CTAA>-	Pathogenic	Coding sequence variant, frameshift variant
rs1242667371	CT>-	Pathogenic	Coding sequence variant, frameshift variant
rs1430793861	->A	Pathogenic	Coding sequence variant, frameshift variant
rs1554020702	T>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1561159768	GAAA>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1561179853	GTTA>-	Pathogenic	Coding sequence variant, frameshift variant
rs1580117891	G>A	Pathogenic	Stop gained, coding sequence variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017803	hsa-miR-335-5p	Microarray	18185580
MIRT022009	hsa-miR-128-3p	Sequencing	20371350
MIRT023796	hsa-miR-1-3p	Microarray	18668037
MIRT027384	hsa-miR-101-3p	Sequencing	20371350
MIRT027645	hsa-miR-98-5p	Microarray	19088304
MIRT028740	hsa-miR-27a-3p	Sequencing	20371350
MIRT030857	hsa-miR-21-5p	Microarray	18591254
MIRT036142	hsa-miR-1296-5p	CLASH	23622248
MIRT052913	hsa-miR-203a-3p	Luciferase reporter assay, Western blot	24247238
MIRT052913	hsa-miR-203a-3p	Luciferase reporter assay, Western blot	24247238
MIRT052913	hsa-miR-203a-3p	Luciferase reporter assay, Western blot	24247238
MIRT052913	hsa-miR-203a-3p	Luciferase reporter assay, Western blot	24247238
MIRT053792	hsa-miR-125a-5p	Luciferase reporter assay, Western blot	21788734
MIRT702264	hsa-miR-8060	HITS-CLIP	23313552
MIRT702263	hsa-miR-4304	HITS-CLIP	23313552
MIRT702262	hsa-miR-184	HITS-CLIP	23313552
MIRT702260	hsa-miR-3653-3p	HITS-CLIP	23313552
MIRT702261	hsa-miR-4804-5p	HITS-CLIP	23313552
MIRT702259	hsa-miR-3658	HITS-CLIP	23313552
MIRT556576	hsa-miR-30e-5p	PAR-CLIP	21572407
MIRT556575	hsa-miR-30b-5p	PAR-CLIP	21572407
MIRT556574	hsa-miR-30d-5p	PAR-CLIP	21572407
MIRT556573	hsa-miR-30a-5p	PAR-CLIP	21572407
MIRT556572	hsa-miR-30c-5p	PAR-CLIP	21572407
MIRT556571	hsa-miR-144-3p	PAR-CLIP	21572407
MIRT556570	hsa-miR-216a-3p	PAR-CLIP	21572407
MIRT556569	hsa-miR-3681-3p	PAR-CLIP	21572407
MIRT028740	hsa-miR-27a-3p	PAR-CLIP	21572407
MIRT022009	hsa-miR-128-3p	PAR-CLIP	21572407
MIRT556568	hsa-miR-27b-3p	PAR-CLIP	21572407
MIRT556567	hsa-miR-4760-3p	PAR-CLIP	21572407
MIRT096536	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT556566	hsa-miR-26b-3p	PAR-CLIP	21572407
MIRT556565	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT556564	hsa-miR-513a-5p	PAR-CLIP	21572407
MIRT556563	hsa-miR-6083	PAR-CLIP	21572407
MIRT547614	hsa-miR-132-3p	PAR-CLIP	21572407
MIRT547613	hsa-miR-212-3p	PAR-CLIP	21572407
MIRT547612	hsa-miR-5003-3p	PAR-CLIP	21572407
MIRT547611	hsa-miR-340-5p	PAR-CLIP	21572407
MIRT547610	hsa-miR-3692-3p	PAR-CLIP	21572407
MIRT536317	hsa-miR-1252-3p	PAR-CLIP	22012620
MIRT536316	hsa-miR-7-1-3p	PAR-CLIP	22012620
MIRT536315	hsa-miR-7-2-3p	PAR-CLIP	22012620
MIRT536314	hsa-miR-4785	PAR-CLIP	22012620
MIRT474156	hsa-miR-3120-3p	PAR-CLIP	23592263
MIRT474155	hsa-miR-451b	PAR-CLIP	23592263
MIRT474154	hsa-miR-3927-5p	PAR-CLIP	23592263
MIRT474153	hsa-miR-499a-3p	PAR-CLIP	23592263
MIRT052913	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT450819	hsa-miR-3614-3p	PAR-CLIP	22100165
MIRT450818	hsa-miR-4678	PAR-CLIP	22100165
MIRT450817	hsa-miR-5697	PAR-CLIP	22100165
MIRT450816	hsa-miR-4635	PAR-CLIP	22100165
MIRT450815	hsa-miR-493-3p	PAR-CLIP	22100165
MIRT450814	hsa-miR-103a-2-5p	PAR-CLIP	22100165
MIRT450813	hsa-miR-331-5p	PAR-CLIP	22100165
MIRT450812	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT450811	hsa-miR-6126	PAR-CLIP	22100165
MIRT450810	hsa-miR-6864-5p	PAR-CLIP	22100165
MIRT053792	hsa-miR-125a-5p	Luciferase reporter assay, Western blot	25962054
MIRT733895	hsa-miR-548ba	Luciferase reporter assay, Microarray, qRT-PCR	32042028
MIRT702264	hsa-miR-8060	HITS-CLIP	23313552
MIRT702263	hsa-miR-4304	HITS-CLIP	23313552
MIRT702262	hsa-miR-184	HITS-CLIP	23313552
MIRT702260	hsa-miR-3653-3p	HITS-CLIP	23313552
MIRT702261	hsa-miR-4804-5p	HITS-CLIP	23313552
MIRT702259	hsa-miR-3658	HITS-CLIP	23313552
MIRT556576	hsa-miR-30e-5p	PAR-CLIP	21572407
MIRT556575	hsa-miR-30b-5p	PAR-CLIP	21572407
MIRT556574	hsa-miR-30d-5p	PAR-CLIP	21572407
MIRT556573	hsa-miR-30a-5p	PAR-CLIP	21572407
MIRT556572	hsa-miR-30c-5p	PAR-CLIP	21572407
MIRT556571	hsa-miR-144-3p	PAR-CLIP	21572407
MIRT556570	hsa-miR-216a-3p	PAR-CLIP	21572407
MIRT556569	hsa-miR-3681-3p	PAR-CLIP	21572407
MIRT028740	hsa-miR-27a-3p	PAR-CLIP	21572407
MIRT022009	hsa-miR-128-3p	PAR-CLIP	21572407
MIRT556568	hsa-miR-27b-3p	PAR-CLIP	21572407
MIRT556567	hsa-miR-4760-3p	PAR-CLIP	21572407
MIRT096536	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT556566	hsa-miR-26b-3p	PAR-CLIP	21572407
MIRT556565	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT556564	hsa-miR-513a-5p	PAR-CLIP	21572407
MIRT556563	hsa-miR-6083	PAR-CLIP	21572407
MIRT547614	hsa-miR-132-3p	PAR-CLIP	21572407
MIRT547613	hsa-miR-212-3p	PAR-CLIP	21572407
MIRT547612	hsa-miR-5003-3p	PAR-CLIP	21572407
MIRT547611	hsa-miR-340-5p	PAR-CLIP	21572407
MIRT547610	hsa-miR-3692-3p	PAR-CLIP	21572407
MIRT536317	hsa-miR-1252-3p	PAR-CLIP	22012620
MIRT536316	hsa-miR-7-1-3p	PAR-CLIP	22012620
MIRT536315	hsa-miR-7-2-3p	PAR-CLIP	22012620
MIRT536314	hsa-miR-4785	PAR-CLIP	22012620
MIRT474156	hsa-miR-3120-3p	PAR-CLIP	23592263
MIRT474155	hsa-miR-451b	PAR-CLIP	23592263
MIRT474154	hsa-miR-3927-5p	PAR-CLIP	23592263
MIRT474153	hsa-miR-499a-3p	PAR-CLIP	23592263
MIRT052913	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT450819	hsa-miR-3614-3p	PAR-CLIP	22100165
MIRT450818	hsa-miR-4678	PAR-CLIP	22100165
MIRT450817	hsa-miR-5697	PAR-CLIP	22100165
MIRT450816	hsa-miR-4635	PAR-CLIP	22100165
MIRT450815	hsa-miR-493-3p	PAR-CLIP	22100165
MIRT450814	hsa-miR-103a-2-5p	PAR-CLIP	22100165
MIRT450813	hsa-miR-331-5p	PAR-CLIP	22100165
MIRT450812	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT450811	hsa-miR-6126	PAR-CLIP	22100165
MIRT450810	hsa-miR-6864-5p	PAR-CLIP	22100165
MIRT1109109	hsa-miR-1207-5p	CLIP-seq
MIRT1109110	hsa-miR-1251	CLIP-seq
MIRT1109111	hsa-miR-1253	CLIP-seq
MIRT1109112	hsa-miR-128	CLIP-seq
MIRT1109113	hsa-miR-1291	CLIP-seq
MIRT1109114	hsa-miR-1305	CLIP-seq
MIRT1109115	hsa-miR-138	CLIP-seq
MIRT1109116	hsa-miR-144	CLIP-seq
MIRT1109117	hsa-miR-1470	CLIP-seq
MIRT1109118	hsa-miR-154	CLIP-seq
MIRT1109119	hsa-miR-155	CLIP-seq
MIRT1109120	hsa-miR-1825	CLIP-seq
MIRT1109121	hsa-miR-19a	CLIP-seq
MIRT1109122	hsa-miR-19b	CLIP-seq
MIRT1109123	hsa-miR-221	CLIP-seq
MIRT1109124	hsa-miR-222	CLIP-seq
MIRT1109125	hsa-miR-2277-3p	CLIP-seq
MIRT1109126	hsa-miR-27a	CLIP-seq
MIRT1109127	hsa-miR-27b	CLIP-seq
MIRT1109128	hsa-miR-297	CLIP-seq
MIRT1109129	hsa-miR-300	CLIP-seq
MIRT1109130	hsa-miR-30a	CLIP-seq
MIRT1109131	hsa-miR-30b	CLIP-seq
MIRT1109132	hsa-miR-30c	CLIP-seq
MIRT1109133	hsa-miR-30d	CLIP-seq
MIRT1109134	hsa-miR-30e	CLIP-seq
MIRT1109135	hsa-miR-3148	CLIP-seq
MIRT1109136	hsa-miR-3149	CLIP-seq
MIRT1109137	hsa-miR-3171	CLIP-seq
MIRT1109138	hsa-miR-3192	CLIP-seq
MIRT1109139	hsa-miR-3616-3p	CLIP-seq
MIRT1109140	hsa-miR-365	CLIP-seq
MIRT1109141	hsa-miR-3653	CLIP-seq
MIRT1109142	hsa-miR-3662	CLIP-seq
MIRT1109143	hsa-miR-3714	CLIP-seq
MIRT1109144	hsa-miR-377	CLIP-seq
MIRT1109145	hsa-miR-381	CLIP-seq
MIRT1109146	hsa-miR-3919	CLIP-seq
MIRT1109147	hsa-miR-3925-5p	CLIP-seq
MIRT1109148	hsa-miR-3942-3p	CLIP-seq
MIRT1109149	hsa-miR-3960	CLIP-seq
MIRT1109150	hsa-miR-3973	CLIP-seq
MIRT1109151	hsa-miR-3978	CLIP-seq
MIRT1109152	hsa-miR-421	CLIP-seq
MIRT1109153	hsa-miR-4307	CLIP-seq
MIRT1109154	hsa-miR-4308	CLIP-seq
MIRT1109155	hsa-miR-4330	CLIP-seq
MIRT1109156	hsa-miR-4434	CLIP-seq
MIRT1109157	hsa-miR-4436b-3p	CLIP-seq
MIRT1109158	hsa-miR-4474-5p	CLIP-seq
MIRT1109159	hsa-miR-4516	CLIP-seq
MIRT1109160	hsa-miR-4520a-3p	CLIP-seq
MIRT1109161	hsa-miR-4643	CLIP-seq
MIRT1109162	hsa-miR-4659a-3p	CLIP-seq
MIRT1109163	hsa-miR-4659b-3p	CLIP-seq
MIRT1109164	hsa-miR-4661-3p	CLIP-seq
MIRT1109165	hsa-miR-4666-5p	CLIP-seq
MIRT1109166	hsa-miR-4667-3p	CLIP-seq
MIRT1109167	hsa-miR-4668-5p	CLIP-seq
MIRT1109168	hsa-miR-4672	CLIP-seq
MIRT1109169	hsa-miR-4705	CLIP-seq
MIRT1109170	hsa-miR-4709-5p	CLIP-seq
MIRT1109171	hsa-miR-4731-3p	CLIP-seq
MIRT1109172	hsa-miR-4738-3p	CLIP-seq
MIRT1109173	hsa-miR-4763-3p	CLIP-seq
MIRT1109174	hsa-miR-4773	CLIP-seq
MIRT1109175	hsa-miR-4801	CLIP-seq
MIRT1109176	hsa-miR-485-3p	CLIP-seq
MIRT1109177	hsa-miR-512-3p	CLIP-seq
MIRT1109178	hsa-miR-513a-3p	CLIP-seq
MIRT1109179	hsa-miR-518a-5p	CLIP-seq
MIRT1109180	hsa-miR-520d-5p	CLIP-seq
MIRT1109181	hsa-miR-524-5p	CLIP-seq
MIRT1109182	hsa-miR-527	CLIP-seq
MIRT1109183	hsa-miR-548a-5p	CLIP-seq
MIRT1109184	hsa-miR-548ab	CLIP-seq
MIRT1109185	hsa-miR-548ak	CLIP-seq
MIRT1109186	hsa-miR-548b-5p	CLIP-seq
MIRT1109187	hsa-miR-548c-5p	CLIP-seq
MIRT1109188	hsa-miR-548d-5p	CLIP-seq
MIRT1109189	hsa-miR-548h	CLIP-seq
MIRT1109190	hsa-miR-548i	CLIP-seq
MIRT1109191	hsa-miR-548j	CLIP-seq
MIRT1109192	hsa-miR-548l	CLIP-seq
MIRT1109193	hsa-miR-548w	CLIP-seq
MIRT1109194	hsa-miR-548y	CLIP-seq
MIRT1109195	hsa-miR-554	CLIP-seq
MIRT1109196	hsa-miR-559	CLIP-seq
MIRT1109197	hsa-miR-570	CLIP-seq
MIRT1109198	hsa-miR-579	CLIP-seq
MIRT1109199	hsa-miR-589	CLIP-seq
MIRT1109200	hsa-miR-590-3p	CLIP-seq
MIRT1109201	hsa-miR-671-5p	CLIP-seq
MIRT1109202	hsa-miR-940	CLIP-seq
MIRT1109203	hsa-miR-1208	CLIP-seq
MIRT1109204	hsa-miR-1273f	CLIP-seq
MIRT1109112	hsa-miR-128	CLIP-seq
MIRT1109205	hsa-miR-143	CLIP-seq
MIRT1109116	hsa-miR-144	CLIP-seq
MIRT1109117	hsa-miR-1470	CLIP-seq
MIRT1109206	hsa-miR-21	CLIP-seq
MIRT1109207	hsa-miR-219-2-3p	CLIP-seq
MIRT1109126	hsa-miR-27a	CLIP-seq
MIRT1109127	hsa-miR-27b	CLIP-seq
MIRT1109208	hsa-miR-2964a-3p	CLIP-seq
MIRT1109130	hsa-miR-30a	CLIP-seq
MIRT1109131	hsa-miR-30b	CLIP-seq
MIRT1109132	hsa-miR-30c	CLIP-seq
MIRT1109133	hsa-miR-30d	CLIP-seq
MIRT1109134	hsa-miR-30e	CLIP-seq
MIRT1109209	hsa-miR-3125	CLIP-seq
MIRT1109210	hsa-miR-3147	CLIP-seq
MIRT1109211	hsa-miR-3150b-3p	CLIP-seq
MIRT1109212	hsa-miR-3163	CLIP-seq
MIRT1109213	hsa-miR-3606	CLIP-seq
MIRT1109214	hsa-miR-3691-5p	CLIP-seq
MIRT1109215	hsa-miR-3916	CLIP-seq
MIRT1109216	hsa-miR-3920	CLIP-seq
MIRT1109217	hsa-miR-4274	CLIP-seq
MIRT1109218	hsa-miR-4282	CLIP-seq
MIRT1109153	hsa-miR-4307	CLIP-seq
MIRT1109219	hsa-miR-4425	CLIP-seq
MIRT1109220	hsa-miR-4461	CLIP-seq
MIRT1109221	hsa-miR-4519	CLIP-seq
MIRT1109161	hsa-miR-4643	CLIP-seq
MIRT1109164	hsa-miR-4661-3p	CLIP-seq
MIRT1109166	hsa-miR-4667-3p	CLIP-seq
MIRT1109222	hsa-miR-4668-3p	CLIP-seq
MIRT1109223	hsa-miR-4670-3p	CLIP-seq
MIRT1109224	hsa-miR-4708-5p	CLIP-seq
MIRT1109172	hsa-miR-4738-3p	CLIP-seq
MIRT1109225	hsa-miR-4752	CLIP-seq
MIRT1109226	hsa-miR-4762-3p	CLIP-seq
MIRT1109227	hsa-miR-4770	CLIP-seq
MIRT1109228	hsa-miR-4784	CLIP-seq
MIRT1109229	hsa-miR-509-3p	CLIP-seq
MIRT1109230	hsa-miR-561	CLIP-seq
MIRT1109231	hsa-miR-587	CLIP-seq
MIRT1109232	hsa-miR-590-5p	CLIP-seq
MIRT1109201	hsa-miR-671-5p	CLIP-seq
MIRT1109233	hsa-miR-877	CLIP-seq
MIRT1109234	hsa-miR-892b	CLIP-seq
MIRT2030228	hsa-miR-1185	CLIP-seq
MIRT1109203	hsa-miR-1208	CLIP-seq
MIRT2030229	hsa-miR-1224-5p	CLIP-seq
MIRT2030230	hsa-miR-1236	CLIP-seq
MIRT2030231	hsa-miR-1257	CLIP-seq
MIRT1109112	hsa-miR-128	CLIP-seq
MIRT1109113	hsa-miR-1291	CLIP-seq
MIRT1109114	hsa-miR-1305	CLIP-seq
MIRT2030232	hsa-miR-142-3p	CLIP-seq
MIRT2030233	hsa-miR-142-5p	CLIP-seq
MIRT1109117	hsa-miR-1470	CLIP-seq
MIRT2030234	hsa-miR-149	CLIP-seq
MIRT2030235	hsa-miR-151-3p	CLIP-seq
MIRT1109118	hsa-miR-154	CLIP-seq
MIRT1109120	hsa-miR-1825	CLIP-seq
MIRT2030236	hsa-miR-203	CLIP-seq
MIRT2030237	hsa-miR-2054	CLIP-seq
MIRT1109206	hsa-miR-21	CLIP-seq
MIRT2030238	hsa-miR-2113	CLIP-seq
MIRT2030239	hsa-miR-216a	CLIP-seq
MIRT1109123	hsa-miR-221	CLIP-seq
MIRT1109124	hsa-miR-222	CLIP-seq
MIRT1109126	hsa-miR-27a	CLIP-seq
MIRT1109127	hsa-miR-27b	CLIP-seq
MIRT2030240	hsa-miR-3064-5p	CLIP-seq
MIRT1109130	hsa-miR-30a	CLIP-seq
MIRT1109131	hsa-miR-30b	CLIP-seq
MIRT1109132	hsa-miR-30c	CLIP-seq
MIRT1109133	hsa-miR-30d	CLIP-seq
MIRT1109134	hsa-miR-30e	CLIP-seq
MIRT2030241	hsa-miR-3117-3p	CLIP-seq
MIRT2030242	hsa-miR-3117-5p	CLIP-seq
MIRT2030243	hsa-miR-3119	CLIP-seq
MIRT2030244	hsa-miR-3136-5p	CLIP-seq
MIRT2030245	hsa-miR-3143	CLIP-seq
MIRT2030246	hsa-miR-3145-3p	CLIP-seq
MIRT1109210	hsa-miR-3147	CLIP-seq
MIRT2030247	hsa-miR-3158-3p	CLIP-seq
MIRT2030248	hsa-miR-3169	CLIP-seq
MIRT1109137	hsa-miR-3171	CLIP-seq
MIRT2030249	hsa-miR-3183	CLIP-seq
MIRT1109138	hsa-miR-3192	CLIP-seq
MIRT2030250	hsa-miR-326	CLIP-seq
MIRT2030251	hsa-miR-328	CLIP-seq
MIRT2030252	hsa-miR-330-5p	CLIP-seq
MIRT2030253	hsa-miR-340	CLIP-seq
MIRT2030254	hsa-miR-3605-5p	CLIP-seq
MIRT1109213	hsa-miR-3606	CLIP-seq
MIRT2030255	hsa-miR-3607-3p	CLIP-seq
MIRT2030256	hsa-miR-3614-5p	CLIP-seq
MIRT2030257	hsa-miR-3616-5p	CLIP-seq
MIRT2030258	hsa-miR-3647-5p	CLIP-seq
MIRT1109140	hsa-miR-365	CLIP-seq
MIRT2030259	hsa-miR-3652	CLIP-seq
MIRT1109142	hsa-miR-3662	CLIP-seq
MIRT2030260	hsa-miR-3667-3p	CLIP-seq
MIRT2030261	hsa-miR-3679-5p	CLIP-seq
MIRT2030262	hsa-miR-3686	CLIP-seq
MIRT2030263	hsa-miR-3689a-5p	CLIP-seq
MIRT2030264	hsa-miR-3689b	CLIP-seq
MIRT2030265	hsa-miR-3689e	CLIP-seq
MIRT2030266	hsa-miR-3689f	CLIP-seq
MIRT1109214	hsa-miR-3691-5p	CLIP-seq
MIRT2030267	hsa-miR-3692	CLIP-seq
MIRT1109143	hsa-miR-3714	CLIP-seq
MIRT2030268	hsa-miR-371-5p	CLIP-seq
MIRT2030269	hsa-miR-371b-5p	CLIP-seq
MIRT2030270	hsa-miR-380	CLIP-seq
MIRT2030271	hsa-miR-3915	CLIP-seq
MIRT2030272	hsa-miR-3923	CLIP-seq
MIRT2030273	hsa-miR-4264	CLIP-seq
MIRT2030274	hsa-miR-4276	CLIP-seq
MIRT1109218	hsa-miR-4282	CLIP-seq
MIRT2030275	hsa-miR-4302	CLIP-seq
MIRT2030276	hsa-miR-4303	CLIP-seq
MIRT1109153	hsa-miR-4307	CLIP-seq
MIRT1109154	hsa-miR-4308	CLIP-seq
MIRT2030277	hsa-miR-4314	CLIP-seq
MIRT2030278	hsa-miR-4320	CLIP-seq
MIRT2030279	hsa-miR-4323	CLIP-seq
MIRT2030280	hsa-miR-4328	CLIP-seq
MIRT1109155	hsa-miR-4330	CLIP-seq
MIRT1109219	hsa-miR-4425	CLIP-seq
MIRT2030281	hsa-miR-4430	CLIP-seq
MIRT2030282	hsa-miR-4439	CLIP-seq
MIRT2030283	hsa-miR-4446-3p	CLIP-seq
MIRT2030284	hsa-miR-4457	CLIP-seq
MIRT2030285	hsa-miR-4462	CLIP-seq
MIRT2030286	hsa-miR-448	CLIP-seq
MIRT2030287	hsa-miR-4505	CLIP-seq
MIRT2030288	hsa-miR-4513	CLIP-seq
MIRT2030289	hsa-miR-452	CLIP-seq
MIRT2030290	hsa-miR-4639-3p	CLIP-seq
MIRT1109161	hsa-miR-4643	CLIP-seq
MIRT2030291	hsa-miR-4646-5p	CLIP-seq
MIRT1109162	hsa-miR-4659a-3p	CLIP-seq
MIRT1109163	hsa-miR-4659b-3p	CLIP-seq
MIRT1109166	hsa-miR-4667-3p	CLIP-seq
MIRT1109223	hsa-miR-4670-3p	CLIP-seq
MIRT2030292	hsa-miR-4675	CLIP-seq
MIRT2030293	hsa-miR-4676-3p	CLIP-seq
MIRT2030294	hsa-miR-4682	CLIP-seq
MIRT2030295	hsa-miR-4689	CLIP-seq
MIRT2030296	hsa-miR-4704-3p	CLIP-seq
MIRT2030297	hsa-miR-4704-5p	CLIP-seq
MIRT2030298	hsa-miR-4719	CLIP-seq
MIRT2030299	hsa-miR-4723-3p	CLIP-seq
MIRT2030300	hsa-miR-4724-5p	CLIP-seq
MIRT2030301	hsa-miR-4741	CLIP-seq
MIRT1109225	hsa-miR-4752	CLIP-seq
MIRT2030302	hsa-miR-4759	CLIP-seq
MIRT2030303	hsa-miR-4762-5p	CLIP-seq
MIRT2030304	hsa-miR-4778-3p	CLIP-seq
MIRT2030305	hsa-miR-4794	CLIP-seq
MIRT2030306	hsa-miR-4795-5p	CLIP-seq
MIRT2030307	hsa-miR-4797-3p	CLIP-seq
MIRT2030308	hsa-miR-4799-5p	CLIP-seq
MIRT1109177	hsa-miR-512-3p	CLIP-seq
MIRT2030309	hsa-miR-513b	CLIP-seq
MIRT1109180	hsa-miR-520d-5p	CLIP-seq
MIRT1109181	hsa-miR-524-5p	CLIP-seq
MIRT2030310	hsa-miR-526b	CLIP-seq
MIRT2030311	hsa-miR-539	CLIP-seq
MIRT2030312	hsa-miR-548n	CLIP-seq
MIRT2030313	hsa-miR-549	CLIP-seq
MIRT1109230	hsa-miR-561	CLIP-seq
MIRT2030314	hsa-miR-573	CLIP-seq
MIRT1109232	hsa-miR-590-5p	CLIP-seq
MIRT2030315	hsa-miR-591	CLIP-seq
MIRT2030316	hsa-miR-603	CLIP-seq
MIRT2030317	hsa-miR-624	CLIP-seq
MIRT2030318	hsa-miR-633	CLIP-seq
MIRT2030319	hsa-miR-642a	CLIP-seq
MIRT2030320	hsa-miR-668	CLIP-seq
MIRT2030321	hsa-miR-889	CLIP-seq
MIRT2030322	hsa-miR-935	CLIP-seq
MIRT2030236	hsa-miR-203	CLIP-seq
MIRT1109126	hsa-miR-27a	CLIP-seq
MIRT1109127	hsa-miR-27b	CLIP-seq
MIRT2030243	hsa-miR-3119	CLIP-seq
MIRT1109212	hsa-miR-3163	CLIP-seq
MIRT2030253	hsa-miR-340	CLIP-seq
MIRT1109218	hsa-miR-4282	CLIP-seq
MIRT1109183	hsa-miR-548a-5p	CLIP-seq
MIRT1109184	hsa-miR-548ab	CLIP-seq
MIRT1109185	hsa-miR-548ak	CLIP-seq
MIRT1109186	hsa-miR-548b-5p	CLIP-seq
MIRT1109187	hsa-miR-548c-5p	CLIP-seq
MIRT1109188	hsa-miR-548d-5p	CLIP-seq
MIRT1109189	hsa-miR-548h	CLIP-seq
MIRT1109190	hsa-miR-548i	CLIP-seq
MIRT1109191	hsa-miR-548j	CLIP-seq
MIRT1109193	hsa-miR-548w	CLIP-seq
MIRT1109194	hsa-miR-548y	CLIP-seq
MIRT1109196	hsa-miR-559	CLIP-seq
MIRT2030231	hsa-miR-1257	CLIP-seq
MIRT2030240	hsa-miR-3064-5p	CLIP-seq
MIRT2030242	hsa-miR-3117-5p	CLIP-seq
MIRT1109210	hsa-miR-3147	CLIP-seq
MIRT1109137	hsa-miR-3171	CLIP-seq
MIRT2030259	hsa-miR-3652	CLIP-seq
MIRT2261047	hsa-miR-3654	CLIP-seq
MIRT2030273	hsa-miR-4264	CLIP-seq
MIRT1109155	hsa-miR-4330	CLIP-seq
MIRT1109219	hsa-miR-4425	CLIP-seq
MIRT2030281	hsa-miR-4430	CLIP-seq
MIRT2030287	hsa-miR-4505	CLIP-seq
MIRT1109160	hsa-miR-4520a-3p	CLIP-seq
MIRT2261048	hsa-miR-4638-3p	CLIP-seq
MIRT1109161	hsa-miR-4643	CLIP-seq
MIRT2261049	hsa-miR-4652-3p	CLIP-seq
MIRT2261050	hsa-miR-4677-3p	CLIP-seq
MIRT2261051	hsa-miR-4679	CLIP-seq
MIRT2030300	hsa-miR-4724-5p	CLIP-seq
MIRT2261052	hsa-miR-4778-5p	CLIP-seq
MIRT1109203	hsa-miR-1208	CLIP-seq
MIRT2030240	hsa-miR-3064-5p	CLIP-seq
MIRT2030241	hsa-miR-3117-3p	CLIP-seq
MIRT1109210	hsa-miR-3147	CLIP-seq
MIRT2030248	hsa-miR-3169	CLIP-seq
MIRT2390139	hsa-miR-3189-5p	CLIP-seq
MIRT1109138	hsa-miR-3192	CLIP-seq
MIRT2030250	hsa-miR-326	CLIP-seq
MIRT2030252	hsa-miR-330-5p	CLIP-seq
MIRT2390140	hsa-miR-3647-3p	CLIP-seq
MIRT2030259	hsa-miR-3652	CLIP-seq
MIRT2030273	hsa-miR-4264	CLIP-seq
MIRT2030277	hsa-miR-4314	CLIP-seq
MIRT1109219	hsa-miR-4425	CLIP-seq
MIRT2030281	hsa-miR-4430	CLIP-seq
MIRT2030287	hsa-miR-4505	CLIP-seq
MIRT1109161	hsa-miR-4643	CLIP-seq
MIRT2030291	hsa-miR-4646-5p	CLIP-seq
MIRT2030296	hsa-miR-4704-3p	CLIP-seq
MIRT2390141	hsa-miR-4758-3p	CLIP-seq
MIRT2030302	hsa-miR-4759	CLIP-seq
MIRT2030316	hsa-miR-603	CLIP-seq
MIRT2430730	hsa-miR-543	CLIP-seq
MIRT2438350	hsa-miR-3161	CLIP-seq
MIRT2030289	hsa-miR-452	CLIP-seq
MIRT2438351	hsa-miR-4528	CLIP-seq
MIRT2030293	hsa-miR-4676-3p	CLIP-seq
MIRT2438352	hsa-miR-4789-5p	CLIP-seq
MIRT2030313	hsa-miR-549	CLIP-seq
MIRT2453023	hsa-miR-1267	CLIP-seq
MIRT2390140	hsa-miR-3647-3p	CLIP-seq
MIRT2261049	hsa-miR-4652-3p	CLIP-seq
MIRT2261052	hsa-miR-4778-5p	CLIP-seq
MIRT2453024	hsa-miR-653	CLIP-seq
MIRT2453025	hsa-miR-873	CLIP-seq
MIRT1109203	hsa-miR-1208	CLIP-seq
MIRT2030230	hsa-miR-1236	CLIP-seq
MIRT2030237	hsa-miR-2054	CLIP-seq
MIRT2561071	hsa-miR-216b	CLIP-seq
MIRT2030240	hsa-miR-3064-5p	CLIP-seq
MIRT1109210	hsa-miR-3147	CLIP-seq
MIRT2561072	hsa-miR-3176	CLIP-seq
MIRT2561073	hsa-miR-3182	CLIP-seq
MIRT2030255	hsa-miR-3607-3p	CLIP-seq
MIRT2030259	hsa-miR-3652	CLIP-seq
MIRT2030262	hsa-miR-3686	CLIP-seq
MIRT1109144	hsa-miR-377	CLIP-seq
MIRT2561074	hsa-miR-3922-3p	CLIP-seq
MIRT1109219	hsa-miR-4425	CLIP-seq
MIRT2030281	hsa-miR-4430	CLIP-seq
MIRT2030287	hsa-miR-4505	CLIP-seq
MIRT2438351	hsa-miR-4528	CLIP-seq
MIRT1109161	hsa-miR-4643	CLIP-seq
MIRT1109162	hsa-miR-4659a-3p	CLIP-seq
MIRT1109163	hsa-miR-4659b-3p	CLIP-seq
MIRT2561075	hsa-miR-4756-3p	CLIP-seq
MIRT2561076	hsa-miR-486-5p	CLIP-seq
MIRT2561077	hsa-miR-548c-3p	CLIP-seq
MIRT2561078	hsa-miR-568	CLIP-seq
MIRT2030315	hsa-miR-591	CLIP-seq
MIRT2561079	hsa-miR-595	CLIP-seq
MIRT2030316	hsa-miR-603	CLIP-seq
MIRT2683887	hsa-miR-181a	CLIP-seq
MIRT2683888	hsa-miR-181b	CLIP-seq
MIRT2683889	hsa-miR-181c	CLIP-seq
MIRT2683890	hsa-miR-181d	CLIP-seq
MIRT2030236	hsa-miR-203	CLIP-seq
MIRT2683891	hsa-miR-3127-3p	CLIP-seq
MIRT2390140	hsa-miR-3647-3p	CLIP-seq
MIRT2683892	hsa-miR-3679-3p	CLIP-seq
MIRT1109144	hsa-miR-377	CLIP-seq
MIRT2683893	hsa-miR-3941	CLIP-seq
MIRT2683894	hsa-miR-409-3p	CLIP-seq
MIRT2683895	hsa-miR-4257	CLIP-seq
MIRT2683896	hsa-miR-4262	CLIP-seq
MIRT2683897	hsa-miR-4446-5p	CLIP-seq
MIRT1109161	hsa-miR-4643	CLIP-seq
MIRT1109162	hsa-miR-4659a-3p	CLIP-seq
MIRT1109163	hsa-miR-4659b-3p	CLIP-seq
MIRT2683898	hsa-miR-466	CLIP-seq
MIRT1109168	hsa-miR-4672	CLIP-seq
MIRT2683899	hsa-miR-4684-3p	CLIP-seq
MIRT2683900	hsa-miR-4789-3p	CLIP-seq
MIRT2561076	hsa-miR-486-5p	CLIP-seq
MIRT2430730	hsa-miR-543	CLIP-seq
MIRT2683901	hsa-miR-548ac	CLIP-seq
MIRT2683902	hsa-miR-548ae	CLIP-seq
MIRT2683903	hsa-miR-548aj	CLIP-seq
MIRT2683904	hsa-miR-548am	CLIP-seq
MIRT2683905	hsa-miR-548d-3p	CLIP-seq
MIRT2683906	hsa-miR-548x	CLIP-seq
MIRT2683907	hsa-miR-548z	CLIP-seq
MIRT2561078	hsa-miR-568	CLIP-seq
MIRT2561079	hsa-miR-595	CLIP-seq

Show/Hide all(32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004896	Function	Cytokine receptor activity	IBA
GO:0004896	Function	Cytokine receptor activity	IEA
GO:0004897	Function	Ciliary neurotrophic factor receptor activity	IDA	12643274
GO:0004923	Function	Leukemia inhibitory factor receptor activity	IDA	8999038, 12643274
GO:0004923	Function	Leukemia inhibitory factor receptor activity	IDA	7957045
GO:0004923	Function	Leukemia inhibitory factor receptor activity	TAS	1915266
GO:0004924	Function	Oncostatin-M receptor activity	IBA
GO:0004924	Function	Oncostatin-M receptor activity	IDA	8999038
GO:0005127	Function	Ciliary neurotrophic factor receptor binding	IBA
GO:0005127	Function	Ciliary neurotrophic factor receptor binding	IPI	12707266
GO:0005515	Function	Protein binding	IPI	16051226, 18775332, 20584990
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	1915266
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	1915266
GO:0008284	Process	Positive regulation of cell population proliferation	IBA
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	7957045
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	8999038
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0009897	Component	External side of plasma membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	IBA
GO:0019221	Process	Cytokine-mediated signaling pathway	IDA	7957045
GO:0019838	Function	Growth factor binding	IPI	8999038
GO:0019955	Function	Cytokine binding	IBA
GO:0034097	Process	Response to cytokine	IDA	8999038
GO:0038165	Process	Oncostatin-M-mediated signaling pathway	IMP	8999038
GO:0043235	Component	Receptor complex	IBA
GO:0043235	Component	Receptor complex	IDA	8999038, 12643274
GO:0048861	Process	Leukemia inhibitory factor signaling pathway	IDA	8999038, 12643274
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0070120	Process	Ciliary neurotrophic factor-mediated signaling pathway	IDA	12643274

MIM	HGNC	e!Ensembl
151443	6597	ENSG00000113594

Protein

UniProt ID

P42702

Protein name

Leukemia inhibitory factor receptor (LIF receptor) (LIF-R) (CD antigen CD118)

Protein function

Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.

PDB

3E0G , 8D6A , 8D74 , 8D7R , 8V29 , 8V2A

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF18207	LIFR_N	52 → 129	Leukemia inhibitory factor receptor N-terminal domain	Domain
PF17971	LIFR_D2	131 → 244	Leukemia inhibitory factor receptor D2 domain	Domain
PF00041	fn3	434 → 523	Fibronectin type III domain	Domain

Sequence

MMDIYVCLKRPSWMVDNKRMRTASNFQWLLSTFILLYLMNQVNSQKKGAPHDLKCVTNNL
QVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPALSHGDYEITINSLHDFGS
STSKFTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKE
SMELVKLVTHNTTLNGKDTLHHWSWASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSP
VKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIK
IRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTA
LVGPRATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQ
STILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQR
NVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPD
TWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDK
NDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYDPNMTCDYVIK
WCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIE
ELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGR
SDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAI
LIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEM
NPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAEPENHVVVSYCPPIIEEEIPN
PAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEE
DLDKTAGYRPQANVNTWNLVSPDSPRSIDSNSEIVSFGSPCSINSRQFLIPPKDEDSPKS
NGGGWSFTNFFQNKPND

Sequence length

1097

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction Signaling pathways regulating pluripotency of stem cells JAK-STAT signaling pathway		IL-6-type cytokine receptor ligand interactions RUNX1 regulates transcription of genes involved in interleukin signaling

Show/Hide Causal Diseases (2)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Congenital anomalies of kidney and urinary tract	Congenital anomaly of kidney and urinary tract	rs1114167358	N/A
Stuve-Wiedemann syndrome	stuve-wiedemann syndrome	rs199775294, rs863225047, rs886042160, rs1554020702, rs779829941, rs1580117891, rs1561159768, rs121912501, rs1744257909, rs1430793861, rs1745753552, rs1561179853	N/A

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Connective Tissue Disease	Connective tissue disorder	N/A	N/A	ClinVar
Glioblastoma	Glioblastoma	N/A	N/A	GWAS

Show/Hide Text Mining Associations (45)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	37543671
Adenoma Pleomorphic	Associate	34390320
Breast Neoplasms	Inhibit	23216692
Breast Neoplasms	Associate	25962054, 33371806, 34477239, 37927213
Carcinogenesis	Associate	25749520
Carcinoma Hepatocellular	Associate	25749520, 34699986
Carcinoma Pancreatic Ductal	Associate	36359879
Colorectal Neoplasms	Inhibit	21617854
Colorectal Neoplasms	Associate	23579219, 35974349
COVID 19	Associate	33260035
Depressive Disorder	Associate	30864711
Diabetes Mellitus Type 2	Associate	39926598
Endometrial Neoplasms	Associate	38139260
Fatigue	Associate	36028644
Glioblastoma	Associate	19288188
Ichthyosis prematurity syndrome	Associate	29693144
Infertility	Associate	18684446
Inflammation	Associate	28228280
Kidney Neoplasms	Associate	30444862
Leukemia Lymphocytic Chronic B Cell	Associate	25749520
Lymphatic Metastasis	Stimulate	34658294
Medulloblastoma	Associate	25915540
Melanoma	Associate	26329521
Mullerian aplasia	Associate	35361250
Multi centric Castleman's Disease	Stimulate	34686774
Neoplasm Metastasis	Associate	28411194, 31142661, 32592689, 37927213
Neoplasms	Associate	19288188, 21191816, 24796549, 25962054, 31142661, 34477239, 34658294, 36359879, 37927213, 38139260
Neoplasms	Inhibit	21617854
Neuroblastoma	Associate	40108662
Nevus Pigmented	Associate	26329521
Pancreatic Neoplasms	Associate	34658294, 36359879
Polycystic Ovary Syndrome	Associate	35551681
Pregnancy Tubal	Associate	25790555
Prostatic Hyperplasia	Associate	39390078
Prostatic Neoplasms	Stimulate	32592689
Prostatic Neoplasms	Associate	35821621
Pulmonary Disease Chronic Obstructive	Associate	33260035
Skin Diseases	Associate	23579219
Skin Neoplasms	Associate	26329521
Stomach Neoplasms	Associate	37752199, 37945798
Stuve Wiedemann syndrome	Associate	14740318, 19603067
Thyroid Nodule	Associate	25749520
Triple Negative Breast Neoplasms	Associate	31142661
Tuberculosis	Inhibit	26776907
Vesico Ureteral Reflux	Associate	36417404

LIFR (LIF receptor subunit alpha)