LHCGR (luteinizing hormone/choriogonadotropin receptor)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3973
Gene name Gene Name - the full gene name approved by the HGNC.
Luteinizing hormone/choriogonadotropin receptor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LHCGR
Synonyms (NCBI Gene) Gene synonyms aliases
HHG, LCGR, LGR2, LH/CG-R, LH/CGR, LHR, LHRHR, LSH-R, ULG5
Disease Acronyms (UniProt) Disease acronyms from UniProt database
LHR
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p16.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene resul
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(29)
miRTarBase ID miRNA Experiments Reference
MIRT019289 hsa-miR-148b-3p Microarray 17612493
MIRT437925 hsa-miR-513a-3p qRT-PCR, Luciferase reporter assay 24747085
MIRT437925 hsa-miR-513a-3p qRT-PCR, Luciferase reporter assay 24747085
MIRT437925 hsa-miR-513a-3p qRT-PCR, Luciferase reporter assay 24747085
MIRT437925 hsa-miR-513a-3p qRT-PCR, Luciferase reporter assay 24747085
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(3)
Transcription factor Regulation Reference
NR2C2 Activation 11682620
NR2F1 Repression 11682620
NR2F6 Repression 11682620
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(29)
GO ID Ontology Definition Evidence Reference
GO:0001541 Process Ovarian follicle development IBA 21873635
GO:0004964 Function Luteinizing hormone receptor activity IBA 21873635
GO:0004964 Function Luteinizing hormone receptor activity IMP 11847099
GO:0005768 Component Endosome TAS 10617611
GO:0005886 Component Plasma membrane IDA 11847099
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
152790 6585 ENSG00000138039
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P22888
Protein name Lutropin-choriogonadotropic hormone receptor (LH/CG-R) (Luteinizing hormone receptor) (LHR) (LSH-R)
Protein function Receptor for lutropin-choriogonadotropic hormone (PubMed:11847099). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099).
PDB 7FIG , 7FIH , 7FII , 7FIJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13306 LRR_5 49 → 149 BspA type Leucine rich repeat region (6 copies) Repeat
PF13306 LRR_5 141 → 267 BspA type Leucine rich repeat region (6 copies) Repeat
PF00001 7tm_1 376 → 623 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Gonadal and thyroid cells.
Sequence 
MKQRFSALQLLKLLLLLQPPLPRALREALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLP
VKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFI
NLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLK
LYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSY
GLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENF
SKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYD
FLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDS
QTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRL
RHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYILTILILNVVAFF
IICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLIT
VTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRRKDFSAYT
SNCKNGFTGSNKPSQSTLKLSTLHCQGTALLDKTRYTEC
Sequence length 699
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Hormone signaling
Ovarian steroidogenesis
Prolactin signaling pathway 		  Hormone ligand-binding receptors
G alpha (s) signalling events
ADORA2B mediated anti-inflammatory cytokines production
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (10)
Causal
Disease term Disease name dbSNP ID References
46, xy disorder of sex development 46, XY Disorders of Sex Development rs387906750, rs797044460, rs387906751, rs13222 19887492, 7719343
46, xy sex reversal 46,XY Sex Reversal 3 rs111033589, rs1592184934, rs121908255, rs121908256, rs606231178, rs104894956, rs104894957, rs104894958, rs104894959, rs104894964, rs606231179, rs104894966, rs104894967, rs104894968, rs104894969
View all (54 more)		 7719343, 19887492
Attention deficit hyperactivity disorder Attention deficit hyperactivity disorder rs786205019
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Show/Hide Unknown Diseases (6)
Unknown
Disease term Disease name Evidence References Source
46,xy disorder of sex development 46,XY Disorder of Sex Development Due To LH Defects ClinVar
Ambiguous genitalia Ambiguous Genitalia 22615892 ClinVar
Leydig Cell Hypoplasia Leydig cell hypoplasia, type 1 GenCC
Male-Limited Precocious Puberty familial male-limited precocious puberty GenCC
Show/Hide Text Mining Associations (62)
Associations from Text Mining
Disease Name Relationship Type References
Abortion Spontaneous Associate 22369774
Acth Independent Macronodular Adrenal Hyperplasia Associate 29183089
Adenoma Associate 21490077
Adrenal Cortex Diseases Associate 30924919
Adrenal Cortex Neoplasms Associate 30924919
Adrenal Gland Diseases Associate 29183089
Adrenal Gland Neoplasms Associate 12519858
Adrenocortical Carcinoma Associate 30924919
Alzheimer Disease Associate 18439297
Alzheimer Disease Inhibit 18439297