LGALS9 (galectin 9)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3965
Gene name Gene Name - the full gene name approved by the HGNC.
Galectin 9
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LGALS9
Synonyms (NCBI Gene) Gene synonyms aliases
HUAT, LGALS9A
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q11.2
Summary Summary of gene provided in NCBI Entrez Gene.
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin`s disease tissue and might participate in
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Show/Hide all(12)
miRTarBase ID miRNA Experiments Reference
MIRT017245 hsa-miR-335-5p Microarray 18185580
MIRT731478 hsa-miR-22-3p Flow, Luciferase reporter assay, qRT-PCR, Western blot 26239725
MIRT731478 hsa-miR-22-3p Flow, Luciferase reporter assay, qRT-PCR, Western blot 26239725
MIRT1108316 hsa-miR-3199 CLIP-seq
MIRT1108317 hsa-miR-3675-5p CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
HDAC3 Unknown 22027828
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0002519 Process Natural killer cell tolerance induction IMP 25578313
GO:0005534 Function Galactose binding TAS 9045665
GO:0005615 Component Extracellular space IDA 20209097
GO:0005634 Component Nucleus IBA 21873635
GO:0005634 Component Nucleus IDA 23242525
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
601879 6570 ENSG00000168961
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
UniProt ID O00182
Protein name Galectin-9 (Gal-9) (Ecalectin) (Tumor antigen HOM-HD-21)
Protein function Binds galactosides (PubMed:18005988). Has high affinity for the Forssman pentasaccharide (PubMed:18005988). Ligand for HAVCR2/TIM3 (PubMed:16286920). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (PubMed:16286920). Also stimul
PDB 2EAK , 2EAL , 2YY1 , 2ZHK , 2ZHL , 2ZHM , 2ZHN , 3LSD , 3LSE , 3NV1 , 3NV2 , 3NV3 , 3NV4 , 3WLU , 3WV6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00337 Gal-bind_lectin 16 → 147 Galactoside-binding lectin Domain
PF00337 Gal-bind_lectin 226 → 355 Galactoside-binding lectin Domain
Tissue specificity TISSUE SPECIFICITY: Peripheral blood leukocytes and lymphatic tissues. Expressed in lung, liver, breast and kidney with higher levels in tumor endothelial cells than normal endothelium (at protein level) (PubMed:24333696). Expressed in trophoblast cells i
Sequence
Sequence length 355
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Oligodendroglioma Oligodendroglioma GWAS
Show/Hide Text Mining Associations (136)
Associations from Text Mining
Disease Name Relationship Type References
Abortion Spontaneous Associate 32319832, 40068377
Acquired Immunodeficiency Syndrome Associate 36569879
Acute On Chronic Liver Failure Stimulate 39333198
Adenomyosis Stimulate 32319832
Arthritis Rheumatoid Associate 30150656, 31600237, 33692448
Arthritis Rheumatoid Stimulate 31430907, 37470226
Asthma Inhibit 23121677
Autoimmune Diseases Inhibit 23741502
Autoimmune Diseases Associate 32319832
Breast Neoplasms Associate 18264727, 26823850, 36751105