Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	3959
Gene name	Galectin 3 binding protein
Gene symbol	LGALS3BP
Synonyms (NCBI Gene)	90KBTBD17BCyCAPM2BPMAC-2-BPTANGO10Bgp90
Chromosome	17
Chromosome location	17q25.3
Summary	The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency viru

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miRTarBase ID	miRNA	Experiments	Reference
MIRT007309	hsa-miR-596	Luciferase reporter assayWestern blot	23233740
MIRT007309	hsa-miR-596	Luciferase reporter assayWestern blot	23233740
MIRT024048	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT025918	hsa-miR-7-5p	Microarray	19073608
MIRT046598	hsa-miR-222-3p	CLASH	23622248
MIRT039290	hsa-miR-671-5p	CLASH	23622248
MIRT038953	hsa-miR-26b-3p	CLASH	23622248
MIRT038443	hsa-miR-296-3p	CLASH	23622248
MIRT052728	hsa-miR-1260b	CLASH	23622248
MIRT451324	hsa-miR-3974	PAR-CLIP	23592263
MIRT451323	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT451322	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT451321	hsa-miR-3125	PAR-CLIP	23592263
MIRT451320	hsa-miR-3916	PAR-CLIP	23592263
MIRT451319	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT007309	hsa-miR-596	PAR-CLIP	23592263
MIRT451318	hsa-miR-4476	PAR-CLIP	23592263
MIRT451317	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT451316	hsa-miR-4779	PAR-CLIP	23592263
MIRT451315	hsa-miR-4317	PAR-CLIP	23592263
MIRT451314	hsa-miR-151a-5p	PAR-CLIP	23592263
MIRT451313	hsa-miR-151b	PAR-CLIP	23592263
MIRT451312	hsa-miR-17-3p	PAR-CLIP	23592263
MIRT451311	hsa-miR-1252-5p	PAR-CLIP	23592263
MIRT451310	hsa-miR-493-3p	PAR-CLIP	23592263
MIRT451309	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT451308	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT039290	hsa-miR-671-5p	PAR-CLIP	23592263
MIRT451307	hsa-miR-4533	PAR-CLIP	23592263
MIRT451306	hsa-miR-6827-5p	PAR-CLIP	23592263
MIRT451305	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT451304	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT451303	hsa-miR-616-3p	PAR-CLIP	23592263
MIRT451302	hsa-miR-1273h-3p	PAR-CLIP	23592263
MIRT451301	hsa-miR-3678-3p	PAR-CLIP	23592263
MIRT451300	hsa-miR-3158-5p	PAR-CLIP	23592263
MIRT451324	hsa-miR-3974	PAR-CLIP	27292025
MIRT451310	hsa-miR-493-3p	PAR-CLIP	27292025
MIRT451303	hsa-miR-616-3p	PAR-CLIP	27292025
MIRT451324	hsa-miR-3974	PAR-CLIP	23592263
MIRT451323	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT451322	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT451321	hsa-miR-3125	PAR-CLIP	23592263
MIRT451320	hsa-miR-3916	PAR-CLIP	23592263
MIRT451319	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT007309	hsa-miR-596	PAR-CLIP	23592263
MIRT451318	hsa-miR-4476	PAR-CLIP	23592263
MIRT451317	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT451316	hsa-miR-4779	PAR-CLIP	23592263
MIRT451315	hsa-miR-4317	PAR-CLIP	23592263
MIRT451314	hsa-miR-151a-5p	PAR-CLIP	23592263
MIRT451313	hsa-miR-151b	PAR-CLIP	23592263
MIRT451312	hsa-miR-17-3p	PAR-CLIP	23592263
MIRT451311	hsa-miR-1252-5p	PAR-CLIP	23592263
MIRT451310	hsa-miR-493-3p	PAR-CLIP	23592263
MIRT451309	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT451308	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT039290	hsa-miR-671-5p	PAR-CLIP	23592263
MIRT451307	hsa-miR-4533	PAR-CLIP	23592263
MIRT451306	hsa-miR-6827-5p	PAR-CLIP	23592263
MIRT451305	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT451304	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT451303	hsa-miR-616-3p	PAR-CLIP	23592263
MIRT451302	hsa-miR-1273h-3p	PAR-CLIP	23592263
MIRT451301	hsa-miR-3678-3p	PAR-CLIP	23592263
MIRT451300	hsa-miR-3158-5p	PAR-CLIP	23592263
MIRT1550729	hsa-miR-151-5p	CLIP-seq
MIRT2029919	hsa-miR-4743	CLIP-seq
MIRT2029920	hsa-miR-493	CLIP-seq
MIRT2029921	hsa-miR-616	CLIP-seq
MIRT2029922	hsa-miR-653	CLIP-seq
MIRT2260784	hsa-miR-4261	CLIP-seq
MIRT2260785	hsa-miR-619	CLIP-seq
MIRT2260786	hsa-miR-875-3p	CLIP-seq
MIRT2438339	hsa-miR-3150a-5p	CLIP-seq
MIRT2438340	hsa-miR-3150b-5p	CLIP-seq
MIRT2438341	hsa-miR-3151	CLIP-seq
MIRT2438342	hsa-miR-4447	CLIP-seq
MIRT2438343	hsa-miR-4472	CLIP-seq
MIRT2438344	hsa-miR-4525	CLIP-seq
MIRT2438345	hsa-miR-4675	CLIP-seq
MIRT2438346	hsa-miR-4713-3p	CLIP-seq
MIRT2438347	hsa-miR-4741	CLIP-seq
MIRT2438348	hsa-miR-491-5p	CLIP-seq
MIRT2560778	hsa-miR-127-5p	CLIP-seq
MIRT2560779	hsa-miR-1294	CLIP-seq
MIRT2560780	hsa-miR-145	CLIP-seq
MIRT2560781	hsa-miR-146a	CLIP-seq
MIRT2560782	hsa-miR-146b-5p	CLIP-seq
MIRT2438339	hsa-miR-3150a-5p	CLIP-seq
MIRT2438340	hsa-miR-3150b-5p	CLIP-seq
MIRT2438341	hsa-miR-3151	CLIP-seq
MIRT2560783	hsa-miR-3165	CLIP-seq
MIRT2560784	hsa-miR-3190	CLIP-seq
MIRT2560785	hsa-miR-339-3p	CLIP-seq
MIRT2560786	hsa-miR-3681	CLIP-seq
MIRT2560787	hsa-miR-3934	CLIP-seq
MIRT2260784	hsa-miR-4261	CLIP-seq
MIRT2438342	hsa-miR-4447	CLIP-seq
MIRT2438343	hsa-miR-4472	CLIP-seq
MIRT2438344	hsa-miR-4525	CLIP-seq
MIRT2560788	hsa-miR-4635	CLIP-seq
MIRT2560789	hsa-miR-4663	CLIP-seq
MIRT2438345	hsa-miR-4675	CLIP-seq
MIRT2560790	hsa-miR-4710	CLIP-seq
MIRT2560791	hsa-miR-4712-5p	CLIP-seq
MIRT2438346	hsa-miR-4713-3p	CLIP-seq
MIRT2560792	hsa-miR-4738-3p	CLIP-seq
MIRT2438347	hsa-miR-4741	CLIP-seq
MIRT2029919	hsa-miR-4743	CLIP-seq
MIRT2560793	hsa-miR-4792	CLIP-seq
MIRT2560794	hsa-miR-4800-5p	CLIP-seq
MIRT2438348	hsa-miR-491-5p	CLIP-seq
MIRT2029920	hsa-miR-493	CLIP-seq
MIRT2560795	hsa-miR-526b	CLIP-seq
MIRT2560796	hsa-miR-541	CLIP-seq
MIRT2560797	hsa-miR-578	CLIP-seq
MIRT2560798	hsa-miR-582-3p	CLIP-seq
MIRT2029921	hsa-miR-616	CLIP-seq
MIRT2260785	hsa-miR-619	CLIP-seq
MIRT2029922	hsa-miR-653	CLIP-seq
MIRT2560799	hsa-miR-654-5p	CLIP-seq
MIRT2560800	hsa-miR-711	CLIP-seq
MIRT2560801	hsa-miR-770-5p	CLIP-seq
MIRT2260786	hsa-miR-875-3p	CLIP-seq
MIRT2683877	hsa-miR-1252	CLIP-seq
MIRT2683878	hsa-miR-1273	CLIP-seq
MIRT2560778	hsa-miR-127-5p	CLIP-seq
MIRT2560779	hsa-miR-1294	CLIP-seq
MIRT2560780	hsa-miR-145	CLIP-seq
MIRT2560781	hsa-miR-146a	CLIP-seq
MIRT2560782	hsa-miR-146b-5p	CLIP-seq
MIRT1550729	hsa-miR-151-5p	CLIP-seq
MIRT2438339	hsa-miR-3150a-5p	CLIP-seq
MIRT2438340	hsa-miR-3150b-5p	CLIP-seq
MIRT2438341	hsa-miR-3151	CLIP-seq
MIRT2560783	hsa-miR-3165	CLIP-seq
MIRT2560784	hsa-miR-3190	CLIP-seq
MIRT2560785	hsa-miR-339-3p	CLIP-seq
MIRT2560786	hsa-miR-3681	CLIP-seq
MIRT2560787	hsa-miR-3934	CLIP-seq
MIRT2260784	hsa-miR-4261	CLIP-seq
MIRT2438342	hsa-miR-4447	CLIP-seq
MIRT2438343	hsa-miR-4472	CLIP-seq
MIRT2438344	hsa-miR-4525	CLIP-seq
MIRT2560788	hsa-miR-4635	CLIP-seq
MIRT2560789	hsa-miR-4663	CLIP-seq
MIRT2438345	hsa-miR-4675	CLIP-seq
MIRT2560790	hsa-miR-4710	CLIP-seq
MIRT2560791	hsa-miR-4712-5p	CLIP-seq
MIRT2438346	hsa-miR-4713-3p	CLIP-seq
MIRT2560792	hsa-miR-4738-3p	CLIP-seq
MIRT2438347	hsa-miR-4741	CLIP-seq
MIRT2029919	hsa-miR-4743	CLIP-seq
MIRT2560793	hsa-miR-4792	CLIP-seq
MIRT2560794	hsa-miR-4800-5p	CLIP-seq
MIRT2438348	hsa-miR-491-5p	CLIP-seq
MIRT2029920	hsa-miR-493	CLIP-seq
MIRT2560795	hsa-miR-526b	CLIP-seq
MIRT2560796	hsa-miR-541	CLIP-seq
MIRT2560797	hsa-miR-578	CLIP-seq
MIRT2560798	hsa-miR-582-3p	CLIP-seq
MIRT2029921	hsa-miR-616	CLIP-seq
MIRT2260785	hsa-miR-619	CLIP-seq
MIRT2029922	hsa-miR-653	CLIP-seq
MIRT2560799	hsa-miR-654-5p	CLIP-seq
MIRT2560800	hsa-miR-711	CLIP-seq
MIRT2560801	hsa-miR-770-5p	CLIP-seq
MIRT2260786	hsa-miR-875-3p	CLIP-seq
MIRT2683879	hsa-miR-939	CLIP-seq

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Transcription factor	Regulation	Reference
CREB5	Repression	21132541
STAT3	Repression	18594176

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005044	Function	Scavenger receptor activity	TAS	8390986
GO:0005515	Function	Protein binding	IPI	22939624, 26618866, 28514442, 29162697, 29924966, 30833792, 32814053, 33961781, 38825040
GO:0005576	Component	Extracellular region	HDA	27068509
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	16502470
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	25645918
GO:0005615	Component	Extracellular space	TAS	8390986
GO:0006968	Process	Cellular defense response	TAS	8034587
GO:0007155	Process	Cell adhesion	IEA
GO:0007165	Process	Signal transduction	TAS	8390986
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0031012	Component	Extracellular matrix	HDA	20551380
GO:0031012	Component	Extracellular matrix	HDA	27559042
GO:0031089	Component	Platelet dense granule lumen	TAS
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708, 21362503, 23533145
GO:0072562	Component	Blood microparticle	HDA	22516433

MIM	HGNC	e!Ensembl
600626	6564	ENSG00000108679

Q08380

Protein name

Galectin-3-binding protein (Basement membrane autoantigen p105) (Lectin galactoside-binding soluble 3-binding protein) (Mac-2-binding protein) (MAC2BP) (Mac-2 BP) (Tumor-associated antigen 90K)

Protein function

Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.

PDB

1BY2 , 6GFB

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00530	SRCR	27 → 124	Scavenger receptor cysteine-rich domain	Domain
PF07707	BACK	260 → 360	BTB And C-terminal Kelch	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine. Expressed by keratinocytes and fibroblasts. {ECO:0000269|PubMed:8034587, ECO:0000269|PubMed:8390986, ECO:0000269|PubMed:8757764}.

Sequence

MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLWDLTDASV
VCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNCRHERDAG
VVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHTVILTANL
EAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSVKCFHKLASAYGARQLQ
GYCASLFAILLPQDPSFQMPLDLYAYAVATGDALLEKLCLQFLAWNFEALTQAEAWPSVP
TDLLQLLLPRSDLAVPSELALLKAVDTWSWGERASHEEVEGLVEKIRFPMMLPEELFELQ
FNLSLYWSHEALFQKKTLQALEFHTVPFQLLARYKGLNLTEDTYKPRIYTSPTWSAFVTD
SSWSARKSQLVYQSRRGPLVKYSSDYFQAPSDYRYYPYQSFQTPQHPSFLFQDKRVSWSL
VYLPTIQSCWNYGFSCSSDELPVLGLTKSGGSDRTIAYENKALMLCEGLFVADVTDFEGW
KAAIPSALDTNSSKSTSSFPCPAGHFNGFRTVIRPFYLTNSSGVD

Sequence length

585

Interactions

View interactions

	Reactome
			Platelet degranulation

LGALS3BP (galectin 3 binding protein)