LGALS2 (galectin 2)

Gene Gene information from NCBI Gene database.
Gene SNPs Gene ontology Other IDs Protein Associated diseases
Entrez ID 3957
Gene name Galectin 2
Gene symbol LGALS2
Synonyms (NCBI Gene)
HL14
Chromosome 22
Chromosome location 22q13.1
Summary The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of
SNPs SNP information provided by dbSNP.
1
Gene SNPs Gene ontology Other IDs Protein Associated diseases
Show/Hide all (1)
SNP ID Visualize variation Clinical significance Consequence
rs7291467 G>A Risk-factor Intron variant
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10
Gene SNPs Gene ontology Other IDs Protein Associated diseases
Show/Hide all (10)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956, 31515488, 32296183
GO:0016936 Function Galactoside binding IBA
GO:0030246 Function Carbohydrate binding IBA
GO:0030246 Function Carbohydrate binding IEA
GO:0043029 Process T cell homeostasis IDA 15356130
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene SNPs Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
150571 6562 ENSG00000100079
Protein Protein information from UniProt database.
Gene SNPs Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P05162
Protein name Galectin-2 (Gal-2) (Beta-galactoside-binding lectin L-14-II) (HL14) (Lactose-binding lectin 2) (S-Lac lectin 2)
Protein function This protein binds beta-galactoside. Its physiological function is not yet known.
PDB 1HLC , 5DG1 , 5DG2 , 5EWS
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00337 Gal-bind_lectin 4 → 130 Galactoside-binding lectin Domain
Sequence
Sequence length 132
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
2
Gene SNPs Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
LGALS2-related disorder Likely benign rs201214648 RCV003904044
Myocardial infarction, susceptibility to risk factor rs7291467 RCV001799609
Show/Hide Text Mining Associations (20)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Abortion Habitual Inhibit 27136536
Abortion Spontaneous Inhibit 27136536
Arthritis Rheumatoid Associate 19330599, 36389761
Behcet Syndrome Associate 26890122
Breast Neoplasms Associate 37838802
Colitis Ulcerative Associate 26885508
Colorectal Neoplasms Associate 11414198, 29098769, 29659199
Coronary Disease Associate 26045830
Diabetes Gestational Associate 32244351
Feeding and Eating Disorders Associate 29093763