LGALS2 (galectin 2)

Gene
Gene SNPs Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3957
Gene name Gene Name - the full gene name approved by the HGNC.
Galectin 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LGALS2
Synonyms (NCBI Gene) Gene synonyms aliases
HL14
Chromosome Chromosome number
22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
22q13.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of
SNPs SNP information provided by dbSNP.
Gene SNPs Gene ontology Other IDs Protein Associated diseases
Show/Hide all(1)
SNP ID Visualize variation Clinical significance Consequence
rs7291467 G>A Risk-factor Intron variant
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Gene ontology Other IDs Protein Associated diseases
Show/Hide all(4)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956, 31515488, 32296183
GO:0005737 Component Cytoplasm IBA 21873635
GO:0016936 Function Galactoside binding IBA 21873635
GO:0030246 Function Carbohydrate binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
150571 6562 ENSG00000100079
Protein
Gene SNPs Gene ontology Other IDs Protein Associated diseases
UniProt ID P05162
Protein name Galectin-2 (Gal-2) (Beta-galactoside-binding lectin L-14-II) (HL14) (Lactose-binding lectin 2) (S-Lac lectin 2)
Protein function This protein binds beta-galactoside. Its physiological function is not yet known.
PDB 1HLC , 5DG1 , 5DG2 , 5EWS
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00337 Gal-bind_lectin 4 → 130 Galactoside-binding lectin Domain
Sequence
Sequence length 132
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene SNPs Gene ontology Other IDs Protein Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Myocardial infarction Myocardial Infarction 15129282 ClinVar
Show/Hide Text Mining Associations (20)
Associations from Text Mining
Disease Name Relationship Type References
Abortion Habitual Inhibit 27136536
Abortion Spontaneous Inhibit 27136536
Arthritis Rheumatoid Associate 19330599, 36389761
Behcet Syndrome Associate 26890122
Breast Neoplasms Associate 37838802
Colitis Ulcerative Associate 26885508
Colorectal Neoplasms Associate 11414198, 29098769, 29659199
Coronary Disease Associate 26045830
Diabetes Gestational Associate 32244351
Feeding and Eating Disorders Associate 29093763