LGALS1 (galectin 1)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3956
Gene name Gene Name - the full gene name approved by the HGNC.
Galectin 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LGALS1
Synonyms (NCBI Gene) Gene synonyms aliases
GAL1, GBP
Chromosome Chromosome number
22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
22q13.1
Summary Summary of gene provided in NCBI Entrez Gene.
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT023570 hsa-miR-1-3p Proteomics 18668040
MIRT437402 hsa-miR-22-3p Immunofluorescence, qRT-PCR, Western blot 24496460
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
PTTG1 Activation 19351864
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0002317 Process Plasma cell differentiation IEA
GO:0003723 Function RNA binding HDA 22658674
GO:0005515 Function Protein binding IPI 10369126, 23131994, 24529377, 24945728, 28514442, 32814053
GO:0005576 Component Extracellular region HDA 27068509
GO:0005615 Component Extracellular space HDA 20551380
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
150570 6561 ENSG00000100097
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P09382
Protein name Galectin-1 (Gal-1) (14 kDa laminin-binding protein) (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac l
Protein function Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Ly
PDB 1GZW , 1W6M , 1W6N , 1W6O , 1W6P , 1W6Q , 2KM2 , 2ZKN , 3OY8 , 3OYW , 3T2T , 3W58 , 3W59 , 4Q1P , 4Q1R , 4Q26 , 4Q27 , 4Q2F , 4XBL , 4Y1U , 4Y1V , 4Y1X , 4Y1Y , 4Y1Z , 4Y20 , 4Y22 , 4Y24 , 5MWT , 5MWX , 6B94 , 6F83 , 6M5Y , 7LTA , 7NML , 8B0W , 8B0Z , 8OJP , 8R74 , 8RDC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00337 Gal-bind_lectin 5 → 134 Galactoside-binding lectin Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in a
Sequence
Sequence length 135
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Lung carcinoma Non-Small Cell Lung Carcinoma rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355
View all (44 more)		 17094902
Show/Hide Text Mining Associations (168)
Associations from Text Mining
Disease Name Relationship Type References
Abortion Habitual Inhibit 27136536
Abortion Spontaneous Inhibit 27136536
Acquired ichthyosis Associate 36303457
Adenocarcinoma Mucinous Associate 27533245
Adenocarcinoma of Lung Stimulate 24361865
Anodontia Associate 26497328
Anophthalmia with pulmonary hypoplasia Associate 22785208
Anthropophobia Associate 35029197
Aortic Valve Stenosis Associate 31856737
Arthritis Stimulate 33082382