LECT2 (leukocyte cell derived chemotaxin 2)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3950
Gene name Gene Name - the full gene name approved by the HGNC.
Leukocyte cell derived chemotaxin 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LECT2
Synonyms (NCBI Gene) Gene synonyms aliases
chm-II, chm2
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q31.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-indu
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(9)
miRTarBase ID miRNA Experiments Reference
MIRT051767 hsa-let-7c-5p CLASH 23622248
MIRT2260520 hsa-miR-4438 CLIP-seq
MIRT2260521 hsa-miR-5095 CLIP-seq
MIRT2560531 hsa-miR-2054 CLIP-seq
MIRT2260520 hsa-miR-4438 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(10)
GO ID Ontology Definition Evidence Reference
GO:0001501 Process Skeletal system development TAS 9545637
GO:0005515 Function Protein binding IPI 27334921
GO:0005576 Component Extracellular region IEA
GO:0005615 Component Extracellular space TAS 9266841
GO:0005737 Component Cytoplasm IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
602882 6550 ENSG00000145826
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID O14960
Protein name Leukocyte cell-derived chemotaxin-2 (LECT-2) (hLECT2)
Protein function Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation (PubMed:9524238). Does not show metalloendopeptidase activity (PubMed:27334921).
PDB 5B0H , 7N2I , 8G2V
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01551 Peptidase_M23 51 → 149 Peptidase family M23 Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in adult and fetal liver and weakly in testis. Not expressed in bone marrow. {ECO:0000269|PubMed:9524238, ECO:0000269|PubMed:9832057}.
Sequence
Sequence length 151
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Insomnia Insomnia (standard GWA) N/A N/A GWAS
Show/Hide Text Mining Associations (12)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Amyloidosis Associate 24415538, 33617884
Amyloidosis familial visceral Associate 20951486, 38537700
Arthritis Rheumatoid Associate 27334921
Carcinoma Hepatocellular Associate 27334921
Chemical and Drug Induced Liver Injury Associate 32763823
Chronic Disease Associate 32763823
Metabolic Diseases Associate 31919514
Multiple Myeloma Associate 33617884, 38537700
Obesity Associate 27334921
Osteoarthritis Associate 23937207