Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	395
Gene name Gene Name - the full gene name approved by the HGNC.	Rho GTPase activating protein 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ARHGAP6
Synonyms (NCBI Gene) Gene synonyms aliases	RHOGAP6, RHOGAPX-1
Chromosome Chromosome number	X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	Xp22.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-ac

Show/Hide all(47)

miRTarBase ID	miRNA	Experiments	Reference
MIRT638978	hsa-miR-369-3p	HITS-CLIP	23824327
MIRT638977	hsa-miR-5692b	HITS-CLIP	23824327
MIRT638976	hsa-miR-5692c	HITS-CLIP	23824327
MIRT638975	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT638974	hsa-miR-374c-5p	HITS-CLIP	23824327
MIRT638973	hsa-miR-655-3p	HITS-CLIP	23824327
MIRT638972	hsa-miR-374a-5p	HITS-CLIP	23824327
MIRT638971	hsa-miR-374b-5p	HITS-CLIP	23824327
MIRT638970	hsa-miR-623	HITS-CLIP	23824327
MIRT638969	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT638968	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT638967	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT638966	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT638965	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT638978	hsa-miR-369-3p	HITS-CLIP	23824327
MIRT638977	hsa-miR-5692b	HITS-CLIP	23824327
MIRT638976	hsa-miR-5692c	HITS-CLIP	23824327
MIRT638975	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT638974	hsa-miR-374c-5p	HITS-CLIP	23824327
MIRT638973	hsa-miR-655-3p	HITS-CLIP	23824327
MIRT638972	hsa-miR-374a-5p	HITS-CLIP	23824327
MIRT638971	hsa-miR-374b-5p	HITS-CLIP	23824327
MIRT638970	hsa-miR-623	HITS-CLIP	23824327
MIRT638969	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT638968	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT638967	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT638966	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT638965	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT756475	hsa-miR-96-5p	Luciferase reporter assay, Western blotting, qRT-PCR	34338998
MIRT795014	hsa-miR-1207-3p	CLIP-seq
MIRT795015	hsa-miR-186	CLIP-seq
MIRT795016	hsa-miR-3148	CLIP-seq
MIRT795017	hsa-miR-4646-5p	CLIP-seq
MIRT795018	hsa-miR-4668-5p	CLIP-seq
MIRT795019	hsa-miR-4712-5p	CLIP-seq
MIRT795020	hsa-miR-770-5p	CLIP-seq
MIRT795021	hsa-miR-1257	CLIP-seq
MIRT795022	hsa-miR-3611	CLIP-seq
MIRT795023	hsa-miR-4753-3p	CLIP-seq
MIRT795024	hsa-miR-4768-5p	CLIP-seq
MIRT795025	hsa-miR-758	CLIP-seq
MIRT795017	hsa-miR-4646-5p	CLIP-seq
MIRT2174529	hsa-miR-1238	CLIP-seq
MIRT2174530	hsa-miR-1271	CLIP-seq
MIRT2174531	hsa-miR-182	CLIP-seq
MIRT2174532	hsa-miR-595	CLIP-seq
MIRT2174533	hsa-miR-96	CLIP-seq

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IEA
GO:0005737	Component	Cytoplasm	IMP	10699171
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005884	Component	Actin filament	NAS	10699171
GO:0007202	Process	Activation of phospholipase C activity	IBA	21873635
GO:0007266	Process	Rho protein signal transduction	NAS	10699171
GO:0015629	Component	Actin cytoskeleton	ISS	10699171
GO:0016004	Function	Phospholipase activator activity	IBA	21873635
GO:0017124	Function	SH3 domain binding	IEA
GO:0030041	Process	Actin filament polymerization	NAS	10699171
GO:0043274	Function	Phospholipase binding	IBA	21873635
GO:0043547	Process	Positive regulation of GTPase activity	IEA
GO:0048041	Process	Focal adhesion assembly	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:0051497	Process	Negative regulation of stress fiber assembly	IMP	10699171
GO:0051895	Process	Negative regulation of focal adhesion assembly	IMP	10699171

MIM	HGNC	e!Ensembl
300118	676	ENSG00000047648

Protein

UniProt ID

O43182

Protein name

Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1)

Protein function

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00620	RhoGAP	411 → 572	RhoGAP domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in kidney, heart and skeletal muscle followed by retina, lymphoblast, placenta, lung, brain, pancreas and liver.

Sequence

MSAQSLLHSVFSCSSPASSSAASAKGFSKRKLRQTRSLDPALIGGCGSDEAGAEGSARGA
TAGRLYSPSLPAESLGPRLASSSRGPPPRATRLPPPGPLCSSFSTPSTPQEKSPSGSFHF
DYEVPLGRGGLKKSMAWDLPSVLAGPASSRSASSILCSSGGGPNGIFASPRRWLQQRKFQ
SPPDSRGHPYVVWKSEGDFTWNSMSGRSVRLRSVPIQSLSELERARLQEVAFYQLQQDCD
LSCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVIANDRAYKLKQDL
QRDEQKDASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRARRRG
AMSVDSITDLDDNQSRLLEALQLSLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDSCCQH
LEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPL
LTRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKD
GQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAIIAVVQKMIENYEA
LFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEVSFSVGGRHSSTDSNK
ASSGDISPYDNNSPVLSERSLLAMQEDAAPGGSEKLYRVPGQFMLVGHLSSSKSRESSPG
PRLGKDLSEEPFDIWGTWHSTLKSGSKDPGMTGSSGDIFESSSLRAGPCSLSQGNLSPNW
PRWQGSPAELDSDTQGARRTQAAAPATEGRAHPAVSRACSTPHVQVAGKAERPTARSEQY
LTLSGAHDLSESELDVAGLQSRATPQCQRPHGSGRDDKRPPPPYPGPGKPAAAAAWIQGP
PEGVETPTDQGGQAAEREQQVTQKKLSSANSLPAGEQDSPRLGDAGWLDWQRERWQIWEL
LSTDNPDALPETLV

Sequence length

974

Interactions

View interactions

	Reactome
			Rho GTPase cycle

Show/Hide Causal Diseases (4)

Disease term	Disease name	dbSNP ID	References
Causal
Amelogenesis imperfecta	Amelogenesis Imperfecta, Hypomaturation Type, with Snow-Capped Teeth	rs267607178, rs143816093, rs606231351, rs137854435, rs137854440, rs137854441, rs137854444, rs587776587, rs121908109, rs587776588, rs140213840, rs104894704, rs387906487, rs387906488, rs387906489 View all (70 more)
Syndromic microphthalmia	MICROPHTHALMIA, SYNDROMIC 7	rs786205873, rs104894464, rs786205874, rs104894465, rs387906701, rs1566623121, rs786205879, rs1566624472, rs397514463, rs1566623392, rs387907252, rs397518481, rs397518482, rs397518483, rs587776457 View all (19 more)
Prostate cancer	Prostate carcinoma, Prostate cancer, familial	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	29892016
Prostate cancer, hereditary	PROSTATE CANCER, HEREDITARY, 1	rs387906327, rs193929331, rs74315365, rs397516896, rs794729219, rs121913349, rs587782641, rs1114167673, rs1597371666, rs2073394466	29892016

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References
Associations from Text Mining
Aniridia	Associate	27124303
Aniridia cerebellar ataxia mental deficiency	Associate	27124303
Arthritis Rheumatoid	Associate	30518319
Colorectal Neoplasms	Associate	19960375, 22276153
Nasopharyngeal Carcinoma	Associate	30909962
Uterine Cervical Neoplasms	Associate	28351298

ARHGAP6 (Rho GTPase activating protein 6)