ARHGAP5 (Rho GTPase activating protein 5)

Gene

• Entrez ID: 394
• Gene name: Rho GTPase activating protein 5
• Gene symbol: ARHGAP5
• Synonyms (NCBI Gene): GFI2, RhoGAP5, p190-B, p190BRhoGAP
• Chromosome: 14
• Chromosome location: 14q12
• Summary: Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by R

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016745	hsa-miR-335-5p	Microarray	18185580
MIRT021887	hsa-miR-128-3p	Microarray	17612493
MIRT050904	hsa-miR-17-5p	CLASH	23622248
MIRT048327	hsa-miR-106a-5p	CLASH	23622248
MIRT053295	hsa-miR-486-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	23474761
MIRT438172	hsa-miR-494-3p	FACS, Luciferase reporter assay, qRT-PCR, Western blot	24316134
MIRT438172	hsa-miR-494-3p	FACS, Luciferase reporter assay, qRT-PCR, Western blot	24316134
MIRT438172	hsa-miR-494-3p	FACS, Luciferase reporter assay, qRT-PCR, Western blot	24316134
MIRT438172	hsa-miR-494-3p	FACS, Luciferase reporter assay, qRT-PCR, Western blot	24316134
MIRT438172	hsa-miR-494-3p	FACS, Luciferase reporter assay, qRT-PCR, Western blot	24316134
MIRT438172	hsa-miR-494-3p	FACS, Luciferase reporter assay, qRT-PCR, Western blot	24316134
MIRT438172	hsa-miR-494-3p	FACS, Luciferase reporter assay, qRT-PCR, Western blot	24316134
MIRT438172	hsa-miR-494-3p	FACS, Luciferase reporter assay, qRT-PCR, Western blot	24316134
MIRT438172	hsa-miR-494-3p	FACS, Luciferase reporter assay, qRT-PCR, Western blot	24316134
MIRT438172	hsa-miR-494-3p	FACS, Luciferase reporter assay, qRT-PCR, Western blot	24316134
MIRT441200	hsa-miR-493-3p	HITS-CLIP	24374217
MIRT441199	hsa-miR-493-5p	HITS-CLIP	24374217
MIRT441198	hsa-miR-770-5p	HITS-CLIP	24374217
MIRT441200	hsa-miR-493-3p	HITS-CLIP	24374217
MIRT441199	hsa-miR-493-5p	HITS-CLIP	24374217
MIRT441198	hsa-miR-770-5p	HITS-CLIP	24374217
MIRT794922	hsa-miR-1206	CLIP-seq
MIRT794923	hsa-miR-1261	CLIP-seq
MIRT794924	hsa-miR-140-3p	CLIP-seq
MIRT794925	hsa-miR-145	CLIP-seq
MIRT794926	hsa-miR-15a	CLIP-seq
MIRT794927	hsa-miR-15b	CLIP-seq
MIRT794928	hsa-miR-16	CLIP-seq
MIRT794929	hsa-miR-182	CLIP-seq
MIRT794930	hsa-miR-18a	CLIP-seq
MIRT794931	hsa-miR-18b	CLIP-seq
MIRT794932	hsa-miR-194	CLIP-seq
MIRT794933	hsa-miR-195	CLIP-seq
MIRT794934	hsa-miR-199a-3p	CLIP-seq
MIRT794935	hsa-miR-199b-3p	CLIP-seq
MIRT794936	hsa-miR-219-2-3p	CLIP-seq
MIRT794937	hsa-miR-2964a-3p	CLIP-seq
MIRT794938	hsa-miR-3129-5p	CLIP-seq
MIRT794939	hsa-miR-3145-3p	CLIP-seq
MIRT794940	hsa-miR-3157-5p	CLIP-seq
MIRT794941	hsa-miR-3201	CLIP-seq
MIRT794942	hsa-miR-338-5p	CLIP-seq
MIRT794943	hsa-miR-3607-3p	CLIP-seq
MIRT794944	hsa-miR-3613-3p	CLIP-seq
MIRT794945	hsa-miR-3619-3p	CLIP-seq
MIRT794946	hsa-miR-3647-3p	CLIP-seq
MIRT794947	hsa-miR-3653	CLIP-seq
MIRT794948	hsa-miR-3658	CLIP-seq
MIRT794949	hsa-miR-3692	CLIP-seq
MIRT794950	hsa-miR-369-3p	CLIP-seq
MIRT794951	hsa-miR-371b-5p	CLIP-seq
MIRT794952	hsa-miR-374a	CLIP-seq
MIRT794953	hsa-miR-374b	CLIP-seq
MIRT794954	hsa-miR-421	CLIP-seq
MIRT794955	hsa-miR-424	CLIP-seq
MIRT794956	hsa-miR-4274	CLIP-seq
MIRT794957	hsa-miR-4276	CLIP-seq
MIRT794958	hsa-miR-4282	CLIP-seq
MIRT794959	hsa-miR-4293	CLIP-seq
MIRT794960	hsa-miR-4302	CLIP-seq
MIRT794961	hsa-miR-4427	CLIP-seq
MIRT794962	hsa-miR-4470	CLIP-seq
MIRT794963	hsa-miR-4477b	CLIP-seq
MIRT794964	hsa-miR-4494	CLIP-seq
MIRT794965	hsa-miR-4499	CLIP-seq
MIRT794966	hsa-miR-4513	CLIP-seq
MIRT794967	hsa-miR-4528	CLIP-seq
MIRT794968	hsa-miR-4640-3p	CLIP-seq
MIRT794969	hsa-miR-4662a-3p	CLIP-seq
MIRT794970	hsa-miR-4666-5p	CLIP-seq
MIRT794971	hsa-miR-4670-3p	CLIP-seq
MIRT794972	hsa-miR-4680-3p	CLIP-seq
MIRT794973	hsa-miR-4691-3p	CLIP-seq
MIRT794974	hsa-miR-4699-3p	CLIP-seq
MIRT794975	hsa-miR-4704-3p	CLIP-seq
MIRT794976	hsa-miR-4709-5p	CLIP-seq
MIRT794977	hsa-miR-4712-5p	CLIP-seq
MIRT794978	hsa-miR-4719	CLIP-seq
MIRT794979	hsa-miR-4733-5p	CLIP-seq
MIRT794980	hsa-miR-4735-3p	CLIP-seq
MIRT794981	hsa-miR-4757-5p	CLIP-seq
MIRT794982	hsa-miR-4776-5p	CLIP-seq
MIRT794983	hsa-miR-4791	CLIP-seq
MIRT794984	hsa-miR-4797-3p	CLIP-seq
MIRT794985	hsa-miR-495	CLIP-seq
MIRT794986	hsa-miR-497	CLIP-seq
MIRT794987	hsa-miR-499-3p	CLIP-seq
MIRT794988	hsa-miR-499a-3p	CLIP-seq
MIRT794989	hsa-miR-500a	CLIP-seq
MIRT794990	hsa-miR-501-5p	CLIP-seq
MIRT794991	hsa-miR-542-3p	CLIP-seq
MIRT794992	hsa-miR-548c-3p	CLIP-seq
MIRT794993	hsa-miR-548g	CLIP-seq
MIRT794994	hsa-miR-548u	CLIP-seq
MIRT794995	hsa-miR-549	CLIP-seq
MIRT794996	hsa-miR-580	CLIP-seq
MIRT794997	hsa-miR-590-3p	CLIP-seq
MIRT794998	hsa-miR-596	CLIP-seq
MIRT794999	hsa-miR-659	CLIP-seq
MIRT795000	hsa-miR-936	CLIP-seq
MIRT795001	hsa-miR-944	CLIP-seq
MIRT795002	hsa-miR-101	CLIP-seq
MIRT795003	hsa-miR-144	CLIP-seq
MIRT795004	hsa-miR-3163	CLIP-seq
MIRT795005	hsa-miR-374c	CLIP-seq
MIRT795006	hsa-miR-3925-5p	CLIP-seq
MIRT795007	hsa-miR-412	CLIP-seq
MIRT795008	hsa-miR-4311	CLIP-seq
MIRT795009	hsa-miR-4698	CLIP-seq
MIRT795010	hsa-miR-4773	CLIP-seq
MIRT795011	hsa-miR-4774-5p	CLIP-seq
MIRT794985	hsa-miR-495	CLIP-seq
MIRT794993	hsa-miR-548g	CLIP-seq
MIRT795012	hsa-miR-582-3p	CLIP-seq
MIRT795013	hsa-miR-655	CLIP-seq
MIRT1545505	hsa-miR-103a	CLIP-seq
MIRT1545506	hsa-miR-107	CLIP-seq
MIRT1545507	hsa-miR-4775	CLIP-seq
MIRT1545508	hsa-miR-586	CLIP-seq
MIRT1545509	hsa-miR-186	CLIP-seq
MIRT1545510	hsa-miR-494	CLIP-seq
MIRT1545507	hsa-miR-4775	CLIP-seq
MIRT1934728	hsa-miR-23a	CLIP-seq
MIRT1934729	hsa-miR-23b	CLIP-seq
MIRT1934730	hsa-miR-23c	CLIP-seq
MIRT1934731	hsa-miR-3074-5p	CLIP-seq
MIRT1934732	hsa-miR-3119	CLIP-seq
MIRT1934733	hsa-miR-3140-3p	CLIP-seq
MIRT1934734	hsa-miR-3155	CLIP-seq
MIRT1934735	hsa-miR-3155b	CLIP-seq
MIRT1934736	hsa-miR-320a	CLIP-seq
MIRT1934737	hsa-miR-320b	CLIP-seq
MIRT1934738	hsa-miR-320c	CLIP-seq
MIRT1934739	hsa-miR-320d	CLIP-seq
MIRT794942	hsa-miR-338-5p	CLIP-seq
MIRT1934740	hsa-miR-3545-3p	CLIP-seq
MIRT794946	hsa-miR-3647-3p	CLIP-seq
MIRT1934741	hsa-miR-3672	CLIP-seq
MIRT1934742	hsa-miR-3680	CLIP-seq
MIRT794949	hsa-miR-3692	CLIP-seq
MIRT1934743	hsa-miR-376c	CLIP-seq
MIRT1934744	hsa-miR-4429	CLIP-seq
MIRT1934745	hsa-miR-4517	CLIP-seq
MIRT794974	hsa-miR-4699-3p	CLIP-seq
MIRT1934746	hsa-miR-4712-3p	CLIP-seq
MIRT1934747	hsa-miR-4766-5p	CLIP-seq
MIRT795011	hsa-miR-4774-5p	CLIP-seq
MIRT1545507	hsa-miR-4775	CLIP-seq
MIRT1934748	hsa-miR-484	CLIP-seq
MIRT1934749	hsa-miR-513a-3p	CLIP-seq
MIRT794992	hsa-miR-548c-3p	CLIP-seq
MIRT794994	hsa-miR-548u	CLIP-seq
MIRT1934750	hsa-miR-579	CLIP-seq
MIRT794997	hsa-miR-590-3p	CLIP-seq
MIRT795001	hsa-miR-944	CLIP-seq
MIRT795002	hsa-miR-101	CLIP-seq
MIRT1545505	hsa-miR-103a	CLIP-seq
MIRT2174460	hsa-miR-106a	CLIP-seq
MIRT2174461	hsa-miR-106b	CLIP-seq
MIRT1545506	hsa-miR-107	CLIP-seq
MIRT2174462	hsa-miR-1183	CLIP-seq
MIRT2174463	hsa-miR-1205	CLIP-seq
MIRT794922	hsa-miR-1206	CLIP-seq
MIRT2174464	hsa-miR-1284	CLIP-seq
MIRT795003	hsa-miR-144	CLIP-seq
MIRT794926	hsa-miR-15a	CLIP-seq
MIRT794927	hsa-miR-15b	CLIP-seq
MIRT794928	hsa-miR-16	CLIP-seq
MIRT2174465	hsa-miR-17	CLIP-seq
MIRT794932	hsa-miR-194	CLIP-seq
MIRT794933	hsa-miR-195	CLIP-seq
MIRT2174466	hsa-miR-200b	CLIP-seq
MIRT2174467	hsa-miR-200c	CLIP-seq
MIRT2174468	hsa-miR-2052	CLIP-seq
MIRT2174469	hsa-miR-2054	CLIP-seq
MIRT2174470	hsa-miR-20a	CLIP-seq
MIRT2174471	hsa-miR-20b	CLIP-seq
MIRT2174472	hsa-miR-217	CLIP-seq
MIRT2174473	hsa-miR-219-1-3p	CLIP-seq
MIRT2174474	hsa-miR-223	CLIP-seq
MIRT2174475	hsa-miR-2355-3p	CLIP-seq
MIRT2174476	hsa-miR-2355-5p	CLIP-seq
MIRT1934728	hsa-miR-23a	CLIP-seq
MIRT1934729	hsa-miR-23b	CLIP-seq
MIRT1934730	hsa-miR-23c	CLIP-seq
MIRT2174477	hsa-miR-3064-3p	CLIP-seq
MIRT1934731	hsa-miR-3074-5p	CLIP-seq
MIRT2174478	hsa-miR-3121-5p	CLIP-seq
MIRT1934733	hsa-miR-3140-3p	CLIP-seq
MIRT794939	hsa-miR-3145-3p	CLIP-seq
MIRT2174479	hsa-miR-3145-5p	CLIP-seq
MIRT794940	hsa-miR-3157-5p	CLIP-seq
MIRT795004	hsa-miR-3163	CLIP-seq
MIRT1934736	hsa-miR-320a	CLIP-seq
MIRT1934737	hsa-miR-320b	CLIP-seq
MIRT1934738	hsa-miR-320c	CLIP-seq
MIRT1934739	hsa-miR-320d	CLIP-seq
MIRT2174480	hsa-miR-323-3p	CLIP-seq
MIRT2174481	hsa-miR-331-5p	CLIP-seq
MIRT794942	hsa-miR-338-5p	CLIP-seq
MIRT1934740	hsa-miR-3545-3p	CLIP-seq
MIRT794944	hsa-miR-3613-3p	CLIP-seq
MIRT2174482	hsa-miR-362-5p	CLIP-seq
MIRT794946	hsa-miR-3647-3p	CLIP-seq
MIRT2174483	hsa-miR-3662	CLIP-seq
MIRT2174484	hsa-miR-3665	CLIP-seq
MIRT2174485	hsa-miR-3671	CLIP-seq
MIRT794949	hsa-miR-3692	CLIP-seq
MIRT794950	hsa-miR-369-3p	CLIP-seq
MIRT794951	hsa-miR-371b-5p	CLIP-seq
MIRT794952	hsa-miR-374a	CLIP-seq
MIRT794953	hsa-miR-374b	CLIP-seq
MIRT795005	hsa-miR-374c	CLIP-seq
MIRT1934743	hsa-miR-376c	CLIP-seq
MIRT2174486	hsa-miR-382	CLIP-seq
MIRT795006	hsa-miR-3925-5p	CLIP-seq
MIRT2174487	hsa-miR-3973	CLIP-seq
MIRT795007	hsa-miR-412	CLIP-seq
MIRT794954	hsa-miR-421	CLIP-seq
MIRT794955	hsa-miR-424	CLIP-seq
MIRT794956	hsa-miR-4274	CLIP-seq
MIRT794957	hsa-miR-4276	CLIP-seq
MIRT794958	hsa-miR-4282	CLIP-seq
MIRT2174488	hsa-miR-429	CLIP-seq
MIRT794960	hsa-miR-4302	CLIP-seq
MIRT795008	hsa-miR-4311	CLIP-seq
MIRT2174489	hsa-miR-4328	CLIP-seq
MIRT2174490	hsa-miR-4418	CLIP-seq
MIRT2174491	hsa-miR-4420	CLIP-seq
MIRT1934744	hsa-miR-4429	CLIP-seq
MIRT2174492	hsa-miR-448	CLIP-seq
MIRT2174493	hsa-miR-4490	CLIP-seq
MIRT794964	hsa-miR-4494	CLIP-seq
MIRT794965	hsa-miR-4499	CLIP-seq
MIRT2174494	hsa-miR-4504	CLIP-seq
MIRT2174495	hsa-miR-450b-5p	CLIP-seq
MIRT2174496	hsa-miR-4637	CLIP-seq
MIRT794968	hsa-miR-4640-3p	CLIP-seq
MIRT2174497	hsa-miR-4646-3p	CLIP-seq
MIRT794969	hsa-miR-4662a-3p	CLIP-seq
MIRT794970	hsa-miR-4666-5p	CLIP-seq
MIRT794971	hsa-miR-4670-3p	CLIP-seq
MIRT2174498	hsa-miR-4678	CLIP-seq
MIRT794973	hsa-miR-4691-3p	CLIP-seq
MIRT2174499	hsa-miR-4693-5p	CLIP-seq
MIRT2174500	hsa-miR-4697-3p	CLIP-seq
MIRT795009	hsa-miR-4698	CLIP-seq
MIRT794974	hsa-miR-4699-3p	CLIP-seq
MIRT794975	hsa-miR-4704-3p	CLIP-seq
MIRT794976	hsa-miR-4709-5p	CLIP-seq
MIRT2174501	hsa-miR-4715-3p	CLIP-seq
MIRT2174502	hsa-miR-4729	CLIP-seq
MIRT794979	hsa-miR-4733-5p	CLIP-seq
MIRT2174503	hsa-miR-4753-3p	CLIP-seq
MIRT795010	hsa-miR-4773	CLIP-seq
MIRT795011	hsa-miR-4774-5p	CLIP-seq
MIRT1545507	hsa-miR-4775	CLIP-seq
MIRT2174504	hsa-miR-4777-5p	CLIP-seq
MIRT2174505	hsa-miR-4793-5p	CLIP-seq
MIRT2174506	hsa-miR-4796-5p	CLIP-seq
MIRT2174507	hsa-miR-490-5p	CLIP-seq
MIRT794985	hsa-miR-495	CLIP-seq
MIRT794986	hsa-miR-497	CLIP-seq
MIRT794987	hsa-miR-499-3p	CLIP-seq
MIRT794988	hsa-miR-499a-3p	CLIP-seq
MIRT2174508	hsa-miR-500b	CLIP-seq
MIRT794990	hsa-miR-501-5p	CLIP-seq
MIRT2174509	hsa-miR-507	CLIP-seq
MIRT2174510	hsa-miR-509-3-5p	CLIP-seq
MIRT2174511	hsa-miR-509-5p	CLIP-seq
MIRT2174512	hsa-miR-513b	CLIP-seq
MIRT2174513	hsa-miR-519a	CLIP-seq
MIRT2174514	hsa-miR-519b-3p	CLIP-seq
MIRT2174515	hsa-miR-519c-3p	CLIP-seq
MIRT2174516	hsa-miR-519d	CLIP-seq
MIRT794992	hsa-miR-548c-3p	CLIP-seq
MIRT794993	hsa-miR-548g	CLIP-seq
MIRT2174517	hsa-miR-548l	CLIP-seq
MIRT2174518	hsa-miR-548t	CLIP-seq
MIRT794994	hsa-miR-548u	CLIP-seq
MIRT794995	hsa-miR-549	CLIP-seq
MIRT2174519	hsa-miR-553	CLIP-seq
MIRT2174520	hsa-miR-556-3p	CLIP-seq
MIRT2174521	hsa-miR-557	CLIP-seq
MIRT2174522	hsa-miR-571	CLIP-seq
MIRT795012	hsa-miR-582-3p	CLIP-seq
MIRT794997	hsa-miR-590-3p	CLIP-seq
MIRT2174523	hsa-miR-606	CLIP-seq
MIRT2174524	hsa-miR-607	CLIP-seq
MIRT2174525	hsa-miR-646	CLIP-seq
MIRT795013	hsa-miR-655	CLIP-seq
MIRT2174526	hsa-miR-657	CLIP-seq
MIRT794999	hsa-miR-659	CLIP-seq
MIRT2174527	hsa-miR-888	CLIP-seq
MIRT2174528	hsa-miR-93	CLIP-seq
MIRT795001	hsa-miR-944	CLIP-seq
MIRT1545505	hsa-miR-103a	CLIP-seq
MIRT1545506	hsa-miR-107	CLIP-seq
MIRT2384424	hsa-miR-1184	CLIP-seq
MIRT2174464	hsa-miR-1284	CLIP-seq
MIRT2174472	hsa-miR-217	CLIP-seq
MIRT1934733	hsa-miR-3140-3p	CLIP-seq
MIRT1934736	hsa-miR-320a	CLIP-seq
MIRT1934737	hsa-miR-320b	CLIP-seq
MIRT1934738	hsa-miR-320c	CLIP-seq
MIRT1934739	hsa-miR-320d	CLIP-seq
MIRT794946	hsa-miR-3647-3p	CLIP-seq
MIRT795008	hsa-miR-4311	CLIP-seq
MIRT2174490	hsa-miR-4418	CLIP-seq
MIRT1934744	hsa-miR-4429	CLIP-seq
MIRT794974	hsa-miR-4699-3p	CLIP-seq
MIRT2174505	hsa-miR-4793-5p	CLIP-seq
MIRT2174506	hsa-miR-4796-5p	CLIP-seq
MIRT2174510	hsa-miR-509-3-5p	CLIP-seq
MIRT2174511	hsa-miR-509-5p	CLIP-seq
MIRT794994	hsa-miR-548u	CLIP-seq
MIRT2174475	hsa-miR-2355-3p	CLIP-seq
MIRT1934733	hsa-miR-3140-3p	CLIP-seq
MIRT795004	hsa-miR-3163	CLIP-seq
MIRT795006	hsa-miR-3925-5p	CLIP-seq
MIRT795008	hsa-miR-4311	CLIP-seq
MIRT2174497	hsa-miR-4646-3p	CLIP-seq
MIRT2426420	hsa-miR-4724-5p	CLIP-seq
MIRT794979	hsa-miR-4733-5p	CLIP-seq
MIRT794981	hsa-miR-4757-5p	CLIP-seq
MIRT795010	hsa-miR-4773	CLIP-seq
MIRT2174504	hsa-miR-4777-5p	CLIP-seq
MIRT1545510	hsa-miR-494	CLIP-seq
MIRT794993	hsa-miR-548g	CLIP-seq
MIRT2174524	hsa-miR-607	CLIP-seq
MIRT794995	hsa-miR-549	CLIP-seq
MIRT2443922	hsa-miR-1185	CLIP-seq
MIRT2443923	hsa-miR-1197	CLIP-seq
MIRT2443924	hsa-miR-1272	CLIP-seq
MIRT2443925	hsa-miR-3605-5p	CLIP-seq
MIRT2443926	hsa-miR-3679-5p	CLIP-seq
MIRT2478011	hsa-miR-137	CLIP-seq
MIRT2478012	hsa-miR-188-5p	CLIP-seq
MIRT2174474	hsa-miR-223	CLIP-seq
MIRT2174475	hsa-miR-2355-3p	CLIP-seq
MIRT2478013	hsa-miR-3121-3p	CLIP-seq
MIRT2174478	hsa-miR-3121-5p	CLIP-seq
MIRT1934733	hsa-miR-3140-3p	CLIP-seq
MIRT794940	hsa-miR-3157-5p	CLIP-seq
MIRT2478014	hsa-miR-3189-3p	CLIP-seq
MIRT1934736	hsa-miR-320a	CLIP-seq
MIRT1934737	hsa-miR-320b	CLIP-seq
MIRT1934738	hsa-miR-320c	CLIP-seq
MIRT1934739	hsa-miR-320d	CLIP-seq
MIRT2174481	hsa-miR-331-5p	CLIP-seq
MIRT2478015	hsa-miR-3606	CLIP-seq
MIRT2174482	hsa-miR-362-5p	CLIP-seq
MIRT794947	hsa-miR-3653	CLIP-seq
MIRT794948	hsa-miR-3658	CLIP-seq
MIRT2174485	hsa-miR-3671	CLIP-seq
MIRT1934742	hsa-miR-3680	CLIP-seq
MIRT2174486	hsa-miR-382	CLIP-seq
MIRT2478016	hsa-miR-3908	CLIP-seq
MIRT2478017	hsa-miR-3929	CLIP-seq
MIRT2174487	hsa-miR-3973	CLIP-seq
MIRT2478018	hsa-miR-4419b	CLIP-seq
MIRT2478019	hsa-miR-4422	CLIP-seq
MIRT1934744	hsa-miR-4429	CLIP-seq
MIRT2478020	hsa-miR-4478	CLIP-seq
MIRT2478021	hsa-miR-4495	CLIP-seq
MIRT2174497	hsa-miR-4646-3p	CLIP-seq
MIRT2478022	hsa-miR-4662a-5p	CLIP-seq
MIRT2174498	hsa-miR-4678	CLIP-seq
MIRT2478023	hsa-miR-4690-5p	CLIP-seq
MIRT794973	hsa-miR-4691-3p	CLIP-seq
MIRT2174500	hsa-miR-4697-3p	CLIP-seq
MIRT2174502	hsa-miR-4729	CLIP-seq
MIRT795010	hsa-miR-4773	CLIP-seq
MIRT2174504	hsa-miR-4777-5p	CLIP-seq
MIRT1545510	hsa-miR-494	CLIP-seq
MIRT794985	hsa-miR-495	CLIP-seq
MIRT794989	hsa-miR-500a	CLIP-seq
MIRT2174508	hsa-miR-500b	CLIP-seq
MIRT794990	hsa-miR-501-5p	CLIP-seq
MIRT2174509	hsa-miR-507	CLIP-seq
MIRT2174517	hsa-miR-548l	CLIP-seq
MIRT794995	hsa-miR-549	CLIP-seq
MIRT2174521	hsa-miR-557	CLIP-seq
MIRT1934750	hsa-miR-579	CLIP-seq
MIRT2478024	hsa-miR-921	CLIP-seq
MIRT2478012	hsa-miR-188-5p	CLIP-seq
MIRT2174474	hsa-miR-223	CLIP-seq
MIRT2174475	hsa-miR-2355-3p	CLIP-seq
MIRT2478013	hsa-miR-3121-3p	CLIP-seq
MIRT2174478	hsa-miR-3121-5p	CLIP-seq
MIRT1934733	hsa-miR-3140-3p	CLIP-seq
MIRT794940	hsa-miR-3157-5p	CLIP-seq
MIRT2478014	hsa-miR-3189-3p	CLIP-seq
MIRT2478015	hsa-miR-3606	CLIP-seq
MIRT2174482	hsa-miR-362-5p	CLIP-seq
MIRT2174485	hsa-miR-3671	CLIP-seq
MIRT1934742	hsa-miR-3680	CLIP-seq
MIRT2174486	hsa-miR-382	CLIP-seq
MIRT2478016	hsa-miR-3908	CLIP-seq
MIRT2478017	hsa-miR-3929	CLIP-seq
MIRT2174487	hsa-miR-3973	CLIP-seq
MIRT2478018	hsa-miR-4419b	CLIP-seq
MIRT2478019	hsa-miR-4422	CLIP-seq
MIRT2478020	hsa-miR-4478	CLIP-seq
MIRT2478021	hsa-miR-4495	CLIP-seq
MIRT2174497	hsa-miR-4646-3p	CLIP-seq
MIRT2478022	hsa-miR-4662a-5p	CLIP-seq
MIRT2478023	hsa-miR-4690-5p	CLIP-seq
MIRT794973	hsa-miR-4691-3p	CLIP-seq
MIRT2174500	hsa-miR-4697-3p	CLIP-seq
MIRT2174502	hsa-miR-4729	CLIP-seq
MIRT2174504	hsa-miR-4777-5p	CLIP-seq
MIRT1545510	hsa-miR-494	CLIP-seq
MIRT794985	hsa-miR-495	CLIP-seq
MIRT2174508	hsa-miR-500b	CLIP-seq
MIRT794990	hsa-miR-501-5p	CLIP-seq
MIRT2174509	hsa-miR-507	CLIP-seq
MIRT2174517	hsa-miR-548l	CLIP-seq
MIRT794995	hsa-miR-549	CLIP-seq
MIRT2174521	hsa-miR-557	CLIP-seq
MIRT1934750	hsa-miR-579	CLIP-seq
MIRT2478024	hsa-miR-921	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003924	Function	GTPase activity	IEA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	23622247
GO:0005525	Function	GTP binding	IEA
GO:0005737	Component	Cytoplasm	TAS	8537347
GO:0005783	Component	Endoplasmic reticulum	IBA	21873635
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0007155	Process	Cell adhesion	TAS	8537347
GO:0007266	Process	Rho protein signal transduction	TAS	8537347
GO:0030879	Process	Mammary gland development	IEA
GO:0042169	Function	SH2 domain binding	IBA	21873635
GO:0042169	Function	SH2 domain binding	IPI	1689011
GO:0043547	Process	Positive regulation of GTPase activity	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS

Other IDs

• MIM: 602680
• HGNC: 675
• e!Ensembl: ENSG00000100852

Protein

• UniProt ID: Q13017
• Protein name: Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B)
• Protein function: GTPase-activating protein for Rho family members (PubMed:8537347).
• PDB: 2EE4, 2EE5, 5U4V
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00071	Ras	142 → 248	Ras family	Domain
  PF16512	RhoGAP-FF1	260 → 338	p190-A and -B Rho GAPs FF domain	Domain
  PF01846	FF	485 → 545	FF domain	Family
  PF00620	RhoGAP	1275 → 1426	RhoGAP domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected in skin fibroblasts (at protein level) (PubMed:8537347). {ECO:0000269|PubMed:8537347}.
• Sequence:

  MMAKNKEPRPPSYTISIVGLSGTEKDKGNCGVGKSCLCNRFVRSKADEYYPEHTSVLSTI
  DFGGRVVNNDHFLYWGDIIQNSEDGVECKIHVIEQTEFIDDQTFLPHRSTNLQPYIKRAA
  ASKLQSAEKLMYICTDQLGLEQDFEQKQMPEGKLNVDGFLLCIDVSQGCNRKFDDQLKFV
  NNLFVQLSKSKKPVIIAATKCDECVDHYLREVQAFASNKKNLLVVETSARFNVNIETCFT
  ALVQMLDKTRSKPKIIPYLDAYKTQRQLVVTATDKFEKLVQTVRDYHATWKTVSNKLKNH
  PDYEEYINLEGTRKARNTFSKHIEQLKQEHIRKRREEYINTLPRAFNTLLPNLEEIEHLN
  WSEALKLMEKRADFQLCFVVLEKTPWDETDHIDKINDRRIPFDLLSTLEAEKVYQNHVQH
  LISEKRRVEMKEKFKKTLEKIQFISPGQPWEEVMCFVMEDEAYKYITEADSKEVYGRHQR
  EIVEKAKEEFQEMLFEHSELFYDLDLNATPSSDKMSEIHTVLSEEPRYKALQKLAPDRES
  LLLKHIGFVYHPTKETCLSGQNCTDIKVEQLLASSLLQLDHGRLRLYHDSTNIDKVNLFI
  LGKDGLAQELANEIRTQSTDDEYALDGKIYELDLRPVDAKSPYFLSQLWTAAFKPHGCFC
  VFNSIESLSFIGEFIGKIRTEASQIRKDKYMANLPFTLILANQRDSISKNLPILRHQGQQ
  LANKLQCPFVDVPAGTYPRKFNETQIKQALRGVLESVKHNLDVVSPIPANKDLSEADLRI
  VMCAMCGDPFSVDLILSPFLDSHSCSAAQAGQNNSLMLDKIIGEKRRRIQITILSYHSSI
  GVRKDELVHGYILVYSAKRKASMGMLRAFLSEVQDTIPVQLVAVTDSQADFFENEAIKEL
  MTEGEHIATEITAKFTALYSLSQYHRQTEVFTLFFSDVLEKKNMIENSYLSDNTRESTHQ
  SEDVFLPSPRDCFPYNNYPDSDDDTEAPPPYSPIGDDVQLLPTPSDRSRYRLDLEGNEYP
  IHSTPNCHDHERNHKVPPPIKPKPVVPKTNVKKLDPNLLKTIEAGIGKNPRKQTSRVPLA
  HPEDMDPSDNYAEPIDTIFKQKGYSDEIYVVPDDSQNRIKIRNSFVNNTQGDEENGFSDR
  TSKSHGERRPSKYKYKSKTLFSKAKSYYRRTHSDASDDEAFTTSKTKRKGRHRGSEEDPL
  LSPVETWKGGIDNPAITSDQELDDKKMKKKTHKVKEDKKQKKKTKNFNPPTRRNWESNYF
  GMPLQDLVTAEKPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNINL
  VSMEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHPV
  NYDVFRYVITHLNRVSQQHKINLMTADNLSICFWPTLMRPDFENREFLSTTKIHQSVVET
  FIQQCQFFFYNGEIVETTNIVAPPPPSNPGQLVEPMVPLQLPPPLQPQLIQPQLQTDPLG
  II

• Sequence length: 1502

Pathways

KEGG:

Focal adhesion
Leukocyte transendothelial migration

Reactome:

Rho GTPase cycle

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038	29059683

Unknown
Disease term	Disease name	Evidence	References	Source
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma of Lung	Associate	35946559
Breast Neoplasms	Associate	34370213, 36077054
Capillary Leak Syndrome	Associate	29097442
Carcinoma Hepatocellular	Associate	36354136
Carcinoma Squamous Cell	Associate	36632741
Colorectal Neoplasms	Inhibit	37845228
Critical Illness	Associate	29097442
Glioma	Associate	24316134
Lung Neoplasms	Associate	23474761
Neoplasm Metastasis	Associate	23474761, 35946559
Neoplasms	Associate	23474761, 37424068
Neoplasms	Inhibit	37845228
Osteoporosis	Associate	35757478
Stomach Neoplasms	Associate	31097692
Urinary Bladder Neoplasms	Associate	34285193, 35894701, 36595859
Uterine Cervical Neoplasms	Associate	36632741