Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3939
Gene name Gene Name - the full gene name approved by the HGNC.	Lactate dehydrogenase A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	LDHA
Synonyms (NCBI Gene) Gene synonyms aliases	GSD11, HEL-S-133P, LDHM, PIG19
Disease Acronyms (UniProt) Disease acronyms from UniProt database	GSD11
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11p15.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations i

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miRTarBase ID	miRNA	Experiments	Reference
MIRT025431	hsa-miR-34a-5p	Reporter assay;Proteomics	21566225
MIRT028212	hsa-miR-33a-5p	Sequencing	20371350
MIRT051827	hsa-let-7c-5p	CLASH	23622248
MIRT050430	hsa-miR-23a-3p	CLASH	23622248
MIRT043959	hsa-miR-378a-3p	CLASH	23622248
MIRT043554	hsa-miR-331-3p	CLASH	23622248
MIRT043068	hsa-miR-324-5p	CLASH	23622248
MIRT036678	hsa-miR-935	CLASH	23622248
MIRT036157	hsa-miR-320c	CLASH	23622248
MIRT050430	hsa-miR-23a-3p	Luciferase reporter assay, qRT-PCR	23064179
MIRT054320	hsa-miR-24-3p	Luciferase reporter assay, qRT-PCR	23064179
MIRT054321	hsa-miR-210-3p	Luciferase reporter assay, qRT-PCR	23064179
MIRT702292	hsa-miR-383-5p	HITS-CLIP	23313552
MIRT702295	hsa-miR-8080	HITS-CLIP	23313552
MIRT702294	hsa-miR-34b-3p	HITS-CLIP	23313552
MIRT702293	hsa-miR-577	HITS-CLIP	23313552
MIRT702292	hsa-miR-383-5p	HITS-CLIP	23313552
MIRT702291	hsa-miR-1288-5p	HITS-CLIP	23313552
MIRT702290	hsa-miR-302a-5p	HITS-CLIP	23313552
MIRT656755	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT656756	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT656754	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT656753	hsa-miR-4284	HITS-CLIP	23824327
MIRT054320	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT656752	hsa-miR-4713-3p	HITS-CLIP	23824327
MIRT656751	hsa-miR-638	HITS-CLIP	23824327
MIRT656750	hsa-miR-4654	HITS-CLIP	23824327
MIRT656749	hsa-miR-4769-5p	HITS-CLIP	23824327
MIRT656748	hsa-miR-8057	HITS-CLIP	23824327
MIRT656747	hsa-miR-450b-3p	HITS-CLIP	23824327
MIRT656746	hsa-miR-769-3p	HITS-CLIP	23824327
MIRT504908	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT504907	hsa-miR-5190	PAR-CLIP	23446348
MIRT504906	hsa-miR-1252-5p	PAR-CLIP	23446348
MIRT367770	hsa-miR-4670-3p	PAR-CLIP	23446348
MIRT367768	hsa-miR-505-5p	PAR-CLIP	23446348
MIRT504905	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504904	hsa-miR-4276	PAR-CLIP	23446348
MIRT265634	hsa-miR-4524b-3p	PAR-CLIP	23592263
MIRT332416	hsa-miR-425-5p	PAR-CLIP	23592263
MIRT265632	hsa-miR-4305	PAR-CLIP	23592263
MIRT265630	hsa-miR-203a-3p	PAR-CLIP	23592263
MIRT332419	hsa-miR-3913-3p	PAR-CLIP	23592263
MIRT474211	hsa-miR-190a-5p	PAR-CLIP	23592263
MIRT474210	hsa-miR-190b	PAR-CLIP	23592263
MIRT332417	hsa-miR-489-3p	PAR-CLIP	23592263
MIRT025431	hsa-miR-34a-5p	Luciferase reporter assay	26902416
MIRT025431	hsa-miR-34a-5p	Luciferase reporter assay	26902416
MIRT732042	hsa-miR-34a-3p	Luciferase reporter assay, qRT-PCR, Western blot	27186405
MIRT732042	hsa-miR-34a-3p	Luciferase reporter assay, qRT-PCR, Western blot	27186405
MIRT732042	hsa-miR-34a-3p	Luciferase reporter assay, qRT-PCR, Western blot	25333573
MIRT025431	hsa-miR-34a-5p	PAR-CLIP	26701625
MIRT025431	hsa-miR-34a-5p	PAR-CLIP	26701625
MIRT025431	hsa-miR-34a-5p	PAR-CLIP	26701625
MIRT025431	hsa-miR-34a-5p	PAR-CLIP	26701625
MIRT702292	hsa-miR-383-5p	Luciferase reporter assay, qRT-PCR	31637133
MIRT736695	hsa-miR-329-3p	Luciferase reporter assay, Western blotting, qRT-PCR	33058436
MIRT702292	hsa-miR-383-5p	HITS-CLIP	23313552
MIRT702295	hsa-miR-8080	HITS-CLIP	23313552
MIRT702294	hsa-miR-34b-3p	HITS-CLIP	23313552
MIRT702293	hsa-miR-577	HITS-CLIP	23313552
MIRT702292	hsa-miR-383-5p	HITS-CLIP	23313552
MIRT702291	hsa-miR-1288-5p	HITS-CLIP	23313552
MIRT702290	hsa-miR-302a-5p	HITS-CLIP	23313552
MIRT656755	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT656756	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT656754	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT656753	hsa-miR-4284	HITS-CLIP	23824327
MIRT054320	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT656752	hsa-miR-4713-3p	HITS-CLIP	23824327
MIRT656751	hsa-miR-638	HITS-CLIP	23824327
MIRT656750	hsa-miR-4654	HITS-CLIP	23824327
MIRT656749	hsa-miR-4769-5p	HITS-CLIP	23824327
MIRT656748	hsa-miR-8057	HITS-CLIP	23824327
MIRT656747	hsa-miR-450b-3p	HITS-CLIP	23824327
MIRT656746	hsa-miR-769-3p	HITS-CLIP	23824327
MIRT504908	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT504907	hsa-miR-5190	PAR-CLIP	23446348
MIRT504906	hsa-miR-1252-5p	PAR-CLIP	23446348
MIRT367770	hsa-miR-4670-3p	PAR-CLIP	23446348
MIRT367768	hsa-miR-505-5p	PAR-CLIP	23446348
MIRT504905	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504904	hsa-miR-4276	PAR-CLIP	23446348
MIRT265634	hsa-miR-4524b-3p	PAR-CLIP	23592263
MIRT332416	hsa-miR-425-5p	PAR-CLIP	23592263
MIRT265632	hsa-miR-4305	PAR-CLIP	23592263
MIRT265630	hsa-miR-203a-3p	PAR-CLIP	23592263
MIRT332419	hsa-miR-3913-3p	PAR-CLIP	23592263
MIRT474211	hsa-miR-190a-5p	PAR-CLIP	23592263
MIRT474210	hsa-miR-190b	PAR-CLIP	23592263
MIRT332417	hsa-miR-489-3p	PAR-CLIP	23592263
MIRT332417	hsa-miR-489-3p	Luciferase reporter assay, Western blotting, qRT-PCR	34868902
MIRT1106284	hsa-miR-105	CLIP-seq
MIRT1106285	hsa-miR-1243	CLIP-seq
MIRT1106286	hsa-miR-1261	CLIP-seq
MIRT1106287	hsa-miR-1265	CLIP-seq
MIRT1106288	hsa-miR-1269	CLIP-seq
MIRT1106289	hsa-miR-1269b	CLIP-seq
MIRT1106290	hsa-miR-1290	CLIP-seq
MIRT1106291	hsa-miR-134	CLIP-seq
MIRT1106292	hsa-miR-141	CLIP-seq
MIRT1106293	hsa-miR-1915	CLIP-seq
MIRT1106294	hsa-miR-200a	CLIP-seq
MIRT1106295	hsa-miR-297	CLIP-seq
MIRT1106296	hsa-miR-30a	CLIP-seq
MIRT1106297	hsa-miR-30b	CLIP-seq
MIRT1106298	hsa-miR-30c	CLIP-seq
MIRT1106299	hsa-miR-30d	CLIP-seq
MIRT1106300	hsa-miR-30e	CLIP-seq
MIRT1106301	hsa-miR-3118	CLIP-seq
MIRT1106302	hsa-miR-3120-3p	CLIP-seq
MIRT1106303	hsa-miR-3145-3p	CLIP-seq
MIRT1106304	hsa-miR-3148	CLIP-seq
MIRT1106305	hsa-miR-3149	CLIP-seq
MIRT1106306	hsa-miR-3153	CLIP-seq
MIRT1106307	hsa-miR-3164	CLIP-seq
MIRT1106308	hsa-miR-3167	CLIP-seq
MIRT1106309	hsa-miR-323-3p	CLIP-seq
MIRT1106310	hsa-miR-338-3p	CLIP-seq
MIRT1106311	hsa-miR-33a	CLIP-seq
MIRT1106312	hsa-miR-33b	CLIP-seq
MIRT1106313	hsa-miR-34a	CLIP-seq
MIRT1106314	hsa-miR-3614-5p	CLIP-seq
MIRT1106315	hsa-miR-3668	CLIP-seq
MIRT1106316	hsa-miR-374c	CLIP-seq
MIRT1106317	hsa-miR-377	CLIP-seq
MIRT1106318	hsa-miR-3935	CLIP-seq
MIRT1106319	hsa-miR-409-3p	CLIP-seq
MIRT1106320	hsa-miR-410	CLIP-seq
MIRT1106321	hsa-miR-4259	CLIP-seq
MIRT1106322	hsa-miR-4310	CLIP-seq
MIRT1106323	hsa-miR-449b	CLIP-seq
MIRT1106324	hsa-miR-4501	CLIP-seq
MIRT1106325	hsa-miR-4528	CLIP-seq
MIRT1106326	hsa-miR-4529-3p	CLIP-seq
MIRT1106327	hsa-miR-4530	CLIP-seq
MIRT1106328	hsa-miR-4646-5p	CLIP-seq
MIRT1106329	hsa-miR-4668-5p	CLIP-seq
MIRT1106330	hsa-miR-4688	CLIP-seq
MIRT1106331	hsa-miR-4709-3p	CLIP-seq
MIRT1106332	hsa-miR-4711-5p	CLIP-seq
MIRT1106333	hsa-miR-4715-5p	CLIP-seq
MIRT1106334	hsa-miR-4726-3p	CLIP-seq
MIRT1106335	hsa-miR-4731-3p	CLIP-seq
MIRT1106336	hsa-miR-4764-5p	CLIP-seq
MIRT1106337	hsa-miR-4781-3p	CLIP-seq
MIRT1106338	hsa-miR-4789-5p	CLIP-seq
MIRT1106339	hsa-miR-4801	CLIP-seq
MIRT1106340	hsa-miR-567	CLIP-seq
MIRT1106341	hsa-miR-655	CLIP-seq
MIRT1106342	hsa-miR-675	CLIP-seq
MIRT1106343	hsa-miR-876-5p	CLIP-seq
MIRT1106344	hsa-miR-890	CLIP-seq
MIRT1106284	hsa-miR-105	CLIP-seq
MIRT1106285	hsa-miR-1243	CLIP-seq
MIRT1106286	hsa-miR-1261	CLIP-seq
MIRT1106287	hsa-miR-1265	CLIP-seq
MIRT1106290	hsa-miR-1290	CLIP-seq
MIRT1106291	hsa-miR-134	CLIP-seq
MIRT1106345	hsa-miR-149	CLIP-seq
MIRT1106293	hsa-miR-1915	CLIP-seq
MIRT1106346	hsa-miR-24	CLIP-seq
MIRT1106295	hsa-miR-297	CLIP-seq
MIRT1106296	hsa-miR-30a	CLIP-seq
MIRT1106297	hsa-miR-30b	CLIP-seq
MIRT1106298	hsa-miR-30c	CLIP-seq
MIRT1106299	hsa-miR-30d	CLIP-seq
MIRT1106300	hsa-miR-30e	CLIP-seq
MIRT1106301	hsa-miR-3118	CLIP-seq
MIRT1106302	hsa-miR-3120-3p	CLIP-seq
MIRT1106303	hsa-miR-3145-3p	CLIP-seq
MIRT1106305	hsa-miR-3149	CLIP-seq
MIRT1106347	hsa-miR-3156-5p	CLIP-seq
MIRT1106307	hsa-miR-3164	CLIP-seq
MIRT1106308	hsa-miR-3167	CLIP-seq
MIRT1106309	hsa-miR-323-3p	CLIP-seq
MIRT1106311	hsa-miR-33a	CLIP-seq
MIRT1106312	hsa-miR-33b	CLIP-seq
MIRT1106313	hsa-miR-34a	CLIP-seq
MIRT1106348	hsa-miR-3617	CLIP-seq
MIRT1106315	hsa-miR-3668	CLIP-seq
MIRT1106349	hsa-miR-3680	CLIP-seq
MIRT1106318	hsa-miR-3935	CLIP-seq
MIRT1106321	hsa-miR-4259	CLIP-seq
MIRT1106322	hsa-miR-4310	CLIP-seq
MIRT1106323	hsa-miR-449b	CLIP-seq
MIRT1106324	hsa-miR-4501	CLIP-seq
MIRT1106325	hsa-miR-4528	CLIP-seq
MIRT1106350	hsa-miR-455-3p	CLIP-seq
MIRT1106328	hsa-miR-4646-5p	CLIP-seq
MIRT1106330	hsa-miR-4688	CLIP-seq
MIRT1106351	hsa-miR-4704-5p	CLIP-seq
MIRT1106333	hsa-miR-4715-5p	CLIP-seq
MIRT1106352	hsa-miR-4719	CLIP-seq
MIRT1106334	hsa-miR-4726-3p	CLIP-seq
MIRT1106336	hsa-miR-4764-5p	CLIP-seq
MIRT1106338	hsa-miR-4789-5p	CLIP-seq
MIRT1106353	hsa-miR-491-3p	CLIP-seq
MIRT1106354	hsa-miR-501-3p	CLIP-seq
MIRT1106355	hsa-miR-501-5p	CLIP-seq
MIRT1106356	hsa-miR-502-3p	CLIP-seq
MIRT1106357	hsa-miR-513b	CLIP-seq
MIRT1106340	hsa-miR-567	CLIP-seq
MIRT1106358	hsa-miR-641	CLIP-seq
MIRT1106342	hsa-miR-675	CLIP-seq
MIRT1106343	hsa-miR-876-5p	CLIP-seq
MIRT1106284	hsa-miR-105	CLIP-seq
MIRT1106290	hsa-miR-1290	CLIP-seq
MIRT1106345	hsa-miR-149	CLIP-seq
MIRT1106346	hsa-miR-24	CLIP-seq
MIRT1106296	hsa-miR-30a	CLIP-seq
MIRT1106297	hsa-miR-30b	CLIP-seq
MIRT1106298	hsa-miR-30c	CLIP-seq
MIRT1106299	hsa-miR-30d	CLIP-seq
MIRT1106300	hsa-miR-30e	CLIP-seq
MIRT1106302	hsa-miR-3120-3p	CLIP-seq
MIRT1550698	hsa-miR-3121-5p	CLIP-seq
MIRT1106347	hsa-miR-3156-5p	CLIP-seq
MIRT1106308	hsa-miR-3167	CLIP-seq
MIRT1106310	hsa-miR-338-3p	CLIP-seq
MIRT1106348	hsa-miR-3617	CLIP-seq
MIRT1550699	hsa-miR-3691-5p	CLIP-seq
MIRT1106322	hsa-miR-4310	CLIP-seq
MIRT1106327	hsa-miR-4530	CLIP-seq
MIRT1106330	hsa-miR-4688	CLIP-seq
MIRT1106332	hsa-miR-4711-5p	CLIP-seq
MIRT1106352	hsa-miR-4719	CLIP-seq
MIRT1106335	hsa-miR-4731-3p	CLIP-seq
MIRT1550700	hsa-miR-4752	CLIP-seq
MIRT1106339	hsa-miR-4801	CLIP-seq
MIRT1106353	hsa-miR-491-3p	CLIP-seq
MIRT1106354	hsa-miR-501-3p	CLIP-seq
MIRT1106355	hsa-miR-501-5p	CLIP-seq
MIRT1106356	hsa-miR-502-3p	CLIP-seq
MIRT1106357	hsa-miR-513b	CLIP-seq
MIRT1550701	hsa-miR-520d-5p	CLIP-seq
MIRT1550702	hsa-miR-524-5p	CLIP-seq
MIRT1106358	hsa-miR-641	CLIP-seq
MIRT1550703	hsa-miR-7	CLIP-seq
MIRT1106343	hsa-miR-876-5p	CLIP-seq
MIRT1106284	hsa-miR-105	CLIP-seq
MIRT1106285	hsa-miR-1243	CLIP-seq
MIRT2029418	hsa-miR-1252	CLIP-seq
MIRT1106287	hsa-miR-1265	CLIP-seq
MIRT1106288	hsa-miR-1269	CLIP-seq
MIRT1106289	hsa-miR-1269b	CLIP-seq
MIRT1106290	hsa-miR-1290	CLIP-seq
MIRT1106291	hsa-miR-134	CLIP-seq
MIRT1106345	hsa-miR-149	CLIP-seq
MIRT1106293	hsa-miR-1915	CLIP-seq
MIRT2029419	hsa-miR-219-1-3p	CLIP-seq
MIRT1106346	hsa-miR-24	CLIP-seq
MIRT1106296	hsa-miR-30a	CLIP-seq
MIRT1106297	hsa-miR-30b	CLIP-seq
MIRT1106298	hsa-miR-30c	CLIP-seq
MIRT1106299	hsa-miR-30d	CLIP-seq
MIRT1106300	hsa-miR-30e	CLIP-seq
MIRT1106301	hsa-miR-3118	CLIP-seq
MIRT1106302	hsa-miR-3120-3p	CLIP-seq
MIRT1550698	hsa-miR-3121-5p	CLIP-seq
MIRT1106303	hsa-miR-3145-3p	CLIP-seq
MIRT1106304	hsa-miR-3148	CLIP-seq
MIRT1106306	hsa-miR-3153	CLIP-seq
MIRT1106347	hsa-miR-3156-5p	CLIP-seq
MIRT1106307	hsa-miR-3164	CLIP-seq
MIRT1106308	hsa-miR-3167	CLIP-seq
MIRT1106310	hsa-miR-338-3p	CLIP-seq
MIRT1106313	hsa-miR-34a	CLIP-seq
MIRT1106348	hsa-miR-3617	CLIP-seq
MIRT1106349	hsa-miR-3680	CLIP-seq
MIRT1550699	hsa-miR-3691-5p	CLIP-seq
MIRT1106316	hsa-miR-374c	CLIP-seq
MIRT1106317	hsa-miR-377	CLIP-seq
MIRT1106319	hsa-miR-409-3p	CLIP-seq
MIRT1106320	hsa-miR-410	CLIP-seq
MIRT1106321	hsa-miR-4259	CLIP-seq
MIRT2029420	hsa-miR-4263	CLIP-seq
MIRT1106322	hsa-miR-4310	CLIP-seq
MIRT2029421	hsa-miR-4433	CLIP-seq
MIRT2029422	hsa-miR-4459	CLIP-seq
MIRT1106323	hsa-miR-449b	CLIP-seq
MIRT1106324	hsa-miR-4501	CLIP-seq
MIRT1106326	hsa-miR-4529-3p	CLIP-seq
MIRT1106327	hsa-miR-4530	CLIP-seq
MIRT1106328	hsa-miR-4646-5p	CLIP-seq
MIRT1106329	hsa-miR-4668-5p	CLIP-seq
MIRT1106330	hsa-miR-4688	CLIP-seq
MIRT1106331	hsa-miR-4709-3p	CLIP-seq
MIRT1106332	hsa-miR-4711-5p	CLIP-seq
MIRT1106333	hsa-miR-4715-5p	CLIP-seq
MIRT1106334	hsa-miR-4726-3p	CLIP-seq
MIRT1106335	hsa-miR-4731-3p	CLIP-seq
MIRT1550700	hsa-miR-4752	CLIP-seq
MIRT1106336	hsa-miR-4764-5p	CLIP-seq
MIRT2029423	hsa-miR-4768-3p	CLIP-seq
MIRT1106337	hsa-miR-4781-3p	CLIP-seq
MIRT1106338	hsa-miR-4789-5p	CLIP-seq
MIRT1106339	hsa-miR-4801	CLIP-seq
MIRT1106353	hsa-miR-491-3p	CLIP-seq
MIRT1106354	hsa-miR-501-3p	CLIP-seq
MIRT1106355	hsa-miR-501-5p	CLIP-seq
MIRT1106356	hsa-miR-502-3p	CLIP-seq
MIRT1550701	hsa-miR-520d-5p	CLIP-seq
MIRT1550702	hsa-miR-524-5p	CLIP-seq
MIRT2029424	hsa-miR-576-5p	CLIP-seq
MIRT1106358	hsa-miR-641	CLIP-seq
MIRT1106341	hsa-miR-655	CLIP-seq
MIRT1106342	hsa-miR-675	CLIP-seq
MIRT1550703	hsa-miR-7	CLIP-seq
MIRT1106343	hsa-miR-876-5p	CLIP-seq
MIRT1106284	hsa-miR-105	CLIP-seq
MIRT2029418	hsa-miR-1252	CLIP-seq
MIRT1106286	hsa-miR-1261	CLIP-seq
MIRT1106288	hsa-miR-1269	CLIP-seq
MIRT1106289	hsa-miR-1269b	CLIP-seq
MIRT2260265	hsa-miR-1275	CLIP-seq
MIRT1106290	hsa-miR-1290	CLIP-seq
MIRT1106292	hsa-miR-141	CLIP-seq
MIRT1106345	hsa-miR-149	CLIP-seq
MIRT1106294	hsa-miR-200a	CLIP-seq
MIRT1106346	hsa-miR-24	CLIP-seq
MIRT1106302	hsa-miR-3120-3p	CLIP-seq
MIRT1550698	hsa-miR-3121-5p	CLIP-seq
MIRT1106303	hsa-miR-3145-3p	CLIP-seq
MIRT1106304	hsa-miR-3148	CLIP-seq
MIRT1106306	hsa-miR-3153	CLIP-seq
MIRT1106347	hsa-miR-3156-5p	CLIP-seq
MIRT1106308	hsa-miR-3167	CLIP-seq
MIRT1106310	hsa-miR-338-3p	CLIP-seq
MIRT1106313	hsa-miR-34a	CLIP-seq
MIRT1106314	hsa-miR-3614-5p	CLIP-seq
MIRT1106348	hsa-miR-3617	CLIP-seq
MIRT1106349	hsa-miR-3680	CLIP-seq
MIRT1550699	hsa-miR-3691-5p	CLIP-seq
MIRT1106316	hsa-miR-374c	CLIP-seq
MIRT1106317	hsa-miR-377	CLIP-seq
MIRT1106319	hsa-miR-409-3p	CLIP-seq
MIRT1106320	hsa-miR-410	CLIP-seq
MIRT1106321	hsa-miR-4259	CLIP-seq
MIRT1106322	hsa-miR-4310	CLIP-seq
MIRT1106323	hsa-miR-449b	CLIP-seq
MIRT1106326	hsa-miR-4529-3p	CLIP-seq
MIRT1106327	hsa-miR-4530	CLIP-seq
MIRT1106328	hsa-miR-4646-5p	CLIP-seq
MIRT2260266	hsa-miR-4665-5p	CLIP-seq
MIRT1106329	hsa-miR-4668-5p	CLIP-seq
MIRT1106330	hsa-miR-4688	CLIP-seq
MIRT1106331	hsa-miR-4709-3p	CLIP-seq
MIRT1106332	hsa-miR-4711-5p	CLIP-seq
MIRT1106333	hsa-miR-4715-5p	CLIP-seq
MIRT1106335	hsa-miR-4731-3p	CLIP-seq
MIRT1550700	hsa-miR-4752	CLIP-seq
MIRT1106337	hsa-miR-4781-3p	CLIP-seq
MIRT1106339	hsa-miR-4801	CLIP-seq
MIRT1106353	hsa-miR-491-3p	CLIP-seq
MIRT1106354	hsa-miR-501-3p	CLIP-seq
MIRT1106355	hsa-miR-501-5p	CLIP-seq
MIRT1106356	hsa-miR-502-3p	CLIP-seq
MIRT1106358	hsa-miR-641	CLIP-seq
MIRT1106341	hsa-miR-655	CLIP-seq
MIRT1106342	hsa-miR-675	CLIP-seq
MIRT1550703	hsa-miR-7	CLIP-seq
MIRT1106343	hsa-miR-876-5p	CLIP-seq
MIRT1106344	hsa-miR-890	CLIP-seq
MIRT2260265	hsa-miR-1275	CLIP-seq
MIRT1106310	hsa-miR-338-3p	CLIP-seq
MIRT1106316	hsa-miR-374c	CLIP-seq
MIRT1106321	hsa-miR-4259	CLIP-seq
MIRT1106327	hsa-miR-4530	CLIP-seq
MIRT2260266	hsa-miR-4665-5p	CLIP-seq
MIRT1106332	hsa-miR-4711-5p	CLIP-seq
MIRT1106333	hsa-miR-4715-5p	CLIP-seq
MIRT1106335	hsa-miR-4731-3p	CLIP-seq
MIRT1106339	hsa-miR-4801	CLIP-seq
MIRT1106341	hsa-miR-655	CLIP-seq
MIRT1106290	hsa-miR-1290	CLIP-seq
MIRT1550698	hsa-miR-3121-5p	CLIP-seq
MIRT1106303	hsa-miR-3145-3p	CLIP-seq
MIRT1106347	hsa-miR-3156-5p	CLIP-seq
MIRT1106308	hsa-miR-3167	CLIP-seq
MIRT1106348	hsa-miR-3617	CLIP-seq
MIRT1106352	hsa-miR-4719	CLIP-seq
MIRT1106353	hsa-miR-491-3p	CLIP-seq
MIRT1106354	hsa-miR-501-3p	CLIP-seq
MIRT1106355	hsa-miR-501-5p	CLIP-seq
MIRT1106356	hsa-miR-502-3p	CLIP-seq
MIRT1106357	hsa-miR-513b	CLIP-seq
MIRT1106358	hsa-miR-641	CLIP-seq
MIRT1550703	hsa-miR-7	CLIP-seq
MIRT1106343	hsa-miR-876-5p	CLIP-seq
MIRT1106284	hsa-miR-105	CLIP-seq
MIRT2029418	hsa-miR-1252	CLIP-seq
MIRT1106288	hsa-miR-1269	CLIP-seq
MIRT1106289	hsa-miR-1269b	CLIP-seq
MIRT1106290	hsa-miR-1290	CLIP-seq
MIRT1106345	hsa-miR-149	CLIP-seq
MIRT1106346	hsa-miR-24	CLIP-seq
MIRT1106296	hsa-miR-30a	CLIP-seq
MIRT1106297	hsa-miR-30b	CLIP-seq
MIRT1106298	hsa-miR-30c	CLIP-seq
MIRT1106299	hsa-miR-30d	CLIP-seq
MIRT1106300	hsa-miR-30e	CLIP-seq
MIRT1106302	hsa-miR-3120-3p	CLIP-seq
MIRT1550698	hsa-miR-3121-5p	CLIP-seq
MIRT1106303	hsa-miR-3145-3p	CLIP-seq
MIRT1106304	hsa-miR-3148	CLIP-seq
MIRT1106306	hsa-miR-3153	CLIP-seq
MIRT1106347	hsa-miR-3156-5p	CLIP-seq
MIRT1106308	hsa-miR-3167	CLIP-seq
MIRT1106310	hsa-miR-338-3p	CLIP-seq
MIRT1106313	hsa-miR-34a	CLIP-seq
MIRT1106348	hsa-miR-3617	CLIP-seq
MIRT1106349	hsa-miR-3680	CLIP-seq
MIRT1550699	hsa-miR-3691-5p	CLIP-seq
MIRT1106316	hsa-miR-374c	CLIP-seq
MIRT1106317	hsa-miR-377	CLIP-seq
MIRT1106319	hsa-miR-409-3p	CLIP-seq
MIRT1106320	hsa-miR-410	CLIP-seq
MIRT1106322	hsa-miR-4310	CLIP-seq
MIRT1106323	hsa-miR-449b	CLIP-seq
MIRT1106326	hsa-miR-4529-3p	CLIP-seq
MIRT1106327	hsa-miR-4530	CLIP-seq
MIRT1106328	hsa-miR-4646-5p	CLIP-seq
MIRT1106329	hsa-miR-4668-5p	CLIP-seq
MIRT1106330	hsa-miR-4688	CLIP-seq
MIRT1106331	hsa-miR-4709-3p	CLIP-seq
MIRT1106332	hsa-miR-4711-5p	CLIP-seq
MIRT1106352	hsa-miR-4719	CLIP-seq
MIRT1106335	hsa-miR-4731-3p	CLIP-seq
MIRT1550700	hsa-miR-4752	CLIP-seq
MIRT1106337	hsa-miR-4781-3p	CLIP-seq
MIRT1106338	hsa-miR-4789-5p	CLIP-seq
MIRT1106339	hsa-miR-4801	CLIP-seq
MIRT1106353	hsa-miR-491-3p	CLIP-seq
MIRT1106354	hsa-miR-501-3p	CLIP-seq
MIRT1106355	hsa-miR-501-5p	CLIP-seq
MIRT1106356	hsa-miR-502-3p	CLIP-seq
MIRT1106357	hsa-miR-513b	CLIP-seq
MIRT1550701	hsa-miR-520d-5p	CLIP-seq
MIRT1550702	hsa-miR-524-5p	CLIP-seq
MIRT1106358	hsa-miR-641	CLIP-seq
MIRT1106341	hsa-miR-655	CLIP-seq
MIRT1106342	hsa-miR-675	CLIP-seq
MIRT1550703	hsa-miR-7	CLIP-seq
MIRT1106343	hsa-miR-876-5p	CLIP-seq
MIRT1106284	hsa-miR-105	CLIP-seq
MIRT2029418	hsa-miR-1252	CLIP-seq
MIRT1106288	hsa-miR-1269	CLIP-seq
MIRT1106289	hsa-miR-1269b	CLIP-seq
MIRT1106290	hsa-miR-1290	CLIP-seq
MIRT1106345	hsa-miR-149	CLIP-seq
MIRT1106346	hsa-miR-24	CLIP-seq
MIRT1106296	hsa-miR-30a	CLIP-seq
MIRT1106297	hsa-miR-30b	CLIP-seq
MIRT1106298	hsa-miR-30c	CLIP-seq
MIRT1106299	hsa-miR-30d	CLIP-seq
MIRT1106300	hsa-miR-30e	CLIP-seq
MIRT1106302	hsa-miR-3120-3p	CLIP-seq
MIRT1550698	hsa-miR-3121-5p	CLIP-seq
MIRT1106303	hsa-miR-3145-3p	CLIP-seq
MIRT1106304	hsa-miR-3148	CLIP-seq
MIRT1106306	hsa-miR-3153	CLIP-seq
MIRT1106347	hsa-miR-3156-5p	CLIP-seq
MIRT1106308	hsa-miR-3167	CLIP-seq
MIRT1106310	hsa-miR-338-3p	CLIP-seq
MIRT1106313	hsa-miR-34a	CLIP-seq
MIRT1106348	hsa-miR-3617	CLIP-seq
MIRT1106349	hsa-miR-3680	CLIP-seq
MIRT1550699	hsa-miR-3691-5p	CLIP-seq
MIRT1106316	hsa-miR-374c	CLIP-seq
MIRT1106317	hsa-miR-377	CLIP-seq
MIRT1106319	hsa-miR-409-3p	CLIP-seq
MIRT1106320	hsa-miR-410	CLIP-seq
MIRT2029420	hsa-miR-4263	CLIP-seq
MIRT1106322	hsa-miR-4310	CLIP-seq
MIRT1106323	hsa-miR-449b	CLIP-seq
MIRT1106326	hsa-miR-4529-3p	CLIP-seq
MIRT1106327	hsa-miR-4530	CLIP-seq
MIRT1106328	hsa-miR-4646-5p	CLIP-seq
MIRT1106329	hsa-miR-4668-5p	CLIP-seq
MIRT1106330	hsa-miR-4688	CLIP-seq
MIRT1106331	hsa-miR-4709-3p	CLIP-seq
MIRT1106332	hsa-miR-4711-5p	CLIP-seq
MIRT1106352	hsa-miR-4719	CLIP-seq
MIRT1106335	hsa-miR-4731-3p	CLIP-seq
MIRT1550700	hsa-miR-4752	CLIP-seq
MIRT1106337	hsa-miR-4781-3p	CLIP-seq
MIRT1106338	hsa-miR-4789-5p	CLIP-seq
MIRT1106339	hsa-miR-4801	CLIP-seq
MIRT1106353	hsa-miR-491-3p	CLIP-seq
MIRT1106354	hsa-miR-501-3p	CLIP-seq
MIRT1106355	hsa-miR-501-5p	CLIP-seq
MIRT1106356	hsa-miR-502-3p	CLIP-seq
MIRT1106357	hsa-miR-513b	CLIP-seq
MIRT1550701	hsa-miR-520d-5p	CLIP-seq
MIRT1550702	hsa-miR-524-5p	CLIP-seq
MIRT2029424	hsa-miR-576-5p	CLIP-seq
MIRT1106358	hsa-miR-641	CLIP-seq
MIRT1106341	hsa-miR-655	CLIP-seq
MIRT1106342	hsa-miR-675	CLIP-seq
MIRT1550703	hsa-miR-7	CLIP-seq
MIRT1106343	hsa-miR-876-5p	CLIP-seq

Transcription factors

Show/Hide all(6)

Transcription factor	Regulation	Reference
ATF1	Unknown	9632793
HIF1A	Activation	8955077
HSF1	Activation	19668225
JUN	Activation	9723176
MYC	Activation	9723176
SP1	Activation	9723176

Show/Hide all(24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001666	Process	Response to hypoxia	IEA
GO:0004459	Function	L-lactate dehydrogenase activity	IBA	21873635
GO:0004459	Function	L-lactate dehydrogenase activity	NAS	1953713
GO:0005515	Function	Protein binding	IPI	21988832, 23523103, 28514442, 31515488
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005829	Component	Cytosol	TAS
GO:0006089	Process	Lactate metabolic process	IEA
GO:0006090	Process	Pyruvate metabolic process	TAS
GO:0006096	Process	Glycolytic process	NAS	1953713
GO:0007584	Process	Response to nutrient	IEA
GO:0009749	Process	Response to glucose	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0019674	Process	NAD metabolic process	IEA
GO:0019900	Function	Kinase binding	IEA
GO:0042493	Process	Response to drug	IEA
GO:0042542	Process	Response to hydrogen peroxide	IEA
GO:0042802	Function	Identical protein binding	IPI	21988832, 25502805, 31515488
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0043627	Process	Response to estrogen	IEA
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0048569	Process	Post-embryonic animal organ development	IEA
GO:0051287	Function	NAD binding	IEA
GO:0051591	Process	Response to cAMP	IEA
GO:0070062	Component	Extracellular exosome	HDA	11487543, 19056867, 20458337, 23533145

MIM	HGNC	e!Ensembl
150000	6535	ENSG00000134333

Protein

UniProt ID

P00338

Protein name

L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59)

Protein function

Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).

PDB

1I10 , 4AJP , 4JNK , 4L4R , 4L4S , 4M49 , 4OJN , 4OKN , 4QO7 , 4QO8 , 4QSM , 4QT0 , 4R68 , 4R69 , 4RLS , 4ZVV , 5IXS , 5IXY , 5W8H , 5W8I , 5W8J , 5W8K , 5W8L , 5ZJD , 5ZJE , 5ZJF , 6BAD , 6BAG , 6BAX , 6BAZ , 6BB0 , 6BB1 , 6BB2 , 6BB3 , 6MV8 , 6MVA , 6Q0D , 6Q13 , 6SBU , 6SBV , 6ZZR , 7M2N , 8FW6 , 9BK2 , 9BK3

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00056	Ldh_1_N	21 → 160	lactate/malate dehydrogenase, NAD binding domain	Family
PF02866	Ldh_1_C	163 → 331	lactate/malate dehydrogenase, alpha/beta C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed in anaerobic tissues such as skeletal muscle and liver. {ECO:0000305|PubMed:11276087}.

Sequence

MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
SDLVKVTLTSEEEARLKKSADTLWGIQKELQF

Sequence length

332

Interactions

View interactions

	KEGG		Reactome
	Glycolysis / Gluconeogenesis Cysteine and methionine metabolism Pyruvate metabolism Propanoate metabolism Metabolic pathways HIF-1 signaling pathway Glucagon signaling pathway Central carbon metabolism in cancer		Pyruvate metabolism

Show/Hide Causal Diseases (5)

Disease term	Disease name	dbSNP ID	References
Causal
Cardiomyopathy	Cardiomyopathies, Primary, Cardiomyopathies	rs267607003, rs267607002, rs267607004, rs63750743, rs121908333, rs121908334, rs104894655, rs121434420, rs121434421, rs193922674, rs111517471, rs121908987, rs193922384, rs121909374, rs121909377 View all (900 more)	15231041
Glycogen storage disease	Glycogen Storage Disease, Glycogen storage disease due to lactate dehydrogenase M-subunit deficiency	rs10250779, rs387906244, rs113994126, rs113994129, rs113994134, rs369973784, rs199922945, rs118203964, rs113994132, rs387906246, rs113994128, rs267606639, rs267606640, rs755419857, rs895690691 View all (721 more)	27604308, 6517049
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370 View all (5 more)	27602772
Pancreatic cancer	Malignant neoplasm of pancreas	rs118203998, rs180177143, rs587776417, rs587776527, rs864622498, rs876659571, rs587778587, rs886039619, rs745533713, rs1555460431	29384525
Renal insufficiency	Renal Insufficiency	rs1596536873

Show/Hide Unknown Diseases (2)

Disease term	Disease name	References	Source
Unknown
Mental depression	Mental Depression, Unipolar Depression, Major Depressive Disorder	23333658	ClinVar
Myocardial infarction	Myocardial Infarction	3279722	ClinVar

Show/Hide Text Mining Associations (111)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma	Associate	29170050
Adenocarcinoma of Lung	Associate	25342384, 33287749, 34323652, 35325730, 35733175, 36564744, 37965333, 38594917
Altitude Sickness	Associate	39173139
Arthritis Psoriatic	Associate	36292720
Arthritis Rheumatoid	Associate	34403518, 37973217
Astrocytoma	Associate	14578171
Ataxia Telangiectasia	Associate	34637921
Bone Resorption	Associate	37973217
Brain Neoplasms	Associate	32372141
Breast Neoplasms	Associate	20144215, 25575825, 28314283, 28729678, 30618169, 30878502, 31903982, 33353120, 33626175, 34625424, 36418319, 36737428
Burkitt Lymphoma	Associate	26312753
Burns	Associate	25844669
Carcinogenesis	Associate	22961700, 25048361, 25838393, 37684649
Carcinoma Hepatocellular	Associate	26506419, 28325773, 30755064, 32084009, 32572027, 33289700, 33407546, 33771191, 33880589, 35286894, 36033372, 36157928, 37567069, 38025761
Carcinoma Non Small Cell Lung	Associate	25342384, 28800787, 29321091, 30368888, 32463461, 33902615, 36628612, 37730658
Carcinoma Renal Cell	Associate	24504108, 24885701, 35525866, 37547725, 37925501
Cardiomyopathies	Associate	37750583
Cholangiocarcinoma	Associate	24679073
Chondrosarcoma	Stimulate	24748236
Chronic Disease	Associate	34975312
Colorectal Neoplasms	Associate	33994363, 34110068, 34791830, 35832094, 36071678, 36923931, 37406987, 37626036, 38548218
COVID 19	Associate	33936072, 35733175
Death	Associate	37326348
Dermatitis	Associate	36292720
Diabetes Mellitus	Stimulate	33276040
Diabetes Mellitus Type 1	Associate	33572095
Diabetes Mellitus Type 2	Stimulate	34217973
Diabetes Mellitus Type 2	Associate	37406987
Diabetic Cardiomyopathies	Associate	30246236
Drug Related Side Effects and Adverse Reactions	Inhibit	32360863
Endometrial Neoplasms	Associate	21305022, 31298316
Endometriosis	Associate	24796928, 34278456
Erectile Dysfunction	Associate	38111702
Esophageal Neoplasms	Associate	27239113, 36555705
Esophageal Squamous Cell Carcinoma	Associate	22961700, 30861255, 35703190
Fibrocartilaginous embolism	Associate	34222486
Flatfoot	Associate	35197508
Gastrointestinal Stromal Tumors	Associate	26509967
Glioblastoma	Associate	26694942, 32611766, 40093910
Glioma	Associate	24223867, 27374173, 31187466, 31665443
Glioma	Inhibit	27437179
Glycogen Storage Disease	Associate	36292720
Growth Disorders	Associate	32877669
Heart Diseases	Associate	37750583
Heart Failure	Associate	32877669
Hematoma	Associate	21409457
Hodgkin Disease	Associate	23228169
Hyperoxaluria Primary	Associate	37118061
Hypoxia	Stimulate	21409457, 21632858, 28193910, 30886157, 34278456, 36157928, 36656644
Hypoxia	Associate	21984181, 23419171, 24344305, 26059435, 29426376, 30165351, 31078780, 31554233, 32316196, 33300073, 34637697, 34853621, 35789607, 37067635, 37277450 View all (4 more)
Hypoxia	Inhibit	24275138
Hypoxia Brain	Associate	25880801, 26059435, 28590414, 37277450
Idiopathic Pulmonary Fibrosis	Associate	34711218, 36870568, 37653539
Infections	Associate	35197508
Inflammation	Associate	35197508, 37684649, 37852977
Intervertebral Disc Degeneration	Associate	34222486
Iron Overload	Associate	32877669
Kidney Diseases	Associate	34456629
Lactate dehydrogenase deficiency type A	Associate	36292720
Laryngeal Neoplasms	Associate	28269752
Leiomyosarcoma	Associate	29620641
Leukemia Myeloid Acute	Associate	31298387
Leukoplakia	Stimulate	36776920
Lichen Planus	Stimulate	34672419
Liver Cirrhosis	Associate	30744642
Lung Neoplasms	Associate	25838393, 37965333
Lymphatic Metastasis	Associate	21319141, 33962616
Lymphatic Metastasis	Stimulate	33677931
Lymphoma B Cell	Associate	29444941
Lymphoma Non Hodgkin	Stimulate	29170050
Melanoma	Associate	37684649
Mouth Diseases	Stimulate	34278456
Mouth Neoplasms	Associate	31638999
Multiple Myeloma	Associate	23321518, 26545722
Muscular Diseases	Associate	36292720
Myelodysplastic Syndromes	Associate	37852977
Myoclonic Epilepsies Progressive	Associate	23228169
Myoma	Associate	29620641
Nasopharyngeal Carcinoma	Associate	28693517, 32679194, 33102573
Necrosis	Stimulate	28710417
Neoplasm Metastasis	Associate	25342384, 26021472, 28693517, 31298316, 33795650, 37875474
Neoplasms	Associate	16948864, 19033423, 21177384, 22961700, 23228169, 23516535, 24679073, 25266796, 25838393, 25880801, 25913622, 25983002, 26021472, 26261559, 26509967 View all (39 more)
Neoplasms	Stimulate	28729678, 33795650, 35191522, 36776920
Nerve Degeneration	Associate	34222486
Neuroblastoma	Associate	27919448
Osteoporosis	Associate	37973217
Ovarian Neoplasms	Associate	29866066, 34919531, 38583177
Pancreatic Neoplasms	Associate	26021472, 26989901, 28193910, 29170050, 34632851, 34660806, 35789607, 36937004, 37277450, 37875474
Pancreatic Neoplasms	Stimulate	37391503
Papillomavirus Infections	Stimulate	35615882
Personality Disorders	Associate	26989901, 31665443
Plaque Atherosclerotic	Inhibit	27775792
Precancerous Conditions	Associate	26989901
Prostatic Neoplasms	Associate	24714743, 25983002, 29891507, 35242214, 35278714, 35571619
Psoriasis	Associate	36292720
Pulmonary Arterial Hypertension	Associate	35145193
Sarcoma	Associate	16948864, 29620641
Sepsis	Inhibit	35090526
Severe Combined Immunodeficiency Autosomal Recessive T Cell Negative B Cell Positive NK Cell Positive	Associate	36937004
Squamous Cell Carcinoma of Head and Neck	Associate	25048361, 34463208, 34768921, 37194791, 37365531, 37762374
Stomach Neoplasms	Associate	20699381, 26261559, 30165351, 34455762
Thyroid Cancer Papillary	Associate	25880801, 33677931, 33795650, 37031273, 37750019
Thyroid Neoplasms	Associate	25880801, 30768848, 33677931, 37864896
Thyroiditis	Associate	33677931
Triple Negative Breast Neoplasms	Associate	28729678, 32350346, 34440660
Tuberculosis	Associate	35197508
Urethral Neoplasms	Associate	34181805
Urinary Bladder Neoplasms	Associate	25266796, 26733163, 30864733, 34181805
Uterine Cervical Dysplasia	Associate	35615882
Uterine Cervical Neoplasms	Associate	33645623, 35615882, 36894874, 37326348
Uterine Cervical Neoplasms	Stimulate	35191522

LDHA (lactate dehydrogenase A)