Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	3936
Gene name	Lymphocyte cytosolic protein 1
Gene symbol	LCP1
Synonyms (NCBI Gene)	CP64HEL-S-37L-PLASTINLC64PLPLPLS2
Chromosome	13
Chromosome location	13q14.13
Summary	Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as

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miRTarBase ID	miRNA	Experiments	Reference
MIRT023871	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT041160	hsa-miR-520a-3p	CLASH	23622248
MIRT727320	hsa-miR-30a-5p	HITS-CLIP	22473208
MIRT727319	hsa-miR-30b-5p	HITS-CLIP	22473208
MIRT727317	hsa-miR-30c-5p	HITS-CLIP	22473208
MIRT727318	hsa-miR-30d-5p	HITS-CLIP	22473208
MIRT727316	hsa-miR-30e-5p	HITS-CLIP	22473208
MIRT1106097	hsa-miR-101	CLIP-seq
MIRT1106098	hsa-miR-1184	CLIP-seq
MIRT1106099	hsa-miR-1207-5p	CLIP-seq
MIRT1106100	hsa-miR-1238	CLIP-seq
MIRT1106101	hsa-miR-124	CLIP-seq
MIRT1106102	hsa-miR-1273f	CLIP-seq
MIRT1106103	hsa-miR-127-5p	CLIP-seq
MIRT1106104	hsa-miR-1279	CLIP-seq
MIRT1106105	hsa-miR-1301	CLIP-seq
MIRT1106106	hsa-miR-1321	CLIP-seq
MIRT1106107	hsa-miR-1323	CLIP-seq
MIRT1106108	hsa-miR-139-5p	CLIP-seq
MIRT1106109	hsa-miR-144	CLIP-seq
MIRT1106110	hsa-miR-1827	CLIP-seq
MIRT1106111	hsa-miR-197	CLIP-seq
MIRT1106112	hsa-miR-2467-5p	CLIP-seq
MIRT1106113	hsa-miR-2682	CLIP-seq
MIRT1106114	hsa-miR-302f	CLIP-seq
MIRT1106115	hsa-miR-3134	CLIP-seq
MIRT1106116	hsa-miR-3136-3p	CLIP-seq
MIRT1106117	hsa-miR-3136-5p	CLIP-seq
MIRT1106118	hsa-miR-3143	CLIP-seq
MIRT1106119	hsa-miR-3145-5p	CLIP-seq
MIRT1106120	hsa-miR-3148	CLIP-seq
MIRT1106121	hsa-miR-3149	CLIP-seq
MIRT1106122	hsa-miR-3152-5p	CLIP-seq
MIRT1106123	hsa-miR-3159	CLIP-seq
MIRT1106124	hsa-miR-3185	CLIP-seq
MIRT1106125	hsa-miR-3188	CLIP-seq
MIRT1106126	hsa-miR-3189-3p	CLIP-seq
MIRT1106127	hsa-miR-3200-5p	CLIP-seq
MIRT1106128	hsa-miR-320e	CLIP-seq
MIRT1106129	hsa-miR-331-3p	CLIP-seq
MIRT1106130	hsa-miR-3612	CLIP-seq
MIRT1106131	hsa-miR-362-5p	CLIP-seq
MIRT1106132	hsa-miR-3677-5p	CLIP-seq
MIRT1106133	hsa-miR-3691-3p	CLIP-seq
MIRT1106134	hsa-miR-3714	CLIP-seq
MIRT1106135	hsa-miR-377	CLIP-seq
MIRT1106136	hsa-miR-3908	CLIP-seq
MIRT1106137	hsa-miR-3910	CLIP-seq
MIRT1106138	hsa-miR-3975	CLIP-seq
MIRT1106139	hsa-miR-3978	CLIP-seq
MIRT1106140	hsa-miR-409-3p	CLIP-seq
MIRT1106141	hsa-miR-4254	CLIP-seq
MIRT1106142	hsa-miR-4308	CLIP-seq
MIRT1106143	hsa-miR-4418	CLIP-seq
MIRT1106144	hsa-miR-4439	CLIP-seq
MIRT1106145	hsa-miR-4476	CLIP-seq
MIRT1106146	hsa-miR-4477a	CLIP-seq
MIRT1106147	hsa-miR-449c	CLIP-seq
MIRT1106148	hsa-miR-4513	CLIP-seq
MIRT1106149	hsa-miR-4534	CLIP-seq
MIRT1106150	hsa-miR-4633-3p	CLIP-seq
MIRT1106151	hsa-miR-4646-3p	CLIP-seq
MIRT1106152	hsa-miR-4649-3p	CLIP-seq
MIRT1106153	hsa-miR-4653-3p	CLIP-seq
MIRT1106154	hsa-miR-4660	CLIP-seq
MIRT1106155	hsa-miR-4662a-5p	CLIP-seq
MIRT1106156	hsa-miR-4678	CLIP-seq
MIRT1106157	hsa-miR-4739	CLIP-seq
MIRT1106158	hsa-miR-4753-3p	CLIP-seq
MIRT1106159	hsa-miR-4756-5p	CLIP-seq
MIRT1106160	hsa-miR-4763-3p	CLIP-seq
MIRT1106161	hsa-miR-4777-5p	CLIP-seq
MIRT1106162	hsa-miR-4786-3p	CLIP-seq
MIRT1106163	hsa-miR-485-5p	CLIP-seq
MIRT1106164	hsa-miR-500b	CLIP-seq
MIRT1106165	hsa-miR-501-5p	CLIP-seq
MIRT1106166	hsa-miR-5047	CLIP-seq
MIRT1106167	hsa-miR-506	CLIP-seq
MIRT1106168	hsa-miR-509-3-5p	CLIP-seq
MIRT1106169	hsa-miR-509-5p	CLIP-seq
MIRT1106170	hsa-miR-5096	CLIP-seq
MIRT1106171	hsa-miR-543	CLIP-seq
MIRT1106172	hsa-miR-548aa	CLIP-seq
MIRT1106173	hsa-miR-548o	CLIP-seq
MIRT1106174	hsa-miR-548v	CLIP-seq
MIRT1106175	hsa-miR-579	CLIP-seq
MIRT1106176	hsa-miR-586	CLIP-seq
MIRT1106177	hsa-miR-603	CLIP-seq
MIRT1106178	hsa-miR-619	CLIP-seq
MIRT1106179	hsa-miR-625	CLIP-seq
MIRT1106180	hsa-miR-650	CLIP-seq
MIRT1106181	hsa-miR-663b	CLIP-seq
MIRT1106182	hsa-miR-671-5p	CLIP-seq
MIRT1106183	hsa-miR-802	CLIP-seq
MIRT1106184	hsa-miR-875-3p	CLIP-seq
MIRT1106185	hsa-miR-940	CLIP-seq
MIRT1106186	hsa-miR-943	CLIP-seq
MIRT2029297	hsa-miR-1200	CLIP-seq
MIRT2029298	hsa-miR-1224-3p	CLIP-seq
MIRT1106101	hsa-miR-124	CLIP-seq
MIRT2029299	hsa-miR-1260	CLIP-seq
MIRT2029300	hsa-miR-1260b	CLIP-seq
MIRT2029301	hsa-miR-1280	CLIP-seq
MIRT2029302	hsa-miR-1281	CLIP-seq
MIRT2029303	hsa-miR-1291	CLIP-seq
MIRT2029304	hsa-miR-1302	CLIP-seq
MIRT2029305	hsa-miR-1343	CLIP-seq
MIRT2029306	hsa-miR-145	CLIP-seq
MIRT2029307	hsa-miR-15a	CLIP-seq
MIRT2029308	hsa-miR-15b	CLIP-seq
MIRT2029309	hsa-miR-16	CLIP-seq
MIRT2029310	hsa-miR-195	CLIP-seq
MIRT2029311	hsa-miR-198	CLIP-seq
MIRT2029312	hsa-miR-200b	CLIP-seq
MIRT2029313	hsa-miR-200c	CLIP-seq
MIRT2029314	hsa-miR-2355-3p	CLIP-seq
MIRT1106112	hsa-miR-2467-5p	CLIP-seq
MIRT1106113	hsa-miR-2682	CLIP-seq
MIRT2029315	hsa-miR-3119	CLIP-seq
MIRT2029316	hsa-miR-3122	CLIP-seq
MIRT1106117	hsa-miR-3136-5p	CLIP-seq
MIRT1106118	hsa-miR-3143	CLIP-seq
MIRT1106121	hsa-miR-3149	CLIP-seq
MIRT2029317	hsa-miR-3160-5p	CLIP-seq
MIRT2029318	hsa-miR-3174	CLIP-seq
MIRT1106125	hsa-miR-3188	CLIP-seq
MIRT2029319	hsa-miR-3199	CLIP-seq
MIRT1106127	hsa-miR-3200-5p	CLIP-seq
MIRT2029320	hsa-miR-328	CLIP-seq
MIRT1106130	hsa-miR-3612	CLIP-seq
MIRT2029321	hsa-miR-3672	CLIP-seq
MIRT2029322	hsa-miR-3673	CLIP-seq
MIRT2029323	hsa-miR-3679-3p	CLIP-seq
MIRT2029324	hsa-miR-3682-5p	CLIP-seq
MIRT2029325	hsa-miR-3690	CLIP-seq
MIRT1106134	hsa-miR-3714	CLIP-seq
MIRT1106137	hsa-miR-3910	CLIP-seq
MIRT2029326	hsa-miR-3913-5p	CLIP-seq
MIRT2029327	hsa-miR-3925-3p	CLIP-seq
MIRT2029328	hsa-miR-3929	CLIP-seq
MIRT1106138	hsa-miR-3975	CLIP-seq
MIRT2029329	hsa-miR-421	CLIP-seq
MIRT2029330	hsa-miR-424	CLIP-seq
MIRT1106141	hsa-miR-4254	CLIP-seq
MIRT2029331	hsa-miR-429	CLIP-seq
MIRT2029332	hsa-miR-4298	CLIP-seq
MIRT2029333	hsa-miR-4303	CLIP-seq
MIRT2029334	hsa-miR-4324	CLIP-seq
MIRT2029335	hsa-miR-4329	CLIP-seq
MIRT2029336	hsa-miR-4419b	CLIP-seq
MIRT2029337	hsa-miR-4433	CLIP-seq
MIRT1106144	hsa-miR-4439	CLIP-seq
MIRT2029338	hsa-miR-4443	CLIP-seq
MIRT2029339	hsa-miR-4459	CLIP-seq
MIRT1106146	hsa-miR-4477a	CLIP-seq
MIRT2029340	hsa-miR-4478	CLIP-seq
MIRT2029341	hsa-miR-4493	CLIP-seq
MIRT1106147	hsa-miR-449c	CLIP-seq
MIRT2029342	hsa-miR-4502	CLIP-seq
MIRT1106148	hsa-miR-4513	CLIP-seq
MIRT1106151	hsa-miR-4646-3p	CLIP-seq
MIRT2029343	hsa-miR-4659a-3p	CLIP-seq
MIRT2029344	hsa-miR-4659b-3p	CLIP-seq
MIRT2029345	hsa-miR-4667-3p	CLIP-seq
MIRT2029346	hsa-miR-4682	CLIP-seq
MIRT2029347	hsa-miR-4709-5p	CLIP-seq
MIRT2029348	hsa-miR-4712-5p	CLIP-seq
MIRT2029349	hsa-miR-4762-3p	CLIP-seq
MIRT2029350	hsa-miR-4768-3p	CLIP-seq
MIRT2029351	hsa-miR-4781-3p	CLIP-seq
MIRT1106163	hsa-miR-485-5p	CLIP-seq
MIRT2029352	hsa-miR-497	CLIP-seq
MIRT1106167	hsa-miR-506	CLIP-seq
MIRT2029353	hsa-miR-508-5p	CLIP-seq
MIRT2029354	hsa-miR-532-3p	CLIP-seq
MIRT1106171	hsa-miR-543	CLIP-seq
MIRT2029355	hsa-miR-544b	CLIP-seq
MIRT2029356	hsa-miR-545	CLIP-seq
MIRT2029357	hsa-miR-548p	CLIP-seq
MIRT1106175	hsa-miR-579	CLIP-seq
MIRT1106179	hsa-miR-625	CLIP-seq
MIRT2029358	hsa-miR-630	CLIP-seq
MIRT1106180	hsa-miR-650	CLIP-seq
MIRT2029359	hsa-miR-658	CLIP-seq
MIRT2029360	hsa-miR-770-5p	CLIP-seq
MIRT1106183	hsa-miR-802	CLIP-seq
MIRT2029361	hsa-miR-885-5p	CLIP-seq
MIRT1106186	hsa-miR-943	CLIP-seq
MIRT2029307	hsa-miR-15a	CLIP-seq
MIRT2029308	hsa-miR-15b	CLIP-seq
MIRT2029309	hsa-miR-16	CLIP-seq
MIRT2029310	hsa-miR-195	CLIP-seq
MIRT2029312	hsa-miR-200b	CLIP-seq
MIRT2029313	hsa-miR-200c	CLIP-seq
MIRT1106138	hsa-miR-3975	CLIP-seq
MIRT2029330	hsa-miR-424	CLIP-seq
MIRT1106141	hsa-miR-4254	CLIP-seq
MIRT2029331	hsa-miR-429	CLIP-seq
MIRT2029352	hsa-miR-497	CLIP-seq
MIRT2029356	hsa-miR-545	CLIP-seq
MIRT2029357	hsa-miR-548p	CLIP-seq

Show/Hide all (62)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001725	Component	Stress fiber	IMP	16636079
GO:0001726	Component	Ruffle	IEA
GO:0001726	Component	Ruffle	IMP	16636079
GO:0001726	Component	Ruffle	ISS
GO:0001891	Component	Phagocytic cup	IEA
GO:0001891	Component	Phagocytic cup	ISS
GO:0002102	Component	Podosome	IDA
GO:0002286	Process	T cell activation involved in immune response	IDA	17294403
GO:0003779	Function	Actin binding	IEA
GO:0003779	Function	Actin binding	NAS	2252891
GO:0005178	Function	Integrin binding	IPI	20183869
GO:0005509	Function	Calcium ion binding	IEA
GO:0005509	Function	Calcium ion binding	NAS	2378651
GO:0005615	Component	Extracellular space	HDA	16502470, 22664934
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	16636079
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	2378651
GO:0005829	Component	Cytosol	IDA	2111166, 17294403
GO:0005856	Component	Cytoskeleton	IEA
GO:0005884	Component	Actin filament	IBA
GO:0005884	Component	Actin filament	IEA
GO:0005884	Component	Actin filament	IMP	16636079
GO:0005884	Component	Actin filament	ISS
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005925	Component	Focal adhesion	IMP	16636079
GO:0010737	Process	Protein kinase A signaling	IMP	16636079
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0015629	Component	Actin cytoskeleton	IEA
GO:0016020	Component	Membrane	IEA
GO:0016477	Process	Cell migration	IMP	16636079
GO:0022617	Process	Extracellular matrix disassembly	IMP
GO:0030054	Component	Cell junction	TAS
GO:0030175	Component	Filopodium	IMP	16636079
GO:0030866	Process	Cortical actin cytoskeleton organization	ISS
GO:0031100	Process	Animal organ regeneration	IEA
GO:0032432	Component	Actin filament bundle	IBA
GO:0032432	Component	Actin filament bundle	IMP	16636079
GO:0032587	Component	Ruffle membrane	IEA
GO:0033157	Process	Regulation of intracellular protein transport	IDA	17294403
GO:0042802	Function	Identical protein binding	IEA
GO:0042995	Component	Cell projection	IEA
GO:0044319	Process	Wound healing, spreading of cells	IMP	16636079
GO:0046872	Function	Metal ion binding	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	20183869
GO:0051015	Function	Actin filament binding	IBA
GO:0051015	Function	Actin filament binding	IEA
GO:0051015	Function	Actin filament binding	IMP	16636079
GO:0051015	Function	Actin filament binding	ISS
GO:0051017	Process	Actin filament bundle assembly	IBA
GO:0051017	Process	Actin filament bundle assembly	IEA
GO:0051017	Process	Actin filament bundle assembly	IEA
GO:0051017	Process	Actin filament bundle assembly	IMP	16636079
GO:0051017	Process	Actin filament bundle assembly	ISS
GO:0051020	Function	GTPase binding	IPI	24337748
GO:0051639	Process	Actin filament network formation	IBA
GO:0051764	Process	Actin crosslink formation	ISS
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:0070161	Component	Anchoring junction	IEA
GO:0071803	Process	Positive regulation of podosome assembly	IMP
GO:0097386	Component	Glial cell projection	IEA

MIM	HGNC	e!Ensembl
153430	6528	ENSG00000136167

P13796

Protein name

Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1)

Protein function

Actin-binding protein (PubMed:16636079, PubMed:17294403, PubMed:28493397). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Modulates the cell surface expression of IL2RA/C

PDB

2D85 , 5JOJ , 5JOL , 6VEC

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00036	EF-hand_1	13 → 41	EF hand	Domain
PF00307	CH	120 → 236	Calponin homology (CH) domain	Domain
PF00307	CH	264 → 376	Calponin homology (CH) domain	Domain
PF00307	CH	394 → 504	Calponin homology (CH) domain	Domain
PF00307	CH	515 → 625	Calponin homology (CH) domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T-lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells

Sequence

MARGSVSDEEMMELREAFAKVDTDGNGYISFNELNDLFKAACLPLPGYRVREITENLMAT
GDLDQDGRISFDEFIKIFHGLKSTDVAKTFRKAINKKEGICAIGGTSEQSSVGTQHSYSE
EEKYAFVNWINKALENDPDCRHVIPMNPNTNDLFNAVGDGIVLCKMINLSVPDTIDERTI
NKKKLTPFTIQENLNLALNSASAIGCHVVNIGAEDLKEGKPYLVLGLLWQVIKIGLFADI
ELSRNEALIALLREGESLEDLMKLSPEELLLRWANYHLENAGCNKIGNFSTDIKDSKAYY
HLLEQVAPKGDEEGVPAVVIDMSGLREKDDIQRAECMLQQAERLGCRQFVTATDVVRGNP
KLNLAFIANLFNRYPALHKPENQDIDWGALEGETREERTFRNWMNSLGVNPRVNHLYSDL
SDALVIFQLYEKIKVPVDWNRVNKPPYPKLGGNMKKLENCNYAVELGKNQAKFSLVGIGG
QDLNEGNRTLTLALIWQLMRRYTLNILEEIGGGQKVNDDIIVNWVNETLREAKKSSSISS
FKDPKISTSLPVLDLIDAIQPGSINYDLLKTENLNDDEKLNNAKYAISMARKIGARVYAL
PEDLVEVNPKMVMTVFACLMGKGMKRV

Sequence length

627

Interactions

View interactions

	Reactome
			Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Hereditary breast ovarian cancer syndrome	Pathogenic	rs1376923782	RCV001374476

Show/Hide Text Mining Associations (38)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Arthritis Rheumatoid	Associate	33430905, 40048636
Arthritis Rheumatoid	Stimulate	35008858
Breast Neoplasms	Associate	26413813, 33618712
Calcinosis Cutis	Associate	33618712
Carcinogenesis	Stimulate	8428953
Cardiovascular Diseases	Associate	33009409
Carotid Stenosis	Associate	36823662
Cholangitis Sclerosing	Associate	39683940
Chondrocalcinosis 2	Associate	35008858
Chromosome Inversion	Associate	38086496
Cognition Disorders	Stimulate	28746408
Diabetes Mellitus Type 2	Associate	22606001
Disease Progression	Stimulate	30479022
Drug Related Side Effects and Adverse Reactions	Associate	19799649
Inflammation	Associate	35008858
Leukemia Lymphocytic Chronic B Cell	Associate	28679620
Leukocyte Disorders	Associate	34991157
Liver Cirrhosis	Associate	39683940
Lymphatic Metastasis	Associate	28230172, 28981098
Lymphohistiocytosis Hemophagocytic	Associate	37653176
Mental Disorders	Associate	38086496
Mouth Neoplasms	Associate	28230172
Multiple Myeloma	Associate	29882856
Nasal Polyps	Associate	30479022
Neoplasm Metastasis	Associate	28981098
Neoplasms	Associate	12231175, 18288642, 25435355, 26945069, 30918060, 31501427, 3211125, 32986657, 39683940, 9176394
Neoplasms	Stimulate	2378651, 8428953
Nephrosis Lipoid	Stimulate	18697798
Neutropenia	Associate	34991157
Non alcoholic Fatty Liver Disease	Associate	23213074, 35789605
Osteoarthritis	Associate	35008858
Periodontitis	Associate	22606001
Prostatic Neoplasms	Associate	28981098
Prostatitis	Associate	9176394
Schizophrenia	Associate	38086496
Squamous Cell Carcinoma of Head and Neck	Associate	28230172
Stomach Neoplasms	Associate	32986657
Urinary Bladder Neoplasms	Associate	18288642

LCP1 (lymphocyte cytosolic protein 1)