LCN2 (lipocalin 2)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3934
Gene name Gene Name - the full gene name approved by the HGNC.
Lipocalin 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LCN2
Synonyms (NCBI Gene) Gene synonyms aliases
24p3, MSFI, NGAL, p25
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9q34.11
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(8)
miRTarBase ID miRNA Experiments Reference
MIRT438755 hsa-miR-138-5p Luciferase reporter assay, qRT-PCR, Western blot 23300839
MIRT438755 hsa-miR-138-5p Luciferase reporter assay, qRT-PCR, Western blot 23300839
MIRT438755 hsa-miR-138-5p Luciferase reporter assay, qRT-PCR, Western blot 23300839
MIRT438755 hsa-miR-138-5p Luciferase reporter assay, qRT-PCR, Western blot 23300839
MIRT2029206 hsa-miR-1293 CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(6)
Transcription factor Regulation Reference
NFKB1 Activation 15536164
NFKB1 Unknown 19707556;20220144;24391115
NR3C2 Unknown 22469622
RELA Activation 15536164
RELA Unknown 19707556;20220144;24391115
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(24)
GO ID Ontology Definition Evidence Reference
GO:0005506 Function Iron ion binding IDA 27780864
GO:0005506 Function Iron ion binding ISS
GO:0005515 Function Protein binding IPI 32296183
GO:0005576 Component Extracellular region HDA 27068509
GO:0005576 Component Extracellular region ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
600181 6526 ENSG00000148346
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P80188
Protein name Neutrophil gelatinase-associated lipocalin (NGAL) (25 kDa alpha-2-microglobulin-related subunit of MMP-9) (Lipocalin-2) (Oncogene 24p3) (Siderocalin) (p25)
Protein function Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (PubMed:12453413, PubMed:20581821, PubMed:27780864). Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a sid
PDB 1DFV , 1L6M , 1NGL , 1QQS , 1X71 , 1X89 , 1X8U , 3BY0 , 3CBC , 3CMP , 3DSZ , 3DTQ , 3FW4 , 3FW5 , 3HWD , 3HWE , 3HWF , 3HWG , 3I0A , 3K3L , 3PEC , 3PED , 3T1D , 3TF6 , 3TZS , 3U0D , 4GH7 , 4IAW , 4IAX , 4K19 , 4MVI , 4MVK , 4MVL , 4QAE , 4ZFX , 4ZHC , 4ZHD , 4ZHF , 4ZHG , 4ZHH , 5JR8 , 5KHP , 5KIC , 5KID , 5MHH , 5N47 , 5N48 , 5NKN , 6GQZ , 6GR0 , 6O5D
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00061 Lipocalin 48 → 193 Lipocalin / cytosolic fatty-acid binding protein family Domain
Tissue specificity TISSUE SPECIFICITY: Detected in neutrophils (at protein level) (PubMed:7683678, PubMed:8298140). Expressed in bone marrow and in tissues that are prone to exposure to microorganism (PubMed:9339356). High expression is found in bone marrow as well as in ut
Sequence
Sequence length 198
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  IL-17 signaling pathway   Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
Metal sequestration by antimicrobial proteins
Iron uptake and transport
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (8)
Causal
Disease term Disease name dbSNP ID References
Beta thalassemia beta Thalassemia rs33930165, rs33946267, rs33950507, rs34378160, rs33960103, rs35424040, rs33933298, rs33972047, rs334, rs33969677, rs33940204, rs35256489, rs33986703, rs11549407, rs63750783
View all (204 more)		 16755567
Dermatitis Contact Dermatitis rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 25724174
Hemoglobinopathy Hemoglobin F Disease rs35693898, rs34160180, rs33916412, rs35424040, rs33933298, rs33966761, rs35890959, rs35002698, rs33969677, rs33974936, rs33922842, rs35662066, rs34856846, rs35383398, rs63750532
View all (21 more)		 16755567
Kidney disease Kidney Diseases, Chronic Kidney Diseases rs74315342, rs749740335, rs757649673, rs112417755, rs35138315 20181666, 27026710, 20438795, 19349640, 24714768
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Celiac disease Celiac Disease 30097691 ClinVar
Thalassemia Thalassemia Minor, Thalassemia Intermedia 16755567 ClinVar
Show/Hide Text Mining Associations (257)
Associations from Text Mining
Disease Name Relationship Type References
Acne Vulgaris Associate 21466536
Acute Disease Associate 26952930
Acute Kidney Injury Stimulate 12605707, 23317940, 24820190, 25944130, 31062866, 32132597, 33249927, 34112226, 35933485
Acute Kidney Injury Associate 18337554, 20056755, 20827258, 22418979, 22562534, 23324582, 23439619, 23595019, 24067438, 25093671, 26063008, 26947538, 26952930, 28003188, 28640195
View all (5 more)
Acute On Chronic Liver Failure Stimulate 26988732
Adenocarcinoma Associate 16060857, 25921719, 26952930, 30988316
Adenocarcinoma Stimulate 29684978
Adenocarcinoma Follicular Associate 29321030
Adenocarcinoma of Lung Associate 25542236, 38295916
Adenoma Associate 21555394, 23736029, 26317775