Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	3930
Gene name	Lamin B receptor
Gene symbol	LBR
Synonyms (NCBI Gene)	C14SRDHCR14BLMN2RPHAPHASKTDRD18
Chromosome	1
Chromosome location	1q42.12
Summary	The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of t

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SNP ID	Visualize variation	Clinical significance	Consequence
rs148541545	C>T	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant, non coding transcript variant
rs200180113	G>A	Likely-pathogenic	Missense variant, intron variant, coding sequence variant
rs374343844	T>A,C	Pathogenic	Coding sequence variant, missense variant, non coding transcript variant
rs387906416	TAGAAGA>CTTCTAG	Pathogenic	Inframe indel, coding sequence variant, stop gained, non coding transcript variant
rs573510559	C>T	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs587777171	T>C	Likely-pathogenic	Coding sequence variant, missense variant, non coding transcript variant
rs587777172	C>A,T	Pathogenic	Coding sequence variant, missense variant, non coding transcript variant
rs754049402	C>T	Uncertain-significance, pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs863223326	ACCA>-	Pathogenic	Coding sequence variant, frameshift variant, non coding transcript variant
rs869312905	G>A	Pathogenic	Coding sequence variant, stop gained, non coding transcript variant
rs886037616	ATAAAA>-	Pathogenic	Intron variant
rs886037655	A>-	Pathogenic	Frameshift variant, non coding transcript variant, coding sequence variant
rs1057516045	G>A	Likely-pathogenic	Stop gained, coding sequence variant, non coding transcript variant
rs1131691304	G>C	Likely-pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs1236962991	C>T	Pathogenic	Coding sequence variant, intron variant, missense variant
rs1558655670	ATG>TTTCTCATCA	Pathogenic	Frameshift variant, non coding transcript variant, coding sequence variant

668

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miRTarBase ID	miRNA	Experiments	Reference
MIRT019632	hsa-miR-340-5p	Sequencing	20371350
MIRT020277	hsa-miR-130b-3p	Sequencing	20371350
MIRT021190	hsa-miR-186-5p	Sequencing	20371350
MIRT022092	hsa-miR-128-3p	Sequencing	20371350
MIRT025202	hsa-miR-181a-5p	Sequencing	20371350
MIRT026004	hsa-miR-148a-3p	Sequencing	20371350
MIRT026051	hsa-miR-196a-5p	Sequencing	20371350
MIRT027366	hsa-miR-101-3p	Sequencing	20371350
MIRT028716	hsa-miR-27a-3p	Sequencing	20371350
MIRT030542	hsa-miR-24-3p	Sequencing	20371350
MIRT031247	hsa-miR-19b-3p	Sequencing	20371350
MIRT032162	hsa-let-7d-5p	Sequencing	20371350
MIRT032443	hsa-let-7b-5p	Proteomics	18668040
MIRT047214	hsa-miR-182-5p	CLASH	23622248
MIRT046348	hsa-miR-23b-3p	CLASH	23622248
MIRT041836	hsa-miR-484	CLASH	23622248
MIRT039426	hsa-miR-421	CLASH	23622248
MIRT566967	hsa-miR-4280	PAR-CLIP	20371350
MIRT566966	hsa-miR-5586-5p	PAR-CLIP	20371350
MIRT566965	hsa-miR-520g-3p	PAR-CLIP	20371350
MIRT566964	hsa-miR-520h	PAR-CLIP	20371350
MIRT566963	hsa-miR-383-3p	PAR-CLIP	20371350
MIRT566962	hsa-miR-4742-3p	PAR-CLIP	20371350
MIRT063747	hsa-miR-144-5p	PAR-CLIP	20371350
MIRT566961	hsa-miR-103a-3p	PAR-CLIP	20371350
MIRT566960	hsa-miR-107	PAR-CLIP	20371350
MIRT566959	hsa-miR-3161	PAR-CLIP	20371350
MIRT566958	hsa-miR-7156-3p	PAR-CLIP	20371350
MIRT566957	hsa-miR-1301-3p	PAR-CLIP	20371350
MIRT566956	hsa-miR-5047	PAR-CLIP	20371350
MIRT566955	hsa-miR-599	PAR-CLIP	20371350
MIRT566989	hsa-miR-3133	PAR-CLIP	20371350
MIRT021190	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT566988	hsa-miR-7-1-3p	PAR-CLIP	20371350
MIRT566987	hsa-miR-7-2-3p	PAR-CLIP	20371350
MIRT566986	hsa-miR-541-5p	PAR-CLIP	20371350
MIRT336416	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT063764	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT566985	hsa-miR-3671	PAR-CLIP	20371350
MIRT566984	hsa-miR-607	PAR-CLIP	20371350
MIRT566983	hsa-miR-603	PAR-CLIP	20371350
MIRT025202	hsa-miR-181a-5p	PAR-CLIP	20371350
MIRT566982	hsa-miR-181b-5p	PAR-CLIP	20371350
MIRT566981	hsa-miR-181c-5p	PAR-CLIP	20371350
MIRT566980	hsa-miR-181d-5p	PAR-CLIP	20371350
MIRT566979	hsa-miR-4262	PAR-CLIP	20371350
MIRT336389	hsa-miR-1278	PAR-CLIP	20371350
MIRT566978	hsa-miR-4307	PAR-CLIP	20371350
MIRT566977	hsa-miR-6504-3p	PAR-CLIP	20371350
MIRT566976	hsa-miR-4251	PAR-CLIP	20371350
MIRT566975	hsa-miR-589-5p	PAR-CLIP	20371350
MIRT566974	hsa-miR-146a-5p	PAR-CLIP	20371350
MIRT566973	hsa-miR-146b-5p	PAR-CLIP	20371350
MIRT566972	hsa-miR-7153-5p	PAR-CLIP	20371350
MIRT566971	hsa-miR-556-3p	PAR-CLIP	20371350
MIRT566970	hsa-miR-6826-3p	PAR-CLIP	20371350
MIRT566969	hsa-miR-488-3p	PAR-CLIP	20371350
MIRT566968	hsa-miR-5088-5p	PAR-CLIP	20371350
MIRT566967	hsa-miR-4280	PAR-CLIP	20371350
MIRT566966	hsa-miR-5586-5p	PAR-CLIP	20371350
MIRT566965	hsa-miR-520g-3p	PAR-CLIP	20371350
MIRT566964	hsa-miR-520h	PAR-CLIP	20371350
MIRT566963	hsa-miR-383-3p	PAR-CLIP	20371350
MIRT566962	hsa-miR-4742-3p	PAR-CLIP	20371350
MIRT063747	hsa-miR-144-5p	PAR-CLIP	20371350
MIRT566961	hsa-miR-103a-3p	PAR-CLIP	20371350
MIRT566960	hsa-miR-107	PAR-CLIP	20371350
MIRT566959	hsa-miR-3161	PAR-CLIP	20371350
MIRT566958	hsa-miR-7156-3p	PAR-CLIP	20371350
MIRT566957	hsa-miR-1301-3p	PAR-CLIP	20371350
MIRT566956	hsa-miR-5047	PAR-CLIP	20371350
MIRT566955	hsa-miR-599	PAR-CLIP	20371350
MIRT496937	hsa-miR-655-5p	PAR-CLIP	22291592
MIRT496936	hsa-miR-377-5p	PAR-CLIP	22291592
MIRT496935	hsa-miR-6086	PAR-CLIP	22291592
MIRT442418	hsa-miR-4729	PAR-CLIP	22100165
MIRT442417	hsa-miR-3653-3p	PAR-CLIP	22100165
MIRT185488	hsa-miR-5696	PAR-CLIP	22100165
MIRT185483	hsa-miR-579-3p	PAR-CLIP	22100165
MIRT185487	hsa-miR-664b-3p	PAR-CLIP	22100165
MIRT442415	hsa-miR-3658	PAR-CLIP	22100165
MIRT442416	hsa-miR-335-3p	PAR-CLIP	22100165
MIRT025202	hsa-miR-181a-5p	HITS-CLIP	22473208
MIRT566982	hsa-miR-181b-5p	HITS-CLIP	22473208
MIRT566981	hsa-miR-181c-5p	HITS-CLIP	22473208
MIRT566980	hsa-miR-181d-5p	HITS-CLIP	22473208
MIRT028716	hsa-miR-27a-3p	HITS-CLIP	22473208
MIRT727321	hsa-miR-27b-3p	HITS-CLIP	22473208
MIRT019632	hsa-miR-340-5p	ImmunofluorescenceLuciferase reporter assayqRT-PCRWestern blotting	34181735
MIRT566967	hsa-miR-4280	PAR-CLIP	20371350
MIRT566966	hsa-miR-5586-5p	PAR-CLIP	20371350
MIRT566965	hsa-miR-520g-3p	PAR-CLIP	20371350
MIRT566964	hsa-miR-520h	PAR-CLIP	20371350
MIRT566963	hsa-miR-383-3p	PAR-CLIP	20371350
MIRT566962	hsa-miR-4742-3p	PAR-CLIP	20371350
MIRT063747	hsa-miR-144-5p	PAR-CLIP	20371350
MIRT566961	hsa-miR-103a-3p	PAR-CLIP	20371350
MIRT566960	hsa-miR-107	PAR-CLIP	20371350
MIRT566959	hsa-miR-3161	PAR-CLIP	20371350
MIRT566958	hsa-miR-7156-3p	PAR-CLIP	20371350
MIRT566957	hsa-miR-1301-3p	PAR-CLIP	20371350
MIRT566956	hsa-miR-5047	PAR-CLIP	20371350
MIRT566955	hsa-miR-599	PAR-CLIP	20371350
MIRT566989	hsa-miR-3133	PAR-CLIP	20371350
MIRT021190	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT566988	hsa-miR-7-1-3p	PAR-CLIP	20371350
MIRT566987	hsa-miR-7-2-3p	PAR-CLIP	20371350
MIRT566986	hsa-miR-541-5p	PAR-CLIP	20371350
MIRT336416	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT063764	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT566985	hsa-miR-3671	PAR-CLIP	20371350
MIRT566984	hsa-miR-607	PAR-CLIP	20371350
MIRT566983	hsa-miR-603	PAR-CLIP	20371350
MIRT025202	hsa-miR-181a-5p	PAR-CLIP	20371350
MIRT566982	hsa-miR-181b-5p	PAR-CLIP	20371350
MIRT566981	hsa-miR-181c-5p	PAR-CLIP	20371350
MIRT566980	hsa-miR-181d-5p	PAR-CLIP	20371350
MIRT566979	hsa-miR-4262	PAR-CLIP	20371350
MIRT336389	hsa-miR-1278	PAR-CLIP	20371350
MIRT566978	hsa-miR-4307	PAR-CLIP	20371350
MIRT566977	hsa-miR-6504-3p	PAR-CLIP	20371350
MIRT566976	hsa-miR-4251	PAR-CLIP	20371350
MIRT566975	hsa-miR-589-5p	PAR-CLIP	20371350
MIRT566974	hsa-miR-146a-5p	PAR-CLIP	20371350
MIRT566973	hsa-miR-146b-5p	PAR-CLIP	20371350
MIRT566972	hsa-miR-7153-5p	PAR-CLIP	20371350
MIRT566971	hsa-miR-556-3p	PAR-CLIP	20371350
MIRT566970	hsa-miR-6826-3p	PAR-CLIP	20371350
MIRT566969	hsa-miR-488-3p	PAR-CLIP	20371350
MIRT566968	hsa-miR-5088-5p	PAR-CLIP	20371350
MIRT566967	hsa-miR-4280	PAR-CLIP	20371350
MIRT566966	hsa-miR-5586-5p	PAR-CLIP	20371350
MIRT566965	hsa-miR-520g-3p	PAR-CLIP	20371350
MIRT566964	hsa-miR-520h	PAR-CLIP	20371350
MIRT566963	hsa-miR-383-3p	PAR-CLIP	20371350
MIRT566962	hsa-miR-4742-3p	PAR-CLIP	20371350
MIRT063747	hsa-miR-144-5p	PAR-CLIP	20371350
MIRT566961	hsa-miR-103a-3p	PAR-CLIP	20371350
MIRT566960	hsa-miR-107	PAR-CLIP	20371350
MIRT566959	hsa-miR-3161	PAR-CLIP	20371350
MIRT566958	hsa-miR-7156-3p	PAR-CLIP	20371350
MIRT566957	hsa-miR-1301-3p	PAR-CLIP	20371350
MIRT566956	hsa-miR-5047	PAR-CLIP	20371350
MIRT566955	hsa-miR-599	PAR-CLIP	20371350
MIRT496937	hsa-miR-655-5p	PAR-CLIP	22291592
MIRT496936	hsa-miR-377-5p	PAR-CLIP	22291592
MIRT496935	hsa-miR-6086	PAR-CLIP	22291592
MIRT442418	hsa-miR-4729	PAR-CLIP	22100165
MIRT442417	hsa-miR-3653-3p	PAR-CLIP	22100165
MIRT185488	hsa-miR-5696	PAR-CLIP	22100165
MIRT185483	hsa-miR-579-3p	PAR-CLIP	22100165
MIRT185487	hsa-miR-664b-3p	PAR-CLIP	22100165
MIRT442415	hsa-miR-3658	PAR-CLIP	22100165
MIRT442416	hsa-miR-335-3p	PAR-CLIP	22100165
MIRT1105372	hsa-miR-101	CLIP-seq
MIRT1105373	hsa-miR-103a	CLIP-seq
MIRT1105374	hsa-miR-105	CLIP-seq
MIRT1105375	hsa-miR-1179	CLIP-seq
MIRT1105376	hsa-miR-1248	CLIP-seq
MIRT1105377	hsa-miR-128	CLIP-seq
MIRT1105378	hsa-miR-1283	CLIP-seq
MIRT1105379	hsa-miR-129-5p	CLIP-seq
MIRT1105380	hsa-miR-1301	CLIP-seq
MIRT1105381	hsa-miR-1305	CLIP-seq
MIRT1105382	hsa-miR-141	CLIP-seq
MIRT1105383	hsa-miR-200a	CLIP-seq
MIRT1105384	hsa-miR-208a	CLIP-seq
MIRT1105385	hsa-miR-208b	CLIP-seq
MIRT1105386	hsa-miR-217	CLIP-seq
MIRT1105387	hsa-miR-221	CLIP-seq
MIRT1105388	hsa-miR-222	CLIP-seq
MIRT1105389	hsa-miR-224	CLIP-seq
MIRT1105390	hsa-miR-24	CLIP-seq
MIRT1105391	hsa-miR-27a	CLIP-seq
MIRT1105392	hsa-miR-27b	CLIP-seq
MIRT1105393	hsa-miR-3160-5p	CLIP-seq
MIRT1105394	hsa-miR-3163	CLIP-seq
MIRT1105395	hsa-miR-329	CLIP-seq
MIRT1105396	hsa-miR-3613-3p	CLIP-seq
MIRT1105397	hsa-miR-362-3p	CLIP-seq
MIRT1105398	hsa-miR-3662	CLIP-seq
MIRT1105399	hsa-miR-3941	CLIP-seq
MIRT1105400	hsa-miR-410	CLIP-seq
MIRT1105401	hsa-miR-412	CLIP-seq
MIRT1105402	hsa-miR-4284	CLIP-seq
MIRT1105403	hsa-miR-4291	CLIP-seq
MIRT1105404	hsa-miR-4310	CLIP-seq
MIRT1105405	hsa-miR-4432	CLIP-seq
MIRT1105406	hsa-miR-4470	CLIP-seq
MIRT1105407	hsa-miR-4477a	CLIP-seq
MIRT1105408	hsa-miR-448	CLIP-seq
MIRT1105409	hsa-miR-4694-3p	CLIP-seq
MIRT1105410	hsa-miR-4703-3p	CLIP-seq
MIRT1105411	hsa-miR-4747-3p	CLIP-seq
MIRT1105412	hsa-miR-4799-5p	CLIP-seq
MIRT1105413	hsa-miR-499-5p	CLIP-seq
MIRT1105414	hsa-miR-5096	CLIP-seq
MIRT1105415	hsa-miR-513a-5p	CLIP-seq
MIRT1105416	hsa-miR-520d-5p	CLIP-seq
MIRT1105417	hsa-miR-522	CLIP-seq
MIRT1105418	hsa-miR-524-5p	CLIP-seq
MIRT1105419	hsa-miR-548a-5p	CLIP-seq
MIRT1105420	hsa-miR-548ab	CLIP-seq
MIRT1105421	hsa-miR-548ae	CLIP-seq
MIRT1105422	hsa-miR-548aj	CLIP-seq
MIRT1105423	hsa-miR-548ak	CLIP-seq
MIRT1105424	hsa-miR-548am	CLIP-seq
MIRT1105425	hsa-miR-548b-5p	CLIP-seq
MIRT1105426	hsa-miR-548c-5p	CLIP-seq
MIRT1105427	hsa-miR-548d-5p	CLIP-seq
MIRT1105428	hsa-miR-548h	CLIP-seq
MIRT1105429	hsa-miR-548i	CLIP-seq
MIRT1105430	hsa-miR-548j	CLIP-seq
MIRT1105431	hsa-miR-548n	CLIP-seq
MIRT1105432	hsa-miR-548v	CLIP-seq
MIRT1105433	hsa-miR-548w	CLIP-seq
MIRT1105434	hsa-miR-548x	CLIP-seq
MIRT1105435	hsa-miR-548y	CLIP-seq
MIRT1105436	hsa-miR-559	CLIP-seq
MIRT1105437	hsa-miR-656	CLIP-seq
MIRT1105438	hsa-miR-889	CLIP-seq
MIRT1105439	hsa-let-7a	CLIP-seq
MIRT1105440	hsa-let-7b	CLIP-seq
MIRT1105441	hsa-let-7c	CLIP-seq
MIRT1105442	hsa-let-7d	CLIP-seq
MIRT1105443	hsa-let-7e	CLIP-seq
MIRT1105444	hsa-let-7f	CLIP-seq
MIRT1105445	hsa-let-7g	CLIP-seq
MIRT1105446	hsa-let-7i	CLIP-seq
MIRT1105372	hsa-miR-101	CLIP-seq
MIRT1105373	hsa-miR-103a	CLIP-seq
MIRT1105374	hsa-miR-105	CLIP-seq
MIRT1105375	hsa-miR-1179	CLIP-seq
MIRT1105447	hsa-miR-1183	CLIP-seq
MIRT1105448	hsa-miR-1207-3p	CLIP-seq
MIRT1105449	hsa-miR-1257	CLIP-seq
MIRT1105377	hsa-miR-128	CLIP-seq
MIRT1105378	hsa-miR-1283	CLIP-seq
MIRT1105450	hsa-miR-1284	CLIP-seq
MIRT1105451	hsa-miR-1286	CLIP-seq
MIRT1105380	hsa-miR-1301	CLIP-seq
MIRT1105452	hsa-miR-132	CLIP-seq
MIRT1105382	hsa-miR-141	CLIP-seq
MIRT1105453	hsa-miR-144	CLIP-seq
MIRT1105454	hsa-miR-181a	CLIP-seq
MIRT1105455	hsa-miR-181b	CLIP-seq
MIRT1105456	hsa-miR-181c	CLIP-seq
MIRT1105457	hsa-miR-181d	CLIP-seq
MIRT1105458	hsa-miR-186	CLIP-seq
MIRT1105383	hsa-miR-200a	CLIP-seq
MIRT1105459	hsa-miR-200b	CLIP-seq
MIRT1105460	hsa-miR-200c	CLIP-seq
MIRT1105461	hsa-miR-202	CLIP-seq
MIRT1105462	hsa-miR-2052	CLIP-seq
MIRT1105463	hsa-miR-2053	CLIP-seq
MIRT1105384	hsa-miR-208a	CLIP-seq
MIRT1105385	hsa-miR-208b	CLIP-seq
MIRT1105464	hsa-miR-212	CLIP-seq
MIRT1105386	hsa-miR-217	CLIP-seq
MIRT1105387	hsa-miR-221	CLIP-seq
MIRT1105388	hsa-miR-222	CLIP-seq
MIRT1105389	hsa-miR-224	CLIP-seq
MIRT1105465	hsa-miR-23a	CLIP-seq
MIRT1105466	hsa-miR-23b	CLIP-seq
MIRT1105467	hsa-miR-23c	CLIP-seq
MIRT1105391	hsa-miR-27a	CLIP-seq
MIRT1105392	hsa-miR-27b	CLIP-seq
MIRT1105468	hsa-miR-2964a-3p	CLIP-seq
MIRT1105469	hsa-miR-300	CLIP-seq
MIRT1105470	hsa-miR-3074-3p	CLIP-seq
MIRT1105471	hsa-miR-3153	CLIP-seq
MIRT1105472	hsa-miR-323-3p	CLIP-seq
MIRT1105473	hsa-miR-338-5p	CLIP-seq
MIRT1105474	hsa-miR-342-3p	CLIP-seq
MIRT1105475	hsa-miR-3606	CLIP-seq
MIRT1105396	hsa-miR-3613-3p	CLIP-seq
MIRT1105476	hsa-miR-3647-3p	CLIP-seq
MIRT1105477	hsa-miR-3667-3p	CLIP-seq
MIRT1105478	hsa-miR-381	CLIP-seq
MIRT1105401	hsa-miR-412	CLIP-seq
MIRT1105479	hsa-miR-4270	CLIP-seq
MIRT1105480	hsa-miR-4282	CLIP-seq
MIRT1105481	hsa-miR-429	CLIP-seq
MIRT1105403	hsa-miR-4291	CLIP-seq
MIRT1105404	hsa-miR-4310	CLIP-seq
MIRT1105482	hsa-miR-4433	CLIP-seq
MIRT1105483	hsa-miR-4441	CLIP-seq
MIRT1105484	hsa-miR-4452	CLIP-seq
MIRT1105485	hsa-miR-4458	CLIP-seq
MIRT1105486	hsa-miR-4464	CLIP-seq
MIRT1105407	hsa-miR-4477a	CLIP-seq
MIRT1105408	hsa-miR-448	CLIP-seq
MIRT1105487	hsa-miR-4500	CLIP-seq
MIRT1105488	hsa-miR-4540	CLIP-seq
MIRT1105489	hsa-miR-4666-3p	CLIP-seq
MIRT1105490	hsa-miR-4698	CLIP-seq
MIRT1105491	hsa-miR-4719	CLIP-seq
MIRT1105492	hsa-miR-4722-5p	CLIP-seq
MIRT1105493	hsa-miR-4748	CLIP-seq
MIRT1105494	hsa-miR-4760-3p	CLIP-seq
MIRT1105495	hsa-miR-4804-3p	CLIP-seq
MIRT1105496	hsa-miR-496	CLIP-seq
MIRT1105413	hsa-miR-499-5p	CLIP-seq
MIRT1105497	hsa-miR-5095	CLIP-seq
MIRT1105414	hsa-miR-5096	CLIP-seq
MIRT1105415	hsa-miR-513a-5p	CLIP-seq
MIRT1105498	hsa-miR-513b	CLIP-seq
MIRT1105416	hsa-miR-520d-5p	CLIP-seq
MIRT1105418	hsa-miR-524-5p	CLIP-seq
MIRT1105421	hsa-miR-548ae	CLIP-seq
MIRT1105422	hsa-miR-548aj	CLIP-seq
MIRT1105424	hsa-miR-548am	CLIP-seq
MIRT1105499	hsa-miR-548g	CLIP-seq
MIRT1105500	hsa-miR-548p	CLIP-seq
MIRT1105432	hsa-miR-548v	CLIP-seq
MIRT1105434	hsa-miR-548x	CLIP-seq
MIRT1105437	hsa-miR-656	CLIP-seq
MIRT1105501	hsa-miR-885-3p	CLIP-seq
MIRT1105438	hsa-miR-889	CLIP-seq
MIRT1105502	hsa-miR-98	CLIP-seq
MIRT1105389	hsa-miR-224	CLIP-seq
MIRT1105416	hsa-miR-520d-5p	CLIP-seq
MIRT1105418	hsa-miR-524-5p	CLIP-seq
MIRT1105437	hsa-miR-656	CLIP-seq
MIRT1105389	hsa-miR-224	CLIP-seq
MIRT1105416	hsa-miR-520d-5p	CLIP-seq
MIRT1105418	hsa-miR-524-5p	CLIP-seq
MIRT1105437	hsa-miR-656	CLIP-seq
MIRT1105439	hsa-let-7a	CLIP-seq
MIRT1105440	hsa-let-7b	CLIP-seq
MIRT1105441	hsa-let-7c	CLIP-seq
MIRT1105442	hsa-let-7d	CLIP-seq
MIRT1105443	hsa-let-7e	CLIP-seq
MIRT1105444	hsa-let-7f	CLIP-seq
MIRT1105445	hsa-let-7g	CLIP-seq
MIRT1105446	hsa-let-7i	CLIP-seq
MIRT1105376	hsa-miR-1248	CLIP-seq
MIRT1105379	hsa-miR-129-5p	CLIP-seq
MIRT2029069	hsa-miR-142-5p	CLIP-seq
MIRT1105454	hsa-miR-181a	CLIP-seq
MIRT1105455	hsa-miR-181b	CLIP-seq
MIRT1105456	hsa-miR-181c	CLIP-seq
MIRT1105457	hsa-miR-181d	CLIP-seq
MIRT1105461	hsa-miR-202	CLIP-seq
MIRT1105386	hsa-miR-217	CLIP-seq
MIRT1105395	hsa-miR-329	CLIP-seq
MIRT2029070	hsa-miR-340	CLIP-seq
MIRT2029071	hsa-miR-346	CLIP-seq
MIRT1105397	hsa-miR-362-3p	CLIP-seq
MIRT1105399	hsa-miR-3941	CLIP-seq
MIRT2029072	hsa-miR-4288	CLIP-seq
MIRT1105403	hsa-miR-4291	CLIP-seq
MIRT1105404	hsa-miR-4310	CLIP-seq
MIRT1105484	hsa-miR-4452	CLIP-seq
MIRT1105485	hsa-miR-4458	CLIP-seq
MIRT1105406	hsa-miR-4470	CLIP-seq
MIRT2029073	hsa-miR-4484	CLIP-seq
MIRT1105487	hsa-miR-4500	CLIP-seq
MIRT2029074	hsa-miR-450b-5p	CLIP-seq
MIRT2029075	hsa-miR-4709-5p	CLIP-seq
MIRT1105411	hsa-miR-4747-3p	CLIP-seq
MIRT2029076	hsa-miR-495	CLIP-seq
MIRT1105414	hsa-miR-5096	CLIP-seq
MIRT2029077	hsa-miR-548an	CLIP-seq
MIRT1105500	hsa-miR-548p	CLIP-seq
MIRT2029078	hsa-miR-632	CLIP-seq
MIRT1105438	hsa-miR-889	CLIP-seq
MIRT1105502	hsa-miR-98	CLIP-seq
MIRT1105439	hsa-let-7a	CLIP-seq
MIRT1105440	hsa-let-7b	CLIP-seq
MIRT1105441	hsa-let-7c	CLIP-seq
MIRT1105442	hsa-let-7d	CLIP-seq
MIRT1105443	hsa-let-7e	CLIP-seq
MIRT1105444	hsa-let-7f	CLIP-seq
MIRT1105445	hsa-let-7g	CLIP-seq
MIRT1105446	hsa-let-7i	CLIP-seq
MIRT1105372	hsa-miR-101	CLIP-seq
MIRT1105373	hsa-miR-103a	CLIP-seq
MIRT1105374	hsa-miR-105	CLIP-seq
MIRT2260048	hsa-miR-10a	CLIP-seq
MIRT2260049	hsa-miR-10b	CLIP-seq
MIRT1105447	hsa-miR-1183	CLIP-seq
MIRT1105377	hsa-miR-128	CLIP-seq
MIRT1105378	hsa-miR-1283	CLIP-seq
MIRT1105450	hsa-miR-1284	CLIP-seq
MIRT2260050	hsa-miR-1290	CLIP-seq
MIRT1105380	hsa-miR-1301	CLIP-seq
MIRT2260051	hsa-miR-130a	CLIP-seq
MIRT2260052	hsa-miR-130b	CLIP-seq
MIRT1105382	hsa-miR-141	CLIP-seq
MIRT2029069	hsa-miR-142-5p	CLIP-seq
MIRT2260053	hsa-miR-148a	CLIP-seq
MIRT2260054	hsa-miR-148b	CLIP-seq
MIRT2260055	hsa-miR-152	CLIP-seq
MIRT1105454	hsa-miR-181a	CLIP-seq
MIRT1105455	hsa-miR-181b	CLIP-seq
MIRT1105456	hsa-miR-181c	CLIP-seq
MIRT1105457	hsa-miR-181d	CLIP-seq
MIRT1105383	hsa-miR-200a	CLIP-seq
MIRT1105459	hsa-miR-200b	CLIP-seq
MIRT1105460	hsa-miR-200c	CLIP-seq
MIRT1105461	hsa-miR-202	CLIP-seq
MIRT1105384	hsa-miR-208a	CLIP-seq
MIRT1105385	hsa-miR-208b	CLIP-seq
MIRT1105387	hsa-miR-221	CLIP-seq
MIRT1105388	hsa-miR-222	CLIP-seq
MIRT2260056	hsa-miR-223	CLIP-seq
MIRT1105389	hsa-miR-224	CLIP-seq
MIRT1105465	hsa-miR-23a	CLIP-seq
MIRT1105466	hsa-miR-23b	CLIP-seq
MIRT1105467	hsa-miR-23c	CLIP-seq
MIRT1105391	hsa-miR-27a	CLIP-seq
MIRT1105392	hsa-miR-27b	CLIP-seq
MIRT1105469	hsa-miR-300	CLIP-seq
MIRT2260057	hsa-miR-301a	CLIP-seq
MIRT2260058	hsa-miR-301b	CLIP-seq
MIRT2260059	hsa-miR-3065-5p	CLIP-seq
MIRT1105394	hsa-miR-3163	CLIP-seq
MIRT2260060	hsa-miR-3182	CLIP-seq
MIRT2260061	hsa-miR-337-3p	CLIP-seq
MIRT1105473	hsa-miR-338-5p	CLIP-seq
MIRT2260062	hsa-miR-339-5p	CLIP-seq
MIRT2029070	hsa-miR-340	CLIP-seq
MIRT1105474	hsa-miR-342-3p	CLIP-seq
MIRT2029071	hsa-miR-346	CLIP-seq
MIRT1105475	hsa-miR-3606	CLIP-seq
MIRT1105396	hsa-miR-3613-3p	CLIP-seq
MIRT2260063	hsa-miR-3617	CLIP-seq
MIRT2260064	hsa-miR-3666	CLIP-seq
MIRT1105478	hsa-miR-381	CLIP-seq
MIRT2260065	hsa-miR-3924	CLIP-seq
MIRT2260066	hsa-miR-3942-3p	CLIP-seq
MIRT1105400	hsa-miR-410	CLIP-seq
MIRT1105401	hsa-miR-412	CLIP-seq
MIRT2029072	hsa-miR-4288	CLIP-seq
MIRT1105481	hsa-miR-429	CLIP-seq
MIRT2260067	hsa-miR-4295	CLIP-seq
MIRT1105405	hsa-miR-4432	CLIP-seq
MIRT1105485	hsa-miR-4458	CLIP-seq
MIRT1105406	hsa-miR-4470	CLIP-seq
MIRT1105407	hsa-miR-4477a	CLIP-seq
MIRT2029073	hsa-miR-4484	CLIP-seq
MIRT1105487	hsa-miR-4500	CLIP-seq
MIRT2260068	hsa-miR-4502	CLIP-seq
MIRT2260069	hsa-miR-4503	CLIP-seq
MIRT2260070	hsa-miR-4519	CLIP-seq
MIRT2260071	hsa-miR-454	CLIP-seq
MIRT1105488	hsa-miR-4540	CLIP-seq
MIRT2260072	hsa-miR-4652-3p	CLIP-seq
MIRT1105489	hsa-miR-4666-3p	CLIP-seq
MIRT2260073	hsa-miR-4697-3p	CLIP-seq
MIRT1105490	hsa-miR-4698	CLIP-seq
MIRT2260074	hsa-miR-4699-3p	CLIP-seq
MIRT1105410	hsa-miR-4703-3p	CLIP-seq
MIRT2260075	hsa-miR-4725-5p	CLIP-seq
MIRT2260076	hsa-miR-483-3p	CLIP-seq
MIRT2029076	hsa-miR-495	CLIP-seq
MIRT1105413	hsa-miR-499-5p	CLIP-seq
MIRT2260077	hsa-miR-504	CLIP-seq
MIRT1105497	hsa-miR-5095	CLIP-seq
MIRT1105415	hsa-miR-513a-5p	CLIP-seq
MIRT1105498	hsa-miR-513b	CLIP-seq
MIRT1105416	hsa-miR-520d-5p	CLIP-seq
MIRT2260078	hsa-miR-520g	CLIP-seq
MIRT1105417	hsa-miR-522	CLIP-seq
MIRT1105418	hsa-miR-524-5p	CLIP-seq
MIRT2260079	hsa-miR-548ac	CLIP-seq
MIRT1105421	hsa-miR-548ae	CLIP-seq
MIRT1105422	hsa-miR-548aj	CLIP-seq
MIRT1105424	hsa-miR-548am	CLIP-seq
MIRT2029077	hsa-miR-548an	CLIP-seq
MIRT2260080	hsa-miR-548c-3p	CLIP-seq
MIRT2260081	hsa-miR-548d-3p	CLIP-seq
MIRT1105500	hsa-miR-548p	CLIP-seq
MIRT1105432	hsa-miR-548v	CLIP-seq
MIRT1105434	hsa-miR-548x	CLIP-seq
MIRT2260082	hsa-miR-548z	CLIP-seq
MIRT2260083	hsa-miR-561	CLIP-seq
MIRT2260084	hsa-miR-579	CLIP-seq
MIRT2029078	hsa-miR-632	CLIP-seq
MIRT2260085	hsa-miR-641	CLIP-seq
MIRT1105437	hsa-miR-656	CLIP-seq
MIRT1105502	hsa-miR-98	CLIP-seq
MIRT1105373	hsa-miR-103a	CLIP-seq
MIRT1105450	hsa-miR-1284	CLIP-seq
MIRT1105380	hsa-miR-1301	CLIP-seq
MIRT1105381	hsa-miR-1305	CLIP-seq
MIRT1105390	hsa-miR-24	CLIP-seq
MIRT1105469	hsa-miR-300	CLIP-seq
MIRT1105473	hsa-miR-338-5p	CLIP-seq
MIRT1105478	hsa-miR-381	CLIP-seq
MIRT1105400	hsa-miR-410	CLIP-seq
MIRT1105402	hsa-miR-4284	CLIP-seq
MIRT1105489	hsa-miR-4666-3p	CLIP-seq
MIRT1105409	hsa-miR-4694-3p	CLIP-seq
MIRT1105412	hsa-miR-4799-5p	CLIP-seq
MIRT1105417	hsa-miR-522	CLIP-seq
MIRT1105454	hsa-miR-181a	CLIP-seq
MIRT1105455	hsa-miR-181b	CLIP-seq
MIRT1105456	hsa-miR-181c	CLIP-seq
MIRT1105457	hsa-miR-181d	CLIP-seq
MIRT1105372	hsa-miR-101	CLIP-seq
MIRT1105374	hsa-miR-105	CLIP-seq
MIRT1105375	hsa-miR-1179	CLIP-seq
MIRT1105447	hsa-miR-1183	CLIP-seq
MIRT1105377	hsa-miR-128	CLIP-seq
MIRT2560307	hsa-miR-1287	CLIP-seq
MIRT1105381	hsa-miR-1305	CLIP-seq
MIRT1105382	hsa-miR-141	CLIP-seq
MIRT1105454	hsa-miR-181a	CLIP-seq
MIRT1105455	hsa-miR-181b	CLIP-seq
MIRT1105456	hsa-miR-181c	CLIP-seq
MIRT1105457	hsa-miR-181d	CLIP-seq
MIRT1105458	hsa-miR-186	CLIP-seq
MIRT1105383	hsa-miR-200a	CLIP-seq
MIRT1105459	hsa-miR-200b	CLIP-seq
MIRT1105460	hsa-miR-200c	CLIP-seq
MIRT1105384	hsa-miR-208a	CLIP-seq
MIRT1105385	hsa-miR-208b	CLIP-seq
MIRT1105386	hsa-miR-217	CLIP-seq
MIRT1105389	hsa-miR-224	CLIP-seq
MIRT1105465	hsa-miR-23a	CLIP-seq
MIRT1105466	hsa-miR-23b	CLIP-seq
MIRT1105467	hsa-miR-23c	CLIP-seq
MIRT1105390	hsa-miR-24	CLIP-seq
MIRT1105391	hsa-miR-27a	CLIP-seq
MIRT1105392	hsa-miR-27b	CLIP-seq
MIRT2560308	hsa-miR-3135b	CLIP-seq
MIRT1105394	hsa-miR-3163	CLIP-seq
MIRT1105395	hsa-miR-329	CLIP-seq
MIRT1105474	hsa-miR-342-3p	CLIP-seq
MIRT1105396	hsa-miR-3613-3p	CLIP-seq
MIRT1105397	hsa-miR-362-3p	CLIP-seq
MIRT1105398	hsa-miR-3662	CLIP-seq
MIRT2260065	hsa-miR-3924	CLIP-seq
MIRT1105399	hsa-miR-3941	CLIP-seq
MIRT1105400	hsa-miR-410	CLIP-seq
MIRT1105401	hsa-miR-412	CLIP-seq
MIRT1105480	hsa-miR-4282	CLIP-seq
MIRT1105402	hsa-miR-4284	CLIP-seq
MIRT1105481	hsa-miR-429	CLIP-seq
MIRT2560309	hsa-miR-433	CLIP-seq
MIRT1105405	hsa-miR-4432	CLIP-seq
MIRT1105406	hsa-miR-4470	CLIP-seq
MIRT1105407	hsa-miR-4477a	CLIP-seq
MIRT1105408	hsa-miR-448	CLIP-seq
MIRT1105409	hsa-miR-4694-3p	CLIP-seq
MIRT1105490	hsa-miR-4698	CLIP-seq
MIRT2260074	hsa-miR-4699-3p	CLIP-seq
MIRT1105410	hsa-miR-4703-3p	CLIP-seq
MIRT1105412	hsa-miR-4799-5p	CLIP-seq
MIRT1105413	hsa-miR-499-5p	CLIP-seq
MIRT1105415	hsa-miR-513a-5p	CLIP-seq
MIRT1105416	hsa-miR-520d-5p	CLIP-seq
MIRT1105417	hsa-miR-522	CLIP-seq
MIRT1105418	hsa-miR-524-5p	CLIP-seq
MIRT1105419	hsa-miR-548a-5p	CLIP-seq
MIRT2560310	hsa-miR-548aa	CLIP-seq
MIRT1105420	hsa-miR-548ab	CLIP-seq
MIRT1105421	hsa-miR-548ae	CLIP-seq
MIRT1105422	hsa-miR-548aj	CLIP-seq
MIRT1105423	hsa-miR-548ak	CLIP-seq
MIRT1105424	hsa-miR-548am	CLIP-seq
MIRT1105425	hsa-miR-548b-5p	CLIP-seq
MIRT2260080	hsa-miR-548c-3p	CLIP-seq
MIRT1105426	hsa-miR-548c-5p	CLIP-seq
MIRT1105427	hsa-miR-548d-5p	CLIP-seq
MIRT1105428	hsa-miR-548h	CLIP-seq
MIRT1105429	hsa-miR-548i	CLIP-seq
MIRT1105430	hsa-miR-548j	CLIP-seq
MIRT1105431	hsa-miR-548n	CLIP-seq
MIRT2560311	hsa-miR-548u	CLIP-seq
MIRT1105433	hsa-miR-548w	CLIP-seq
MIRT1105434	hsa-miR-548x	CLIP-seq
MIRT1105435	hsa-miR-548y	CLIP-seq
MIRT1105436	hsa-miR-559	CLIP-seq
MIRT1105437	hsa-miR-656	CLIP-seq
MIRT1105372	hsa-miR-101	CLIP-seq
MIRT1105374	hsa-miR-105	CLIP-seq
MIRT1105375	hsa-miR-1179	CLIP-seq
MIRT1105447	hsa-miR-1183	CLIP-seq
MIRT1105377	hsa-miR-128	CLIP-seq
MIRT2560307	hsa-miR-1287	CLIP-seq
MIRT1105381	hsa-miR-1305	CLIP-seq
MIRT1105382	hsa-miR-141	CLIP-seq
MIRT1105454	hsa-miR-181a	CLIP-seq
MIRT1105455	hsa-miR-181b	CLIP-seq
MIRT1105456	hsa-miR-181c	CLIP-seq
MIRT1105457	hsa-miR-181d	CLIP-seq
MIRT1105458	hsa-miR-186	CLIP-seq
MIRT1105383	hsa-miR-200a	CLIP-seq
MIRT1105459	hsa-miR-200b	CLIP-seq
MIRT1105460	hsa-miR-200c	CLIP-seq
MIRT1105384	hsa-miR-208a	CLIP-seq
MIRT1105385	hsa-miR-208b	CLIP-seq
MIRT1105386	hsa-miR-217	CLIP-seq
MIRT1105389	hsa-miR-224	CLIP-seq
MIRT1105465	hsa-miR-23a	CLIP-seq
MIRT1105466	hsa-miR-23b	CLIP-seq
MIRT1105467	hsa-miR-23c	CLIP-seq
MIRT1105390	hsa-miR-24	CLIP-seq
MIRT1105391	hsa-miR-27a	CLIP-seq
MIRT1105392	hsa-miR-27b	CLIP-seq
MIRT2683802	hsa-miR-302f	CLIP-seq
MIRT1105470	hsa-miR-3074-3p	CLIP-seq
MIRT2560308	hsa-miR-3135b	CLIP-seq
MIRT2683803	hsa-miR-3143	CLIP-seq
MIRT1105394	hsa-miR-3163	CLIP-seq
MIRT2260060	hsa-miR-3182	CLIP-seq
MIRT2683804	hsa-miR-320a	CLIP-seq
MIRT2683805	hsa-miR-320b	CLIP-seq
MIRT2683806	hsa-miR-320c	CLIP-seq
MIRT2683807	hsa-miR-320d	CLIP-seq
MIRT1105395	hsa-miR-329	CLIP-seq
MIRT1105474	hsa-miR-342-3p	CLIP-seq
MIRT1105396	hsa-miR-3613-3p	CLIP-seq
MIRT1105397	hsa-miR-362-3p	CLIP-seq
MIRT1105398	hsa-miR-3662	CLIP-seq
MIRT2683808	hsa-miR-3672	CLIP-seq
MIRT2260065	hsa-miR-3924	CLIP-seq
MIRT1105399	hsa-miR-3941	CLIP-seq
MIRT1105400	hsa-miR-410	CLIP-seq
MIRT1105401	hsa-miR-412	CLIP-seq
MIRT1105480	hsa-miR-4282	CLIP-seq
MIRT1105402	hsa-miR-4284	CLIP-seq
MIRT1105481	hsa-miR-429	CLIP-seq
MIRT2560309	hsa-miR-433	CLIP-seq
MIRT2683809	hsa-miR-4429	CLIP-seq
MIRT1105405	hsa-miR-4432	CLIP-seq
MIRT1105406	hsa-miR-4470	CLIP-seq
MIRT1105407	hsa-miR-4477a	CLIP-seq
MIRT1105408	hsa-miR-448	CLIP-seq
MIRT2683810	hsa-miR-4639-5p	CLIP-seq
MIRT2260072	hsa-miR-4652-3p	CLIP-seq
MIRT1105409	hsa-miR-4694-3p	CLIP-seq
MIRT1105490	hsa-miR-4698	CLIP-seq
MIRT2260074	hsa-miR-4699-3p	CLIP-seq
MIRT1105412	hsa-miR-4799-5p	CLIP-seq
MIRT2683811	hsa-miR-4803	CLIP-seq
MIRT2683812	hsa-miR-491-3p	CLIP-seq
MIRT1105413	hsa-miR-499-5p	CLIP-seq
MIRT2683813	hsa-miR-501-3p	CLIP-seq
MIRT2683814	hsa-miR-502-3p	CLIP-seq
MIRT1105415	hsa-miR-513a-5p	CLIP-seq
MIRT1105416	hsa-miR-520d-5p	CLIP-seq
MIRT1105417	hsa-miR-522	CLIP-seq
MIRT1105418	hsa-miR-524-5p	CLIP-seq
MIRT1105419	hsa-miR-548a-5p	CLIP-seq
MIRT2560310	hsa-miR-548aa	CLIP-seq
MIRT1105420	hsa-miR-548ab	CLIP-seq
MIRT1105421	hsa-miR-548ae	CLIP-seq
MIRT1105422	hsa-miR-548aj	CLIP-seq
MIRT1105423	hsa-miR-548ak	CLIP-seq
MIRT1105424	hsa-miR-548am	CLIP-seq
MIRT1105425	hsa-miR-548b-5p	CLIP-seq
MIRT2260080	hsa-miR-548c-3p	CLIP-seq
MIRT1105426	hsa-miR-548c-5p	CLIP-seq
MIRT1105427	hsa-miR-548d-5p	CLIP-seq
MIRT1105428	hsa-miR-548h	CLIP-seq
MIRT1105429	hsa-miR-548i	CLIP-seq
MIRT1105430	hsa-miR-548j	CLIP-seq
MIRT1105431	hsa-miR-548n	CLIP-seq
MIRT2560311	hsa-miR-548u	CLIP-seq
MIRT1105433	hsa-miR-548w	CLIP-seq
MIRT1105434	hsa-miR-548x	CLIP-seq
MIRT1105435	hsa-miR-548y	CLIP-seq
MIRT1105436	hsa-miR-559	CLIP-seq
MIRT1105437	hsa-miR-656	CLIP-seq

Show/Hide all (49)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001650	Component	Fibrillar center	IDA
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	TAS	8157662
GO:0003723	Function	RNA binding	HDA	22681889
GO:0005515	Function	Protein binding	IPI	8663349, 26009488, 28514442, 28565870, 32296183, 32694168, 33961781, 35271311
GO:0005521	Function	Lamin binding	TAS	8157662
GO:0005634	Component	Nucleus	IDA	21327084
GO:0005634	Component	Nucleus	IEA
GO:0005635	Component	Nuclear envelope	IEA
GO:0005635	Component	Nuclear envelope	TAS
GO:0005637	Component	Nuclear inner membrane	IBA
GO:0005637	Component	Nuclear inner membrane	IDA	32694168
GO:0005637	Component	Nuclear inner membrane	IEA
GO:0005637	Component	Nuclear inner membrane	TAS	8157662
GO:0005652	Component	Nuclear lamina	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	21327084
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	21327084
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006694	Process	Steroid biosynthetic process	IEA
GO:0006695	Process	Cholesterol biosynthetic process	IBA
GO:0006695	Process	Cholesterol biosynthetic process	IDA	16784888
GO:0006695	Process	Cholesterol biosynthetic process	IEA
GO:0006695	Process	Cholesterol biosynthetic process	IMP	27336722
GO:0006695	Process	Cholesterol biosynthetic process	TAS
GO:0008202	Process	Steroid metabolic process	IEA
GO:0008203	Process	Cholesterol metabolic process	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IDA	15698635
GO:0016020	Component	Membrane	IEA
GO:0016126	Process	Sterol biosynthetic process	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016628	Function	Oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	IEA
GO:0030223	Process	Neutrophil differentiation	IEA
GO:0030223	Process	Neutrophil differentiation	ISS
GO:0031965	Component	Nuclear membrane	IDA
GO:0031965	Component	Nuclear membrane	IEA
GO:0050613	Function	Delta14-sterol reductase activity	IBA
GO:0050613	Function	Delta14-sterol reductase activity	IDA	9630650, 16784888
GO:0050613	Function	Delta14-sterol reductase activity	IEA
GO:0050613	Function	Delta14-sterol reductase activity	IMP	12618959, 21327084, 27336722
GO:0050613	Function	Delta14-sterol reductase activity	TAS
GO:0060816	Process	Random inactivation of X chromosome	IEA
GO:0070087	Function	Chromo shadow domain binding	IPI	15882967
GO:0070402	Function	NADPH binding	IMP	27336722
GO:0140463	Function	Chromatin-protein adaptor activity	IEA

MIM	HGNC	e!Ensembl
600024	6518	ENSG00000143815

Q14739

Protein name

Delta(14)-sterol reductase LBR (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Integral nuclear envelope inner membrane protein) (LMN2R) (Lamin-B receptor) (Sterol C14-reductase)

Protein function

Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722, PubMed:9630650). Plays a critical role i

PDB

2DIG

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09465	LBR_tudor	1 → 55	Lamin-B receptor of TUDOR domain	Domain
PF01222	ERG4_ERG24	183 → 615	Ergosterol biosynthesis ERG4/ERG24 family	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in the bone marrow, liver, heart, adrenal gland, lung, placenta and uterus (PubMed:16784888). Expressed in osteoclasts and osteoblast-like cells (PubMed:21327084). {ECO:0000269|PubMed:16784888, ECO:0000269|PubMed:21327084}.

Sequence

MPSRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELKENDIKPLTSF
RQRKGGSTSSSPSRRRGSRSRSRSRSPGRPPKSARRSASASHQADIKEARREVEVKLTPL
ILKPFGNSISRYNGEPEHIERNDAPHKNTQEKFSLSQESSYIATQYSLRPRREEVKLKEI
DSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQKDPSL
LNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFY
AFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPAS
SGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAM
ILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPN
EVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWW
GFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWE
KYCQRVPYRIFPYIY

Sequence length

615

Interactions

View interactions

	KEGG		Reactome
	Steroid biosynthesis Metabolic pathways Cytoskeleton in muscle cells		Cholesterol biosynthesis Initiation of Nuclear Envelope (NE) Reformation Regulation of MECP2 expression and activity

254

Show/Hide Causal Diseases (9)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Acute myeloid leukemia	Pathogenic	rs374343844	RCV005893843
Anadysplasia-like, spontaneously remitting spondylometaphyseal dysplasia	Pathogenic	rs374343844, rs869312905	RCV000210471 RCV000210455
Greenberg dysplasia	Likely pathogenic; Pathogenic	rs587777171, rs587777172, rs863223326, rs886037655, rs2150958142, rs2150945343, rs374343844, rs869312905, rs387906416, rs754049402, rs573510559	RCV000087263 RCV000087264 RCV000087265 RCV000087267 RCV001824087 RCV001824088 RCV001250665 RCV001250666 RCV000010137 RCV005860087 RCV003163026
Jeune thoracic dystrophy	Likely pathogenic; Pathogenic	rs754049402, rs1236962991	RCV000516056 RCV000515924
LBR-related disorder	Pathogenic; Likely pathogenic	rs374343844, rs2527778968, rs754049402	RCV004530256 RCV004534269 RCV003987561
	Likely pathogenic; Pathogenic	rs587777171, rs863223326, rs1363715209, rs886037616, rs886037617, rs387906416, rs886037618, rs137852606, rs573510559	RCV001197988 RCV000087266 RCV002221980 RCV000010135 RCV000010136 RCV000087262 RCV000010139 RCV000010140 RCV001836859
Regressive spondylometaphyseal dysplasia	Likely pathogenic; Pathogenic	rs754049402, rs573510559	RCV001330715 RCV000656653
Reynolds syndrome	Pathogenic; Likely pathogenic	rs374343844, rs573510559	RCV001330716 RCV004796263
RHIZOMELIC SKELETAL DYSPLASIA WITH PELGER-HUET ANOMALY	Pathogenic; Likely pathogenic	rs374343844, rs869312905, rs886037616, rs587777172, rs1131691304, rs1558655670	RCV002284375 RCV002284376 RCV001824015 RCV001836611 RCV001836612 RCV001824058

Show/Hide Unknown Diseases (16)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cervical cancer	Benign; Likely benign; Conflicting classifications of pathogenicity	rs116020594, rs201212744, rs1216210580	RCV005915315 RCV005911911 RCV005903070
Cholangiocarcinoma	Benign	rs116020594, rs79557502	RCV005915321 RCV005920532
Colorectal cancer	Likely benign	rs78306811	RCV005871376
Connective tissue disorder	Uncertain significance; Conflicting classifications of pathogenicity; Benign; Likely benign	rs773644529, rs1165682529, rs201609720, rs80299691, rs61749338, rs2230416, rs112582692, rs2230422, rs61749339, rs377110126, rs143164834, rs151100686, rs146953852, rs369094974, rs565288775, rs372250618 View all (1 more)	RCV002278768 RCV002278769 RCV002278770 RCV002277584 RCV002278377 RCV002278381 RCV002278378 RCV002278379 RCV002278380 RCV002279263 RCV002279291 RCV002279616 RCV002279619 RCV002279632 RCV002279680 RCV002276624
Familial cancer of breast	Likely benign	rs78306811	RCV005871375
Gastric cancer	Benign	rs116020594, rs10799307, rs79557502	RCV005915318 RCV005919747 RCV005920529
Lung cancer	Benign; Conflicting classifications of pathogenicity	rs116020594, rs10799307, rs1216210580	RCV005915322 RCV005919749 RCV005903072
Malignant lymphoma, large B-cell, diffuse	Benign	rs116020594, rs10799307, rs79557502	RCV005915316 RCV005919746 RCV005920527
Malignant tumor of esophagus	Conflicting classifications of pathogenicity	rs1216210580	RCV005903069
Malignant tumor of urinary bladder	Conflicting classifications of pathogenicity	rs565288775	RCV005912087
Ovarian serous cystadenocarcinoma	Likely benign	rs76951153, rs201212744	RCV005919228 RCV005911912
RHIZOMELIC SKELETAL DYSPLASIA WITHOUT PELGER-HUET ANOMALY	Conflicting classifications of pathogenicity	rs377110126	RCV001824057
Sarcoma	Benign; Conflicting classifications of pathogenicity	rs116020594, rs79557502, rs1216210580	RCV005915317 RCV005920528 RCV005903071
Thymoma	Benign	rs116020594, rs79557502	RCV005915320 RCV005920531
Uterine carcinosarcoma	Benign	rs116020594, rs10799307, rs79557502	RCV005915319 RCV005919748 RCV005920530
Uterine corpus endometrial carcinoma	Likely benign	rs76951153, rs78306811	RCV005919229 RCV005871377

Show/Hide Text Mining Associations (36)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Acquired Immunodeficiency Syndrome	Associate	6334551
Bone Diseases Developmental	Associate	25348816
Breast Neoplasms	Associate	24293108, 27246191, 30484986
Congenital Hereditary and Neonatal Diseases and Abnormalities	Associate	27336722
Death	Associate	19940018
Diabetes Mellitus	Associate	26489030
Diabetes Mellitus Type 2	Associate	10433077
Glomerulonephritis IGA	Stimulate	2785227
HEM dysplasia	Associate	12618959, 19940018, 27336722, 30561119
Hepatitis B	Associate	19940018, 30518689
HIV Infections	Associate	18364393
Laminopathies	Associate	30561119
Leukemia	Stimulate	2460160
Leukemia Hairy Cell	Associate	6978742
Leukemia Lymphocytic Chronic B Cell	Associate	5129303
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	6583283
Leukemia Myeloid Acute	Associate	3857945, 6932979
Lung Neoplasms	Associate	2942252
Macular Degeneration	Associate	27266510
Mandibuloacral dysplasia with type A lipodystrophy	Associate	16046620
Melanoma	Associate	35883595
Metaphyseal anadysplasia	Associate	25348816, 30561119
Multiple Myeloma	Associate	3664530
Muscular Diseases	Associate	33958580
Neoplasms	Associate	24293108, 31481734
Neuromuscular Diseases	Associate	33958580
Optic Disk Drusen	Associate	39865650
Osteosarcoma	Associate	32316379
Pelger Huet Anomaly	Associate	12618959, 19940018, 21103616, 21327094, 23355469, 27336722, 27684937, 30561119
Pemphigus	Associate	6432916
Polypoidal Choroidal Vasculopathy	Associate	27266510
Psychomotor Disorders	Associate	28286461
Short rib polydactyly syndrome Beemer type	Associate	29068549
Status Asthmaticus	Associate	10725262
Strudwick syndrome	Associate	25348816, 30561119
Thyroid Cancer Papillary	Associate	21103616

LBR (lamin B receptor)