GRID2IP (Grid2 interacting protein)

Gene

• Entrez ID: 392862
• Gene name: Grid2 interacting protein
• Gene symbol: GRID2IP
• Synonyms (NCBI Gene): DELPHILIN
• Chromosome: 7
• Chromosome location: 7p22.1
• Summary: Glutamate receptor delta-2 (GRID2; MIM 602368) is predominantly expressed at parallel fiber-Purkinje cell postsynapses and plays crucial roles in synaptogenesis and synaptic plasticity. GRID2IP1 interacts with GRID2 and may control GRID2 signaling in Purk

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT048784	hsa-miR-93-5p	CLASH	23622248
MIRT720909	hsa-miR-6865-3p	HITS-CLIP	19536157
MIRT720908	hsa-miR-663b	HITS-CLIP	19536157
MIRT720907	hsa-miR-4701-5p	HITS-CLIP	19536157
MIRT720906	hsa-miR-588	HITS-CLIP	19536157
MIRT720905	hsa-miR-2054	HITS-CLIP	19536157
MIRT720904	hsa-miR-7108-5p	HITS-CLIP	19536157
MIRT720909	hsa-miR-6865-3p	HITS-CLIP	19536157
MIRT720908	hsa-miR-663b	HITS-CLIP	19536157
MIRT720907	hsa-miR-4701-5p	HITS-CLIP	19536157
MIRT720906	hsa-miR-588	HITS-CLIP	19536157
MIRT720905	hsa-miR-2054	HITS-CLIP	19536157
MIRT720904	hsa-miR-7108-5p	HITS-CLIP	19536157
MIRT1034212	hsa-miR-1231	CLIP-seq
MIRT1034213	hsa-miR-1285	CLIP-seq
MIRT1034214	hsa-miR-1915	CLIP-seq
MIRT1034215	hsa-miR-3155	CLIP-seq
MIRT1034216	hsa-miR-3155b	CLIP-seq
MIRT1034217	hsa-miR-3187-5p	CLIP-seq
MIRT1034218	hsa-miR-34a	CLIP-seq
MIRT1034219	hsa-miR-34c-5p	CLIP-seq
MIRT1034220	hsa-miR-378g	CLIP-seq
MIRT1034221	hsa-miR-4286	CLIP-seq
MIRT1034222	hsa-miR-4486	CLIP-seq
MIRT1034223	hsa-miR-449a	CLIP-seq
MIRT1034224	hsa-miR-449b	CLIP-seq
MIRT1034225	hsa-miR-4726-3p	CLIP-seq
MIRT1034226	hsa-miR-484	CLIP-seq
MIRT1034227	hsa-miR-612	CLIP-seq
MIRT2006744	hsa-miR-1205	CLIP-seq
MIRT2239150	hsa-miR-1976	CLIP-seq
MIRT2239151	hsa-miR-370	CLIP-seq
MIRT2239152	hsa-miR-4268	CLIP-seq
MIRT2239153	hsa-miR-4448	CLIP-seq
MIRT2239154	hsa-miR-4774-5p	CLIP-seq
MIRT2239155	hsa-miR-591	CLIP-seq
MIRT2388758	hsa-miR-661	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0060292	Process	Long-term synaptic depression	IEA
GO:0098688	Component	Parallel fiber to Purkinje cell synapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099072	Process	Regulation of postsynaptic membrane neurotransmitter receptor levels	IEA
GO:0099092	Component	Postsynaptic density, intracellular component	IEA
GO:0099566	Process	Regulation of postsynaptic cytosolic calcium ion concentration	IEA
GO:0150048	Component	Cerebellar granule cell to Purkinje cell synapse	IEA

Other IDs

• MIM: 610639
• HGNC: 18464
• e!Ensembl: ENSG00000215045

Protein

• UniProt ID: A4D2P6
• Protein name: Delphilin (Glutamate receptor, ionotropic, delta 2-interacting protein 1)
• Protein function: Postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00595	PDZ	10 → 80	PDZ domain	Domain
  PF00595	PDZ	279 → 353	PDZ domain	Domain
  PF02181	FH2	820 → 1188	Formin Homology 2 Domain	Family

• Sequence:

  MATTATPATNQGWPEDFGFRLGGSGPCFVLEVAKGSSAHAGGLRPGDQILEVEGLAVGGL
  SRERLVRLARRCPRVPPSLGVLPAPDGGPGPGSGPAAPTTVLRAPRCGRGLALGRELLRL
  AGRKRPDAVHRERRRKAQEFSRKVDEILGDQPTAKEQVFAALKQFAAEQRVDDLVWTLTL
  ALPREACGPLLDNLRIFIPKKHRARFDEVVSQGLLGKLCRARRAQGAQRLRRSRSEERPE
  RLLVSTRASAPPRRPDEPPPRRASLLVGGLAGPGGARRTVRVYKGNKSFGFTLRGHGPVW
  IESVLPGSPADNAALKSGDRILFLNGLDMRNCSHDKVVSMLQGSGAMPTLVVEEGLVPFA
  SDSDSLDSPNPSSALTSLQWVAEILPSSIRVQGRTFSQQLEHLLTPPERYGVCRALESFF
  QHRNIDTLIVDVYPVLDTPAKQVLWQFIYQLLTYEEQELCQEKIACFLGYTAMTAEPEPE
  LDLESEPTPEPQPRSSLRASSMCRRSLRSQGLEAGLSCGPSECPEMPLPLIPGERQAGDG
  TSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLSGVSW
  PSERLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPGPGPICPDSPPSPDPTR
  PPSRRKLFTFSHPVRSRDTDRFLDVLSEQLGPRVTIVDDFLTPENDYEEMSFHDDQGSFV
  TNERSSASDCISSSEEGSSLTYSSISDHIPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGP
  AQALAKPLTQLSHPVPPPPPPPLPPPVPCAPPMLSRGLGHRRSETSHMSVKRLRWEQVEN
  SEGTIWGQLGEDSDYDKLSDMVKYLDLELHFGTQKPAKPVPGPEPFRKKEVVEILSHKKA
  YNTSILLAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRL
  SEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKIL
  EFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLG
  FAQDLPTVPLAAKVNQRALTSDLADLHGTISEIQDACQSISPSSEDKFAMVMSSFLETAQ
  PALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFAEFMSKFERALSDLQAGEGL
  RSSGMVSPLAW

• Sequence length: 1211

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CROHN'S DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Primary degenerative dementia of the Alzheimer type, presenile onset	Uncertain significance	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
ULCERATIVE COLITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Colorectal Neoplasms	Associate	37964339	★☆☆☆☆ Found in Text Mining only
Dementia	Associate	31836585	★☆☆☆☆ Found in Text Mining only