Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	392862
Gene name Gene Name - the full gene name approved by the HGNC.	Grid2 interacting protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GRID2IP
Synonyms (NCBI Gene) Gene synonyms aliases	DELPHILIN
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7p22.1
Summary Summary of gene provided in NCBI Entrez Gene.	Glutamate receptor delta-2 (GRID2; MIM 602368) is predominantly expressed at parallel fiber-Purkinje cell postsynapses and plays crucial roles in synaptogenesis and synaptic plasticity. GRID2IP1 interacts with GRID2 and may control GRID2 signaling in Purk

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miRTarBase ID	miRNA	Experiments	Reference
MIRT048784	hsa-miR-93-5p	CLASH	23622248
MIRT720909	hsa-miR-6865-3p	HITS-CLIP	19536157
MIRT720908	hsa-miR-663b	HITS-CLIP	19536157
MIRT720907	hsa-miR-4701-5p	HITS-CLIP	19536157
MIRT720906	hsa-miR-588	HITS-CLIP	19536157
MIRT720905	hsa-miR-2054	HITS-CLIP	19536157
MIRT720904	hsa-miR-7108-5p	HITS-CLIP	19536157
MIRT720909	hsa-miR-6865-3p	HITS-CLIP	19536157
MIRT720908	hsa-miR-663b	HITS-CLIP	19536157
MIRT720907	hsa-miR-4701-5p	HITS-CLIP	19536157
MIRT720906	hsa-miR-588	HITS-CLIP	19536157
MIRT720905	hsa-miR-2054	HITS-CLIP	19536157
MIRT720904	hsa-miR-7108-5p	HITS-CLIP	19536157
MIRT1034212	hsa-miR-1231	CLIP-seq
MIRT1034213	hsa-miR-1285	CLIP-seq
MIRT1034214	hsa-miR-1915	CLIP-seq
MIRT1034215	hsa-miR-3155	CLIP-seq
MIRT1034216	hsa-miR-3155b	CLIP-seq
MIRT1034217	hsa-miR-3187-5p	CLIP-seq
MIRT1034218	hsa-miR-34a	CLIP-seq
MIRT1034219	hsa-miR-34c-5p	CLIP-seq
MIRT1034220	hsa-miR-378g	CLIP-seq
MIRT1034221	hsa-miR-4286	CLIP-seq
MIRT1034222	hsa-miR-4486	CLIP-seq
MIRT1034223	hsa-miR-449a	CLIP-seq
MIRT1034224	hsa-miR-449b	CLIP-seq
MIRT1034225	hsa-miR-4726-3p	CLIP-seq
MIRT1034226	hsa-miR-484	CLIP-seq
MIRT1034227	hsa-miR-612	CLIP-seq
MIRT2006744	hsa-miR-1205	CLIP-seq
MIRT2239150	hsa-miR-1976	CLIP-seq
MIRT2239151	hsa-miR-370	CLIP-seq
MIRT2239152	hsa-miR-4268	CLIP-seq
MIRT2239153	hsa-miR-4448	CLIP-seq
MIRT2239154	hsa-miR-4774-5p	CLIP-seq
MIRT2239155	hsa-miR-591	CLIP-seq
MIRT2388758	hsa-miR-661	CLIP-seq

Show/Hide all(11)

GO ID	Ontology	Definition	Evidence
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0060292	Process	Long-term synaptic depression	IEA
GO:0098688	Component	Parallel fiber to Purkinje cell synapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099072	Process	Regulation of postsynaptic membrane neurotransmitter receptor levels	IEA
GO:0099092	Component	Postsynaptic density, intracellular component	IEA
GO:0099566	Process	Regulation of postsynaptic cytosolic calcium ion concentration	IEA
GO:0150048	Component	Cerebellar granule cell to Purkinje cell synapse	IEA

MIM	HGNC	e!Ensembl
610639	18464	ENSG00000215045

Protein

UniProt ID

A4D2P6

Protein name

Delphilin (Glutamate receptor, ionotropic, delta 2-interacting protein 1)

Protein function

Postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00595	PDZ	10 → 80	PDZ domain	Domain
PF00595	PDZ	279 → 353	PDZ domain	Domain
PF02181	FH2	820 → 1188	Formin Homology 2 Domain	Family

Sequence

MATTATPATNQGWPEDFGFRLGGSGPCFVLEVAKGSSAHAGGLRPGDQILEVEGLAVGGL
SRERLVRLARRCPRVPPSLGVLPAPDGGPGPGSGPAAPTTVLRAPRCGRGLALGRELLRL
AGRKRPDAVHRERRRKAQEFSRKVDEILGDQPTAKEQVFAALKQFAAEQRVDDLVWTLTL
ALPREACGPLLDNLRIFIPKKHRARFDEVVSQGLLGKLCRARRAQGAQRLRRSRSEERPE
RLLVSTRASAPPRRPDEPPPRRASLLVGGLAGPGGARRTVRVYKGNKSFGFTLRGHGPVW
IESVLPGSPADNAALKSGDRILFLNGLDMRNCSHDKVVSMLQGSGAMPTLVVEEGLVPFA
SDSDSLDSPNPSSALTSLQWVAEILPSSIRVQGRTFSQQLEHLLTPPERYGVCRALESFF
QHRNIDTLIVDVYPVLDTPAKQVLWQFIYQLLTYEEQELCQEKIACFLGYTAMTAEPEPE
LDLESEPTPEPQPRSSLRASSMCRRSLRSQGLEAGLSCGPSECPEMPLPLIPGERQAGDG
TSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLSGVSW
PSERLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPGPGPICPDSPPSPDPTR
PPSRRKLFTFSHPVRSRDTDRFLDVLSEQLGPRVTIVDDFLTPENDYEEMSFHDDQGSFV
TNERSSASDCISSSEEGSSLTYSSISDHIPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGP
AQALAKPLTQLSHPVPPPPPPPLPPPVPCAPPMLSRGLGHRRSETSHMSVKRLRWEQVEN
SEGTIWGQLGEDSDYDKLSDMVKYLDLELHFGTQKPAKPVPGPEPFRKKEVVEILSHKKA
YNTSILLAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRL
SEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKIL
EFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLG
FAQDLPTVPLAAKVNQRALTSDLADLHGTISEIQDACQSISPSSEDKFAMVMSSFLETAQ
PALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFAEFMSKFERALSDLQAGEGL
RSSGMVSPLAW

Sequence length

1211

Interactions

View interactions

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Alzheimer disease	Primary degenerative dementia of the Alzheimer type, presenile onset	N/A	N/A	ClinVar
Inflammatory Bowel Disease	Inflammatory bowel disease	N/A	N/A	GWAS
Ulcerative colitis	Ulcerative colitis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Colorectal Neoplasms	Associate	37964339
Dementia	Associate	31836585

GRID2IP (Grid2 interacting protein)