Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3927
Gene name Gene Name - the full gene name approved by the HGNC.
LIM and SH3 protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LASP1
Synonyms (NCBI Gene) Gene synonyms aliases
Lasp-1, MLN50
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q12
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling pr
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003708 hsa-miR-218-5p qRT-PCR 19168627
MIRT003708 hsa-miR-218-5p Microarray, qRT-PCR 19168627
MIRT002808 hsa-miR-1-3p Microarray 15685193
MIRT002808 hsa-miR-1-3p Luciferase reporter assay, qRT-PCR, Western blot 20843712
MIRT005813 hsa-miR-133a-3p Luciferase reporter assay, qRT-PCR, Western blot 20843712
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003779 Function Actin binding IEA
GO:0005515 Function Protein binding IPI 16189514, 19060904, 21516116, 22665060, 24705354, 25416956, 25814554, 27107012, 31515488, 32296183, 32814053
GO:0005737 Component Cytoplasm IDA 25468996
GO:0005737 Component Cytoplasm IEA
GO:0005856 Component Cytoskeleton IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602920 6513 ENSG00000002834
Protein
UniProt ID Q14847
Protein name LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50)
Protein function Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but
PDB 3I35
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00412 LIM 5 61 LIM domain Domain
PF00880 Nebulin 67 94 Nebulin repeat Repeat
PF00880 Nebulin 103 130 Nebulin repeat Repeat
PF14604 SH3_9 209 259 Variant SH3 domain Domain
Sequence
Sequence length 261
Interactions View interactions
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