Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3927
Gene name Gene Name - the full gene name approved by the HGNC.
LIM and SH3 protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LASP1
Synonyms (NCBI Gene) Gene synonyms aliases
Lasp-1, MLN50
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q12
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling pr
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003708 hsa-miR-218-5p qRT-PCR 19168627
MIRT003708 hsa-miR-218-5p Microarray, qRT-PCR 19168627
MIRT002808 hsa-miR-1-3p Microarray 15685193
MIRT002808 hsa-miR-1-3p Luciferase reporter assay, qRT-PCR, Western blot 20843712
MIRT005813 hsa-miR-133a-3p Luciferase reporter assay, qRT-PCR, Western blot 20843712
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 16189514, 19060904, 21516116, 22665060, 25416956, 25814554, 31515488
GO:0005737 Component Cytoplasm IDA 25468996
GO:0005925 Component Focal adhesion HDA 21423176
GO:0005925 Component Focal adhesion IBA 21873635
GO:0006811 Process Ion transport ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602920 6513 ENSG00000002834
Protein
UniProt ID Q14847
Protein name LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50)
Protein function Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but
PDB 3I35
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00412 LIM 5 61 LIM domain Domain
PF00880 Nebulin 67 94 Nebulin repeat Repeat
PF00880 Nebulin 103 130 Nebulin repeat Repeat
PF14604 SH3_9 209 259 Variant SH3 domain Domain
Sequence
Sequence length 261
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Autism Autistic Disorder rs121964908, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699
View all (8 more)
17376794
Endometrial carcinoma Endometrial Carcinoma rs34612342, rs587776667, rs587776701, rs63750955, rs587776706, rs121434629, rs80359605, rs121913530, rs104894365, rs79184941, rs121913478, rs63750781, rs193922343, rs267608094, rs267608077
View all (247 more)
28232485
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
23040864
Associations from Text Mining
Disease Name Relationship Type References
Acute Coronary Syndrome Associate 28666417
Adenomyosis Associate 35379225
Breast Neoplasms Associate 17211471, 17956604, 18419822, 20461080, 24980827, 25982273, 27588391, 32075106, 7589475
Carcinoma Hepatocellular Associate 19177205, 22897902, 25760690, 28266596, 32344996, 35081873, 36670097
Carcinoma Renal Cell Associate 24955835
Chondrosarcoma Associate 35507100
Chordoma Associate 35507100
Colorectal Neoplasms Associate 20812987, 25196260, 27156963, 28606091
Coronary Artery Disease Associate 28666417
Dyskinesias Associate 24386158