Gene Gene information from NCBI Gene database.
Entrez ID 3927
Gene name LIM and SH3 protein 1
Gene symbol LASP1
Synonyms (NCBI Gene)
Lasp-1MLN50
Chromosome 17
Chromosome location 17q12
Summary This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling pr
miRNA miRNA information provided by mirtarbase database.
1510
miRTarBase ID miRNA Experiments Reference
MIRT003708 hsa-miR-218-5p qRT-PCR 19168627
MIRT003708 hsa-miR-218-5p MicroarrayqRT-PCR 19168627
MIRT002808 hsa-miR-1-3p Microarray 15685193
MIRT002808 hsa-miR-1-3p Luciferase reporter assayqRT-PCRWestern blot 20843712
MIRT005813 hsa-miR-133a-3p Luciferase reporter assayqRT-PCRWestern blot 20843712
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
21
GO ID Ontology Definition Evidence Reference
GO:0003779 Function Actin binding IEA
GO:0005515 Function Protein binding IPI 16189514, 19060904, 21516116, 22665060, 24705354, 25416956, 25814554, 27107012, 31515488, 32296183, 32814053
GO:0005737 Component Cytoplasm IDA 25468996
GO:0005737 Component Cytoplasm IEA
GO:0005856 Component Cytoskeleton IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602920 6513 ENSG00000002834
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q14847
Protein name LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50)
Protein function Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but
PDB 3I35
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00412 LIM 5 61 LIM domain Domain
PF00880 Nebulin 67 94 Nebulin repeat Repeat
PF00880 Nebulin 103 130 Nebulin repeat Repeat
PF14604 SH3_9 209 259 Variant SH3 domain Domain
Sequence
Sequence length 261
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
3
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Benign rs141320621 RCV005907590
Gastric cancer Benign rs141320621 RCV005907591
Hereditary breast ovarian cancer syndrome Uncertain significance rs746452006 RCV001374495
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acute Coronary Syndrome Associate 28666417
Adenomyosis Associate 35379225
Breast Neoplasms Associate 17211471, 17956604, 18419822, 20461080, 24980827, 25982273, 27588391, 32075106, 7589475
Carcinoma Hepatocellular Associate 19177205, 22897902, 25760690, 28266596, 32344996, 35081873, 36670097
Carcinoma Renal Cell Associate 24955835
Chondrosarcoma Associate 35507100
Chordoma Associate 35507100
Colorectal Neoplasms Associate 20812987, 25196260, 27156963, 28606091
Coronary Artery Disease Associate 28666417
Dyskinesias Associate 24386158