Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	392636
Gene name Gene Name - the full gene name approved by the HGNC.	Alkylglycerol monooxygenase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	AGMO
Synonyms (NCBI Gene) Gene synonyms aliases	TMEM195
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7p21.2
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a tetrahydrobiopterin- and iron-dependent enzyme that cleaves the ether bond of alkylglycerols. Sequence comparisons distinguish this protein as forming a third, distinct class of tetrahydrobiopterin-dependent enzymes.

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SNP ID	Visualize variation	Clinical significance	Consequence
rs139309795	G>A	Conflicting-interpretations-of-pathogenicity	Non coding transcript variant, coding sequence variant, stop gained

Show/Hide all(134)

miRTarBase ID	miRNA	Experiments	Reference
MIRT663516	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT663515	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT663514	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT663513	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT663512	hsa-miR-1976	HITS-CLIP	23824327
MIRT663511	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT663510	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT663509	hsa-miR-4279	HITS-CLIP	23824327
MIRT663508	hsa-miR-498	HITS-CLIP	23824327
MIRT619697	hsa-miR-3680-5p	HITS-CLIP	23824327
MIRT619696	hsa-miR-3145-5p	HITS-CLIP	23824327
MIRT619695	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT619694	hsa-miR-6777-3p	HITS-CLIP	23824327
MIRT619693	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT619692	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT619691	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT619690	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT619689	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT619688	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT619687	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT619686	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT619685	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT619684	hsa-miR-5698	HITS-CLIP	23824327
MIRT663516	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT663515	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT663514	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT663513	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT663512	hsa-miR-1976	HITS-CLIP	23824327
MIRT663511	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT663510	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT663509	hsa-miR-4279	HITS-CLIP	23824327
MIRT663508	hsa-miR-498	HITS-CLIP	23824327
MIRT619697	hsa-miR-3680-5p	HITS-CLIP	23824327
MIRT619696	hsa-miR-3145-5p	HITS-CLIP	23824327
MIRT619695	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT619694	hsa-miR-6777-3p	HITS-CLIP	23824327
MIRT619693	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT619692	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT619691	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT619690	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT619689	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT619688	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT619687	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT619686	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT619685	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT619684	hsa-miR-5698	HITS-CLIP	23824327
MIRT772196	hsa-miR-122	CLIP-seq
MIRT772197	hsa-miR-139-3p	CLIP-seq
MIRT772198	hsa-miR-3135b	CLIP-seq
MIRT772199	hsa-miR-326	CLIP-seq
MIRT772200	hsa-miR-330-5p	CLIP-seq
MIRT772201	hsa-miR-3652	CLIP-seq
MIRT772202	hsa-miR-3675-3p	CLIP-seq
MIRT772203	hsa-miR-378	CLIP-seq
MIRT772204	hsa-miR-378b	CLIP-seq
MIRT772205	hsa-miR-378c	CLIP-seq
MIRT772206	hsa-miR-378d	CLIP-seq
MIRT772207	hsa-miR-378e	CLIP-seq
MIRT772208	hsa-miR-378f	CLIP-seq
MIRT772209	hsa-miR-378h	CLIP-seq
MIRT772210	hsa-miR-378i	CLIP-seq
MIRT772211	hsa-miR-422a	CLIP-seq
MIRT772212	hsa-miR-4294	CLIP-seq
MIRT772213	hsa-miR-433	CLIP-seq
MIRT772214	hsa-miR-4430	CLIP-seq
MIRT772215	hsa-miR-4454	CLIP-seq
MIRT772216	hsa-miR-4535	CLIP-seq
MIRT772217	hsa-miR-4638-3p	CLIP-seq
MIRT772218	hsa-miR-4766-3p	CLIP-seq
MIRT772219	hsa-miR-4775	CLIP-seq
MIRT772220	hsa-miR-492	CLIP-seq
MIRT772221	hsa-miR-548p	CLIP-seq
MIRT772222	hsa-miR-586	CLIP-seq
MIRT772223	hsa-miR-590-3p	CLIP-seq
MIRT772224	hsa-miR-720	CLIP-seq
MIRT772196	hsa-miR-122	CLIP-seq
MIRT1927867	hsa-miR-1915	CLIP-seq
MIRT772198	hsa-miR-3135b	CLIP-seq
MIRT1927868	hsa-miR-3199	CLIP-seq
MIRT772201	hsa-miR-3652	CLIP-seq
MIRT772214	hsa-miR-4430	CLIP-seq
MIRT1927869	hsa-miR-4726-3p	CLIP-seq
MIRT772224	hsa-miR-720	CLIP-seq
MIRT772196	hsa-miR-122	CLIP-seq
MIRT772198	hsa-miR-3135b	CLIP-seq
MIRT1927868	hsa-miR-3199	CLIP-seq
MIRT772201	hsa-miR-3652	CLIP-seq
MIRT772212	hsa-miR-4294	CLIP-seq
MIRT2168727	hsa-miR-4318	CLIP-seq
MIRT772214	hsa-miR-4430	CLIP-seq
MIRT2168728	hsa-miR-4438	CLIP-seq
MIRT2168729	hsa-miR-5095	CLIP-seq
MIRT2168730	hsa-miR-518a-5p	CLIP-seq
MIRT2168731	hsa-miR-527	CLIP-seq
MIRT2168732	hsa-miR-548ag	CLIP-seq
MIRT2168733	hsa-miR-548ai	CLIP-seq
MIRT2168734	hsa-miR-548m	CLIP-seq
MIRT2168735	hsa-miR-663b	CLIP-seq
MIRT772224	hsa-miR-720	CLIP-seq
MIRT772196	hsa-miR-122	CLIP-seq
MIRT2443352	hsa-miR-1323	CLIP-seq
MIRT772197	hsa-miR-139-3p	CLIP-seq
MIRT1927867	hsa-miR-1915	CLIP-seq
MIRT772198	hsa-miR-3135b	CLIP-seq
MIRT772201	hsa-miR-3652	CLIP-seq
MIRT2443353	hsa-miR-4271	CLIP-seq
MIRT772212	hsa-miR-4294	CLIP-seq
MIRT772214	hsa-miR-4430	CLIP-seq
MIRT2443354	hsa-miR-4725-3p	CLIP-seq
MIRT1927869	hsa-miR-4726-3p	CLIP-seq
MIRT2443355	hsa-miR-548a-3p	CLIP-seq
MIRT2443356	hsa-miR-548e	CLIP-seq
MIRT2443357	hsa-miR-548f	CLIP-seq
MIRT2443358	hsa-miR-548o	CLIP-seq
MIRT2443359	hsa-miR-625	CLIP-seq
MIRT772224	hsa-miR-720	CLIP-seq
MIRT772196	hsa-miR-122	CLIP-seq
MIRT772197	hsa-miR-139-3p	CLIP-seq
MIRT1927867	hsa-miR-1915	CLIP-seq
MIRT772198	hsa-miR-3135b	CLIP-seq
MIRT772201	hsa-miR-3652	CLIP-seq
MIRT772212	hsa-miR-4294	CLIP-seq
MIRT772214	hsa-miR-4430	CLIP-seq
MIRT1927869	hsa-miR-4726-3p	CLIP-seq
MIRT772224	hsa-miR-720	CLIP-seq
MIRT772196	hsa-miR-122	CLIP-seq
MIRT772197	hsa-miR-139-3p	CLIP-seq
MIRT1927867	hsa-miR-1915	CLIP-seq
MIRT772198	hsa-miR-3135b	CLIP-seq
MIRT772201	hsa-miR-3652	CLIP-seq
MIRT772212	hsa-miR-4294	CLIP-seq
MIRT772214	hsa-miR-4430	CLIP-seq
MIRT1927869	hsa-miR-4726-3p	CLIP-seq
MIRT772224	hsa-miR-720	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005506	Function	Iron ion binding	IEA
GO:0005506	Function	Iron ion binding	IMP	20643956
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	20643956
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006643	Process	Membrane lipid metabolic process	IBA
GO:0006643	Process	Membrane lipid metabolic process	IDA	20643956
GO:0008610	Process	Lipid biosynthetic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0019432	Process	Triglyceride biosynthetic process	IEA
GO:0019432	Process	Triglyceride biosynthetic process	TAS
GO:0046485	Process	Ether lipid metabolic process	IDA	20643956
GO:0050479	Function	Glyceryl-ether monooxygenase activity	IBA
GO:0050479	Function	Glyceryl-ether monooxygenase activity	IDA	20643956
GO:0050479	Function	Glyceryl-ether monooxygenase activity	IEA
GO:0050479	Function	Glyceryl-ether monooxygenase activity	TAS

MIM	HGNC	e!Ensembl
613738	33784	ENSG00000187546

Protein

UniProt ID

Q6ZNB7

Protein name

Alkylglycerol monooxygenase (EC 1.14.16.5) (Transmembrane protein 195)

Protein function

Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04116	FA_hydroxylase	117 → 249	Fatty acid hydroxylase superfamily	Family

Sequence

MKNPEAQQDVSVSQGFRMLFYTMKPSETSFQTLEEVPDYVKKATPFFISLMLLELVVSWI
LKGKPPGRLDDALTSISAGVLSRLPSLFFRSIELTSYIYIWENYRLFNLPWDSPWTWYSA
FLGVDFGYYWFHRMAHEVNIMWAGHQTHHSSEDYNLSTALRQSVLQIYTSWIFYSPLALF
IPPSVYAVHLQFNLLYQFWIHTEVINNLGPLELILNTPSHHRVHHGRNRYCIDKNYAGVL
IIWDKIFGTFEAENEKVVYGLTHPINTFEPIKVQFHHLFSIWTTFWATPGFFNKFSVIFK
GPGWGPGKPRLGLSEEIPEVTGKEVPFSSSSSQLLKIYTVVQFALMLAFYEETFADTAAL
SQVTLLLRVCFIILTLTSIGFLLDQRPKAAIMETLRCLMFLMLYRFGHLKPLVPSLSSAF
EIVFSICIAFWGVRSMKQLTSHPWK

Sequence length

445

Interactions

View interactions

	Reactome
			Triglyceride biosynthesis

Show/Hide Unknown Diseases (7)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Autism Spectrum Disorder	autism spectrum disorder	N/A	N/A	GenCC
Cataract	Cataract	N/A	N/A	GWAS
Diabetes	Type 2 diabetes, Type 2 diabetes with neurological manifestations (PheCode 250.24), Type 2 diabetes (PheCode 250.2), Diabetes	N/A	N/A	GWAS
Hypertension	Hypertension	N/A	N/A	GWAS
Hypogonadism	Hypogonadism	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Oligodendroglioma	Oligodendroglioma	N/A	N/A	GWAS

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Colorectal Neoplasms	Associate	28446149
Diabetes Mellitus Type 2	Associate	20081858, 31049640
Hypoglycemia	Associate	20870969
Neoplasms	Associate	28446149
Obesity	Associate	27377425, 28446149
Tuberculosis Pulmonary	Associate	26767831

AGMO (alkylglycerol monooxygenase)