Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3925
Gene name Gene Name - the full gene name approved by the HGNC.
Stathmin 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
STMN1
Synonyms (NCBI Gene) Gene synonyms aliases
C1orf215, LAP18, Lag, OP18, PP17, PP19, PR22, SMN
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p36.11
Summary Summary of gene provided in NCBI Entrez Gene.
This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulatio
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000129 hsa-miR-223-3p -7 18555017
MIRT000129 hsa-miR-223-3p -7 18555017
MIRT000129 hsa-miR-223-3p -7 18555017
MIRT006149 hsa-miR-101-3p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 21915098
MIRT006149 hsa-miR-101-3p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 21915098
Transcription factors
Transcription factor Regulation Reference
CREB1 Unknown 23000483
EGR1 Unknown 19786090
JUN Activation 15474303
KLF10 Repression 18930345
LYL1 Unknown 23000483
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000281 Process Mitotic cytokinesis IMP 25122120
GO:0005515 Function Protein binding IPI 15652749, 21423803, 25416956
GO:0005737 Component Cytoplasm IBA 21873635
GO:0005829 Component Cytosol IEA
GO:0005874 Component Microtubule IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
151442 6510 ENSG00000117632
Protein
UniProt ID P16949
Protein name Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17)
Protein function Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Invol
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00836 Stathmin 5 140 Stathmin family Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is read
Sequence
Sequence length 149
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  MAPK signaling pathway
MicroRNAs in cancer
  Nuclear signaling by ERBB4
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
17659439
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
17659439
Carcinoma Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 12376462
Glioma Glioma, mixed gliomas, Malignant Glioma rs121909219, rs121909224, rs587776667, rs587776671, rs121909239, rs121909241, rs28933368, rs121913500, rs55863639, rs786201995, rs786202517, rs786201044, rs398123317, rs1057518425, rs121913499
View all (13 more)
17440165
Unknown
Disease term Disease name Evidence References Source
Mental depression Mental Depression, Depressive disorder 21438138, 23185405, 23668904 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Abortion Spontaneous Inhibit 26272359
Adenocarcinoma Associate 16624860, 24433541, 25921119, 28457543, 33234735
Adenocarcinoma Of Esophagus Stimulate 24433541
Adenocarcinoma of Lung Associate 12644570, 28282798, 28457543
Adrenocortical Carcinoma Associate 35500219
Aneuploidy Stimulate 21242118
Aneuploidy Associate 33247690
Anxiety Associate 23185405
Breast Neoplasms Associate 10638981, 10917544, 17452630, 18563556, 20816848, 22359235, 22480216, 23071542, 23925999, 25014225, 25072257, 26087399, 28766688, 32076022, 33201835
View all (4 more)
Breast Neoplasms Inhibit 17418982