Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	3921
Gene name	Ribosomal protein SA
Gene symbol	RPSA
Synonyms (NCBI Gene)	37LRP67LRICASLAMBRLAMR1LBPLBP/p40LRPLRP/LRNEM/1CHD4SAlamRp40uS2
Chromosome	3
Chromosome location	3p22.1
Summary	Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, n

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SNP ID	Visualize variation	Clinical significance	Consequence
rs398122389	->TCATG	Pathogenic	Coding sequence variant, frameshift variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT031978	hsa-miR-16-5p	Proteomics	18668040
MIRT052459	hsa-let-7a-5p	CLASH	23622248
MIRT051967	hsa-let-7b-5p	CLASH	23622248
MIRT051511	hsa-let-7e-5p	CLASH	23622248
MIRT051008	hsa-miR-17-5p	CLASH	23622248
MIRT050472	hsa-miR-22-3p	CLASH	23622248
MIRT050204	hsa-miR-25-3p	CLASH	23622248
MIRT048301	hsa-miR-107	CLASH	23622248
MIRT045843	hsa-miR-132-3p	CLASH	23622248
MIRT039727	hsa-miR-615-3p	CLASH	23622248
MIRT039076	hsa-miR-769-3p	CLASH	23622248
MIRT036398	hsa-miR-1227-3p	CLASH	23622248
MIRT052824	hsa-miR-3200-3p	CLASH	23622248
MIRT1319054	hsa-miR-4696	CLIP-seq
MIRT1319055	hsa-miR-4720-3p	CLIP-seq
MIRT1319056	hsa-miR-4804-3p	CLIP-seq
MIRT1319057	hsa-miR-587	CLIP-seq
MIRT1319054	hsa-miR-4696	CLIP-seq
MIRT1319055	hsa-miR-4720-3p	CLIP-seq
MIRT1319058	hsa-miR-4773	CLIP-seq
MIRT1319056	hsa-miR-4804-3p	CLIP-seq
MIRT1319057	hsa-miR-587	CLIP-seq
MIRT1319054	hsa-miR-4696	CLIP-seq
MIRT1319055	hsa-miR-4720-3p	CLIP-seq
MIRT1319058	hsa-miR-4773	CLIP-seq
MIRT1319056	hsa-miR-4804-3p	CLIP-seq
MIRT1319057	hsa-miR-587	CLIP-seq

Show/Hide all (45)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000028	Process	Ribosomal small subunit assembly	IBA
GO:0000028	Process	Ribosomal small subunit assembly	IEA
GO:0001618	Function	Virus receptor activity	IEA
GO:0002181	Process	Cytoplasmic translation	IBA
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003677	Function	DNA binding	IDA	38114488
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003735	Function	Structural constituent of ribosome	HDA	15883184
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0005055	Function	Laminin receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	16169070, 16263087, 21044950, 24212136, 24983501, 25277244, 28514442, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IDA	38114488
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	16130169
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	16263087
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005737	Component	Cytoplasm	TAS	16130169
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005886	Component	Plasma membrane	IDA	16263087
GO:0005886	Component	Plasma membrane	IEA
GO:0006338	Process	Chromatin remodeling	IDA	38114488
GO:0006412	Process	Translation	IC	8706699
GO:0006412	Process	Translation	IEA
GO:0007155	Process	Cell adhesion	IEA
GO:0015935	Component	Small ribosomal subunit	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0022627	Component	Cytosolic small ribosomal subunit	IBA
GO:0022627	Component	Cytosolic small ribosomal subunit	IDA	8706699
GO:0022627	Component	Cytosolic small ribosomal subunit	IEA
GO:0022627	Component	Cytosolic small ribosomal subunit	NAS	25901680
GO:0043022	Function	Ribosome binding	IPI	10079194
GO:0043236	Function	Laminin binding	IEA
GO:0046718	Process	Symbiont entry into host cell	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0140374	Process	Antiviral innate immune response	IDA	38114488
GO:0140374	Process	Antiviral innate immune response	IDA	38114488
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
150370	6502	ENSG00000168028

P08865

Protein name

Small ribosomal subunit protein uS2 (37 kDa laminin receptor precursor) (37LRP) (37/67 kDa laminin receptor) (LRP/LR) (40S ribosomal protein SA) (67 kDa laminin receptor) (67LR) (Colon carcinoma laminin-binding protein) (Laminin receptor 1) (LamR) (Lamini

Protein function

Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface recept

PDB

3BCH , 4UG0 , 4V5Z , 4V6X , 5A2Q , 5AJ0 , 5FLX , 5LKS , 5OA3 , 5T2C , 5VYC , 6FEC , 6G18 , 6G4S , 6G51 , 6G53 , 6G5H , 6G5I , 6IP5 , 6IP6 , 6IP8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6YBD , 6YBW , 6Z6L , 6Z6M , 6Z6N , 6ZLW , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZMT , 6ZMW , 6ZN5 , 6ZOJ , 6ZOK , 6ZON , 6ZP4 , 6ZUO

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00318	Ribosomal_S2	18 → 118	Ribosomal protein S2	Family
PF00318	Ribosomal_S2	111 → 184	Ribosomal protein S2	Family
PF16122	40S_SA_C	202 → 295	40S ribosomal protein SA C-terminus	Family

Sequence

MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLL
AARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREPR
LLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAR
EVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTA
TQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTDWS

Sequence length

295

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Familial isolated congenital asplenia	Pathogenic; Likely pathogenic	rs397514759, rs398122389, rs397514760, rs397514761, rs397514762, rs397514763	RCV000054822 RCV000054823 RCV000054824 RCV000054825 RCV000054826 RCV000054827 RCV000054828

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Familial cancer of breast	Likely benign	rs62242645	RCV005934809
Malignant tumor of esophagus	Likely benign	rs62242645	RCV005934810
RPSA-related disorder	Uncertain significance; Likely benign; Benign	rs758186843, rs190008375, rs369708612, rs529221890	RCV003953943 RCV004756408 RCV003427961 RCV003918602
Thymoma	Likely benign	rs62242645	RCV005934811
Thyroid cancer, nonmedullary, 1	Likely benign	rs190008375	RCV005932126

Show/Hide Text Mining Associations (46)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	1443045
Alzheimer Disease	Associate	24048171, 24048412, 35766008, 40037473
Angiodysplasia	Associate	31498527
Arthritis Rheumatoid	Inhibit	30718719
Bone Marrow Diseases	Associate	7911032
Breast Neoplasms	Associate	26427016, 26545108
Carcinogenesis	Associate	40141206
Carcinoma Hepatocellular	Associate	32964027
Cerebral Infarction	Associate	40696650
Classical Lissencephalies and Subcortical Band Heterotopias	Associate	34347028
Colonic Neoplasms	Associate	40141206
Colorectal Neoplasms	Associate	24460263, 26293895, 29843646, 33836696, 40141206
Coronary Artery Disease	Associate	38267845
Creutzfeldt Jakob Syndrome	Associate	21838916
Death	Associate	29843646
Developmental Disabilities	Associate	34347028
Drug Related Side Effects and Adverse Reactions	Associate	20096012, 24048171
Drug Related Side Effects and Adverse Reactions	Stimulate	25013807
Esophageal Neoplasms	Associate	17960614
Esophageal Squamous Cell Carcinoma	Associate	17960614
Glioma	Associate	25778325
Heterotaxy Syndrome	Associate	31498527
Hypoxia	Stimulate	20491781, 28618937
Hypoxia Brain	Associate	28618937
Inflammation	Associate	30718719
Inflammatory Bowel Diseases	Inhibit	29723847
Leukemia	Associate	21056082
Leukemia Myeloid Acute	Associate	23916810
Liposarcoma	Associate	18820673
Lung Diseases	Associate	23472084
Lung Neoplasms	Associate	23374247, 23472084, 28618937, 36579897
Melanoma	Associate	10735498, 20548792
Myocardial Infarction	Associate	36769107
Neoplasm Metastasis	Associate	20491781, 23472084, 25778325, 26545108, 28618937, 30894280, 36579897, 8940117
Neoplasms	Associate	12875970, 1443045, 14614142, 18820673, 20491781, 21895963, 23472084, 25778325, 26062445, 26427016, 36579897, 7911032, 8940117, 8999943
Neoplasms	Stimulate	17960614, 26545108
Nevus Pigmented	Associate	10735498
Ovarian Neoplasms	Associate	21193558
Pancreatic Neoplasms	Associate	30894280
Personality Disorders	Associate	21895963
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	20096012
Prion Diseases	Associate	21838916
Rectal Neoplasms	Associate	24460263
Stomach Neoplasms	Associate	12440778, 20491781, 24706505
Varicose Veins	Associate	31498527
Zika Virus Infection	Associate	34282707

RPSA (ribosomal protein SA)