Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
392
Gene name Gene Name - the full gene name approved by the HGNC.
Rho GTPase activating protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ARHGAP1
Synonyms (NCBI Gene) Gene synonyms aliases
CDC42GAP, RHOGAP, RHOGAP1, p50rhoGAP
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11p11.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated protein family members. [provided b
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020316 hsa-miR-130b-3p Sequencing 20371350
MIRT025280 hsa-miR-34a-5p Proteomics 21566225
MIRT025280 hsa-miR-34a-5p Proteomics 21566225
MIRT025280 hsa-miR-34a-5p Sequencing 20371350
MIRT025280 hsa-miR-34a-5p Proteomics 21566225
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005096 Function GTPase activator activity IDA 8253717, 8288572
GO:0005515 Function Protein binding IPI 9262406, 9846874, 12901880, 16189514, 31467278, 32296183
GO:0005737 Component Cytoplasm IDA 25468996
GO:0005829 Component Cytosol TAS
GO:0007264 Process Small GTPase mediated signal transduction IDA 8253717, 8288572
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602732 673 ENSG00000175220
Protein
UniProt ID Q07960
Protein name Rho GTPase-activating protein 1 (CDC42 GTPase-activating protein) (GTPase-activating protein rhoGAP) (Rho-related small GTPase protein activator) (Rho-type GTPase-activating protein 1) (p50-RhoGAP)
Protein function GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.
PDB 1AM4 , 1GRN , 1OW3 , 1RGP , 1TX4 , 2NGR , 5M6X , 5M70 , 6R3V , 7QSC , 7QTM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13716 CRAL_TRIO_2 82 216 Divergent CRAL/TRIO domain Domain
PF00620 RhoGAP 260 408 RhoGAP domain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous.
Sequence
Sequence length 439
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Rho GTPase cycle
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
22530067
Unknown
Disease term Disease name Evidence References Source
Hypertrophic cardiomyopathy Hypertrophic cardiomyopathy GWAS
Diabetes Diabetes GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 23200924
Adenocarcinoma of Lung Associate 35291911
Breast Neoplasms Associate 27216196, 37511111
Carcinogenesis Associate 36676763
Carcinoma Hepatocellular Associate 24443565, 28000796, 35763041, 36168627
Glioblastoma Associate 23200924
Glioma Associate 24316134
Holt Oram syndrome Associate 31836741
Neoplasm Metastasis Associate 37511111
Neoplasms Associate 18829524, 23684608, 24386239, 25743845, 32606003, 34727930