Gene Gene information from NCBI Gene database.
Entrez ID 392
Gene name Rho GTPase activating protein 1
Gene symbol ARHGAP1
Synonyms (NCBI Gene)
CDC42GAPRHOGAPRHOGAP1p50rhoGAP
Chromosome 11
Chromosome location 11p11.2
Summary This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated protein family members. [provided b
miRNA miRNA information provided by mirtarbase database.
1467
miRTarBase ID miRNA Experiments Reference
MIRT020316 hsa-miR-130b-3p Sequencing 20371350
MIRT025280 hsa-miR-34a-5p Proteomics 21566225
MIRT025280 hsa-miR-34a-5p Proteomics 21566225
MIRT025280 hsa-miR-34a-5p Sequencing 20371350
MIRT025280 hsa-miR-34a-5p Proteomics 21566225
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
33
GO ID Ontology Definition Evidence Reference
GO:0001726 Component Ruffle IEA
GO:0005096 Function GTPase activator activity IBA
GO:0005096 Function GTPase activator activity IDA 8253717, 8288572
GO:0005096 Function GTPase activator activity IEA
GO:0005096 Function GTPase activator activity TAS 8288572
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602732 673 ENSG00000175220
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q07960
Protein name Rho GTPase-activating protein 1 (CDC42 GTPase-activating protein) (GTPase-activating protein rhoGAP) (Rho-related small GTPase protein activator) (Rho-type GTPase-activating protein 1) (p50-RhoGAP)
Protein function GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.
PDB 1AM4 , 1GRN , 1OW3 , 1RGP , 1TX4 , 2NGR , 5M6X , 5M70 , 6R3V , 7QSC , 7QTM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13716 CRAL_TRIO_2 82 216 Divergent CRAL/TRIO domain Domain
PF00620 RhoGAP 260 408 RhoGAP domain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous.
Sequence
Sequence length 439
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Rho GTPase cycle