Gene Gene information from NCBI Gene database.
Entrez ID 3916
Gene name Lysosomal associated membrane protein 1
Gene symbol LAMP1
Synonyms (NCBI Gene)
CD107aLAMPALGP120
Chromosome 13
Chromosome location 13q34
Summary The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008]
miRNA miRNA information provided by mirtarbase database.
140
miRTarBase ID miRNA Experiments Reference
MIRT019659 hsa-miR-378a-3p Sequencing 20371350
MIRT023236 hsa-miR-122-5p Microarray 17612493
MIRT019659 hsa-miR-378a-3p CLASH 23622248
MIRT041727 hsa-miR-484 CLASH 23622248
MIRT039887 hsa-miR-615-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
64
GO ID Ontology Definition Evidence Reference
GO:0000421 Component Autophagosome membrane IEA
GO:0001618 Function Virus receptor activity IEA
GO:0005515 Function Protein binding IPI 21194361, 23394946, 24970085, 32296183, 37390818
GO:0005737 Component Cytoplasm IDA 21266579
GO:0005764 Component Lysosome IDA 15613468
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
153330 6499 ENSG00000185896
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P11279
Protein name Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (CD107 antigen-like family member A) (CD antigen CD107a)
Protein function Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis (PubMed:37390818). Acts as an important regulator of lysosomal lumen pH regulation by acting as
PDB 8ATH , 8FY5 , 8FYF , 9C59 , 9C5A , 9C5B
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01299 Lamp 217 365 Lysosome-associated membrane glycoprotein (Lamp) Family
Sequence
MAAPGSARRPLLLLLLLLLLGLMHCASAAMFMVKNGNGTACIMANFSAAFSVNYDTKSGP
KNMTFDLPSDATVVLNRSSCGKENTSDPSLVIAFGRGHTLTLNFTRNATRYSVQLMSFVY
NLSDTHLFPNASSKEIKTVESITDIRADIDKKYRCVSGTQVHMNNVTVTLHDATIQAYLS
NSSFSRGETRCEQDRPSPTTAPPAPPSPSPSPVPKSPSVDKYNVSGTNGTCLLASMGLQL
NLTYERKDNTTVTRLLNINPNKTSASGSCGAHLVTLELHSEGTTVLLFQFGMNASSSRFF
LQGIQLNTILPDARDPAFKAANGSLRALQATVGNSYKCNAEEHVRVTKAFSVNIFKVWVQ
AFKVE
GGQFGSVEECLLDENSMLIPIAVGGALAGLVLIVLIAYLVGRKRSHAGYQTI
Sequence length 417
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Virion - Hepatitis viruses
Virion - Lassa virus and SFTS virus
Autophagy - animal
Lysosome
Phagosome
Tuberculosis
  Neutrophil degranulation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenocarcinoma of Lung Associate 32873769
★☆☆☆☆
Found in Text Mining only
Adenoma Associate 31784980
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Associate 26627638, 28984607, 37418137
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Alzheimer Disease Stimulate 26936765
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Ascites Inhibit 21203522
★☆☆☆☆
Found in Text Mining only
Asthma Associate 25633562
★☆☆☆☆
Found in Text Mining only
Astrocytoma Associate 23826410
★☆☆☆☆
Found in Text Mining only
Behcet Syndrome Associate 28170096, 30319620
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 19522481, 27560716, 34543006, 7511141
★☆☆☆☆
Found in Text Mining only
Calcinosis Cutis Associate 1544942
★☆☆☆☆
Found in Text Mining only