Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3916
Gene name Gene Name - the full gene name approved by the HGNC.	Lysosomal associated membrane protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	LAMP1
Synonyms (NCBI Gene) Gene synonyms aliases	CD107a, LAMPA, LGP120
Chromosome Chromosome number	13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	13q34
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008]

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miRTarBase ID	miRNA	Experiments	Reference
MIRT019659	hsa-miR-378a-3p	Sequencing	20371350
MIRT023236	hsa-miR-122-5p	Microarray	17612493
MIRT019659	hsa-miR-378a-3p	CLASH	23622248
MIRT041727	hsa-miR-484	CLASH	23622248
MIRT039887	hsa-miR-615-3p	CLASH	23622248
MIRT036408	hsa-miR-1227-3p	CLASH	23622248
MIRT438535	hsa-miR-23a-3p	Luciferase reporter assay, qRT-PCR	25030422
MIRT438535	hsa-miR-23a-3p	Luciferase reporter assay, qRT-PCR	25030422
MIRT438535	hsa-miR-23a-3p	Luciferase reporter assay, qRT-PCR	25030422
MIRT438535	hsa-miR-23a-3p	Luciferase reporter assay, qRT-PCR	25030422
MIRT1103475	hsa-miR-1255a	CLIP-seq
MIRT1103476	hsa-miR-1255b	CLIP-seq
MIRT1103477	hsa-miR-1267	CLIP-seq
MIRT1103478	hsa-miR-153	CLIP-seq
MIRT1103479	hsa-miR-2276	CLIP-seq
MIRT1103480	hsa-miR-23a	CLIP-seq
MIRT1103481	hsa-miR-23b	CLIP-seq
MIRT1103482	hsa-miR-23c	CLIP-seq
MIRT1103483	hsa-miR-3160-3p	CLIP-seq
MIRT1103484	hsa-miR-3176	CLIP-seq
MIRT1103485	hsa-miR-3177-5p	CLIP-seq
MIRT1103486	hsa-miR-320a	CLIP-seq
MIRT1103487	hsa-miR-320b	CLIP-seq
MIRT1103488	hsa-miR-320c	CLIP-seq
MIRT1103489	hsa-miR-320d	CLIP-seq
MIRT1103490	hsa-miR-3545-3p	CLIP-seq
MIRT1103491	hsa-miR-3664-5p	CLIP-seq
MIRT1103492	hsa-miR-3919	CLIP-seq
MIRT1103493	hsa-miR-3922-3p	CLIP-seq
MIRT1103494	hsa-miR-4281	CLIP-seq
MIRT1103495	hsa-miR-4429	CLIP-seq
MIRT1103496	hsa-miR-4433	CLIP-seq
MIRT1103497	hsa-miR-4459	CLIP-seq
MIRT1103498	hsa-miR-4487	CLIP-seq
MIRT1103499	hsa-miR-4539	CLIP-seq
MIRT1103500	hsa-miR-4640-3p	CLIP-seq
MIRT1103501	hsa-miR-4696	CLIP-seq
MIRT1103502	hsa-miR-4714-5p	CLIP-seq
MIRT1103503	hsa-miR-4756-3p	CLIP-seq
MIRT1103504	hsa-miR-4768-3p	CLIP-seq
MIRT1103505	hsa-miR-548al	CLIP-seq
MIRT1103506	hsa-miR-558	CLIP-seq
MIRT1103475	hsa-miR-1255a	CLIP-seq
MIRT1103476	hsa-miR-1255b	CLIP-seq
MIRT2028269	hsa-miR-1265	CLIP-seq
MIRT1103477	hsa-miR-1267	CLIP-seq
MIRT1103478	hsa-miR-153	CLIP-seq
MIRT2028270	hsa-miR-2054	CLIP-seq
MIRT1103479	hsa-miR-2276	CLIP-seq
MIRT2028271	hsa-miR-2392	CLIP-seq
MIRT1103480	hsa-miR-23a	CLIP-seq
MIRT1103481	hsa-miR-23b	CLIP-seq
MIRT1103482	hsa-miR-23c	CLIP-seq
MIRT2028272	hsa-miR-3183	CLIP-seq
MIRT2028273	hsa-miR-3591-3p	CLIP-seq
MIRT2028274	hsa-miR-3613-5p	CLIP-seq
MIRT2028275	hsa-miR-4326	CLIP-seq
MIRT2028276	hsa-miR-452	CLIP-seq
MIRT2028277	hsa-miR-4653-3p	CLIP-seq
MIRT2028278	hsa-miR-4672	CLIP-seq
MIRT2028279	hsa-miR-4676-3p	CLIP-seq
MIRT2028280	hsa-miR-4684-5p	CLIP-seq
MIRT1103501	hsa-miR-4696	CLIP-seq
MIRT2028281	hsa-miR-4723-3p	CLIP-seq
MIRT2028282	hsa-miR-4773	CLIP-seq
MIRT2028283	hsa-miR-548c-3p	CLIP-seq
MIRT2028284	hsa-miR-550a	CLIP-seq
MIRT2028285	hsa-miR-580	CLIP-seq
MIRT2028286	hsa-miR-642a	CLIP-seq
MIRT2028287	hsa-miR-651	CLIP-seq
MIRT2259421	hsa-miR-106a	CLIP-seq
MIRT2259422	hsa-miR-106b	CLIP-seq
MIRT2259423	hsa-miR-1202	CLIP-seq
MIRT1103475	hsa-miR-1255a	CLIP-seq
MIRT1103476	hsa-miR-1255b	CLIP-seq
MIRT1103477	hsa-miR-1267	CLIP-seq
MIRT2259424	hsa-miR-129-3p	CLIP-seq
MIRT2259425	hsa-miR-1303	CLIP-seq
MIRT1103478	hsa-miR-153	CLIP-seq
MIRT2259426	hsa-miR-17	CLIP-seq
MIRT2259427	hsa-miR-20a	CLIP-seq
MIRT2259428	hsa-miR-20b	CLIP-seq
MIRT1103479	hsa-miR-2276	CLIP-seq
MIRT1103480	hsa-miR-23a	CLIP-seq
MIRT1103481	hsa-miR-23b	CLIP-seq
MIRT1103482	hsa-miR-23c	CLIP-seq
MIRT2259429	hsa-miR-3130-5p	CLIP-seq
MIRT2259430	hsa-miR-3158-5p	CLIP-seq
MIRT1103483	hsa-miR-3160-3p	CLIP-seq
MIRT2259431	hsa-miR-3166	CLIP-seq
MIRT2259432	hsa-miR-3194-5p	CLIP-seq
MIRT1103486	hsa-miR-320a	CLIP-seq
MIRT1103487	hsa-miR-320b	CLIP-seq
MIRT1103488	hsa-miR-320c	CLIP-seq
MIRT1103489	hsa-miR-320d	CLIP-seq
MIRT2259433	hsa-miR-342-3p	CLIP-seq
MIRT1103490	hsa-miR-3545-3p	CLIP-seq
MIRT2028273	hsa-miR-3591-3p	CLIP-seq
MIRT1103491	hsa-miR-3664-5p	CLIP-seq
MIRT2259434	hsa-miR-3972	CLIP-seq
MIRT2259435	hsa-miR-421	CLIP-seq
MIRT1103495	hsa-miR-4429	CLIP-seq
MIRT2259436	hsa-miR-4482	CLIP-seq
MIRT1103498	hsa-miR-4487	CLIP-seq
MIRT1103499	hsa-miR-4539	CLIP-seq
MIRT2028278	hsa-miR-4672	CLIP-seq
MIRT2259437	hsa-miR-4695-3p	CLIP-seq
MIRT1103501	hsa-miR-4696	CLIP-seq
MIRT2259438	hsa-miR-4709-5p	CLIP-seq
MIRT1103502	hsa-miR-4714-5p	CLIP-seq
MIRT2259439	hsa-miR-4766-3p	CLIP-seq
MIRT2259440	hsa-miR-4771	CLIP-seq
MIRT2028282	hsa-miR-4773	CLIP-seq
MIRT2259441	hsa-miR-4780	CLIP-seq
MIRT2259442	hsa-miR-4802-5p	CLIP-seq
MIRT2259443	hsa-miR-505	CLIP-seq
MIRT2259444	hsa-miR-518e	CLIP-seq
MIRT2259445	hsa-miR-519d	CLIP-seq
MIRT1103505	hsa-miR-548al	CLIP-seq
MIRT2028283	hsa-miR-548c-3p	CLIP-seq
MIRT2259446	hsa-miR-548p	CLIP-seq
MIRT2259447	hsa-miR-548t	CLIP-seq
MIRT1103506	hsa-miR-558	CLIP-seq
MIRT2259448	hsa-miR-93	CLIP-seq
MIRT2438312	hsa-miR-1247	CLIP-seq
MIRT2438313	hsa-miR-1538	CLIP-seq
MIRT1103484	hsa-miR-3176	CLIP-seq
MIRT2259432	hsa-miR-3194-5p	CLIP-seq
MIRT1103486	hsa-miR-320a	CLIP-seq
MIRT1103487	hsa-miR-320b	CLIP-seq
MIRT1103488	hsa-miR-320c	CLIP-seq
MIRT1103489	hsa-miR-320d	CLIP-seq
MIRT1103490	hsa-miR-3545-3p	CLIP-seq
MIRT1103493	hsa-miR-3922-3p	CLIP-seq
MIRT1103495	hsa-miR-4429	CLIP-seq
MIRT1103499	hsa-miR-4539	CLIP-seq
MIRT2438314	hsa-miR-4691-3p	CLIP-seq
MIRT2438315	hsa-miR-4745-3p	CLIP-seq
MIRT2438316	hsa-miR-644	CLIP-seq
MIRT2438317	hsa-miR-663b	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000421	Component	Autophagosome membrane	IEA
GO:0001618	Function	Virus receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	21194361, 23394946, 24970085, 32296183, 37390818
GO:0005737	Component	Cytoplasm	IDA	21266579
GO:0005764	Component	Lysosome	IDA	15613468
GO:0005764	Component	Lysosome	IDA	15052268, 15292400, 16542649, 22792322, 23704327
GO:0005764	Component	Lysosome	IEA
GO:0005764	Component	Lysosome	TAS	3131762
GO:0005765	Component	Lysosomal membrane	IBA
GO:0005765	Component	Lysosomal membrane	IDA	16176980
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005765	Component	Lysosomal membrane	ISS
GO:0005768	Component	Endosome	IEA
GO:0005770	Component	Late endosome	IDA	15052268, 15292400, 15792797, 16542649, 18388320, 18767904
GO:0005770	Component	Late endosome	IEA
GO:0005771	Component	Multivesicular body	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	20956541
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	3174652
GO:0007042	Process	Lysosomal lumen acidification	IDA	37390818
GO:0007042	Process	Lysosomal lumen acidification	IEA
GO:0008021	Component	Synaptic vesicle	IEA
GO:0008200	Function	Ion channel inhibitor activity	IDA	37390818
GO:0008200	Function	Ion channel inhibitor activity	IEA
GO:0009897	Component	External side of plasma membrane	IEA
GO:0009986	Component	Cell surface	IEA
GO:0010008	Component	Endosome membrane	IEA
GO:0010008	Component	Endosome membrane	ISS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	3174652
GO:0019899	Function	Enzyme binding	IPI	22641697
GO:0019904	Function	Protein domain specific binding	IEA
GO:0031902	Component	Late endosome membrane	IBA
GO:0031902	Component	Late endosome membrane	IEA
GO:0031982	Component	Vesicle	IEA
GO:0035577	Component	Azurophil granule membrane	IEA
GO:0035577	Component	Azurophil granule membrane	TAS
GO:0035752	Process	Lysosomal lumen pH elevation	IDA	35750034
GO:0042383	Component	Sarcolemma	IEA
GO:0042470	Component	Melanosome	IEA
GO:0043323	Process	Positive regulation of natural killer cell degranulation	IMP	23632890
GO:0044194	Component	Cytolytic granule	IEA
GO:0044754	Component	Autolysosome	IEA
GO:0045335	Component	Phagocytic vesicle	IEA
GO:0045954	Process	Positive regulation of natural killer cell mediated cytotoxicity	IMP	23632890
GO:0046718	Process	Symbiont entry into host cell	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IMP	18787122
GO:0050821	Process	Protein stabilization	IEA
GO:0050821	Process	Protein stabilization	ISS
GO:0061474	Component	Phagolysosome membrane	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0072594	Process	Establishment of protein localization to organelle	IBA
GO:0072594	Process	Establishment of protein localization to organelle	IMP	23632890
GO:0090160	Process	Golgi to lysosome transport	IMP	23632890
GO:0101003	Component	Ficolin-1-rich granule membrane	IEA
GO:0101003	Component	Ficolin-1-rich granule membrane	TAS
GO:0101004	Component	Cytolytic granule membrane	IDA	24088571
GO:0101004	Component	Cytolytic granule membrane	IEA
GO:0140507	Process	Granzyme-mediated programmed cell death signaling pathway	IMP	23632890
GO:1902513	Process	Regulation of organelle transport along microtubule	IMP	23632890
GO:1902600	Process	Proton transmembrane transport	IDA	35750034

MIM	HGNC	e!Ensembl
153330	6499	ENSG00000185896

Protein

UniProt ID

P11279

Protein name

Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (CD107 antigen-like family member A) (CD antigen CD107a)

Protein function

Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis (PubMed:37390818). Acts as an important regulator of lysosomal lumen pH regulation by acting as

PDB

8ATH , 8FY5 , 8FYF , 9C59 , 9C5A , 9C5B

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01299	Lamp	217 → 365	Lysosome-associated membrane glycoprotein (Lamp)	Family

Sequence

MAAPGSARRPLLLLLLLLLLGLMHCASAAMFMVKNGNGTACIMANFSAAFSVNYDTKSGP
KNMTFDLPSDATVVLNRSSCGKENTSDPSLVIAFGRGHTLTLNFTRNATRYSVQLMSFVY
NLSDTHLFPNASSKEIKTVESITDIRADIDKKYRCVSGTQVHMNNVTVTLHDATIQAYLS
NSSFSRGETRCEQDRPSPTTAPPAPPSPSPSPVPKSPSVDKYNVSGTNGTCLLASMGLQL
NLTYERKDNTTVTRLLNINPNKTSASGSCGAHLVTLELHSEGTTVLLFQFGMNASSSRFF
LQGIQLNTILPDARDPAFKAANGSLRALQATVGNSYKCNAEEHVRVTKAFSVNIFKVWVQ
AFKVEGGQFGSVEECLLDENSMLIPIAVGGALAGLVLIVLIAYLVGRKRSHAGYQTI

Sequence length

417

Interactions

View interactions

	KEGG		Reactome
	Virion - Hepatitis viruses Virion - Lassa virus and SFTS virus Autophagy - animal Lysosome Phagosome Tuberculosis		Neutrophil degranulation

LAMP1 (lysosomal associated membrane protein 1)