Gene Gene information from NCBI Gene database.
Entrez ID 390
Gene name Rho family GTPase 3
Gene symbol RND3
Synonyms (NCBI Gene)
ARHERho8RhoEmemB
Chromosome 2
Chromosome location 2q23.3
Summary This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Mult
miRNA miRNA information provided by mirtarbase database.
865
miRTarBase ID miRNA Experiments Reference
MIRT006511 hsa-miR-200b-3p Luciferase reporter assay 20683643
MIRT006511 hsa-miR-200b-3p Luciferase reporter assay 20683643
MIRT006511 hsa-miR-200b-3p Luciferase reporter assay 20683643
MIRT006511 hsa-miR-200b-3p Luciferase reporter assay 20683643
MIRT006511 hsa-miR-200b-3p Luciferase reporter assay 20683643
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
AES Activation 23546594
FOXD3 Unknown 21478267
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
22
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000166 Function Nucleotide binding IEA
GO:0003924 Function GTPase activity IBA
GO:0003924 Function GTPase activity IEA
GO:0003924 Function GTPase activity TAS 8649376
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602924 671 ENSG00000115963
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P61587
Protein name Rho-related GTP-binding protein RhoE (Protein MemB) (Rho family GTPase 3) (Rho-related GTP-binding protein Rho8) (Rnd3)
Protein function Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.
PDB 1M7B , 2V55 , 4BG6 , 7OBC , 7OBD , 8B2K , 8BFC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 25 199 Ras family Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous.
Sequence
Sequence length 244
Interactions View interactions