Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
390
Gene name Gene Name - the full gene name approved by the HGNC.
Rho family GTPase 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RND3
Synonyms (NCBI Gene) Gene synonyms aliases
ARHE, Rho8, RhoE, memB
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q23.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Mult
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006511 hsa-miR-200b-3p Luciferase reporter assay 20683643
MIRT006511 hsa-miR-200b-3p Luciferase reporter assay 20683643
MIRT006511 hsa-miR-200b-3p Luciferase reporter assay 20683643
MIRT006511 hsa-miR-200b-3p Luciferase reporter assay 20683643
MIRT006511 hsa-miR-200b-3p Luciferase reporter assay 20683643
Transcription factors
Transcription factor Regulation Reference
AES Activation 23546594
FOXD3 Unknown 21478267
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000166 Function Nucleotide binding IEA
GO:0003924 Function GTPase activity IBA
GO:0003924 Function GTPase activity IEA
GO:0003924 Function GTPase activity TAS 8649376
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602924 671 ENSG00000115963
Protein
UniProt ID P61587
Protein name Rho-related GTP-binding protein RhoE (Protein MemB) (Rho family GTPase 3) (Rho-related GTP-binding protein Rho8) (Rnd3)
Protein function Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.
PDB 1M7B , 2V55 , 4BG6 , 7OBC , 7OBD , 8B2K , 8BFC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 25 199 Ras family Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous.
Sequence
Sequence length 244
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Ovarian cancer Epithelial ovarian cancer N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acute Aortic Syndrome Associate 33953793
Carcinogenesis Associate 25372032
Carcinoma Hepatocellular Associate 15826317, 38218945
Carcinoma Non Small Cell Lung Inhibit 25372032
Cardiovascular Diseases Associate 23420841
Diabetes Mellitus Type 2 Associate 30938105
Ectodermal Dysplasia Anhidrotic with Immunodeficiency Osteopetrosis and Lymphedema Associate 27023521
Endometriosis Associate 23472165, 30010178
Gastroesophageal Reflux Associate 29551738
Glioblastoma Associate 36496976